CN108784698A - The detection of esophagus multi-parameter, physical therapy integrated system and the adaptive electrical stimulation method of esophagus - Google Patents
The detection of esophagus multi-parameter, physical therapy integrated system and the adaptive electrical stimulation method of esophagus Download PDFInfo
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- CN108784698A CN108784698A CN201810885373.XA CN201810885373A CN108784698A CN 108784698 A CN108784698 A CN 108784698A CN 201810885373 A CN201810885373 A CN 201810885373A CN 108784698 A CN108784698 A CN 108784698A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0538—Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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Abstract
The present invention proposes a kind of detection of esophagus multi-parameter, physical therapy integrated system and the adaptive electrical stimulation method of esophagus, the system include control unit, switch arrays unit, impedance detection unit, electrical stimulation unit and include impedance transducer and electro photoluminescence probe duct unit；The parameters of electrical stimulation input terminal of the parameters of electrical stimulation output end connection electrical stimulation unit of control unit, control unit setting parameters of electrical stimulation simultaneously pass to electrical stimulation unit generation stimulus signal；Control unit connects impedance detection unit, and control unit sends impedance detection pumping signal to impedance detection unit, and impedance detection unit sends impedance detection information to control unit；Switch arrays unit is separately connected electrical stimulation unit, impedance detection unit and duct unit, and the switch control output end connecting valve array element of control unit controls switch arrays Unit selection impedance detection unit or electrical stimulation unit.The system structure is simple, alleviates discomfort of patient during detection, physical therapy.
Description
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of detection of esophagus multi-parameter, physical therapy integrated system and esophagus
Adaptive electrical stimulation method.
Background technology
Gastroesophageal reflux disease (GERD) is a kind of digestion dyskinesis disease that clinic is common, generally refers to stomach or 12
Duodenum 12 content reflux causes a variety of uncomfortable or symptoms, has seriously affected the quality of life of patient, most common clinic to oesophagus
Symptom is heartburn, pectoralgia and sour regurgitation.Inspection currently for Gastroesophageal reflux disease is the most frequently used and effective method is in esophagus
Impedance and the monitoring that carries out 24 hours or more of the physiological parameters such as pH value.
The PPI+ operative treatment existing defects in the scheme for the treatment of Gastroesophageal reflux disease, some patientss are being taken PPI and are being connect
Satisfied curative effect cannot be still obtained by operative treatment later.Electro photoluminescence is the low frequency pulse current using some strength, by pre-
The program first set stimulates one or more groups of muscle, induces muscular movement or the normal autokinetic movement of simulation, is improved with reaching
Or restore the purpose for being stimulated muscle or muscle group function.Studies have shown that electrical stimulating therapy is a kind of effective physical therapy gastroesophageal reflux
The mode of disease, so, electrical stimulating therapy just has its market.
Patient is diagnosed as gastroesophageal reflux after being ill after receiving pH impedance detections, is subjected to electrical stimulating therapy and carries out physical therapy,
Meanwhile pH impedance detections can be received again in physical therapy process or later to judge physiotheraping effect.However, currently anti-to stomach esophagus
Disease is detected stream, electro photoluminescence physical therapy is using distinct device.So during pH impedance detections and electro photoluminescence physical therapy,
Operator may will toggle causes patient repeatedly to receive to the internal sensor for being inserted into relevant device using distinct device
(probe), therefore, whole process is cumbersome, while it is greatly uncomfortable also to bring patient.
A kind of conduit is disclosed in the patent document of Publication No. CN103533906A, which includes an elongated shaft,
The elongated shaft can merge at least one treatment or diagnostic function, and to realize physical therapy or diagnostic function, however the document is only
It is to be improved conduit from mechanical structure, there is no the treatment that the conduit is realized from circuit control and diagnosis one
Function, and such conduit volume is larger, is easy to bring sense of discomfort to patient.
Invention content
In order to overcome above-mentioned defect existing in the prior art, the object of the present invention is to provide a kind of inspections of esophagus multi-parameter
Survey, physical therapy integrated system and the adaptive electrical stimulation method of esophagus.
