CN109316628A - A kind of gel and its preparation method and application - Google Patents
A kind of gel and its preparation method and application Download PDFInfo
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- CN109316628A CN109316628A CN201811113276.5A CN201811113276A CN109316628A CN 109316628 A CN109316628 A CN 109316628A CN 201811113276 A CN201811113276 A CN 201811113276A CN 109316628 A CN109316628 A CN 109316628A
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- gel
- hyaluronic acid
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- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 50
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 50
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 50
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 20
- 239000004632 polycaprolactone Substances 0.000 claims abstract description 20
- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 20
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 20
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 24
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 18
- 229960004194 lidocaine Drugs 0.000 claims description 18
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 15
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 15
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 15
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 229960000271 arbutin Drugs 0.000 claims description 13
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 13
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 claims description 13
- 239000003431 cross linking reagent Substances 0.000 claims description 12
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical group OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 10
- 239000000419 plant extract Substances 0.000 claims description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 235000006708 antioxidants Nutrition 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 230000003796 beauty Effects 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 244000248825 Peltandra virginica Species 0.000 claims description 3
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 3
- 235000008599 Poria cocos Nutrition 0.000 claims description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 3
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims description 2
- IBVAQQYNSHJXBV-UHFFFAOYSA-N adipic acid dihydrazide Chemical compound NNC(=O)CCCCC(=O)NN IBVAQQYNSHJXBV-UHFFFAOYSA-N 0.000 claims description 2
- 239000000499 gel Substances 0.000 abstract description 61
- 230000000694 effects Effects 0.000 abstract description 18
- 230000014759 maintenance of location Effects 0.000 abstract description 8
- 230000037303 wrinkles Effects 0.000 abstract description 6
- 230000000638 stimulation Effects 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 244000061520 Angelica archangelica Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- -1 polysaccharides compound Chemical class 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a kind of gels and its preparation method and application, belong to field of medicaments.Gel of the invention, comprises the following components in parts by weight: 3~30 parts of polycaprolactone, 4~35 parts of hyaluronic acid, 2~25 parts of polyethylene glycol.The present invention uses polycaprolactone, hyaluronic acid and the polyethylene glycol of specific components, and stability is high, has no stimulation of the skin, and local retention time is long, plasticity is good, the effect that smoothes away wrinkles is obvious.
Description
Technical field
The present invention relates to a kind of gels and its preparation method and application, belong to field of medicaments.
Background technique
In recent years doctor U.S.A quickly grow, wherein artificial chemistry synthesis high molecular material compared with the material of animal origin,
Due to reducing the risk of infectious disease, use is safe, becomes larger its use scope, in order to meet medical cosmetology at this stage
The growth requirement of industry, urgent need invents one kind has good form and effect in a short time, and medium-term and long-term can retain or stimulate and is subcutaneous
Collagen Proliferation, it is most important that the product that can be degraded and be had no toxic side effect by human body completely.
Application No. is 200810009190.8 patent disclose it is a kind of containing the hyaluronic acid of macromolecule hydrogel or its salt
Suspension and preparation method thereof, but its macromolecular is the cross-linked polysaccharides compound or polymer of one-component, therapeutic effect
It is unobvious, and hyaluronic acid is easy diffusion in vivo and is degraded by the enzyme in injected organism tissue, and retention time is short, cannot play length
The effect of phase beauty.Application No. is 200810009193.1 patents to disclose a kind of mixed gel and preparation method thereof, preparation
Process is cumbersome, and retention time is short in vivo, cannot play the effect of long-term beauty.
Summary of the invention
It is high that a kind of stability is provided it is an object of the invention to overcome in place of above-mentioned the deficiencies in the prior art, to skin without
Stimulation, local retention time is long, plasticity is good, apparent gel of the effect that smoothes away wrinkles and its preparation method and application.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of gel comprises the following components in parts by weight:
3~30 parts of polycaprolactone, 4~35 parts of hyaluronic acid, 2~25 parts of polyethylene glycol.
