CN108902135A - A kind of diflubenzuron urea granules and preparation method thereof - Google Patents
A kind of diflubenzuron urea granules and preparation method thereof Download PDFInfo
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- CN108902135A CN108902135A CN201810621977.3A CN201810621977A CN108902135A CN 108902135 A CN108902135 A CN 108902135A CN 201810621977 A CN201810621977 A CN 201810621977A CN 108902135 A CN108902135 A CN 108902135A
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- Prior art keywords
- urea
- diflubenzuron
- urea granules
- granules
- minutes
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- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title claims abstract description 124
- 239000004202 carbamide Substances 0.000 title claims abstract description 124
- 239000005893 Diflubenzuron Substances 0.000 title claims abstract description 98
- 229940019503 diflubenzuron Drugs 0.000 title claims abstract description 98
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 239000008187 granular material Substances 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 40
- 229940079593 drug Drugs 0.000 claims abstract description 27
- 230000000694 effects Effects 0.000 claims abstract description 18
- 239000000853 adhesive Substances 0.000 claims abstract description 9
- 230000001070 adhesive effect Effects 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims description 17
- 239000002202 Polyethylene glycol Substances 0.000 claims description 16
- 229920001223 polyethylene glycol Polymers 0.000 claims description 16
- 239000010410 layer Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 239000007921 spray Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 239000011229 interlayer Substances 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 7
- 238000007664 blowing Methods 0.000 claims description 6
- 239000012752 auxiliary agent Substances 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 5
- 230000003179 granulation Effects 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 239000013067 intermediate product Substances 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 239000003765 sweetening agent Substances 0.000 claims description 3
- ZJHHPAUQMCHPRB-UHFFFAOYSA-N urea urea Chemical compound NC(N)=O.NC(N)=O ZJHHPAUQMCHPRB-UHFFFAOYSA-N 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 2
- 239000003016 pheromone Substances 0.000 claims 1
- 244000144972 livestock Species 0.000 abstract description 24
- 244000144977 poultry Species 0.000 abstract description 24
- 210000003608 fece Anatomy 0.000 abstract description 22
- 239000005891 Cyromazine Substances 0.000 abstract description 15
- LVQDKIWDGQRHTE-UHFFFAOYSA-N cyromazine Chemical compound NC1=NC(N)=NC(NC2CC2)=N1 LVQDKIWDGQRHTE-UHFFFAOYSA-N 0.000 abstract description 15
- 229950000775 cyromazine Drugs 0.000 abstract description 15
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 239000003337 fertilizer Substances 0.000 abstract description 4
- 230000000241 respiratory effect Effects 0.000 abstract description 3
- 239000000725 suspension Substances 0.000 abstract description 3
- 235000013877 carbamide Nutrition 0.000 description 88
- 235000013594 poultry meat Nutrition 0.000 description 20
- 241000287828 Gallus gallus Species 0.000 description 12
- 235000013330 chicken meat Nutrition 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 229960003511 macrogol Drugs 0.000 description 9
- 239000010871 livestock manure Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000000843 powder Substances 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 4
- 239000002917 insecticide Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000575 pesticide Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 229920000877 Melamine resin Polymers 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 description 3
- 230000010355 oscillation Effects 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000000375 suspending agent Substances 0.000 description 3
- 239000000273 veterinary drug Substances 0.000 description 3
- IGOWHGRNPLFNDJ-ZPHPHTNESA-N (z)-9-tricosene Chemical group CCCCCCCCCCCCC\C=C/CCCCCCCC IGOWHGRNPLFNDJ-ZPHPHTNESA-N 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- 241000723353 Chrysanthemum Species 0.000 description 2
- 235000007516 Chrysanthemum Nutrition 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- QXAITBQSYVNQDR-ZIOPAAQOSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1/N=C/N(C)\C=N\C1=CC=C(C)C=C1C QXAITBQSYVNQDR-ZIOPAAQOSA-N 0.000 description 2
- 229960002587 amitraz Drugs 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- JFILLDQSIUEZPE-UHFFFAOYSA-N azane;piperazine Chemical compound N.C1CNCCN1 JFILLDQSIUEZPE-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000009513 drug distribution Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- NYPJDWWKZLNGGM-UHFFFAOYSA-N fenvalerate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)C(=O)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-UHFFFAOYSA-N 0.000 description 2
- 239000003630 growth substance Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- IGOWHGRNPLFNDJ-UHFFFAOYSA-N tricos-9t-ene Natural products CCCCCCCCCCCCCC=CCCCCCCCC IGOWHGRNPLFNDJ-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000288283 Allata Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241001491790 Bupalus piniaria Species 0.000 description 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241001517923 Douglasiidae Species 0.000 description 1
