CN108815725A - Therapeutic dose method and system for planning - Google Patents
Therapeutic dose method and system for planning Download PDFInfo
- Publication number
- CN108815725A CN108815725A CN201810299688.6A CN201810299688A CN108815725A CN 108815725 A CN108815725 A CN 108815725A CN 201810299688 A CN201810299688 A CN 201810299688A CN 108815725 A CN108815725 A CN 108815725A
- Authority
- CN
- China
- Prior art keywords
- parameter
- tissue
- therapeutic dose
- sound
- organizational
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 49
- 238000011287 therapeutic dose Methods 0.000 title claims abstract description 34
- 230000006378 damage Effects 0.000 claims abstract description 34
- 230000034994 death Effects 0.000 claims abstract description 13
- 210000001519 tissue Anatomy 0.000 claims description 72
- 238000004088 simulation Methods 0.000 claims description 14
- 230000008081 blood perfusion Effects 0.000 claims description 10
- 238000002604 ultrasonography Methods 0.000 claims description 10
- 230000017531 blood circulation Effects 0.000 claims description 8
- 208000027418 Wounds and injury Diseases 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 abstract description 13
- 238000003384 imaging method Methods 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 5
- 230000008520 organization Effects 0.000 description 14
- 239000004744 fabric Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000005311 nuclear magnetism Effects 0.000 description 3
- 206010028851 Necrosis Diseases 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000004980 dosimetry Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Surgical Instruments (AREA)
Abstract
Therapeutic dose method and system for planning provided by the invention, organizational parameter, ultrasonic head parameter and predetermined close parameter based on acquisition calculate and obtain equivalent thermal dose distribution, the range that damage is formed in tissue is judged by the distribution of equivalent heat death theory, and then intended treatment effect is shown for doctor before the treatment, to the dispensing of guiding clinical treatment dosage, the subjective judgement that doctor is influenced because of the reading inaccuracy of real-time imaging monitoring is avoided the problem that.
Description
Technical field
The present invention relates to ultrasonic therapy fields, and in particular, to a kind of therapeutic dose method and system for planning.
Background technique
High intensity focused ultrasound (High Intensity Focused Ultrasound, abbreviation HIFU) is that one kind can essence
But the non-invasive therapy mode of skin incision, principle are not by External ultrasound Voice segment to body to true focusing therapy tumour
It is interior, to form the region that an energy height is concentrated, and make this using the principle of fuel factor, cavitation effect and mechanical effect etc.
Pathological tissues in region generate irreversible coagulation necrosis, and to region outside normal tissue do not have an impact, at present
High-strength focusing ultrasonic therapy tumour is widely used to clinic.
The injected volume of dosage affects final treatment results, if therapeutic dose dispensing is too small, will lead to ablation of tissue
It is imperfect, if therapeutic dose launches excessive, the increase of the patient's sense of discomfort and complication risk that will lead to.
It is in the prior art before the treatment, to rely on the experience subjective judgement setting treatment of doctor to the control method of dosage
Dosage carrys out adjustment for the treatment of dosage by using real-time imaging monitoring over the course for the treatment of.Currently, usually used imaging monitoring
It is monitored including ultrasonography monitoring and nuclear-magnetism.There is the high echo change of lumps in ultrasonography monitoring dependence target area or overall intensity is obvious
Increase, but there may be the unconspicuous situation of grey scale change in therapeutic process, causes doctor quasi- from ultrasonography monitoring
Really judge the actual conditions of tissue.Although it is high that nuclear-magnetism monitoring has image organizational contrast, and can do over the course for the treatment of lossless
The advantages of monitoring temperature, but using nuclear-magnetism monitoring come adjustment for the treatment of dosage mode have certain hysteresis quality so that doctor without
The actual conditions of method timely learning tissue.
Summary of the invention
The present invention is directed at least solve one of the technical problems existing in the prior art, a kind of therapeutic agent gauge is proposed
Method and system are drawn, for assessing the equivalent heat death theory distribution under predetermined close of tissue.