Polycaprolactone has good biocompatibility, good organic polymer compatibility and good biology drop
Xie Xing can be used as cell growth support material, may participate in intracorporal metabolism after degradation, without internal the problem of gathering, in addition,
Polycaprolactone also has good shape memory temperature control property, is widely used in pharmaceutical carrier, medical cosmetology field.Hyalomitome
Acid has special water retention, is the substance that moisture retention is best in presently found nature, referred to as ideal natural guarantor
The wet factor (Natural moisturizing factor, NMF, such as: 2% pure hyaluronic acid aqueous solution can be firmly held
98% moisture), human skin maturation and ageing process also with hyaluronic acid content and metabolism and change, it can change
Kind skin-nourishing metabolism, make skin it is tender, it is smooth, go wrinkle, increase elasticity, prevent aging, be good again while moisturizing
Skin penetration enhancer is used cooperatively with other nutritional ingredients, can play the more preferable effect for promoting nutrient absorption.Poly- second two
Application of the alcohol in cosmetics industry and pharmaceuticals industry is very extensive, has many excellent properties: water solubility, fixedness, life
Reason inertia, mildness, lubricity and makes skin moisturizing, softness, has and feel after happy use etc..The present invention gathers oneself using specific components
Lactone, hyaluronic acid and polyethylene glycol, stability are high, have no stimulation of the skin, local retention time is long, plasticity is good,
The effect that smoothes away wrinkles is obvious.
As the preferred embodiment of gel of the present invention, the gel is comprised the following components in parts by weight: gathering in oneself
20 parts of ester, 25 parts of hyaluronic acid, 20 parts of polyethylene glycol.
As the preferred embodiment of gel of the present invention, the gel further includes the component of following parts by weight: carboxylic first
1~10 part of base cellulose, 1~5 part of plant extracts, 1~10 part of antioxidant, 1~5 part of lidocaine.
As the preferred embodiment of gel of the present invention, the gel further includes the component of following parts by weight: carboxylic first
5 parts of base cellulose, 3 parts of plant extracts, 5 parts of antioxidant, 3 parts of lidocaine.
As the preferred embodiment of gel of the present invention, the antioxidant is arbutin, vitamin C, vitamin
E, at least one of superoxide dismutase.
As the preferred embodiment of gel of the present invention, the plant extracts is safranine flower extract, Radix Angelicae Sinensis mentions
Take at least one of object, tuckahoe extracts, camomile extract, Rhizoma Atractylodis Macrocephalae extract.
Second aspect, the present invention provides the preparation methods of above-mentioned gel, comprising the following steps:
(1) hyaluronic acid gel is made in hyaluronic acid；
(2) other components in addition to hyaluronic acid are mixed according to the ratio and is dissolved in hyaluronic acid water-setting made from step (1)
In glue, gel is obtained.
The preferred embodiment of preparation method as gel of the present invention, in the step (1), hyaluronic acid water-setting
Glue is after hyaluronic acid is dissolved in water, crosslinking agent to be added, is swollen to it.
The preferred embodiment of preparation method as gel of the present invention, in the step (1), the dosage of water is
10 times of bright matter acid weight, the dosage of crosslinking agent are 0.05 times of hyaluronic acid weight, and the crosslinking agent is 1,4-butanediol contracting
At least one of water glycerin ether, adipic dihydrazide.
The third aspect, the present invention provides above-mentioned gel in preparation for the application in the gel of beauty or medical application.
Compared with prior art, the invention has the benefit that the present invention uses the polycaprolactone of specific components, hyalomitome
Acid and polyethylene glycol, gel obtained, stability are high, have no stimulation of the skin, local retention time is long, plasticity is good,
The effect that smoothes away wrinkles is obvious.
Specific embodiment
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Extracting the preparation method comprises the following steps: 10 times of water is added in plant to it for plant extracts of the present invention, is extracted
90~95 DEG C of temperature, extraction time be 4 times, water extract is obtained after concentrate drying；Ethyl alcohol is added in plant after extraction,
Make alcohol content reach 90wt% or more to extract, ethanol extract is obtained after concentrate drying, water extract and ethyl alcohol are extracted
Object merges to get plant extracts.
Embodiment 1
A kind of gel, contains the following parts by weight: 20 parts of polycaprolactone, 25 parts of hyaluronic acid, 20 parts of polyethylene glycol,
5 parts of carboxymethyl cellulose, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
Gel described in the present embodiment the preparation method comprises the following steps:
(1) after hyaluronic acid being dissolved in water, 1,4-butanediol glycidol ether is added as crosslinking agent, is swollen to it
Hyaluronic acid gel, the dosage of water are 10 times of hyaluronic acid weight, and the dosage of crosslinking agent is the 0.05 of hyaluronic acid weight
Times；
(2) by polycaprolactone, polyethylene glycol, carboxymethyl cellulose, safranine flower extract, arbutin, lidocaine by matching
Than mixing and being dissolved in hyaluronic acid gel made from step (1), gel is obtained.