- 241001046947 Ectropis obliqua Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 229940122601 Esterase inhibitor Drugs 0.000 description 1
- 241000255967 Helicoverpa zea Species 0.000 description 1
- 241001531327 Hyphantria cunea Species 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000409991 Mythimna separata Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241001525654 Phyllocnistis citrella Species 0.000 description 1
- 241001525802 Phyllonorycter pomonella Species 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 241000500437 Plutella xylostella Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000256247 Spodoptera exigua Species 0.000 description 1
- 241000985245 Spodoptera litura Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000255901 Tortricidae Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- -1 benzoxy phenyl ureas Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000000991 chicken egg Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 239000002329 esterase inhibitor Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000002468 fat body Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000003986 organophosphate insecticide Substances 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 231100000916 relative toxicity Toxicity 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000004894 snout Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05C—NITROGENOUS FERTILISERS
- C05C9/00—Fertilisers containing urea or urea compounds
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
- C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
- C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
- C05G3/60—Biocides or preservatives, e.g. disinfectants, pesticides or herbicides; Pest repellants or attractants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
In order to solve " killing fly maggot using cyromazine control always; can easily lead to the problem of drug resistance without same effect drug with rotation ", and the problem of " existing diflubenzuron suspension is not suitable for killing fly maggot in feces of livestock and poultry ", the present invention provides a kind of diflubenzuron urea granules and preparation method thereof.The present invention is using urea as carrier and kernel, outer layer adhesive pharmaceutical diflubenzuron.Diflubenzuron urea granules directly dry be sprinkling upon in feces of livestock and poultry is controlled into killing fly maggot, since particle is slowly sunk among excrement compared with Beijing South Maxpower Technology Co. Ltd and is spread, the fly maggot effect for controlling excrement deep place is more preferable.Simultaneously it is dry spread use to livestock and poultry will not generate stress, will not to livestock and poultry respiratory generate stimulate, also will increase the urea content in excrement, increase the fertilizer efficiency of excrement.
Description
Technical field
The present invention relates to a kind of diflubenzuron urea granules and preparation method thereof, belong to veterinary drug and its manufacturing field.
Background technique
Blue montains and green waters is exactly that the theory of Kingsoft Yin Shan gos deep into the whole society.People are higher and higher to livestock and poultry cultivation environmental requirement,
But fly and fly maggot are always a great problem for perplexing farm.Currently, the drug master for controlling fly maggot in feces of livestock and poultry
There are conventional pesticides such as organic phosphates, Amitraz and chrysanthemum ester insecticide, there are also be exactly insect growth regulator, IGR cyromazine.
But using the fly maggot in conventional pesticides control feces of livestock and poultry, there are some drawbacks：Such as organophosphorus insecticides and Amitraz poison
Property larger, the residual height of medicine, feces of livestock and poultry recycle when exist poisoning risk；Chrysanthemum esters medicine relative toxicity is lower, but residual effect is poor
And fly maggot drug resistance generates comparatively fast.Unique dedicated anti-fly maggot drug is insect growth regulator, IGR cyromazine on veterinary drug, although
The effect for killing fly maggot is fine, but is used for decades, with increasingly being grown using the time for cyromazine, it is most likely that
It will appear the fly maggot of resistance to cyromazine, cyromazine additive amount in feed certainly will be caused increasing.The metabolism of cyromazine
The residual quantity of product melamine can also increase therewith.Japan and Europe etc. have forbidden adding cyclopropyl ammonia in feed at present
Piperazine.So urgent need is found one kind and can be used with cyromazine rotation, and to safety of human and livestock, low toxicity, environmental-friendly anti-fly maggot
Drug.Therefore we have developed diflubenzuron urea granules.
Diflubenzuron is a species specificity low toxic pesticide, belongs to benzoxy phenyl ureas insecticide.It is highly-safe, rat warp
Mouth LD50> 5000mg/kg.Its insecticidal mechanism and past common insecticides are completely different, neither never poison, nor gallbladder
Alkali esterase inhibitor, its main function are the chitin synthesis for inhibiting insect cuticle, while in fat-body, corporal allata etc. points
It secretes and has damage destruction again with body of gland, to interfere the smooth molt metamorphosis of insect.Main effect model is stomach toxicity and tags.