In order to realize the above-mentioned purpose of the present invention, the present invention provides a kind of esophagus multi-parameters to detect, physical therapy integrated system,
Including control unit, switch arrays unit, impedance detection unit, electrical stimulation unit and include impedance transducer and electro photoluminescence
The duct unit of probe；
The parameters of electrical stimulation output end of described control unit connects the parameters of electrical stimulation input terminal of the electrical stimulation unit, should
Control unit, which sets parameters of electrical stimulation and passes to electrical stimulation unit, generates stimulus signal；
Described control unit connects the impedance detection unit, and described control unit is sent to the impedance detection unit to be hindered
Anti- detection pumping signal, the impedance detection unit send impedance detection information to described control unit；
The switch arrays unit is separately connected the electrical stimulation unit, impedance detection unit and duct unit, the control
The switch control output end of unit processed connects the switch arrays unit, control the switch arrays Unit selection duct unit with
Impedance detection unit and/or electrical stimulation unit connection.
Esophagus multi-parameter detection, physical therapy integrated system are simple in structure, and impedance detection and physical therapy are integrated in one, and control
Unit processed receives the impedance information that impedance detection unit is detected, and sets electrical stimulation signal parameter and pass to electrical stimulation unit
Generate stimulus signal, also control switch arrays Unit selection impedance detection unit or electrical stimulation unit, with realize impedance detection and
The switching of electro photoluminescence function.
When patient receives impedance detection and electro photoluminescence physical therapy, it is not required to repeatedly be inserted into impedance detection sensors device or electro photoluminescence passes
Sensor need to only be inserted into the primary duct unit, greatly alleviate discomfort of patient during detection, physical therapy, also give
Operator brings convenient.
Further, the impedance transducer and electro photoluminescence probe are metal electrode group, and the impedance transducer and
Electro photoluminescence probe shares same metal electrode group, and the metal electrode group includes at least 2 metal electrodes；
Described control unit controls metal electrode and impedance detection list in the switch arrays Unit selection duct unit
The connection or vacant of one of member, electrical stimulation unit.
This realizes duct unit internal impedance sensor and electro photoluminescence probe multiplexing, saves cost of manufacture, reduces and lead
Pipe volume.
Further, the switch arrays unit connects each metal electrode in the duct unit, and each institute
It states metal electrode and the impedance detection unit or electrical stimulation unit is connected by the switch arrays unit.
Further, further include pressure sensor and pressure sensing cell, the pressure sensor is set to the conduit
On unit, the output end of the pressure sensor connects the pressure sensing cell input terminal, the pressure sensing cell output end
Connect the pressure signal input end of described control unit.This, for the monitoring to esophageal pressure, is esophageal motility obstacle disease
Diagnosis and research oesophagus physiology provide data support.Meanwhile esophageal pressure detection and impedance detection joint detection results can be very
Good reaction esophagus muscular movement state, can be used to judge whether electro photoluminescence physical therapy reaches ideal effect of stimulation in real time.
Further, be integrated with signal processing module in described control unit, to control unit receive detection information into
Row signal processing.So that the detection information received is more accurate.
Further, further include pH sensors and pH detection units, the pH sensors are set in the duct unit,
The output end of the pH sensors connects the pH detection units input terminal, and it is single that the pH detection units output end connects the control
The pH signal input parts of member.Integrated PH sensor and pH detection units, convenient for detecting esophageal pH variation simultaneously.
Further, the impedance detection unit includes signal filter amplification circuit, and amplification is filtered to impedance signal
Processing.
Further, the metal electrode is 8.This can more fully manage the carry out impedance detection of esophagus and electro photoluminescence
It treats.
Further, described control unit is also associated with host computer, convenient for exporting final detection result to host computer.
It is adaptively electric based on above-mentioned esophagus multi-parameter detection, the esophagus of physical therapy integrated system that the invention also provides a kind of
Stimulating method calculates esophagus muscle contraction strength when carrying out electro photoluminescence, and computational methods are esophagus muscle contraction strength Z=altogether
AX+B(X0/Y0) Y, wherein the pressure value that X is detected by pressure sensing cell, the impedance value that Y is detected by impedance detection unit,
A and B is weighted value, is constant, X0、Y0For the calibration value of pressure value and impedance value；
When esophagus muscle contraction strength is more than default threshold value, described control unit controls electrical stimulation unit and reduces electricity
Stimulus intensity；
When esophagus muscle contraction strength is less than default threshold value, described control unit controls electrical stimulation unit enhancing electricity
Stimulus intensity.
