CN108754634A - Electrostatic spinning reception device prepares the method and tubular bracket for being orientated electrostatic spinning tubular bracket - Google Patents
Electrostatic spinning reception device prepares the method and tubular bracket for being orientated electrostatic spinning tubular bracket Download PDFInfo
- Publication number
- CN108754634A CN108754634A CN201810508682.5A CN201810508682A CN108754634A CN 108754634 A CN108754634 A CN 108754634A CN 201810508682 A CN201810508682 A CN 201810508682A CN 108754634 A CN108754634 A CN 108754634A
- Authority
- CN
- China
- Prior art keywords
- bar
- tubular bracket
- holder
- rotating bar
- reception
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000010041 electrostatic spinning Methods 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 18
- 230000005405 multipole Effects 0.000 claims abstract description 16
- 230000005404 monopole Effects 0.000 claims abstract description 10
- 239000002121 nanofiber Substances 0.000 claims description 53
- 238000009987 spinning Methods 0.000 claims description 27
- 238000013519 translation Methods 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 16
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 13
- 239000004626 polylactic acid Substances 0.000 claims description 12
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 10
- 229920001610 polycaprolactone Polymers 0.000 claims description 10
- 229920000159 gelatin Polymers 0.000 claims description 7
- 235000019322 gelatine Nutrition 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 5
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- -1 polyoxyethylene Polymers 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 102000009123 Fibrin Human genes 0.000 claims description 2
- 108010073385 Fibrin Proteins 0.000 claims description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
- 108010022355 Fibroins Proteins 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920002732 Polyanhydride Polymers 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 238000007334 copolymerization reaction Methods 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- 229950003499 fibrin Drugs 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 2
- 239000000622 polydioxanone Substances 0.000 claims description 2
- 239000004633 polyglycolic acid Substances 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920000151 polyglycol Polymers 0.000 claims 1
- 239000010695 polyglycol Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract description 2
- 230000005611 electricity Effects 0.000 description 10
- 239000000835 fiber Substances 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 239000001828 Gelatine Substances 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000000520 microinjection Methods 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000004804 winding Methods 0.000 description 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000002070 nanowire Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 210000000626 ureter Anatomy 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Textile Engineering (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Nonwoven Fabrics (AREA)
Abstract
The present invention relates to methods and tubular bracket that a kind of electrostatic spinning reception device, preparation are orientated electrostatic spinning tubular bracket, electrostatic spinning reception device includes receiving plane, the first driving unit and high pressure allocation unit, the receiving plane is made of the parallelogram region of the first reception bar, the second reception bar, third reception bar and rotating bar successively end to end formation, first driving unit is connected with rotating bar, and rotating bar is driven to rotate along central shaft；The high pressure allocation unit control first receives bar, the second reception bar, third and receives bar and the voltage of rotating bar.The electrostatic spinning reception device can realize the monopole tubular bracket that a variety of orientations are obtained in same reception device and the tubular bracket that multipole is orientated, and prepared tubular bracket belongs to integrated molding, and there is no combine weak spot, excellent in mechanical performance.
Description
Technical field
The present invention relates to the technical fields of electrostatic spinning, are taken more particularly, to a kind of electrostatic spinning reception device, preparation
To the method and tubular bracket of electrostatic spinning tubular bracket.
Background technology
Currently, electrostatic spinning technique is a kind of nanometer for preparing to the highly effective method of micron order fiber, equipment letter
Easily, low-cost, and the tissue engineering bracket prepared has high-specific surface area, the diameter and hole of controllable nano fiber
Rate, the advantages that can especially obtaining the tridimensional network of similar natural extracellular matrix, thus, it is widely used in a group weaver
The preparation of engineering support.In most cases, the holder prepared using static collection device is mostly that plain film is membranaceous.