The poisoning of accumulation property is caused after pests, due to lacking chitin, larva cannot form new epidermis, and husking is difficult, pupates and is obstructed；
Adult is difficult to sprout wings, lay eggs；Ovum be unable to normal development, hatching larva epidermis lack hardness and it is dead, so that it is whole to influence pest
The place of the advantages of a generation, here it is diflubenzurons.
Currently, diflubenzuron is primarily used to pesticide, common dosage form is suspending agent, for preventing and treating each fruit scale wing on crops
Mesh pest, as cabbage caterpillar, diamondback moth, beet armyworm, prodenia litura, apple leaf miner, peach line leaf miner, phyllocnistis citrella stainton, mythimna separata,
Tea geometrid, bollworm, fall webworms, pine moth, leaf roller, leaf roll snout moth's larva etc..It is never used by exploitation in field of veterinary.It removes
The solubility of worm urea in water is relatively low, and every 1L water can only dissolve 0.08mg diflubenzuron.So diflubenzuron is generally made into suspension
Agent.But suspending agent is not suitable for livestock and poultry farm and controls fly maggot by spraying, the reason is that the administration of poultry house internal spraying can cause livestock and poultry
Production performance stress be caused to decline, but also the disease of livestock and poultry respiratory can be induced；Septic tank or excrement accumulation regions make by spraying
Also undesirable with diflubenzuron effect, drug can gentlier swim in the surface of excrement, to live in the fly maggot of excrement deep place without
Method plays a role.
Summary of the invention
In view of the above-mentioned problems, the present invention provides a kind of diflubenzuron urea granules and preparation method thereof.The present invention is with urea
As carrier and kernel, outer layer adhesive pharmaceutical diflubenzuron.Diflubenzuron urea granules are directly sprinkling upon to control in feces of livestock and poultry and are killed
Fly maggot, not only avoid spraying medication to livestock and poultry stress be with the risk that induces respiratory disease, and particle of the present invention is compared with Beijing South Maxpower Technology Co. Ltd
It slowly sinks among excrement and spreads, the fly maggot effect for controlling excrement deep place is more preferable.In addition, carrier of the invention is urine
Element itself is exactly a kind of fertilizer, also adds the content of nitrogen in feces of livestock and poultry.
The technical scheme is that：A kind of diflubenzuron urea granules, characterized in that using urea as medicine deinsectization urea
Carrier.
Preferably, using urea as kernel and carrier, as coating, addition adhesive is made to be removed outer layer covers medicine deinsectization urea
Worm urea urea granules.
Preferably, the preferred polyethylene glycol of adhesive, more preferably Macrogol 6000.
It is further preferred that the content of diflubenzuron is 0.1-15%, and the content of urea is according to weight
85%-99.8%, the content of polyethylene glycol are 0.1%-15%.
Preferably, the particle diameter of urea is 0.1-3 millimeters, and the diameter of diflubenzuron urea granules is 0.1-4.0 millimeters.
Further, the drug of outer layer covers can also be added with the auxiliary agent for luring fly effect, such as other than diflubenzuron
One of biological information element, sweetener, fishy smell agent and amino acid or several combinations.The biological information element is cis-
9- tricosene.The sweetener is one of brown sugar, lactose and sucrose or any combination.The fishy smell agent is fish
One of powder, shrimp paste or two kinds of combination.The amino acid is tryptophan.
Above-mentioned diflubenzuron urea granules can be prepared by following two method.
Preparation method one：Diflubenzuron urea granules are manufactured using boiling granulating, steps are as follows：
(1) diflubenzuron drug is prepared：Polyethylene glycol is dissolved by heating, according to diflubenzuron in pre-manufactured diflubenzuron urea granules
Content, take diflubenzuron raw medicine (can also be added lure fly act on auxiliary agent), put into dissolved polyethylene glycol, mix 3-60
Minute, keep the temperature of polyethylene glycol at 30-130 DEG C in mixed process；
(2) spray granulation：Urea is put into fluid bed granulator, fluid bed granulator is opened；Drug in step (1) is logical
Piping is transported to the top showerhead of fluid bed granulator, Open valve, spray；Drug encounters the lower urea of surface temperature
Grain is quickly cooled down, and forms medicine layer；
(3) cooling：Intermediate product after the completion of spray put into flat mixer and continues to mix 3-60 minutes, and blowing is cooling；
(4) grain is selected：According to the quality standard of product, grain is sorted using Vibration Screen, diflubenzuron urea granules diameter exists
0.1-4 millimeters.