This method alleviates operation difficulty of operator during electro photoluminescence physical therapy, while anti-by the stimulation to patient
The real-time monitoring answered realizes quickly adjustment intensity of electric stimulus, has reached effective induction muscular movement or simulation is normal autonomous
The purpose of movement.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Description of the drawings
The above-mentioned and/or additional aspect and advantage of the present invention will become in the description from combination following accompanying drawings to embodiment
Obviously and it is readily appreciated that, wherein：
Fig. 1 is the structure diagram of the present invention；
Fig. 2 is conduit schematic diagram.
Specific implementation mode
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, and is only used for explaining the present invention, and is not considered as limiting the invention.
In the description of the present invention, unless otherwise specified and limited, it should be noted that term " installation ", " connected ",
" connection " shall be understood in a broad sense, for example, it may be mechanical connection or electrical connection, can also be the connection inside two elements, it can
, can also indirectly connected through an intermediary, for the ordinary skill in the art to be to be connected directly, it can basis
Concrete condition understands the concrete meaning of above-mentioned term.
As shown in Figure 1, the present invention provides a kind of detection of esophagus multi-parameter, physical therapy integrated systems, including control unit, open
Close array element, impedance detection unit, electrical stimulation unit and include impedance transducer and electro photoluminescence probe duct unit.
The parameters of electrical stimulation output end of described control unit connects the parameters of electrical stimulation input terminal of the electrical stimulation unit, should
Control unit, which sets parameters of electrical stimulation and passes to electrical stimulation unit, generates stimulus signal.
Described control unit connects the impedance detection unit, and described control unit is sent to the impedance detection unit to be hindered
Anti- detection pumping signal, the impedance detection unit to described control unit send impedance detection information, described control unit to
The impedance detection unit sends pumping signal.
The switch arrays unit is separately connected the electrical stimulation unit, impedance detection unit and duct unit, the control
The switch control output end of unit processed connects the switch arrays unit, control the switch arrays Unit selection duct unit with
Impedance detection unit and/or electrical stimulation unit connection.
Wherein, signal processing unit, processing detection element output signal are integrated in control unit, control unit is also connected with
There is host computer, host computer is given to for exporting final detection result；Control unit sets electrical stimulation signal parameter and passes to electricity
Stimulating unit generates stimulus signal.Electrical stimulation unit is responsible for, according to signal processing and control unit setup parameter, generating corresponding
Stimulus signal.The impedance detection unit includes signal filter amplification circuit, and enhanced processing is filtered to impedance signal.Electricity thorn
Sharp unit is that (such as electrical stimulation signal generating means in CN201180071074.9, can basis for electrical stimulation signal generative circuit
The waveform and voltage output signal of setting), host computer generates stimulus signal effect after determining stimulus signal, by electrical stimulation unit
In electric stimulation electrode.
Control unit realizes impedance by controlling the switch arrays Unit selection impedance detection unit or electrical stimulation unit
The switching of detection function and electro photoluminescence function avoids and is repeatedly inserted into impedance detection sensors device or electro photoluminescence sensor, need to only insert
Enter the primary duct unit, greatly alleviates discomfort of patient during detection, physical therapy, also brought just to operator
It is prompt.
As the preferred embodiment of the present embodiment, the impedance transducer and electro photoluminescence probe are metal electrode group, and institute
It states impedance transducer and electro photoluminescence probe shares same metal electrode group, the metal electrode group includes at least 2 metal electrodes,
Each metal electrode is unable to simultaneously perform impedance detection and electro photoluminescence.The switch arrays unit connects in the duct unit
Each metal electrode, described control unit control each metal electrode and resistance in the switch arrays Unit selection duct unit
The connection or vacant of one of anti-detection unit, electrical stimulation unit.
After control unit controls switch arrays Unit selection impedance detection unit or electrical stimulation unit, switch arrays unit will
Metal electrode connection impedance detection unit in duct unit or electrical stimulation unit, control unit control switch arrays unit have come
It is selected at the function of any metal electrode.If metal electrode is used for impedance detection, it is connected to impedance detection unit；If for electricity thorn
When swashing physical therapy, it is connected to electrical stimulation unit.
Switch arrays unit can be, but not limited to be realized using multiple relays, be connect with relay by control unit,
Relay normally open contact is connected between each metal electrode and impedance detection unit, electrical stimulation unit in duct unit, to relay
Send high and low level, to realize relay normally opened contact keying, to control each metal electricity on switch arrays unit
Pole selection connect with impedance detection unit or is connect with electrical stimulation unit, or directly vacant.Certain switch arrays unit
Other types of switch may be used to be realized.