A kind of therapeutic dose planing method is provided to achieve the purpose of the present invention, including：
Step S1, acquisition organizational parameter, ultrasonic head parameter and predetermined close parameter；
Step S2 is calculated based on organizational parameter, ultrasonic head parameter and predetermined close parameter and is obtained equivalent thermal dose point
Cloth.
Wherein, step S2 is specifically included：
Step S21 calculates the sound field obtained in tissue according to organizational parameter, ultrasonic head parameter and predetermined close parameter
Distribution；
Step S22 calculates the thermo parameters method obtained in tissue according to sound-filed simulation；
Step S23 calculates the equivalent thermal dose distribution obtained in tissue according to thermo parameters method.
Wherein, in the step s 21, according to organizational parameter, ultrasonic head parameter and predetermined close parameter, acquisition group is calculated
Sound-filed simulation in knitting, specifically includes：Using KZK equation come the sound-filed simulation in computation organization.
Wherein, in step S22, the thermo parameters method obtained in tissue is calculated according to sound-filed simulation, is specifically included：Benefit
With Pennes bioheat transfer equation come the thermo parameters method in computation organization.
Wherein, therapeutic dose planing method further includes：
Step S3 is distributed according to equivalent heat death theory and judges whether each position reaches the standard to form damage in tissue, if
Be, then according to it is all reach to be formed injury criterion position generate damage profile.
Wherein, organizational parameter includes：The velocity of sound of tissue, density, acoustic attenuation, frequency dependent index, nonlinear factor, ratio
Thermal capacitance, thermal coefficient, blood perfusion parameter, upper skin layer thickness, fat deposit thickness, muscle layer thickness and tissue treatment are deep
Degree.
Wherein, ultrasonic head parameter includes internal diameter, outer diameter, working frequency and the focal length of ultrasonic head.
Wherein, predetermined close parameter includes irradiation power, irradiation time, intermittent time and irradiation cycle.
Wherein, the preparation method of blood perfusion parameter includes：
Acquire the mean blood flow velocity at tissue volume and tissue；
According to the mean blood flow velocity at tissue volume and tissue, calculates and obtain blood perfusion parameter.
The present invention also provides a kind of therapeutic dose planning systems comprising：
Input module, for inputting organizational parameter, ultrasonic head parameter and predetermined close parameter；
Computing module, for calculating based on organizational parameter, ultrasonic head parameter and predetermined close parameter and obtaining thermal dose point
Cloth.
The invention has the advantages that：
Therapeutic dose planing method provided by the invention, organizational parameter, ultrasonic head parameter and predetermined agent based on acquisition
It measures parameter and calculates the equivalent thermal dose distribution of acquisition, the range for forming damage in tissue is judged by the distribution of equivalent heat death theory, in turn
Intended treatment effect is shown for doctor before the treatment, so that the dispensing of guiding clinical treatment dosage, avoids because of real-time imaging monitoring
Reading inaccuracy and the problem of influence the subjective judgement of doctor.
Therapeutic dose planning system provided by the invention, input module, for input organizational parameter, ultrasonic head parameter with
And predetermined close parameter；Computing module, for calculating thermit powder based on organizational parameter, ultrasonic head parameter and predetermined close parameter
Amount distribution, and then show intended treatment effect before the treatment for doctor, thus the dispensing of guiding clinical treatment dosage, avoid because
The reading inaccuracy of real-time imaging monitoring and the problem of influence the subjective judgement of doctor.
Detailed description of the invention
Fig. 1 is the flow chart of therapeutic dose planing method provided in an embodiment of the present invention；
Fig. 2 is another flow chart of therapeutic dose planing method provided in an embodiment of the present invention；
Fig. 3 is the damage profile obtained in the therapeutic dose planing method provided through the embodiment of the present invention；And
Fig. 4 be under Fig. 3 the same terms pass through clinical treatment obtain damage profile.
Specific embodiment
To make those skilled in the art more fully understand technical solution of the present invention, come with reference to the accompanying drawing to this hair
The therapeutic dose method and system for planning of bright offer is described in detail.