Preferably, keep the temperature of polyethylene glycol at 40-80 DEG C in step (1) mixed process.
Preferably, the step (3) mixes 3-15 minutes.
Preparation method two：It is granulated using the flat mixer for being equipped with interlayer heating system.The outer wall of flat mixer is equipped with
Interlayer, interlayer is interior to be equipped with circulating-heating pipeline, and steps are as follows：
(1) in urea granules investment flat mixer, it is equipped with heating pipe in mixing machine outer wall interlayer, is passed through heating oil；
Mixing machine is opened, heating urea particle makes the temperature of urea granules reach 30-130 DEG C, mixes 3-60 minutes；
(2) polyethylene glycol is added in the urea of heating, temperature is maintained at 30-130 DEG C, mixes 3-60 minutes.
(3) it by diflubenzuron raw medicine (auxiliary agent for luring fly to act on can also be added), is added in above-mentioned mixed urea, temperature
Degree is kept for 30-130 DEG C, and blowing after mixing 3-30 minutes is cooling；
(4) grain is selected：According to the quality standard of product, grain is sorted using Vibration Screen, diflubenzuron urea granules diameter exists
0.1-4.0 millimeters.
Preferably, keep the temperature of polyethylene glycol at 40-80 DEG C in the step (1)-(3) mixed process.
Preferably, described step (1)-(3) mix 3-15 minutes.
According to the diflubenzuron urea granules that preparation method one of the present invention and preparation method two manufacture, feature is as follows：Deinsectization
Urea urea granules surface color is consistent, and drug distribution is uniform, even particle size, without the diflubenzuron drug powder to fall off.
Invention additionally discloses a kind of diflubenzuron urea granules, characterized in that diflubenzuron raw medicine is added in liquid urea, leads to
It crosses urea prilling tower and directly produces diflubenzuron urea granules, weight percentage, the content of diflubenzuron is 0.1-15%, urine
The content of element is 85%-99.9%.
Specific step is as follows for preparation method：
(1) urea granules are heated to 130-170 DEG C in a reservoir, dissolve it all；
(2) it according to the content of pre-manufactured finished product diflubenzuron, removes worm urea raw powder and is added in liquid urea, mix 10-30
Minute；Uniformly mixed liquid urea is pipelined in granulation tower, according to the general production technology of urea, hydrojet is made
Grain；
(3) according to the quality standard of product, grain is sorted using Vibration Screen, diflubenzuron urea granules diameter is in 0.1-4.0
Millimeter.
According to the diflubenzuron urea granules that preparation method three of the present invention manufactures, feature is as follows：Diflubenzuron urea granules are big
Small uniformity, color is unified, and diflubenzuron content deviation in urea granules is small.
The application method of the diflubenzuron urea granules is：It is dry to spread, every 10m2Use diflubenzuron 100-500g.
The beneficial effects of the invention are as follows：
1, diflubenzuron is used to control the fly maggot killed in feces of livestock and poultry by diflubenzuron urea granules of the invention, is solved and is killed
Go out fly maggot in feces of livestock and poultry, high using the big residual of organophosphorus insecticide toxicity, is also easy to produce patience using fenvalerate residual effect difference
The problems such as, and solve and " kill fly maggot using cyromazine control always, can easily generate drug resistance without same effect drug with rotation
Property " the problem of.
2, the present invention is using urea as carrier and kernel, outer layer adhesive pharmaceutical diflubenzuron.When the diflubenzuron of outer layer acts on
After the fly maggot of excrement, the urea of internal layer increases the content of nitrogen in feces of livestock and poultry.Compared to diflubenzuron suspension, diflubenzuron urea
Grain kill control fly maggot effect it is more preferable, and it is dry spread use to livestock and poultry will not generate stress, will not to livestock and poultry respiratory generate pierce
Swash, also will increase the urea content in excrement, increase the fertilizer efficiency of excrement.
