CN108936597A - A kind of carcinoma of the rectum nutraceutical and preparation method thereof - Google Patents
A kind of carcinoma of the rectum nutraceutical and preparation method thereof Download PDFInfo
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- CN108936597A CN108936597A CN201810433939.5A CN201810433939A CN108936597A CN 108936597 A CN108936597 A CN 108936597A CN 201810433939 A CN201810433939 A CN 201810433939A CN 108936597 A CN108936597 A CN 108936597A
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- Prior art keywords
- vitamin
- raw material
- calcium
- rectal cancer
- nutritional food
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- 201000001275 rectum cancer Diseases 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000002417 nutraceutical Substances 0.000 title abstract 4
- 235000021436 nutraceutical agent Nutrition 0.000 title abstract 4
- 235000013305 food Nutrition 0.000 claims abstract description 39
- 208000015634 Rectal Neoplasms Diseases 0.000 claims abstract description 37
- 235000016709 nutrition Nutrition 0.000 claims abstract description 37
- 206010038038 rectal cancer Diseases 0.000 claims abstract description 37
- 230000035764 nutrition Effects 0.000 claims abstract description 12
- 235000019197 fats Nutrition 0.000 claims abstract description 11
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 9
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 9
- 235000015097 nutrients Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims description 58
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- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 24
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
技术领域technical field
本发明属于营养食品技术领域,具体涉及一种直肠癌营养食品及其制备方法。The invention belongs to the technical field of nutritious food, and in particular relates to a rectal cancer nutritious food and a preparation method thereof.
技术背景technical background
据世界卫生组织国际癌症研究中心(IARC)公布的资料显示,2012年全球直肠癌新发病例约136万例,占全部新发癌症病例的9.7%。中国医学科学院肿瘤医院/国家癌症中心的统计数据显示,我国2015年结直肠癌发病率、死亡率在全部恶性肿瘤中均位居前5位。According to the data released by the International Cancer Research Center (IARC) of the World Health Organization, there were approximately 1.36 million new cases of rectal cancer in the world in 2012, accounting for 9.7% of all new cancer cases. Statistics from the Cancer Hospital of the Chinese Academy of Medical Sciences/National Cancer Center show that the incidence and mortality of colorectal cancer in my country in 2015 ranked among the top five among all malignant tumors.
肿瘤自身的能量消耗,宿主对肿瘤的反应以及各种抗肿瘤治疗的干预等均会导致机体出现异常代谢状态。40%~80%的恶性肿瘤患者伴有不同程度的营养不良,约20%的恶性肿瘤患者直接死于营养不良,营养不良严重影响患者的生存时间及生活质量。营养不良通常是由摄人量减少、生理活动下降、机体代谢紊乱引起,将严重影响临床预后。导致肿瘤病人生活质量下降、预后不良及增加肿瘤病人治疗的不良反应、增加感染的风险和死亡率。因此,提高癌症病人的营养状况十分重要,能帮助病人保持体重、减少化疗及放疗的不良反应、提高生活质量、延长肿瘤病人生存期。The energy consumption of the tumor itself, the host's response to the tumor, and the intervention of various anti-tumor treatments will all lead to an abnormal metabolic state in the body. 40% to 80% of malignant tumor patients are accompanied by various degrees of malnutrition, and about 20% of malignant tumor patients die directly from malnutrition. Malnutrition seriously affects the survival time and quality of life of patients. Malnutrition is usually caused by reduced human intake, decreased physiological activities, and metabolic disorders of the body, which will seriously affect the clinical prognosis. It leads to a decrease in the quality of life of cancer patients, poor prognosis, and increases the adverse reactions of cancer patients' treatment, and increases the risk of infection and mortality. Therefore, it is very important to improve the nutritional status of cancer patients, which can help patients maintain weight, reduce adverse reactions of chemotherapy and radiotherapy, improve the quality of life, and prolong the survival period of cancer patients.
化疗是中晚期直肠癌患者综合治疗的重要手段,但化疗药物引起的消化道反应症、免疫力低下、造血系统受抑等不良反应会进一步使患者营养状况恶化;营养不良又会导致肿瘤患者对进一步的化疗等抗肿瘤治疗的耐受力下降。化疗造成营养不良的原因是多方面的,其直接原因是化疗引起的恶心、呕吐、腹泻、胃肠道黏膜损伤、食欲减退等症状,影响营养物质的摄人,同时与化疗药物干扰人体对营养物质的吸收利用有关。在病人化疗期间,营养不良不仅会影响病人自身的生理和心理状态,而且还会影响后期治疗效果以及病人的生活质量,甚至缩短生存期。早期发现并针对营养不良情况给予适当的治疗十分必要。改善化疗病人的营养状况,不仅有助于机体的恢复,提高免疫功能,而且还能提高对化疗的耐受性、改善治疗效果和生存质量,延长生存期。Chemotherapy is an important means of comprehensive treatment for patients with advanced rectal cancer, but adverse reactions such as gastrointestinal reactions, low immunity, and hematopoietic system inhibition caused by chemotherapy drugs will further deteriorate the nutritional status of patients; The tolerance of further anti-tumor therapy such as chemotherapy decreased. There are many reasons for malnutrition caused by chemotherapy. The direct cause is nausea, vomiting, diarrhea, gastrointestinal mucosal damage, loss of appetite and other symptoms caused by chemotherapy, which affect the intake of nutrients, and at the same time interfere with the body's ability to absorb nutrients with chemotherapy drugs. related to the absorption and utilization of substances. During chemotherapy, malnutrition will not only affect the patient's own physical and psychological state, but also affect the effect of later treatment and the quality of life of the patient, and even shorten the survival period. Early detection and appropriate treatment of malnutrition are essential. Improving the nutritional status of chemotherapy patients will not only help the body recover and improve immune function, but also improve tolerance to chemotherapy, improve treatment effects and quality of life, and prolong survival.