Impedance detection unit is responsible for pumping signal being output to any 2 metal electrodes for having been configured as impedance detection function
Between；Pumping signal will produce corresponding variation under the action of electrode impedance, and impedance detection unit completes variable signal filter
The signal processings such as wave amplification.
As shown in Fig. 2, impedance detection function shares 8 metal electrodes with electro photoluminescence function, control unit is to switch arrays
Unit is controlled, and the function selection of any one metal electrode, impedance detection function or electro photoluminescence function are completed.
When two or more metal electrodes are selected as impedance detection function in duct unit, pumping signal in office 2
It will produce corresponding variation between electrode, the processing such as amplification be filtered to the variable signal by impedance detection unit, then transmit
It is converted into digital signal to the signal processing unit in control unit to be handled, completes impedance measurement function.
When a certain metal electrode is selected as electro photoluminescence function, suitable another metal electrode is selected according to actual needs
Electrode pair is formed, the electrical stimulation signal between electrode pair needs to carry out parameter setting by operator according to clinic, and when setting can lead to
It crosses but is not limited to knob etc to be configured, corresponding stimulus signal is generated by electrical stimulation unit, then pass to electrode pair
Complete electro photoluminescence function.
Since 8 metal electrodes can be configured to electric stimulation electrode, so duct unit can be in situation about not moving
The lower stimulation for completing upper esophagus, stage casing, hypomere, such as：It is optional when electro photoluminescence physical therapy need to be carried out to the sphincter of upper esophagus
The electrode composition electrode pair at the i.e. upper sphincter of conduit upper end electrode is selected, electro photoluminescence physical therapy process is completed.
In order to preferably judge whether electro photoluminescence physical therapy reaches ideal effect of stimulation, esophagus multi-parameter detection, reason
It further includes pressure sensor and pressure sensing cell to treat integrated system, and the pressure sensor is set in the duct unit,
The output end of the pressure sensor connects the pressure sensing cell input terminal, described in the pressure sensing cell output end connection
The pressure signal input end of control unit.This provides data branch for the diagnosis of esophageal motility obstacle disease and research oesophagus physiology
It holds.Meanwhile esophageal pressure detection and impedance detection joint detection results can react esophagus muscular movement state well, it can be real-time
For judging whether electro photoluminescence physical therapy reaches ideal effect of stimulation.
As another preferred embodiment of the present embodiment, as shown in Fig. 2, esophagus multi-parameter detection, physical therapy integrated system are also
Including pH sensors and pH detection units, the pH sensors are set in the duct unit, the output end of the pH sensors
Connect the pH detection units input terminal, the pH signal input parts of the pH detection units output end connection described control unit.
PH sensors generally include reference electrode, multiple antimony electrodes, and patient, can also be real when receiving impedance detection and electro photoluminescence physical therapy
Now to the detection of esophageal pH variation.
Since patient is when carrying out electro photoluminescence physical therapy, since the damage of the esophagus musculature of patient is different, generally require
Intensity of electric stimulus it is also different.Currently, stimulus intensity is mostly manually set by operator according to clinical experience and patient's stimulate the reaction,
For accuracy the bottom of compared with, difficulty is larger.
To solve this problem, the invention also provides a kind of based on above-mentioned esophagus multi-parameter detection, one system of physical therapy
The adaptive electrical stimulation method of esophagus of system calculates esophagus muscle contraction strength when carrying out electro photoluminescence, and computational methods are esophagus altogether
Muscle contraction strength Z=AX+B (X0/Y0) Y, wherein the pressure value that X is detected by pressure sensing cell, Y are impedance detection unit
The impedance value detected, A and B are weighted values, are constant, X0、Y0For the calibration value of pressure value and impedance value.
When esophagus muscle contraction strength is more than default threshold value, it is considered as the too strong state of stimulation, described control unit control
Electrical stimulation unit processed reduces intensity of electric stimulus.
When esophagus muscle contraction strength is less than default threshold value, it is considered as and fails to reach induction muscular movement or muscle fortune
Undesirable state is moved, described control unit, which controls electrical stimulation unit, enhances intensity of electric stimulus.
It, can since esophageal pressure detection and impedance detection joint detection results can react esophagus muscular movement state well
In real time for judging whether electro photoluminescence physical therapy reaches ideal effect of stimulation.