Fig. 1 is the flow chart of therapeutic dose planing method provided in an embodiment of the present invention, as shown in Fig. 1, the therapeutic dose
Planing method includes：
Step S1, acquisition organizational parameter, ultrasonic head parameter and predetermined close parameter；
Step S2 is calculated based on organizational parameter, ultrasonic head parameter and predetermined close parameter and is obtained equivalent thermal dose point
Cloth.
Wherein, organizational parameter includes：The velocity of sound of tissue, density, acoustic attenuation, frequency dependent index, nonlinear factor, ratio
Thermal capacitance, thermal coefficient, blood perfusion parameter, upper skin layer thickness, fat deposit thickness, muscle layer thickness and tissue treatment are deep
Degree.
Tissue refers to biological tissue, since each tissue has uniqueness, i.e., above-mentioned each tissue of different tissues
Parameter can not be identical, by inputting organizational parameter, to determine the special parameter of specific organization, to be directed to specific group
It knits and carries out therapeutic dose planning.Organizational parameter can be obtained by Imaging Method, and Imaging Method includes nuclear magnetic scanning, ultrasound
Scanning etc..
Wherein, the preparation method of above-mentioned blood perfusion parameter includes：
Acquire the mean blood flow velocity u at tissue volume V and tissue；
According to the mean blood flow velocity u at tissue volume V and tissue, calculates and obtain blood perfusion parameter wb, wb=ρ π
R2/V.Wherein, R is vessel radius, and ρ is density of blood.
Wherein, ultrasonic head parameter includes internal diameter, outer diameter, working frequency and the focal length of ultrasonic head.Ultrasonic head refers to surpassing
Sound treatment head, the ultrasound head are the ultrasonic head that will be used in treatment, actual ultrasonic head parameter in the ultrasound head parameter and treatment
Unanimously.
Wherein, predetermined close parameter includes irradiation power, irradiation time, intermittent time and irradiation cycle.Predetermined close
Parameter is the dosimetry parameter that doctor rule of thumb obtains.
Therapeutic dose planing method provided in an embodiment of the present invention, organizational parameter based on acquisition, ultrasonic head parameter and
Predetermined close parameter, which calculates, obtains equivalent thermal dose distribution, judges the model that damage is formed in tissue by the distribution of equivalent heat death theory
It encloses, and then provides the objective basis of therapeutic effect before the treatment for doctor, so that the dispensing of guiding clinical treatment dosage, avoids
The problem of influencing the subjective judgement of doctor because of the reading of real-time imaging monitoring inaccuracy.
The calculation method of step S2 is described in detail below, Fig. 2 is therapeutic agent gauge provided in an embodiment of the present invention
Another flow chart for the method for drawing, as shown in Figure 2.
Step S2 is specifically included：
Step S21, according to organizational parameter, ultrasonic head parameter and predetermined close parameter, the sound field in computation organization is divided
Cloth；
Step S22 calculates the thermo parameters method obtained in tissue according to sound-filed simulation；
Step S23 calculates the equivalent thermal dose distribution obtained in tissue according to thermo parameters method.
It specifically includes in the step s 21：
The ultrasonic wave that ultrasonic hair goes out is calculated using KZK (Khokhlov-Zabolostkaya-Kuznetov) equation
Sound-filed simulation in the tissue.Its equation is：
Wherein, p represents acoustic pressure, and z is the distance along sound wave Propagation direction, τ=t-z/c0For lag time, c0For group
The small signal velocity of sound knitted, δ are the diffusion coefficient of tissue, ρ0For tissue density, β is the nonlinear factor of tissue,For
Laplace operator, due to the sound field of Shell Transducer be it is axisymmetric, use cylindrical coordinate
It should be noted that in above-mentioned parameter, c0、δ、ρ0, β it is related with the position of ultrasonic wave within the organization, with
The propagation of ultrasonic wave within the organization, ultrasonic wave can be by different locations in tissue, in the process, above-mentioned c0、δ、ρ0, β number
Value size can change with the position of ultrasonic wave within the organization difference.For example, when ultrasonic wave is in fat deposit, c0For
The small signal velocity of sound in fat, δ are the diffusion coefficient in fat, ρ0For fat attenuation, β is the nonlinear factor in fat.