以配方食品为形式的肠内营养是直肠癌患者营养支持的首选途径,本发明的配方食品除了能为机体提供充足、全面的营养外,更重要的是增强了肠道黏膜的屏障功能,更符合代谢生理状态,有利于机体蛋白质合成与代谢调节,促进肠道功能和形态恢复,防止细菌和毒素易位,明显减少肠源性感染的发生,是改善化疗患者营养状况的有效手段。对中晚期直肠癌化疗患者的营养状况能够起到一定的改善作用,降低患者不良反应,能有效提高患者的免疫力。Enteral nutrition in the form of formula food is the preferred way of nutritional support for patients with rectal cancer. In addition to providing sufficient and comprehensive nutrition for the body, the formula food of the present invention enhances the barrier function of the intestinal mucosa, making it more It conforms to the physiological state of metabolism, is beneficial to the body’s protein synthesis and metabolic regulation, promotes the recovery of intestinal function and shape, prevents the translocation of bacteria and toxins, and significantly reduces the occurrence of enterogenous infections. It is an effective means to improve the nutritional status of chemotherapy patients. It can improve the nutritional status of patients with advanced rectal cancer chemotherapy, reduce adverse reactions of patients, and effectively improve the immunity of patients.
对于特殊医学用途食品,在美国、欧盟、日本等发达国家都有相应的规定和开发应用;我国GB29922-2013《特殊医学用途配方食品通则》食品安全国家标准中全营养食品明确规定全营养配方食品是指可作为单一营养来源满足患者营养需求的特殊医学用途配方食品。 目前市场上尚无针对直肠癌化疗期间的特殊医学用途食品,特别是针对特定年龄阶段,特定生理状况直肠癌患者进行设计的。而此类食品市场潜力巨大,经济效益高,因此开发此类食品,具有重大的经济效益和社会意义。For foods for special medical purposes, there are corresponding regulations and development and application in the United States, the European Union, Japan and other developed countries; my country's GB29922-2013 "General Rules for Formula Foods for Special Medical Purposes" in the national food safety standard for full-nutrition foods clearly stipulates that full-nutrition formula foods It refers to formula food for special medical purposes that can be used as a single source of nutrition to meet the nutritional needs of patients. At present, there is no food for special medical purpose during chemotherapy of rectal cancer in the market, especially designed for rectal cancer patients with specific ages and specific physiological conditions. And this kind of food has huge market potential and high economic benefits, so the development of this kind of food has great economic benefits and social significance.
发明内容Contents of the invention
本发明的目的是提供一种直肠癌营养食品,能够为机体提供充足、全面的营养外,更重要的是能够增强肠道黏膜的屏障功能,有利于机体蛋白质合成与代谢调节,促进肠道功能和形态恢复,防止细菌和毒素易位,明显减少肠源性感染的发生;本发明同时提供其制备方法。The purpose of the present invention is to provide a nutritional food for rectal cancer, which can provide sufficient and comprehensive nutrition for the body, and more importantly, can enhance the barrier function of the intestinal mucosa, which is beneficial to the protein synthesis and metabolic regulation of the body, and promotes intestinal function. and shape restoration, prevent translocation of bacteria and toxins, and significantly reduce the occurrence of enterogenous infections; the invention also provides a preparation method thereof.
本发明所述的一种直肠癌全营养配方食品,每百克营养食品中营养成分如下:蛋白34g-58g、脂肪1.3g-4g、碳水化合物34g-60g、维生素A 159μg-889μg、维生素D 4μg-13μg、维生素E 4mg-50mg、维生素K1 17μg-185μg、维生素B1 330μg-1mg、维生素B2 332μg-1mg、维生素B6 332μg-1mg、维生素B12 1μg-20μg、烟酸0.9mg-9mg、叶酸88μg-938μg、泛酸2mg-20mg、维生素C 3mg-7.2mg、生物素9μg-85μg、钠300mg-330mg、钾446mg-545mg、铜182μg-230μg、镁73mg-100mg、铁4mg-9mg、锌2mg-8mg、锰99μg-2.5mg、钙215mg-222mg、159mg-164mg、碘27μg-50μg、硒13μg-91μg、铬7μg-228μg、谷氨酰胺1g-6g、精氨酸500mg-1g、银杏黄酮500mg-4g、植物甾醇300mg-600mg。A rectal cancer full nutritional formula food according to the present invention has the following nutritional components per 100 grams of nutritional food: protein 34g-58g, fat 1.3g-4g, carbohydrate 34g-60g, vitamin A 159μg-889μg, vitamin D 4μg -13μg, Vitamin E 4mg-50mg, Vitamin K 1 17μg-185μg, Vitamin B 1 330μg-1mg, Vitamin B 2 332μg-1mg, Vitamin B 6 332μg-1mg, Vitamin B 12 1μg-20μg, Niacin 0.9mg-9mg , folic acid 88μg-938μg, pantothenic acid 2mg-20mg, vitamin C 3mg-7.2mg, biotin 9μg-85μg, sodium 300mg-330mg, potassium 446mg-545mg, copper 182μg-230μg, magnesium 73mg-100mg, iron 4mg-9mg, zinc 2mg-8mg, Manganese 99μg-2.5mg, Calcium 215mg-222mg, 159mg-164mg, Iodine 27μg-50μg, Selenium 13μg-91μg, Chromium 7μg-228μg, Glutamine 1g-6g, Arginine 500mg-1g, Ginkgo flavonoids 500mg-4g, phytosterol 300mg-600mg.