Since human body is much organized, such as blood vessel, nerve channel, ureter etc. is made of tubular structure, for this purpose, portion
Point scholar forms tube chamber by being crimped the static spinning membrane of membrane-like and bonding or suture, tubulose made from this mode
Holder has overlapping in binding site, and binding site belongs to weak part, and mechanical strength is relatively low, easily tears.Meanwhile in human body
Tubular structure all have the nanometre collagen fibre structures of multipole orientations, to support tubular structure in radial and axial bullet
Property movement, and orientation texture axial in nerve trachea also help cell align in the axial direction and nerve pass
It leads, axial orientation texture can avoid the adherency of thrombus and calculus and cause luminal stenosis in blood vessel and ureter；Above described tubular
Radial oriented structure in structure can support the movements such as the holding, contraction, expansion of tubular structure, ensure the function of tubular structure
Property.Therefore, being prepared using electrostatic spinning technique, there is typical multipole to align（It is orientated）Structure（Completely）It is seamless tubular shaped
Holder becomes a research hotspot.
The method for preparing the seamless tubular shaped holder of orientation texture at present mainly has high speed rotary-drum collection and crosspointer electrode to receive
Collection.High speed rotary-drum collection is to collect nanofiber using high-speed rotating roller, forms radial oriented tubular bracket；Crosspointer electricity
It is using two staggered relatively but discontiguous metal needles as collection device, because nanofiber and metal needle rack are deposited that pole, which is collected,
In potential difference, the preferential alternating deposit on two metal needles of nanofiber forms axial orientation in the gap between crosspointer
Tubular bracket.Above two preparation method is only capable of the tubular bracket being orientated in one direction, cannot be satisfied actual clinical
Demand, and at present also no spinning equipment can realize can be obtained in same equipment radial oriented tubular bracket again acquisition
The function for a variety of monopole tubular brackets that axial orientation tubular bracket or other angles are orientated.
Invention content
The present invention is at least one defect overcome described in the above-mentioned prior art, provide a kind of electrostatic spinning reception device,
It is orientated the preparation method and tubular bracket of electrostatic spinning tubular bracket, which can realize connects at same
The monopole tubular bracket of a variety of orientations is obtained on receiving apparatus.
In order to solve the above technical problems, technical scheme is as follows：
A kind of electrostatic spinning reception device, including receiving plane, the first driving unit and high pressure allocation unit, the receiving plane is by
One receive bar, second receive bar, third receives the parallelogram region of bar and rotating bar end to end formation successively and constitutes,
First driving unit is connected with rotating bar, and rotating bar is driven to rotate along central shaft；The high pressure allocation unit
Control first receives bar, the second reception bar, third and receives bar and the voltage of rotating bar.Preferably, first driving unit
It can be motor.
Further, relative translation motion can be made along the axial direction of the two between the second reception bar and rotating bar.It is real
Can be driving rotating bar and/or the there are many mode for making relative translation motion between existing second reception bar and rotating bar is
Two reception bars do translational motion axially along, can also be that driving first receives bar and/or third reception bar swing and then band
Dynamic second reception bar makees relative translation motion with rotating bar.
Further, which further includes the first support, second support, third holder and the 4th for accepting the receiving plane
Holder；The both ends of the rotating bar are connect with the upper end bearing of first support, second support respectively；Described first receives the two of bar
End respectively with the universal connection in the upper end of first support, third holder；Described second receive the both ends of bar respectively with third holder, the
The universal connection in upper end of four holders；The third receive bar both ends respectively with second support, the universal connection in upper end of the 4th holder；
The third holder, the 4th holder can make described second to receive energy between bar and rotating bar by synchronizing moving on its line direction
Enough axial directions along the two make relative translation motion.Universal connection can realize the normal of universal rotational by spherical hinge etc.
Device is advised to realize.
Further, which further includes pedestal；The side of third holder, the 4th holder line described in the pedestal upper edge
Guide rail is set up, the lower end of the third holder and the 4th holder is installed in the guide rail and can be same along guide rail
Moved further；The lower end of the first support, second support is fixed on the base.
Further, which further includes the second driving unit being set to below pedestal, second driving unit
Third holder and the 4th holder can be driven to be moved back and forth along guide rail.Second driving unit can be motor.
Further, which further includes governor, and the governor connects the first driving unit, the governor
The rotary speed of first driving unit can be adjusted.
A kind of preparation method being orientated electrostatic spinning tubular bracket, specifically comprises the following steps：
S1：Electrospun material is dissolved in corresponding solvent, spinning solution is configured to and is transferred to spinning syringe；Specifically,
Spinning solution can be transferred in syringe and on syringe pump, front end of the syringe needle is connected to syringe needle, syringe needle by connecting tube
It is connected downwards and with high voltage power supply；Electrostatic spinning reception device is mounted on immediately below syringe needle；Syringe needle can be stainless pin head.