By step S21, it is calculated as ultrasonic wave is propagated and time change, the changing rule of acoustic pressure, to obtain
Acoustic pressure at each position within the organization.
It should be noted that in the present embodiment, using KZK equation come the sound-filed simulation in computation organization, but this hair
It is bright to be not limited thereto, in practical applications, the sound field in the SBE equation calculation tissue of large angle energy converter can also be utilized
Distribution, as long as in fact, can calculate sound field according to organizational parameter, ultrasonic head parameter and predetermined close parameter and organize
Middle distribution.
In step S22, is calculated according to sound-filed simulation and obtain specifically including for the thermo parameters method in tissue：It utilizes
Pennes bioheat transfer equation (Pennes Bio-heat Transfer Equation) comes the temperature field in computation organization point
Cloth.Its equation is：
Wherein, ρt、ctTissue density, tissue specific heat capacity and the tissue coefficient of heat conduction, w are respectively represented with KbAnd cbFor tissue
Blood perfusion parameter and tissue blood flow specific heat, T1It is the temperature that group is woven in after the heating of ultrasonic wave, T0For in tissue
Blood flow temperature (temperature is identical as the initial temperature in tissue), Q is the heat that ultrasonic wave generates in the tissue of unit volume
Amount, can be acquired by following formula：Q=2 α I, α are heat absorption coefficients of the tissue to ultrasonic wave, and I is the sound intensity of ultrasonic wave.
Further, the sound intensity of ultrasonic wave is further calculated according to the acoustic pressure obtained in step S21, specifically
Formula is：I=p2/2ρtct。
It should be noted that in above-mentioned parameter, ρt、ct、K、wb、cb、T1、T0, position of the α with ultrasonic wave within the organization
It is equipped with pass, with the propagation of step ultrasonic wave within the organization, ultrasonic wave can be in different location in tissue, in the process, on
State ρt、ct、K、wb、 cb、T1、T0, α numerical values recited can be different with the position of ultrasonic wave within the organization and change.
It should be noted that in the present embodiment, being calculated by Pennes bioheat transfer equation in tissue each
The thermo parameters method of a position, but the present invention is not limited thereto, in practical applications, can also use other any ways,
As long as thermo parameters method in tissue can be calculated according to the sound-filed simulation obtained in step S21.
In step S23, calculating the equivalent thermal dose distribution in acquisition tissue according to thermo parameters method includes：According to temperature
The equivalent heat death theory distribution of linear accelerator under assigned temperature.
In the present embodiment, assigned temperature is 43 DEG C.
It is calculated according to CEM43 DEG C (43 DEG C of the Cumulative number of Equivalent Minutes at)
Equivalent heat death theory distribution.Its equation is：
Wherein, T is the temperature organized after the irradiation of the ultrasonic wave of duration t, and T is by Temperature calculating in step S22
The temperature of acquisition, R are constant, and R=0.25 (works as T<At 43 DEG C), R=0.5 (works as T>At 43 DEG C).
After ultrasonic irradiation, organize the temperature of different location different, therefore, it is necessary to will organize the temperature of different location
Equivalent is the equivalent heat death theory at 43 DEG C, for example, a certain position (hereinafter referred to as position A) is shone through ultrasonic wave within the organization
Temperature after penetrating is 120 DEG C, 120 DEG C is scaled duration required for obtaining 120 DEG C at 43 DEG C, which is in tissue
Equivalent heat death theory of the position A at 43 DEG C.
By calculating separately the equivalent heat death theory of each position in tissue, to obtain the equivalent heat death theory point in tissue
Cloth.