其中:in:
蛋白的原料选自豌豆蛋白与乳清蛋白,或豌豆肽与乳清蛋白;The raw material of protein is selected from pea protein and whey protein, or pea peptide and whey protein;
脂肪的原料选自鱼油与大豆油、菜籽油、花生油、玉米籽油、红花油、紫苏油、翅果油、元宝枫籽油、牡丹籽油、地碱蓬籽油等的一种或几种;The raw material of fat is selected from fish oil, soybean oil, rapeseed oil, peanut oil, corn seed oil, safflower oil, perilla oil, samara oil, ingot maple seed oil, peony seed oil, Suaeda salsa seed oil, etc. or several;
碳水化合物的原料选自低聚木糖、低聚半乳糖、果糖、赤藓糖醇、海带多糖、麦芽糊精、羟丙基淀粉、膳食纤维或抗性淀粉中的一种或多种;果糖优选多聚果糖;膳食纤维优选豌豆膳食纤维;抗性淀粉优选豌豆抗性淀粉;Carbohydrate raw materials are selected from one or more of xylo-oligosaccharides, galacto-oligosaccharides, fructose, erythritol, laminarin, maltodextrin, hydroxypropyl starch, dietary fiber or resistant starch; fructose Polyfructose is preferred; dietary fiber is preferably pea dietary fiber; resistant starch is preferably pea resistant starch;
维生素A的原料选自醋酸视黄酯、棕榈酸视黄酯或β-胡萝卜素中的一种或多种;The raw material of vitamin A is selected from one or more of retinyl acetate, retinyl palmitate or β-carotene;
维生素D的原料选自维生素D2、维生素D3中的一种或两种;The raw material of vitamin D is selected from one or both of vitamin D2 and vitamin D3 ;
维生素E的原料选自D-α-生育三烯酚、dl -α-生育三烯酚、维生素E琥珀酸钙中的一种或多种;D-α-生育三烯酚优选D-α-醋酸生育三烯酚、D-α-琥珀酸生育三烯酚、dl -α-生育三烯酚优选dl -α-醋酸生育三烯酚;The raw material of vitamin E is selected from one or more of D-α-tocotrienol, dl-α-tocotrienol, vitamin E calcium succinate; D-α-tocotrienol is preferably D-α- Tocotrienol acetate, D-α-tocotrienol succinate, dl-α-tocotrienol preferably dl-α-tocotrienol acetate;
维生素B1的原料选自盐酸硫胺素、硝酸硫胺素中的一种或两种;The raw material of vitamin B1 is selected from one or both of thiamine hydrochloride and thiamine nitrate;
维生素B2的原料选自核黄素或核黄素5’-磷酸钠中的一种或两种; The raw material of vitamin B2 is selected from one or both of riboflavin or riboflavin 5'-sodium phosphate;
维生素B6的原料选自盐酸吡哆醇;The raw material of vitamin B6 is selected from pyridoxine hydrochloride ;
维生素B12的原料选自氰钴胺; The raw material of vitamin B12 is selected from cyanocobalamin;
烟酸的原料选自烟酸或烟酰胺中的一种或两种;The raw material of niacin is selected from one or both of niacin or niacinamide;
泛酸的原料选自D-泛酸钙;The raw material of pantothenic acid is selected from D-calcium pantothenate;
维生素C的原料选自L-抗坏血酸、L-抗坏血酸钠、L-抗坏血酸钙或抗坏血酸棕榈酸酯中的一种或多种;The raw material of vitamin C is selected from one or more of L-ascorbic acid, L-sodium ascorbate, L-calcium ascorbate or ascorbyl palmitate;
生物素的原料选自D-生物素;The raw material of biotin is selected from D-biotin;
钠的原料选自氯化钠;The raw material of sodium is selected from sodium chloride;
钾的原料选自磷酸氢二钾、磷酸二氢钾、氯化钾、柠檬酸钾中的一种或多种;The raw material of potassium is selected from one or more of dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride, and potassium citrate;
铜的原料选自硫酸铜或葡萄糖酸铜中的一种或两种;The raw material of copper is selected from one or both of copper sulfate or copper gluconate;
镁的原料选自碳酸镁、硫酸镁、氧化镁、氯化镁或L-苏糖酸镁中的一种或多种;The raw material of magnesium is selected from one or more of magnesium carbonate, magnesium sulfate, magnesium oxide, magnesium chloride or magnesium L-threonate;
铁的原料选自葡萄糖酸亚铁、富马酸亚铁、硫酸亚铁、乳酸亚铁或琥珀酸亚铁中的一种或多种;The raw material of iron is selected from one or more of ferrous gluconate, ferrous fumarate, ferrous sulfate, ferrous lactate or ferrous succinate;
锌的原料选自硫酸锌、柠檬酸锌、柠檬酸锌(三水)、葡萄糖酸锌、氧化锌或乳酸锌中的一种或多种;The zinc raw material is selected from one or more of zinc sulfate, zinc citrate, zinc citrate (trihydrate), zinc gluconate, zinc oxide or zinc lactate;
锰的原料选自硫酸锰或葡萄糖酸锰中的一种或两种;The raw material of manganese is selected from one or both of manganese sulfate or manganese gluconate;
钙的原料选自碳酸钙、醋酸钙、氯化钙、柠檬酸钙、葡萄糖酸钙、乳酸钙、磷酸氢钙、磷酸二氢钙、磷酸三钙(磷酸钙)、硫酸钙、L-乳酸钙或甘油磷酸钙中的一种或多种;The raw material of calcium is selected from calcium carbonate, calcium acetate, calcium chloride, calcium citrate, calcium gluconate, calcium lactate, calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate (calcium phosphate), calcium sulfate, L-calcium lactate or one or more of calcium glycerophosphate;
磷的原料选自磷酸二氢钾;The raw material of phosphorus is selected from potassium dihydrogen phosphate;
碘的原料选自碘酸钾;The raw material of iodine is selected from potassium iodate;
硒的原料选自亚硒酸钠、富硒酵母或L-硒-甲基硒代半胱氨酸中的一种或多种;The raw material of selenium is selected from one or more of sodium selenite, selenium-enriched yeast or L-selenium-methylselenocysteine;
铬的原料选自氯化铬。The raw material of chromium is selected from chromium chloride.