S2：Syringe pump is opened, wait having spinning solution after spinning syringe needle squeezes out, opens the high-voltage electricity being connected with syringe needle
Source makes nanofiber be sprayed from syringe needle；
S3：The high pressure allocation unit in reception device is opened to rotating bar and/or receives bar application voltage, it is fine to form orientation nano
Tie up net；
S4：Control rotating bar starts rotation to collect oriented nanofibers net, obtains and is orientated tubular bracket.
Preferably, further include before step S3：Axial direction of the second reception bar of control with rotating bar along the two makees relative translation
Movement stops when the receiving plane that first receives bar, the second reception bar, third reception bar and rotating bar composition is rectangular area
Only second receive the relative translation motion between bar and rotating bar.When the receiving plane is rectangular area, pass through the electricity of step S3
Pressure distribution can form the nanometer fiber net that single-stage axially or radially is orientated, to obtain radial oriented or axial orientation pipe
Shape holder.
Preferably, the step S4 is specifically included：After rotating bar rotation, control first receives bar with rotating bar along its axis
It is orientated tubular bracket to repetition relative displacement acquisition multipole occurs.
Specifically, can be required according to different orientations, the first, second, third rotating bar and reception bar are carried out respectively
Voltage distributes, and nanofiber is influenced by the inhomogeneities of voltage's distribiuting, is orientated ground and collects between the second reception bar and rotating bar
Or first receive between bar and third receive bar, the rotating bar winding then rotated is collected.Until the nanometer in rotating bar
Fiber is collected into certain thickness, closes all high voltage power supplies and stops spinning, specifically, syringe pump can be closed, by collection
Tubular bracket is removed from rotating bar is orientated electrostatic spinning tubular bracket up to monopole or multipole.
The step S3 can specifically include：High pressure allocation unit controls the electricity of three reception bars and a rotating bar
Pressure so that most of nanofiber forms axial orientation web between first receives bar and third receives bar, and has a small amount of
Nanofiber is rotated bar reception.
The step S3 can also include specifically：High pressure allocation unit controls the electricity of three reception bars and a rotating bar
Pressure so that nanofiber forms radial oriented web between the second reception bar and rotating bar.
Specifically, reception device can also include governor, the governor can adjust whether rotating bar rotates simultaneously
Its rotating speed can be adjusted.Rotating bar can be selected to start the opportunity of rotation, as that rotating bar can be made to rotate if starting before spinning,
Can also be first so that spinning allows rotating bar to rotate again between reception bar and rotating bar after first a small amount of spinning.
Further, electrospun material described in step S1 is polylactic acid（PLA）, poly-epsilon-caprolactone, fibroin, polylactic acid
With copolymer, PLA-PEG copolymer, poly-epsilon-caprolactone and the polylactic acid of polyglycolic acid or the copolymerization of polyethylene glycol
Object, polydioxanone, polyanhydride, gelatin, collagen, hyaluronic acid, chitosan, fibrin, pectin, starch and its derivative
Any one in object, cellulose and its etherate, polyoxyethylene, polyvinyl alcohol, polyethylene glycol, Kynoar, polyurethane
Or several mixture.
Further, solvent described in step S1 is ethyl alcohol, methanol, hexafluoroisopropanol, acetone, tetrahydrofuran, dimethyl
Any one or a few mixed solution in formamide, chloroform, dichloromethane, formic acid, acetic acid, dioxane, trifluoroacetic acid.
The operating voltage for the high voltage power supply being connected with syringe needle described in step S3 can be 5 ~ 40kV, preferably 10 ~ 30kV.
The operating voltage of potential distribution system described in step S4 can be -10 ~ 10kv, preferably -4 ~ 4kv；To obtain difference
The nanofiber of differently- oriented directivity, potential distribution system are allocated according to different demands, substantially, preset depositing nanofibers
On bar, add negative high voltage；On the default not bar of depositing nanofibers, add positive high voltage.
Electrospinning syringe needle can be 5 ~ 20cm, preferably 10 ~ 15cm to the distance of bar plane is received in step S2.