3, there are many preparation methods of diflubenzuron urea granules, the third method can be omitted adhesive polyethylene glycol and adopt
It is prepared with common process for prepn. of urea, but diflubenzuron cannot function as the coating of urea, be not suitable for directly spreading fertilizer over the fields.Compared to
Three kinds of methods, first and second kind of method heating temperature of the invention is lower and using diflubenzuron as the coating of urea, convenient for directly spreading
Apply fly eradication maggot.
4, for the present invention using urea as carrier and kernel, outer layer passes through polyethylene glycol adhesive pharmaceutical diflubenzuron, diflubenzuron urine
Crude granule surface color is consistent, and drug distribution is uniform, even particle size, and without the diflubenzuron drug powder to fall off, particle is steady
It is qualitative good.
In short, in order to solve " to kill fly maggot using cyromazine control always, can easily generate with rotation without same effect drug
The problem of drug resistance ", the present invention first pass around research and select substitute of the diflubenzuron as cyromazine.Simultaneously for existing
Diflubenzuron suspension is not suitable for the problem of fly maggot is killed in feces of livestock and poultry, has developed a kind of novel form of diflubenzuron --- diflubenzuron
Urea granules dry can spread use, and have the effect of fly maggot in good killing feces of livestock and poultry.
Specific embodiment
Embodiment 1：
Formula：Urea (granularity 1-3mm) 200kg, diflubenzuron (content 98%) 8.4kg, Macrogol 6000 1.1kg.
Preparation method：
(1) Macrogol 6000 is heated to 55-58 DEG C in liquid dispensing tank, and all after dissolution, addition removes Macrogol 6000
Worm urea raw powder mixes 10 minutes；Said mixture temperature is controlled at 55-58 DEG C；
(2) urea is put into fluid bed granulator, opens fluid bed granulator, the drug that step (1) is uniformly mixed is logical
Piping is transported to the top showerhead of fluid bed granulator, Open valve, spray；Drug encounters the lower urea of surface temperature
Grain is quickly cooled down, and forms medicine layer；
(3) it by the intermediate product after the completion of above-mentioned spray, puts into flat mixer and continuess to mix blowing after five minutes；Drug
It is cooled to room temperature (15-25 DEG C).
(4) oscillation screening grain, the diflubenzuron urea granules diameter of selection are 1-4mm.
Embodiment 2：
Formula：Urea (granularity 1-3mm) 200kg, diflubenzuron (content 98%) 8.8kg, biological information element (cis- 9- 20
Three carbenes) 0.5kg, Macrogol 6000 1.2kg.
Preparation method：
(1) Macrogol 6000 is heated to 55-58 DEG C in liquid dispensing tank, and all after dissolution, addition removes Macrogol 6000
Worm urea raw powder and cis- 9- tricosene mix 10 minutes；Said mixture temperature is controlled at 55-58 DEG C；
(2) urea is put into fluid bed granulator, opens fluid bed granulator, the drug that step (1) is uniformly mixed is logical
Piping is transported to the top showerhead of fluid bed granulator, Open valve, spray；Drug encounters the lower urea of surface temperature
Grain is quickly cooled down, and forms medicine layer；
(3) it by the intermediate product after the completion of above-mentioned spray, puts into flat mixer and continuess to mix blowing after five minutes；Drug
It is cooled to room temperature (15-25 DEG C).
(4) oscillation screening grain, the diflubenzuron urea granules diameter of selection are 1-4mm.
Embodiment 3：
Formula：Urea (granularity 1-3mm) 800kg, diflubenzuron (content 98%) 35.0kg, Macrogol 6000 10kg.
Preparation method：
(1) urea is put into flat mixer first, heating pipe is equipped in mixing machine outer wall interlayer, open mixing
Machine mixes 5 minutes, and heating urea makes the temperature of urea reach 80 DEG C；
(2) Macrogol 6000 is added in the urea of heating, temperature is maintained at 80 DEG C, mixes 40 minutes；
(3) it by diflubenzuron raw medicine, is added in above-mentioned mixed urea, temperature is kept for 80 DEG C, and mixing is put after five minutes
Material, is cooled to room temperature (15-25 DEG C).
(4) oscillation screening grain, the diflubenzuron urea granules diameter of selection are 1-4mm.
Embodiment 4：
Formula：Urea 800kg, diflubenzuron (content 98%) 35.0kg.