In the present invention, operator configures impedance/electric stimulation electrode according to actual demand, and the electrode for impedance detection is known as
Impedance electrodes, the electrode for electro photoluminescence function are known as electric stimulation electrode.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
Centainly refer to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be any
One or more embodiments or example in can be combined in any suitable manner.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
In the case of being detached from the principle of the present invention and objective a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The range of invention is limited by claim and its equivalent.
Claims (10)
1. a kind of esophagus multi-parameter detection, physical therapy integrated system, which is characterized in that including control unit, switch arrays unit, resistance
Anti- detection unit, electrical stimulation unit and include impedance transducer and electro photoluminescence probe duct unit；
The parameters of electrical stimulation output end of described control unit connects the parameters of electrical stimulation input terminal of the electrical stimulation unit, the control
Unit, which sets parameters of electrical stimulation and passes to electrical stimulation unit, generates stimulus signal；
Described control unit connects the impedance detection unit, and described control unit sends impedance inspection to the impedance detection unit
Pumping signal is surveyed, the impedance detection unit sends impedance detection information to described control unit；
The switch arrays unit is separately connected the electrical stimulation unit, impedance detection unit and duct unit, and the control is single
The switch control output end of member connects the switch arrays unit, controls the switch arrays Unit selection duct unit and impedance
Detection unit and/or electrical stimulation unit are connected.
2. esophagus multi-parameter detection according to claim 1, physical therapy integrated system, which is characterized in that the impedance sensing
Device and electro photoluminescence probe are metal electrode group, and the impedance transducer and electro photoluminescence probe share same metal electrode group,
The metal electrode group includes at least 2 metal electrodes；
Described control unit controls metal electrode and impedance detection unit, electricity in the switch arrays Unit selection duct unit
The connection or vacant of one of stimulating unit.
3. esophagus multi-parameter detection according to claim 2, physical therapy integrated system, which is characterized in that the switch arrays
Unit connects each metal electrode in the duct unit, and each metal electrode passes through the switch arrays unit
Connect the impedance detection unit or electrical stimulation unit.
4. esophagus multi-parameter detection according to claim 1, physical therapy integrated system, which is characterized in that further include that pressure passes
Sensor and pressure sensing cell, the pressure sensor are set in the duct unit, and the output end of the pressure sensor connects
Connect the pressure sensing cell input terminal, the pressure signal input of the pressure sensing cell output end connection described control unit
End.
5. esophagus multi-parameter detection according to claim 1, physical therapy integrated system, which is characterized in that described control unit
It is inside integrated with signal processing module, signal processing is carried out to the detection information that control unit receives.
6. esophagus multi-parameter detection according to claim 1, physical therapy integrated system, which is characterized in that further include pH sensings
Device and pH detection units, the pH sensors are set in the duct unit, and the output end of the pH sensors connects the pH
Detection unit input terminal, the pH signal input parts of the pH detection units output end connection described control unit.
7. esophagus multi-parameter detection according to claim 1, physical therapy integrated system, which is characterized in that the impedance detection
Unit includes signal filter amplification circuit, and enhanced processing is filtered to impedance signal.
8. esophagus multi-parameter detection according to claim 2, physical therapy integrated system, which is characterized in that the metal electrode
It is 8.
9. esophagus multi-parameter detection according to claim 1, physical therapy integrated system, which is characterized in that described control unit
It is also associated with host computer.
10. a kind of esophagus multi-parameter based on described in claim 4 detects, the adaptive electro photoluminescence side of esophagus of physical therapy integrated system
Method, which is characterized in that when carrying out electro photoluminescence, calculate esophagus muscle contraction strength, computational methods are that esophagus contraction of muscle is strong altogether
Spend Z=AX+B (X0/Y0) Y, wherein the pressure value that X is detected by pressure sensing cell, the resistance that Y is detected by impedance detection unit
Anti- value, A and B are weighted values, are constant, X0、Y0For the calibration value of pressure value and impedance value；
When esophagus muscle contraction strength is more than default threshold value, described control unit controls electrical stimulation unit and reduces electro photoluminescence
Intensity；
When esophagus muscle contraction strength is less than default threshold value, described control unit, which controls electrical stimulation unit, enhances electro photoluminescence
Intensity.
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| CN111659010A (en) * | 2020-07-16 | 2020-09-15 | 郑州大学 | Limb functional electrical stimulation control method and limb rehabilitation robot |
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