A kind of tubular bracket, the tubular bracket are integrally formed by monopole or multipole oriented nanofibers.The Nanowire
The diameter of dimension can be 0.1 ~ 2 μm, preferably 0.3 ~ 1.5 μm；The aperture of the micropore formed between nanofiber can be 1 ~ 10 μm,
It is preferred that 2 ~ 5 μm.The nanofiber porosity of the tubular bracket is 85% ~ 90%.
Tubular bracket can be that monopole orientation texture may be multipole orientation texture, wherein monopole orientation can be diameter
To orientation, axial orientation or any direction between axial direction and radial direction；Tubular bracket can be multipole orientation texture, more
Pole orientation texture includes the structure sheaf of different orientation, wherein be preferably included within internal layer radial oriented layers of nanofibers and
Axial orientation layers of nanofibers outside internal layer, or different levels different orientation angle can be prepared according to different clinical demands
The multipole of degree is orientated tubular bracket structure.
Compared with prior art, advantageous effect is：
（1）Electrostatic spinning reception device is provided with the parallelogram receiving plane being made of multiple reception bars and rotating bar, passes through
High pressure allocation unit adjusts the voltage in multiple reception bars and rotating bar, can be according to different clinical demands in same electrostatic spinning
The monopole that different orientation is made in reception device is orientated tubular bracket；
（2）The second reception bar and rotating bar can make relative translation motion, can realize the tubulose branch of multi-angle fiber alignment
The preparation of frame and multipole are orientated the preparation of tubular bracket；
（3）The tubular bracket of preparation belongs to integrated molding, and there is no combine weak spot, excellent in mechanical performance；And tubular bracket
Has the orientation texture of different directions, axial orientation also helps carefully while radial oriented structure promotes the tensile property of tube chamber
Born of the same parents align and orient in the axial direction conduction, avoid the adherency of thrombus and calculus and cause luminal stenosis.
Description of the drawings
Fig. 1 is electrostatic spinning reception device structural schematic diagram of the present invention.
Fig. 2 is the structural schematic diagram of another angle of electrostatic means reception device of the present invention.
Fig. 3 is the PLA nano-fiber tubular scaffold pattern photos of five axial orientation of the embodiment of the present invention.
Fig. 4 is the radial oriented PCL nano-fiber tubular scaffold pattern photos of the embodiment of the present invention six.
Fig. 5 is the gelatine nano fiber tubular bracket pattern photo of seven netted double orientation of the embodiment of the present invention.
Fig. 6 is that the PLA nano-fiber tubular scaffolds of five axial orientation of the embodiment of the present invention prepare schematic diagram.
Fig. 7 is that the embodiment of the present invention six radial oriented PCL nano-fiber tubular scaffolds prepare schematic diagram.
Specific implementation mode
The attached figures are only used for illustrative purposes and cannot be understood as limitating the patent；It is attached in order to more preferably illustrate the present embodiment
Scheme certain components to have omission, zoom in or out, does not represent the size of actual product；To those skilled in the art,
The omitting of some known structures and their instructions in the attached drawings are understandable.Being given for example only property of position relationship described in attached drawing
Illustrate, should not be understood as the limitation to this patent.
Embodiment one：
A kind of electrostatic spinning reception device, the device specifically include the first reception bar 1, second and receive bar 2, third reception bar 3, turn
Lever 4, high pressure allocation unit and the first driving unit 5；The described second reception bar 2 is arranged in parallel with rotating bar 4, and described the
One reception bar 1 receives bar 3 with third and is arranged in parallel；First, which receives bar 1, second, receives bar 2, third reception bar 3 and rotating bar 4
Head and the tail are connected by connector, and constitute parallelogram region in the same plane, which is known as receiving
Face；First driving unit 5 can drive rotating bar 4 to be rotated along central shaft, and the rotating bar 4 and first receives bar
1, the second reception bar 2, third receive bar 3 and are separately connected high pressure allocation unit, and the high pressure allocation unit can adjust rotation
Voltage on bar 4 and three reception bars enables spinning to be oriented along different directions.