本发明豌豆肽的制备方法为:将含水量25wt.%的豌豆蛋白进行挤压,挤压后,将挤出物冷却、干燥、粉碎,再用中性蛋白酶进行酶解反应。The preparation method of the pea peptide of the present invention is as follows: extruding pea protein with a water content of 25wt.%, cooling, drying and pulverizing the extruded product after extrusion, and performing enzymolysis reaction with neutral protease.
其中:挤压时的温度为60℃,螺杆转速为165r/min,模孔孔径为12mm。Wherein: the temperature during extrusion is 60°C, the screw speed is 165r/min, and the die hole diameter is 12mm.
酶解反应温度为38℃,酶解反应的pH值为7,酶解反应中豌豆蛋白浓度为8.1 g/mL,中性蛋白酶的用量为豌豆蛋白用量的12%。The temperature of the enzymatic hydrolysis reaction was 38°C, the pH value of the enzymatic hydrolysis reaction was 7, the concentration of pea protein in the enzymatic hydrolysis reaction was 8.1 g/mL, and the dosage of neutral protease was 12% of that of pea protein.
酶解反应后,豌豆肽的DPPH清除率、.OH清除率、O2 .-清除率分别为95%、88%、45%。After the enzymatic hydrolysis reaction, the DPPH scavenging rate, . OH scavenging rate, and O 2 .- scavenging rate of pea peptide were 95%, 88%, and 45%, respectively.
本发明所述的直肠癌营养食品的制备方法如下:以直肠癌营养食品质量100克计,将蛋白、碳水化合物、维生素A、维生素D、维生素E、维生素K1、维生素B1、维生素B2、维生素B6、维生素B12、烟酸、叶酸、泛酸、维生素C、生物素、钠、钾、铜、镁、铁、锌、锰、钙、磷、碘、硒、铬、谷氨酰胺、精氨酸、银杏黄酮、植物甾醇营养成分的原料灭菌后,平均分成5份,形成功能袋;The preparation method of the nutritional food for rectal cancer of the present invention is as follows: based on 100 grams of nutritional food for rectal cancer, protein, carbohydrates, vitamin A, vitamin D, vitamin E, vitamin K 1 , vitamin B 1 , vitamin B 2 , vitamin B 6 , vitamin B 12 , niacin, folic acid, pantothenic acid, vitamin C, biotin, sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, selenium, chromium, glutamine, After the raw materials of arginine, ginkgo flavonoids and phytosterol nutrients are sterilized, they are divided into 5 parts on average to form functional bags;
脂肪营养成分的原料灭菌后,平均分成5份,形成能量袋。After sterilization, the raw materials of fat nutrition ingredients are divided into 5 parts on average to form energy bags.
其中:灭菌功率为400-500W,灭菌时间为100-120s。Among them: the sterilization power is 400-500W, and the sterilization time is 100-120s.
本发明所述的直肠癌营养食品的食用方法如下:The edible method of rectal cancer nutritious food of the present invention is as follows:
目标人群的年龄为18-64岁,不包括孕妇和哺乳期妇女;The age of the target group is 18-64 years old, excluding pregnant and lactating women;
用量为:0.4袋/(kg·d),总量不超过27袋;Dosage: 0.4 bag/(kg·d), the total amount shall not exceed 27 bags;
按照以下两种方法之一食用:Consume in one of two ways:
(1)用100-400mL的开水降温至40-60℃,加入功能袋和能量袋中的营养物质,搅拌、摇匀后,直接饮用或经管饲摄入;(1) Use 100-400mL of boiling water to cool down to 40-60°C, add the nutrients in the functional bag and energy bag, stir and shake well, then drink directly or ingest through tube feeding;
(2)将功能袋中的营养物质添加到不含有食盐的日常饮食中食用,日常饮食中含有的脂肪与能量袋中的脂肪含量一致。(2) Add the nutrients in the functional bag to the daily diet that does not contain salt, and the fat content in the daily diet is consistent with the fat content in the energy bag.
本发明产品的销售方式为直接销售给消费者,不通过医院、超市或药店等场所或途径,减少中间环节,降低费用,实现低价薄利销售的特点,消费者可以更经济、更实惠的食用,满足消费者长期食用的要求。The sales method of the product of the present invention is to sell directly to consumers, without going through places or channels such as hospitals, supermarkets or pharmacies, reducing intermediate links, reducing costs, and realizing the characteristics of low-priced and small-profit sales, and consumers can eat more economically and economically. , to meet the long-term consumption requirements of consumers.