Embodiment 2
A kind of gel, contains the following parts by weight: 3 parts of polycaprolactone, 35 parts of hyaluronic acid, 2 parts of polyethylene glycol, carboxylic
1 part of methylcellulose, 1 part of safranine flower extract, 1 part of arbutin, 1 part of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 3
A kind of gel, contains the following parts by weight: 30 parts of polycaprolactone, 4 parts of hyaluronic acid, 25 parts of polyethylene glycol,
10 parts of carboxymethyl cellulose, 5 parts of safranine flower extract, 10 parts of arbutin, 5 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 4
A kind of gel, contains the following parts by weight: 10 parts of polycaprolactone, 20 parts of hyaluronic acid, 15 parts of polyethylene glycol,
7 parts of carboxymethyl cellulose, 2 parts of safranine flower extract, 4 parts of arbutin, 2 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 5
A kind of gel, contains the following parts by weight: 20 parts of polycaprolactone, 25 parts of hyaluronic acid, 20 parts of polyethylene glycol,
5 parts of carboxymethyl cellulose, 3 parts of angelica extract, 5 parts of vitamin C, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 6
A kind of gel, contains the following parts by weight: 20 parts of polycaprolactone, 25 parts of hyaluronic acid, 20 parts of polyethylene glycol,
5 parts of carboxymethyl cellulose, 3 parts of tuckahoe extracts, 5 parts of vitamin E, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 7
A kind of gel, contains the following parts by weight: 20 parts of polycaprolactone, 25 parts of hyaluronic acid, 20 parts of polyethylene glycol,
5 parts of carboxymethyl cellulose, 3 parts of camomile extract, 5 parts of superoxide dismutase, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Comparative example 1
A kind of gel, contains the following parts by weight: 25 parts of hyaluronic acid, 20 parts of polyethylene glycol, carboxymethyl cellulose 5
Part, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
Gel described in the present embodiment the preparation method comprises the following steps:
(1) after hyaluronic acid being dissolved in water, 1,4-butanediol glycidol ether is added as crosslinking agent, is swollen to it
Hyaluronic acid gel, the dosage of water are 10 times of hyaluronic acid weight, and the dosage of crosslinking agent is the 0.05 of hyaluronic acid weight
Times；
(2) polyethylene glycol, carboxymethyl cellulose, safranine flower extract, arbutin, lidocaine are mixed and molten according to the ratio
In the hyaluronic acid gel made from step (1), gel is obtained.
Comparative example 2
A kind of gel, contains the following parts by weight: 20 parts of polycaprolactone, 25 parts of hyaluronic acid, carboxymethyl cellulose 5
Part, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
Gel described in the present embodiment the preparation method comprises the following steps:
(1) after hyaluronic acid being dissolved in water, 1,4-butanediol glycidol ether is added as crosslinking agent, is swollen to it
Hyaluronic acid gel, the dosage of water are 10 times of hyaluronic acid weight, and the dosage of crosslinking agent is the 0.05 of hyaluronic acid weight
Times；
(2) polycaprolactone, carboxymethyl cellulose, safranine flower extract, arbutin, lidocaine are mixed and molten according to the ratio
In the hyaluronic acid gel made from step (1), gel is obtained.
Comparative example 3
A kind of gel, contains the following parts by weight: 35 parts of polycaprolactone, 1 part of hyaluronic acid, 20 parts of polyethylene glycol,
5 parts of carboxymethyl cellulose, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Comparative example 4
A kind of gel, contains the following parts by weight: 15 parts of polycaprolactone, 40 parts of hyaluronic acid, 30 parts of polyethylene glycol,
5 parts of carboxymethyl cellulose, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Effect example 1
The thrust test of the embodiment of the present invention 1~7 and comparative example 1~4
Under the pressure of 15~50N, gel obtained by Examples 1 to 7 can be easier to release, and comparative example 1~2 uses 27G
Syringe needle is not easy to release, and comparative example 3~4 is not pushed away with 27G syringe needle and flowed out.As it can be seen that gel prepared by the present invention can be not only used for applying
It smears, is also applied for injecting.
Effect example 2
The stability test of the embodiment of the present invention 1~7 and comparative example 1~4
Examples 1 to 7 and the resulting gel of comparative example 1~4 are placed in 4 DEG C of refrigerator to save after a week, taking-up is same to set 35 DEG C
~40 DEG C of heat preservation 10min, Examples 1 to 7 gained gel are uniform suspension, and it is significant heavy to occur in comparative example 1~2
Drop has apparent separation of solid and liquid phenomenon, and comparative example 3~4 has a small amount of floccule to generate, viscosity decline.As it can be seen that prepared by the present invention
Gel is with good stability.
Effect example 3
The clinical application of the embodiment of the present invention 1~7 and comparative example 1~4 is tested
It selects 220 healthy rats as subjects, D- is smeared with the amount of 125mg/kg.d at the back of every rat
Galactose solution, it is continuous to smear 40 days, rat aging model is obtained, 11 groups is then divided it in average into, every group 20, applies respectively
Examples 1 to 7 and the resulting gel of comparative example 1~4 are smeared, smearing dosage is 1ml/kg, every component after smearing 60 days and 180 days
Dead 10 of other places, anatomic observation smear position, and the results are shown in Table 1.