(1) urea granules are heated to 130-170 DEG C in a reservoir, dissolve it all；
(2) it removes worm urea raw powder to be added in liquid urea, mix 20 minutes；Uniformly mixed liquid urea is passed through into pipe
Road is transported in granulation tower, and according to the general production technology of urea, hydrojet is granulated；
(3) according to the quality standard of product, grain is sorted using Vibration Screen, diflubenzuron urea granules diameter is at 1-4 millimeters.
Experimental example：The control of 4% diflubenzuron urea granules and the effect test for killing fly maggot in excrement
1. materials and methods
1.1 test material：4% diflubenzuron urea granules (offer of embodiment 1)；1% cyromazine pre-mixing agent, western Shandong
The production of veterinary drug limited liability company, lot number：20170501.
1.2 test site：Shandong Qihe poetry and songs farm.
1.3 test method：It chooses Shandong Qihe poetry and songs farm's breeding layer chicken and gives up one, cultivation amount Hai Lanbai laying hen
5000, it is divided into 5 groups, every 1000 are one group.Three 4% diflubenzuron urea granules test groups：A group 100g/10m2, B group
200g/10m2With C group 500g/10m2, two control groups：D group is feeding group (1% cyromazine pre-mixing agent of feeding) and E group is empty
White control group.Animal packet and processing see the table below 1.
The grouping of 1 experimental animal of table and processing
A group, B group and C group were started medication from the 6th day, were only used primary.Feeding group was fed since the 5th day contains cyclopropyl
The feed of ammonia piperazine pre-mixing agent, continuous 7 days.
Each group respectively before treatment the phase (the 1st, 3,5 day), use during drug (the 6th, 8,10,12 day) and be discontinued after (the
13,15,17,19 days) acquisition chicken manure.Collection point should be uniformly distributed.The excrement of every group of difference sample point is mixed and mixed thoroughly.Every group
Each total sampling amount is 1L.
Every part of sample is divided into 6 parts and is respectively put into 6 200ml beakers by 1.4 evaluation methods,
Rim of a cup is closed with gauze, is placed on 25 DEG C of temperature, is cultivated 3 weeks in the environment of humidity about 60%.To appearance during this
Fly maggot living and dead fly maggot are counted, and calculate the average mortality and standard deviation of fly maggot in 6 beakers of every part of sample.3
The percentage composition of nitrogen in every part of sample, phosphorus (P are measured after week2O5) percentage composition and potassium (K2O percentage composition).
2 results and discussion
The chicken manure of different disposal, fly maggot average mortality are shown in Table 2.Variance statistic analysis is carried out to these data.
The death rate (%) of fly maggot in 2 excrement of table
Note：A, b and c same row same letter indicates the not significant (P of difference>0.05), same row letter is different indicates difference
Significantly (P<0.05).
The result shows that B group and C group in 4% diflubenzuron urea granules processing the group same day 7 days chickens to after being discontinued upon administration
Fly maggot shows 100% death rate in excrement, the significant difference (P between blank control group<0.05).4% diflubenzuron urea
Fly maggot shows 100% death rate in 4 days chicken manures to after being discontinued within 2 days after A group administration in grain processing group, with blank control group
Between significant difference (P<0.05).Fly maggot also shows 100% to feeding group D group in 1 day chicken manure to after being discontinued within 1 day upon administration
Significant difference (P between the death rate, with blank control group<0.05).
Three 4% 1 property medications of diflubenzuron urea granules test group are compared with feeding cyromazine test group is used in conjunction 7 days
Compared with, with same clinic control fly maggot effect, the not significant (P of difference>0.05).Three 4% diflubenzuron urea granules test groups
Middle A group duration of efficacy is short compared with B group and C group, therefore usage amount is every 10m2, 4% diflubenzuron urea granules 200g or more imitates
Fruit is optimal.
N P and K average content is as shown in table 3 in the chicken manure of different disposal.Variance statistic analysis is carried out to these data.
N P and K average content in 3 chicken manure of table
Note：A and b same row same letter indicates the not significant (P of difference>0.05), same row letter is different indicates that difference is aobvious
Write (P<0.05).
From table 3 it can be seen that nitrogen content is obvious in the chicken manure that three 4% diflubenzuron urea granules test groups are taken
Higher than feeding group and blank control group, significant difference (P<0.05).Show directly significantly improve using the present invention on excrement
The content of nitrogen in chicken manure.