本发明的有益效果如下:The beneficial effects of the present invention are as follows:
本发明直肠癌营养食品的效果取决于营养成分的各自作用和彼此间的协同作用。The effect of the nutritional food for rectal cancer of the present invention depends on the respective effects of the nutritional ingredients and the synergistic effects of each other.
本发明中,豌豆蛋白或豌豆肽具有显著高效的清除各种自由基的功效,其DPPH清除率、.OH清除率、O2 .-清除率分别为95%、88%、45%,还具有抗炎症、免疫调节、抑制肾素和ACE酶活性的作用,特别是具有防治癌症引起的与氧化应激有关的并发症作用,该豌豆蛋白或豌豆肽具有选择性清除引起直肠癌的ROS物质DPPH和.OH,而对于能杀死直肠癌细胞的O2 .-具有较低清除率,从而保证了O2 .-的高存在率和高杀癌细胞效果。同时,豌豆商业品种尚无转基因品种,致敏性低,无饲喂不耐受性;豌豆蛋白肽可以针对性清除肾小球肾炎的氧自由基和MDA,来提高患者身体状态,此外与其他蛋白质或肽相比较,它还富含精氨酸,降低了额外补充精氨酸的量。In the present invention, pea protein or pea peptide has a remarkable and efficient effect of scavenging various free radicals, and its DPPH scavenging rate, . OH scavenging rate, and O 2 . Anti-inflammation, immune regulation, and inhibition of renin and ACE enzyme activity, especially for the prevention and treatment of complications related to oxidative stress caused by cancer. The pea protein or pea peptide has the ability to selectively remove the ROS substance DPPH that causes rectal cancer and .OH, but has a lower clearance rate for O 2 .- which can kill rectal cancer cells, thus ensuring a high presence of O 2 .- and a high cancer-killing effect. At the same time, there are no genetically modified varieties of pea commercial varieties, low allergenicity, and no feeding intolerance; pea protein peptides can specifically remove oxygen free radicals and MDA in glomerulonephritis to improve the physical condition of patients. It is also rich in arginine compared to proteins or peptides, reducing the amount of additional supplemental arginine.
乳清蛋白是优质蛋白质,含有β-乳球蛋白、α-乳白蛋白、免疫球蛋白等多种活性成分;乳清蛋白中脂肪、乳糖含量低,较其他动物性蛋白质中的过量饱和脂肪、胆固醇等有害物质少,必需氨基酸种类和含量齐全,营养价值高,易被消化吸收,能增强免疫,能防止血脂和胆固醇升高,对心血管疾病有益;配方中采用豌豆蛋白和乳清蛋白的混合物的形式,结合了植物蛋白和动物蛋白两者优势,避免了单一蛋白的不足,更重要的是可以改善直肠癌患者的负氮身体状态。Whey protein is a high-quality protein, containing β-lactoglobulin, α-lactalbumin, immunoglobulin and other active ingredients; the content of fat and lactose in whey protein is lower than that of excess saturated fat and cholesterol in other animal proteins There are few harmful substances, complete types and contents of essential amino acids, high nutritional value, easy to be digested and absorbed, can enhance immunity, prevent blood lipids and cholesterol from rising, and be beneficial to cardiovascular diseases; the formula uses a mixture of pea protein and whey protein The form combines the advantages of both plant protein and animal protein, avoids the deficiency of a single protein, and more importantly, can improve the negative nitrogen status of rectal cancer patients.
脂肪的原料选自以富含ω-3不饱和脂肪酸为主的大豆油、菜籽油、花生油、玉米籽油、红花油、紫苏油、翅果油、元宝枫籽油、牡丹籽油、地碱蓬籽油等的一种或几种与鱼油按一定比例组成,这种搭配能够充分发挥ω-3不饱和脂肪酸改善细胞膜结构,改善细胞膜运输和免疫功能,促进T淋巴细胞免疫成熟的作用;此外,这些油通过合理搭配价格便宜、易得,脂肪酸组成符合特医食品要求。谷氨酰胺对直肠癌化疗患者有显著的辅助治疗作用,同时可减少化疗的副作用。通过强抗氧化性可以从根源上选择性清除自由基,保留对直肠癌细胞有杀死作用的超氧离子自由基,此外,氧化应激状态得到调整,也可以对改善直肠癌患者血浆中ADA、GSH、PX、CAT、SOD、MDA的表达水平,从而调节患者的身体状态,有利于患者的康复、避免疾病的恶化或复发。The raw material of fat is selected from soybean oil, rapeseed oil, peanut oil, corn seed oil, safflower oil, perilla oil, samara oil, maple seed oil and peony seed oil mainly rich in omega-3 unsaturated fatty acids One or more of Suaeda salsa seed oil and fish oil in a certain proportion, this combination can give full play to omega-3 unsaturated fatty acids to improve cell membrane structure, improve cell membrane transportation and immune function, and promote immune maturation of T lymphocytes In addition, these oils are cheap and easy to obtain through reasonable matching, and the composition of fatty acids meets the requirements of special medical food. Glutamine has a significant adjuvant therapeutic effect on patients with rectal cancer chemotherapy, and can reduce the side effects of chemotherapy. Through strong anti-oxidation, free radicals can be selectively removed from the source, and superoxide ion free radicals that can kill rectal cancer cells can be retained. In addition, the state of oxidative stress can be adjusted, which can also improve the ADA in the plasma of rectal cancer patients. , GSH, PX, CAT, SOD, and MDA expression levels, thereby regulating the patient's physical state, which is conducive to the recovery of the patient and avoiding the deterioration or recurrence of the disease.