The embodiment of the invention also includes step S3, judge whether each position reaches in tissue according to the distribution of equivalent heat death theory
To formed damage standard, if so, according to it is all reach to be formed injury criterion position generate damage profile.
Wherein, the standard for forming damage is 240 minutes.Why the embodiment of the present invention limits the standard for forming damage
Be 240 minutes, this is because 43 DEG C, by under irradiations in 240 minutes, can make tissue (such as tumour etc.) generate not
Reversible coagulation necrosis.
But the present invention is not limited thereto, in practical applications, different formation can also be arranged depending on the temperature
The standard of damage, as long as can be used to judge whether tissue can to reach damage.
Reach to form the position of injury criterion by all, forms damage profile figure.
In order to verify therapeutic dose planing method provided in an embodiment of the present invention calculate damage results whether with actual clinical
Damage results in treating meet, in the following, by therapeutic dose planing method provided in an embodiment of the present invention damage point obtained
It is compared in cloth, with actual therapeutic with the damage profile obtained under the same terms.Wherein, the same terms refer to that tissue is joined
Number, ultrasonic head parameter and predetermined close parameter are all the same.
For an example patients with uterine myoma, Fig. 3 is that the therapeutic dose planing method provided through the embodiment of the present invention obtains
Damage profile, Fig. 4 is the damage profile obtained by clinical treatment.As shown in figure 3, in the z-axis direction damage the widest part from
1.2mm, the length of the damage of formation in the z-axis direction are deviated towards ultrasonic head (i.e. the origin of Z axis) direction at the position 17cm
For 11.7mm, the length in r axis direction is 4.7mm, area 39.1mm2.As shown in figure 4, with the same terms in actual therapeutic
It is inclined towards ultrasonic head (i.e. the origin of Z axis) direction from the position 17cm to damage the widest part in the z-axis direction for the damage of lower acquisition
1.5mm is moved, the length of the damage of formation in the z-axis direction is 11.2mm, and the length in r axis direction is 5mm, area
35.5mm2。
Two damage profile figures are compared it is found that treatment planing method provided in an embodiment of the present invention calculates the damage obtained
Range can be used for instructing clinical dose delivery amount close to the damage results in clinical treatment.
As another technical solution, therapeutic dose planning system provided by the invention, input module, for inputting group
Knit parameter, ultrasonic head parameter and predetermined close parameter；Computing module, for based on organizational parameter, ultrasonic head parameter and pre-
Determine dosimetry parameter and calculate thermal dose distribution, and then provide the objective basis of therapeutic effect before the treatment for doctor, so that guidance is faced
The dispensing of bed therapeutic dose avoids the problem that the subjective judgement that doctor is influenced because of the reading inaccuracy of real-time imaging monitoring.
It is understood that the principle that embodiment of above is intended to be merely illustrative of the present and the exemplary reality that uses
Mode is applied, however the present invention is not limited thereto.For those skilled in the art, the present invention is not being departed from
Spirit and essence in the case where, various changes and modifications can be made therein, these variations and modifications are also considered as protection of the invention
Range.
Claims (10)
1. a kind of therapeutic dose planing method, which is characterized in that including：
Step S1, acquisition organizational parameter, ultrasonic head parameter and predetermined close parameter；
Step S2 is calculated based on the organizational parameter, the ultrasonic head parameter and the predetermined close parameter and is obtained equivalent heat
Dosage distribution.
2. therapeutic dose planing method according to claim 1, which is characterized in that the step S2 is specifically included：
Step S21 is calculated according to the organizational parameter, the ultrasonic head parameter and the predetermined close parameter and is obtained tissue
In sound-filed simulation；
Step S22 calculates the thermo parameters method obtained in the tissue according to the sound-filed simulation；
Step S23 calculates the equivalent thermal dose distribution obtained in the tissue according to the thermo parameters method.
3. therapeutic dose planing method according to claim 2, which is characterized in that in the step S21, the basis
The organizational parameter, the ultrasonic head parameter and the predetermined close parameter, calculate the sound-filed simulation obtained in the tissue,
It specifically includes：
The sound-filed simulation in the tissue is calculated using KZK equation.