As seen from the above, cyclopropyl is fed with to chicken directly using 4% diflubenzuron urea granules of the invention on feces of livestock and poultry
Ammonia piperazine pre-mixing agent compares, and controlling and kill the fly maggot effect in feces of livestock and poultry does not have difference.But use the present invention more convenient
More economical material benefit.Importantly, feeding cyromazine to chicken, there are the risks of metabolite melamine residual, but use
The present invention is fully able to solve the problems, such as melamine residual in the food such as chicken egg.
Claims (10)
1. a kind of diflubenzuron urea granules, characterized in that using urea as the carrier of medicine deinsectization urea.
2. a kind of diflubenzuron urea granules as described in claim 1, characterized in that using urea as kernel and carrier, outer layer packet
Medicine deinsectization urea is wrapped up in as coating, adhesive is added, diflubenzuron urea granules is made.
3. a kind of diflubenzuron urea granules as claimed in claim 2, characterized in that described adhesive is polyethylene glycol.
4. a kind of diflubenzuron urea granules as claimed in claim 2 or claim 3, characterized in that the drug of outer layer covers is in addition to deinsectization
Other than urea, be also added into luring the auxiliary agent of fly effect, it is described have the auxiliary agent for luring fly effect be biology pheromones, sweetener,
One of fishy smell agent and amino acid or several combinations.
5. a kind of diflubenzuron urea granules as claimed in claim 3, characterized in that according to weight, diflubenzuron
Content be 0.1-15%, the content of urea is 85%-99.8%, and the content of polyethylene glycol is 0.1%-15%.
6. a kind of preparation method of diflubenzuron urea granules as claimed in claim 3, characterized in that removed using boiling granulating manufacture
Worm urea urea granules, include the following steps：
(1) diflubenzuron drug is prepared：Polyethylene glycol is dissolved by heating, diflubenzuron is taken to put into dissolved polyethylene glycol, mixing
3-60 minutes, keep the temperature of polyethylene glycol at 30-130 DEG C in mixed process；
(2) spray granulation：Urea is put into fluid bed granulator, fluid bed granulator is opened；Mixture in step (1) is passed through
Top showerhead of the pipeline to fluid bed granulator, Open valve, spray；Drug encounters the lower urea granules of surface temperature,
It is quickly cooled down, forms medicine layer；
(3) cooling：Intermediate product after the completion of spray put into flat mixer and continues to mix 3-60 minutes, and blowing is cooling.
7. a kind of preparation method of diflubenzuron urea granules as claimed in claim 3, characterized in that be using interlayer heating is equipped with
The flat mixer of system is granulated, and is included the following steps：
(1) in urea granules investment flat mixer, it is equipped with heating pipe in mixing machine outer wall interlayer, is passed through heating oil；It opens
Mixing machine, heating urea particle make the temperature of urea granules reach 30-130 DEG C, mix 3-60 minutes；
(2) polyethylene glycol is added in the urea of heating, temperature is maintained at 30-130 DEG C, mixes 3-60 minutes；
(3) diflubenzuron is added in the mixture of above-mentioned steps (2), after temperature is maintained at 30-130 DEG C, mixing 3-30 minutes
Blowing, it is cooling.
8. a kind of preparation method of diflubenzuron urea granules described in claim 6 or 7, characterized in that product after cooling makes
Grain is sorted with Vibration Screen, diflubenzuron urea granules diameter is at 0.1-4.0 millimeters.
9. a kind of diflubenzuron urea granules as described in claim 1, characterized in that diflubenzuron is added in liquid urea, leads to
It crosses urea prilling tower and directly produces diflubenzuron urea granules, weight percentage, the content of diflubenzuron is 0.1-15%, urine
The content of element is 85%-99.9%.
10. a kind of preparation method of diflubenzuron urea granules as claimed in claim 9, characterized in that include the following steps：
(1) urea granules are heated to 130-170 DEG C in a reservoir, dissolve it all；
(2) it takes diflubenzuron to be added in liquid urea, mixes 10-30 minutes；Uniformly mixed liquid urea is defeated by pipeline
It is sent in granulation tower, according to urea production process, hydrojet is granulated；
(3) grain is sorted using Vibration Screen, diflubenzuron urea granules diameter is at 0.1-4.0 millimeters.
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| CN114145311A (en) * | 2021-12-01 | 2022-03-08 | 武汉回盛生物科技股份有限公司 | Diflubenzuron particles and preparation method and application thereof |
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