与其他功能性低聚糖相比较,低聚木糖具有良好的理化特性和双歧杆菌增殖特性。另外,低聚木糖还有抗氧化性、促进钙吸收、增强机体免疫力、降低直肠癌等作用。赤藓糖醇、低聚半乳糖等可以改善饮食的口感,提高患者的胃口,降低化疗对患者的厌食影响,食用后可以改善患者的抑郁心情,同时与豌豆膳食纤维、抗性淀粉相结合调节肠胃,降低化疗带来的排便不畅等问题。羟丙基淀粉是良好的助悬剂,助悬效果好,不粘壁,易分散,絮凝颗粒细腻。麦芽糊精具有良好的溶解性,可改善产品的流动性。Compared with other functional oligosaccharides, xylooligosaccharides have good physical and chemical properties and bifidobacteria proliferation properties. In addition, xylooligosaccharides also have antioxidant properties, promote calcium absorption, enhance the body's immunity, and reduce rectal cancer. Erythritol, galactooligosaccharides, etc. can improve the taste of the diet, increase the appetite of patients, reduce the anorexia effect of chemotherapy on patients, and improve the depression of patients after eating. At the same time, they can be combined with pea dietary fiber and resistant starch to regulate Stomach, reduce the problems such as poor defecation caused by chemotherapy. Hydroxypropyl starch is a good suspending agent with good suspending effect, non-sticky wall, easy to disperse, and fine flocculated particles. Maltodextrin has good solubility and can improve the fluidity of the product.
精氨酸增强的肠外营养改善晚期直肠癌化疗患者的免疫功能,保护肠黏膜的免疫屏障,效果明显。Arginine-enhanced parenteral nutrition improves immune function and protects the immune barrier of intestinal mucosa in patients with advanced rectal cancer undergoing chemotherapy.
本发明高蛋白、高碳水化合物、低脂肪配方适合直肠癌食用者身体特点,有利于身体处康复。本发明的营养食品除了能为机体提供充足、全面的营养外,更重要的是增强了肠道黏膜的屏障功能,更符合代谢生理状态,有利于机体蛋白质合成与代谢调节,促进肠道功能和形态恢复,防止细菌和毒素易位,明显减少肠源性感染的发生,是改善化疗患者营养状况的有效手段。对中晚期直肠癌化疗患者的营养状况能够起到一定的改善作用,降低患者不良反应,能有效提高患者的免疫力。The high-protein, high-carbohydrate and low-fat formula of the present invention is suitable for the physical characteristics of rectal cancer eaters, and is beneficial to the recovery of the body. In addition to providing sufficient and comprehensive nutrition for the body, the nutritious food of the present invention enhances the barrier function of the intestinal mucosa, is more in line with the metabolic physiological state, is beneficial to the protein synthesis and metabolic regulation of the body, and promotes intestinal function and Morphological recovery, prevention of translocation of bacteria and toxins, and significantly reducing the occurrence of enterogenous infections are effective means to improve the nutritional status of chemotherapy patients. It can improve the nutritional status of patients with advanced rectal cancer chemotherapy, reduce adverse reactions of patients, and effectively improve the immunity of patients.
具体实施方式Detailed ways
以下结合实施例对本发明做进一步描述。The present invention is further described below in conjunction with embodiment.
实施例 1Example 1
每百克直肠癌营养食品营养成分如下:蛋白37g、脂肪2.5g、碳水化合物56.5g、维生素A249.42μg、维生素D 5.2μg、维生素E 4mg、维生素K1 19μg、维生素B1 0.4mg、维生素B2 0.4mg、维生素B6 0.45mg、维生素B12 1μg、烟酸0.915mg、叶酸205μg、泛酸2.43mg、维生素C 7.2mg、生物素15μg、钠61.33mg、钾99.41mg、铜200μg、镁73.2mg、铁4.28mg、锌2.4mg、锰100.13μg、钙47.12mg、磷160.01mg、碘29.67μg、硒15.07μg、铬7.82μg、谷氨酰胺100mg、精氨酸150mg、银杏黄酮150mg、植物甾醇550mg。The nutritional ingredients per 100 grams of rectal cancer nutrition food are as follows: protein 37g, fat 2.5g, carbohydrate 56.5g, vitamin A 249.42μg, vitamin D 5.2μg, vitamin E 4mg, vitamin K 1 19μg, vitamin B 1 0.4mg, vitamin B 2 0.4mg, vitamin B 6 0.45mg, vitamin B 12 1μg, niacin 0.915mg, folic acid 205μg, pantothenic acid 2.43mg, vitamin C 7.2mg, biotin 15μg, sodium 61.33mg, potassium 99.41mg, copper 200μg, magnesium 73.2mg , Iron 4.28mg, Zinc 2.4mg, Manganese 100.13μg, Calcium 47.12mg, Phosphorus 160.01mg, Iodine 29.67μg, Selenium 15.07μg, Chromium 7.82μg, Glutamine 100mg, Arginine 150mg, Ginkgo Flavonoids 150mg, Phytosterol 550mg .