4. therapeutic dose planing method according to claim 2, which is characterized in that in the step S22, the basis
The sound-filed simulation calculates the thermo parameters method obtained in the tissue, specifically includes：
The thermo parameters method in the tissue is calculated using Pennes bioheat transfer equation.
5. therapeutic dose planing method according to claim 1, which is characterized in that further include：
Step S3 is distributed according to the equivalent heat death theory and judges whether each position reaches the standard to form damage in tissue, if
Be, then according to it is all reach to be formed injury criterion position generate damage profile.
6. -5 any therapeutic dose planing method according to claim 1, which is characterized in that the organizational parameter includes：
The velocity of sound of tissue, density, acoustic attenuation, frequency dependent index, nonlinear factor, specific heat capacity, thermal coefficient, blood perfusion parameter,
Upper skin layer thickness, fat deposit thickness, muscle layer thickness and tissue treatment depth.
7. -5 any therapeutic dose planing method according to claim 1, which is characterized in that the ultrasound head parameter includes
Internal diameter, outer diameter, working frequency and the focal length of ultrasonic head.
8. -5 any therapeutic dose planing method according to claim 1, which is characterized in that the predetermined close parameter packet
Include irradiation power, irradiation time, intermittent time and irradiation cycle.
9. therapeutic dose planing method according to claim 6, which is characterized in that the acquisition side of the blood perfusion parameter
Method includes：
Acquire the mean blood flow velocity at the tissue volume and the tissue；
According to the mean blood flow velocity at the tissue volume and the tissue, calculates and obtain the blood perfusion parameter.
10. a kind of therapeutic dose planning system, which is characterized in that including：
Input module, for inputting organizational parameter, ultrasonic head parameter and predetermined close parameter；
Computing module is obtained for being calculated based on the organizational parameter, the ultrasonic head parameter and the predetermined close parameter
Thermal dose distribution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810299688.6A CN108815725A (en) | 2018-04-04 | 2018-04-04 | Therapeutic dose method and system for planning |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810299688.6A CN108815725A (en) | 2018-04-04 | 2018-04-04 | Therapeutic dose method and system for planning |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108815725A true CN108815725A (en) | 2018-11-16 |
Family
ID=64154465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810299688.6A Pending CN108815725A (en) | 2018-04-04 | 2018-04-04 | Therapeutic dose method and system for planning |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108815725A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109999376A (en) * | 2019-03-19 | 2019-07-12 | 深圳市声科生物医学研究院 | A kind of HIFU apparatus control system and its noninvasive temperature estimation method |
| CN113304406A (en) * | 2021-07-28 | 2021-08-27 | 康达洲际医疗器械有限公司 | Self-adaptive radiotherapy method and system based on image processing |
| NO20221187A1 (en) * | 2022-11-04 | 2024-05-06 | Exact Therapeutics As | Method and system for calculating a point estimate of an ultrasound dose |
| US12377146B2 (en) | 2013-09-27 | 2025-08-05 | Exact Therapeutics As | Method of using high-frequency sound waves |
| US12511755B2 (en) | 2025-05-05 | 2025-12-30 | Exact Therapeutics As | Method for reconfiguring ultrasound |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088623A1 (en) * | 2007-10-01 | 2009-04-02 | Insightec, Ltd. | Motion compensated image-guided focused ultrasound therapy system |
-
2018
- 2018-04-04 CN CN201810299688.6A patent/CN108815725A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088623A1 (en) * | 2007-10-01 | 2009-04-02 | Insightec, Ltd. | Motion compensated image-guided focused ultrasound therapy system |
Non-Patent Citations (1)