Table 1
| 60 days dermis thickness (μm) | 180 days dermis thickness (μm) | |
| Embodiment 1 | 710.2±30.5 | 806.6±25.6 |
| Embodiment 2 | 689.3±32.4 | 786.4±27.6 |
| Embodiment 3 | 684.4±28.6 | 784.5±26.7 |
| Embodiment 4 | 685.6±29.5 | 782.9±30.1 |
| Embodiment 5 | 696.9±27.4 | 792.6±28.7 |
| Embodiment 6 | 695.4±31.5 | 786.4±26.8 |
| Embodiment 7 | 684.9±31.7 | 790.6±24.6 |
| Comparative example 1 | 615.3±31.5 | 580.2±30.6 |
| Comparative example 2 | 613.8±30.4 | 578.6±28.7 |
| Comparative example 3 | 606.8±27.6 | 568.5±30.1 |
| Comparative example 4 | 604.5±24.6 | 577.6±28.6 |
As can be seen from Table 1, dissect rat after 60 days, by histological observation, the smearing position of Examples 1 to 7 by compared with
More collagenous fibres claddings, plays preferable filling effect, the smearing position filler of comparative example 1~4 is by a small amount of collagen
Fiber cladding, filling effect are poor；Rat is dissected after 180 days, by histological observation, Examples 1 to 7 smears the true of position
Skin thickness obviously increases, and smears position and coated by a large amount of collagenous fibres, plays permanent filling effect, comparative example
The dermal filler effect at 1~4 smearing position disappears, and does not play permanent filling effect；And to mouse smear embodiment 1~
7 and the resulting gel of comparative example 1~4 after, smear position do not find it is red, swollen, livid purple etc. reaction.
The result shows that gelling properties of the invention are stablized, after smearing, have no stimulation of the skin, in local retention time
Long, plasticity is good, and the effect that smoothes away wrinkles is obvious, is suitable for beauty and medical application.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of gel, which is characterized in that comprise the following components in parts by weight: 3~30 parts of polycaprolactone, hyaluronic acid 4~35
Part, 2~25 parts of polyethylene glycol.
2. gel as described in claim 1, which is characterized in that comprise the following components in parts by weight: 20 parts of polycaprolactone, transparent
25 parts, 20 parts of polyethylene glycol of matter acid.
3. gel as described in claim 1, which is characterized in that further include the component of following parts by weight: carboxymethyl cellulose 1~
10 parts, 1~5 part of plant extracts, 1~10 part of antioxidant, 1~5 part of lidocaine.
4. gel as claimed in claim 3, which is characterized in that further include the component of following parts by weight: carboxymethyl cellulose 5
Part, 3 parts of plant extracts, 5 parts of antioxidant, 3 parts of lidocaine.
5. gel as claimed in claim 3, which is characterized in that the antioxidant be arbutin, vitamin C, vitamin E,
At least one of superoxide dismutase.
6. gel as claimed in claim 3, which is characterized in that the plant extracts is safranine flower extract, Radix Angelicae Sinensis extraction
At least one of object, tuckahoe extracts, camomile extract, Rhizoma Atractylodis Macrocephalae extract.
7. the preparation method of gel as described in any one of claims 1 to 6, which comprises the following steps:
(1) hyaluronic acid gel is made in hyaluronic acid；
(2) other components in addition to hyaluronic acid are mixed according to the ratio and are dissolved in hyaluronic acid gel made from step (1),
Obtain gel.
8. the preparation method of gel as claimed in claim 7, which is characterized in that in the step (1), hyaluronic acid gel
After hyaluronic acid is dissolved in water, crosslinking agent is added, is swollen to it.
9. the preparation method of gel as claimed in claim 8, which is characterized in that in the step (1), the dosage of water is transparent
10 times of matter acid weight, the dosage of crosslinking agent are 0.05 times of hyaluronic acid weight, and the crosslinking agent is 1,4-butanediol shrink
At least one of glycerin ether, adipic dihydrazide.
10. such as gel according to any one of claims 1 to 6 answering in the gel that preparation is used for beauty or medical application
With.
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| CN112552661A (en) * | 2020-12-10 | 2021-03-26 | 广州科莱瑞迪医疗器材股份有限公司 | Plastic tissue compensation glue and preparation method thereof |
| CN115461037A (en) * | 2020-01-22 | 2022-12-09 | 伊伯萨制药有限公司 | Composition comprising hyaluronic acid and a polyol and/or carboxymethylcellulose |
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