制备每百克营养食品中的原料如下:Prepare the raw materials in every hectogram nutritious food as follows:
豌豆肽25g、乳清蛋白12g、大豆油1g、牡丹籽油0.5g、地碱蓬籽油0.5g、鱼油0.5g、果糖30g、豌豆膳食纤维10g、羟丙基淀粉10g、低聚木糖5g、赤藓糖醇1.5g、醋酸视黄酯260μg、维生素D25.2μg、D-α-生育三烯酚16mg、维生素K119μg、盐酸硫胺素400μg、核黄素400μg、盐酸吡哆醇450μg、氰钴胺1μg、烟酸915μg、叶酸205μg、D-泛酸钙2.7mg、L-抗坏血酸7.2mg、D-生物素15μg、氯化钠156mg、柠檬酸钾260mg、硫酸铜500μg、氧化镁122mg、富马酸亚铁13mg、氧化锌3mg、硫酸锰170μg、柠檬酸钙270mg、磷酸二氢钾702mg、碘酸钾50μg、亚硒酸钠33μg、氯化铬40μg、谷氨酰胺100mg、精氨酸150mg、银杏黄酮150mg、植物甾醇550mg。Pea peptide 25g, whey protein 12g, soybean oil 1g, peony seed oil 0.5g, Suaeda salsa seed oil 0.5g, fish oil 0.5g, fructose 30g, pea dietary fiber 10g, hydroxypropyl starch 10g, xylo-oligosaccharide 5g , Erythritol 1.5g, Retinyl Acetate 260μg, Vitamin D 2 5.2μg, D-α-Tocotrienol 16mg, Vitamin K 1 19μg, Thiamine Hydrochloride 400μg, Riboflavin 400μg, Pyridoxine Hydrochloride 450μg, cyanocobalamin 1μg, niacin 915μg, folic acid 205μg, D-calcium pantothenate 2.7mg, L-ascorbic acid 7.2mg, D-biotin 15μg, sodium chloride 156mg, potassium citrate 260mg, copper sulfate 500μg, magnesium oxide 122mg , ferrous fumarate 13mg, zinc oxide 3mg, manganese sulfate 170μg, calcium citrate 270mg, potassium dihydrogen phosphate 702mg, potassium iodate 50μg, sodium selenite 33μg, chromium chloride 40μg, glutamine 100mg, arginine Acid 150mg, Ginkgo flavonoids 150mg, Phytosterol 550mg.
制备方法如下:The preparation method is as follows:
将豌豆肽、乳清蛋白、果糖、豌豆膳食纤维、羟丙基淀粉、低聚木糖、赤藓糖醇、醋酸视黄酯、维生素D2、D-α-醋酸生育三烯酚、维生素K1、盐酸硫胺素、核黄素、盐酸吡哆醇、氰钴胺、烟酸、叶酸、D-泛酸钙、L-抗坏血酸、D-生物素、氯化钠、柠檬酸钾、硫酸铜、氧化镁、富马酸亚铁、氧化锌、硫酸锰、柠檬酸钙、磷酸二氢钾、碘酸钾、亚硒酸钠、氯化铬、谷氨酰胺、精氨酸、银杏黄酮、植物甾醇,于500W的灭菌器中灭菌100s,灭菌后,平均分成5份,形成功能袋。Pea peptide, whey protein, fructose, pea dietary fiber, hydroxypropyl starch, xylooligosaccharide, erythritol, retinyl acetate, vitamin D 2 , D-α-tocotrienol acetate, vitamin K 1. Thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, cyanocobalamin, niacin, folic acid, D-calcium pantothenate, L-ascorbic acid, D-biotin, sodium chloride, potassium citrate, copper sulfate, Magnesium oxide, ferrous fumarate, zinc oxide, manganese sulfate, calcium citrate, potassium dihydrogen phosphate, potassium iodate, sodium selenite, chromium chloride, glutamine, arginine, ginkgo flavonoids, phytosterols , Sterilized in a 500W sterilizer for 100s, after sterilization, divided into 5 parts on average to form functional bags.
将大豆油、牡丹籽油、地碱蓬籽油、鱼油于500W的灭菌器中灭菌100s,灭菌后,平均分成5份,形成能量袋。Sterilize soybean oil, peony seed oil, Suaeda salsa seed oil, and fish oil in a 500W sterilizer for 100 seconds. After sterilization, divide them into 5 parts on average to form energy bags.
豌豆肽的制备方法为:将含水量25wt.%的豌豆蛋白进行挤压,挤压后,将挤出物冷却、干燥、粉碎,再用中性蛋白酶进行酶解反应,酶解反应后,豌豆肽的DPPH清除率、.OH清除率、O2 .-清除率分别为95%、88%、45%。The preparation method of pea peptide is as follows: extrude pea protein with a water content of 25wt.%. The DPPH clearance rate, .OH clearance rate , and O 2 .- clearance rate of the peptide were 95%, 88%, and 45%, respectively.
其中挤压时的温度为60℃,螺杆转速为165r/min,模孔孔径为12mm;酶解反应温度为38℃,酶解反应的pH值为7,酶解反应中豌豆蛋白浓度为8.1g/mL,中性蛋白酶的用量为豌豆蛋白用量的12%。The extrusion temperature is 60°C, the screw speed is 165r/min, and the die hole diameter is 12mm; the enzymolysis reaction temperature is 38°C, the pH value of the enzymolysis reaction is 7, and the concentration of pea protein in the enzymolysis reaction is 8.1g /mL, the dosage of neutral protease is 12% of that of pea protein.