| Title |
|---|
| 宿慧丹、戴思捷、郭各朴、马青玉: "《HIFU焦域的温度分布模拟及其疗效分析》", 《HIFU焦域的温度分布模拟及其疗效分析》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12377146B2 (en) | 2013-09-27 | 2025-08-05 | Exact Therapeutics As | Method of using high-frequency sound waves |
| US12478676B2 (en) | 2013-09-27 | 2025-11-25 | Exact Therapeutics As | Method of imaging |
| CN109999376A (en) * | 2019-03-19 | 2019-07-12 | 深圳市声科生物医学研究院 | A kind of HIFU apparatus control system and its noninvasive temperature estimation method |
| CN109999376B (en) * | 2019-03-19 | 2021-06-29 | 深圳市声科生物医学研究院 | HIFU equipment control system and nondestructive temperature measurement method thereof |
| CN113304406A (en) * | 2021-07-28 | 2021-08-27 | 康达洲际医疗器械有限公司 | Self-adaptive radiotherapy method and system based on image processing |
| CN113304406B (en) * | 2021-07-28 | 2021-11-12 | 康达洲际医疗器械有限公司 | Self-adaptive radiotherapy system based on image processing |
| NO20221187A1 (en) * | 2022-11-04 | 2024-05-06 | Exact Therapeutics As | Method and system for calculating a point estimate of an ultrasound dose |
| US12511755B2 (en) | 2025-05-05 | 2025-12-30 | Exact Therapeutics As | Method for reconfiguring ultrasound |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2950737B1 (en) | Simulation-based focused-ultrasound treatment planning | |
| Hallaj et al. | Simulations of the thermo-acoustic lens effect during focused ultrasound surgery | |
| Fan et al. | The effect of wave reflection and refraction at soft tissue interfaces during ultrasound hyperthermia treatments | |
| CN108815725A (en) | Therapeutic dose method and system for planning | |
| Partanen et al. | Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR‐guided high‐intensity focused ultrasound mediated mild hyperthermia | |
| US11376074B2 (en) | Simulation-based focused-ultrasound treatment planning | |
| Lizzi et al. | Ultrasonic hyperthermia for ophthalmic therapy | |
| US20150238781A1 (en) | Image-guided tissue ablation | |
| Samulski et al. | Clinical experience with a multi-element ultrasonic hyperthermia system: analysis of treatment temperatures | |
| CN102149431B (en) | Healing system for depositing energy | |
| CN105054972A (en) | Ultrasound diagnosis and treatment system and method for treating tumour by adopting same | |
| KR20140113172A (en) | Method and apparatus for making a plan of ultrasonic irradiation, and an ultrasonic irradiation method | |
| Mortazavi et al. | Numerical study of high‐intensity focused ultrasound (HIFU) in fat reduction | |
| Filippou et al. | Experimental evaluation of the near-field and far-field heating of focused ultrasound using the thermal dose concept | |
| Lizzi et al. | Computer model of ultrasonic hyperthermia and ablation for ocular tumors using B-mode data | |
| N’djin et al. | Active MR‐temperature feedback control of dynamic interstitial ultrasound therapy in brain: In vivo experiments and modeling in native and coagulated tissues | |
| Naziba et al. | Simulation of high intensity focused ultrasound device in healthcare application for non-invasive heat induced tissue ablation | |
| Qian et al. | Uniform tissue lesion formation induced by high-intensity focused ultrasound along a spiral pathway | |
| Thomenius | Thermal dosimetry models for diagnostic ultrasound | |
| Gandomi et al. | Thermo-acoustic simulation of a piezoelectric transducer for interstitial thermal ablation with mrti based validation | |
| Zhang et al. | Lesions in porcine liver tissues created by continuous high intensity ultrasound exposures in vitro | |
| Behnia et al. | Finite-element simulation of ultrasound brain surgery: effects of frequency, focal pressure, and scanning path in bone-heating reduction | |
| Zhang et al. | Simulation of standing wave reduction in HIFU transcranial tumors therapy | |
| Cheng et al. | Closed-form solution for the thermal dose delivered during single pulse thermal therapies | |
| Soni et al. | Effect of Nanoparticle Concentration on Thermal Damage in Nanoparticle-Assisted Thermal Therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181116 |
|
| RJ01 | Rejection of invention patent application after publication |