实施例 2Example 2
每百克直肠癌营养食品中营养成分如下:蛋白40g、脂肪2.6g、碳水化合物55g、维生素A287.79μg、维生素D 10μg、维生素E 5mg、维生素K1 22μg、维生素B1 0.45mg、维生素B2 0.5mg、维生素B6 0.6mg、维生素B12 2μg、烟酸1.8mg、叶酸400μg、泛酸2.52mg、维生素C 3.5mg、生物素12μg、钠64.87mg、钾99.415mg、铜220μg、镁75mg、铁8.56mg、锌2.56mg、锰100.13μg、钙52.36mg、磷160.01mg、碘30μg、硒45.66μg、铬156.4μg、谷氨酰胺100mg、精氨酸150mg、银杏黄酮150mg、植物甾醇400mg。The nutritional ingredients in every 100 grams of rectal cancer nutrition food are as follows: protein 40g, fat 2.6g, carbohydrate 55g, vitamin A 287.79μg, vitamin D 10μg, vitamin E 5mg, vitamin K 1 22μg, vitamin B 1 0.45mg, vitamin B 2 0.5mg, Vitamin B 6 0.6mg, Vitamin B 12 2μg, Niacin 1.8mg, Folic acid 400μg, Pantothenic acid 2.52mg, Vitamin C 3.5mg, Biotin 12μg, Sodium 64.87mg, Potassium 99.415mg, Copper 220μg, Magnesium 75mg, Iron 8.56mg, zinc 2.56mg, manganese 100.13μg, calcium 52.36mg, phosphorus 160.01mg, iodine 30μg, selenium 45.66μg, chromium 156.4μg, glutamine 100mg, arginine 150mg, ginkgo flavonoids 150mg, phytosterol 400mg.
制备每百克营养食品中的原料如下:Prepare the raw materials in every hectogram nutritious food as follows:
豌豆蛋白20g、乳清蛋白20g、花生油0.5g、玉米籽油0.5g、翅果油0.5g、元宝枫籽油0.5g、鱼油0.6g、果糖10g、豌豆膳食纤维20g、海带多糖5g、羟丙基淀粉5g、豌豆抗性淀粉10g、赤藓糖醇5g、醋酸视黄酯300μg、维生素D2 10μg、D-α-生育三烯酚20mg、维生素K1 22μg、盐酸硫胺素450μg、核黄素500μg、盐酸吡哆醇600μg、氰钴胺2μg、烟酸1800μg、叶酸400μg、D-泛酸钙2.8mg、L-抗坏血酸3.5mg、D-生物素12μg、氯化钠165mg、柠檬酸钾260mg、硫酸铜550μg、氧化镁125mg、富马酸亚铁26mg、氧化锌3.2mg、硫酸锰170μg、柠檬酸钙300mg、磷酸二氢钾702mg、碘酸钾50.6μg、亚硒酸钠100μg、氯化铬800μg、谷氨酰胺100mg、精氨酸150mg、银杏黄酮150mg、植物甾醇400mg。Pea protein 20g, whey protein 20g, peanut oil 0.5g, corn seed oil 0.5g, samara oil 0.5g, ingot maple oil 0.5g, fish oil 0.6g, fructose 10g, pea dietary fiber 20g, laminarin 5g, hydroxypropyl Base starch 5g, pea resistant starch 10g, erythritol 5g, retinyl acetate 300μg, vitamin D 2 10μg, D-α-tocotrienol 20mg, vitamin K 1 22μg, thiamine hydrochloride 450μg, riboflavin 500μg pyridoxine hydrochloride, 2μg cyanocobalamin, 1800μg niacin, 400μg folic acid, 2.8mg D-calcium pantothenate, 3.5mg L-ascorbic acid, 12μg D-biotin, 165mg sodium chloride, 260mg potassium citrate, Copper sulfate 550μg, magnesium oxide 125mg, ferrous fumarate 26mg, zinc oxide 3.2mg, manganese sulfate 170μg, calcium citrate 300mg, potassium dihydrogen phosphate 702mg, potassium iodate 50.6μg, sodium selenite 100μg, chromium chloride 800μg, glutamine 100mg, arginine 150mg, ginkgo flavonoids 150mg, phytosterol 400mg.
制备方法如下:The preparation method is as follows:
将豌豆蛋白、乳清蛋白、果糖、豌豆膳食纤维、海带多糖、羟丙基淀粉、豌豆抗性淀粉、赤藓糖醇、醋酸视黄酯、维生素D2、D-α-生育三烯酚、维生素K1、盐酸硫胺素、核黄素、盐酸吡哆醇、氰钴胺、烟酸、叶酸、D-泛酸钙、L-抗坏血酸、D-生物素、氯化钠、柠檬酸钾、硫酸铜、氧化镁、富马酸亚铁、氧化锌、硫酸锰、硫酸锰、柠檬酸钙、磷酸二氢钾、碘酸钾、亚硒酸钠、氯化铬、谷氨酰胺、精氨酸、银杏黄酮、植物甾醇,于425W的灭菌器中灭菌120s,灭菌后,平均分成5份,形成功能袋。Pea protein, whey protein, fructose, pea dietary fiber, laminarin, hydroxypropyl starch, pea resistant starch, erythritol, retinyl acetate, vitamin D 2 , D-α-tocotrienol, Vitamin K1, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Cyanocobalamin, Niacin, Folic Acid, Calcium D - Pantothenate, L-Ascorbic Acid, D-Biotin, Sodium Chloride, Potassium Citrate, Sulfuric Acid Copper, magnesium oxide, ferrous fumarate, zinc oxide, manganese sulfate, manganese sulfate, calcium citrate, potassium dihydrogen phosphate, potassium iodate, sodium selenite, chromium chloride, glutamine, arginine, Ginkgo flavonoids and phytosterols are sterilized in a 425W sterilizer for 120s. After sterilization, they are divided into 5 parts on average to form functional bags.
将花生油、玉米籽油、翅果油、元宝枫籽油、鱼油于425W的灭菌器中灭菌120s,灭菌后,平均分成5份,形成能量袋。Sterilize peanut oil, corn seed oil, samara oil, ingot maple seed oil, and fish oil in a 425W sterilizer for 120s. After sterilization, divide them into 5 parts on average to form energy bags.
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