Preferably, the first driving unit 5 can be motor, and the rotating speed of the motor can be 10 ~ 300rpm, preferably 30 ~
150rpm.Too fast rotating speed can be such that nanofiber is pulled off when winding collection in rotating bar；Too low rotating speed cannot make to receive again
Rice fiber is stretched sufficiently collection, therefore it is preferred that 30 ~ 150rpm.Certainly, in the present embodiment, first driving unit can also be
Other power plants, are not limited herein.
Preferably, in the present embodiment, voltage allocation unit by two programmable, exportable positive or negative high voltages high direct voltage
Power supply forms, and the rotating bar on respectively above-mentioned two groups of opposite side of parallelogram/reception bar applies voltage.
Embodiment two：
It can make relative translation motion along the axial direction of the two between the second reception bar 2 and rotating bar 4.It is real in the present embodiment
Make between existing second reception bar 2 and rotating bar 4 relative translation motion mode can there are many, can be driving rotating bar 4 and/or
Second reception bar 2 does translational motion axially along, can also be driving first reception bar 1 and/or third receive bar 3 swing into
And the second reception bar 2 is driven to make relative translation motion with rotating bar 4.
The present embodiment other parts are identical as embodiment one, and details are not described herein again.
Embodiment three：
The electrostatic spinning reception device can also include first support 61, second support 62, third holder 71 and the 4th holder
72；The both ends of the rotating bar 4 are connect with the upper end bearing of first support 61, second support 62 respectively；Described first receives bar 1
Upper end of the both ends respectively with first support 61, third holder 71 pass through spherical hinge connection；Described second receives the both ends of bar 2
The upper end with third holder 71, the 4th holder 72 passes through spherical hinge connection respectively；The third receives 3 both ends of bar respectively with the
Two holders 62, the 4th holder 72 pass through spherical hinge connection；The third holder 71, the 4th holder 72 can be in its line directions
Upper synchronizing moving so that relative translation motion can be made along the axial direction of the two between the second reception bar 2 and rotating bar 4.Wherein,
Pass through spherical hinge connection between the first, second, third reception bar and the first, second, third, fourth holder so that institute
When stating the second reception bar 2 and making relative translation motion with rotating bar 4, first receive bar 1 and third receive bar 3 can accordingly with rotation
Bar 4 forms different angles.
Rotating bar and the diameter for receiving bar can be 0.1 ~ 20mm, preferably 1 ~ 15mm；Length be 20 ~ 200mm, preferably 30
~100mm.In fact, the diameter of rotating bar disclosed by the invention and reception bar, length can be adjusted arbitrarily, but according to tubulose branch
The actual demand of frame, preferably 1 ~ 15mm of diameter, 30 ~ 100mm of length.
Example IV：
Electrostatic spinning reception device can also include pedestal 8；The side of pedestal 8 the upper edge third holder and the 4th holder line
Guide rail 9 is set up；The lower end of the third holder 71 and the 4th holder 72 is installed in the guide rail 9 and can be along
9 synchronizing moving of guide rail；The lower end of the first support 61, second support 62 is fixed on pedestal 8.The second driving can be passed through
Unit 10 drives third holder 71 and the 4th holder 72 along 9 synchronous translational of guide rail.
Preferably, as shown in Fig. 2, the second driving unit 10 is installed on the lower section of pedestal 8, for driving third holder 71 and the
Four holders 72 move back and forth, wherein the second driving unit 10 can be motor, and motor keeps third holder 71 and the 4th holder 72 anti-
The movement speed moved again is 1 ~ 150mm/s, preferably 10 ~ 50mm/s.The pedestal is made of insulating materials, the first reception bar 1,
Second reception bar 2, third receives bar 3 and rotating bar 4 is made of an electrically conducting material, and motor and high voltage power supply carry out insulation processing.
In the present embodiment, the operating voltage for the high voltage power supply being connected with syringe needle can be 5 ~ 40kV, preferably 10 ~ 30kV.Institute
The third holder 71 and the 4th holder 72 stated are the distance between L-shaped, third holder 71 and first support 61 on the pedestal,
The distance between 4th holder 72 and second support 62 by first reception bar 1 and third receive bar 3 length determine, distance range
For 20 ~ 200mm, preferably 30 ~ 100mm.Too small distance can cause excessive nanofiber to be collected in rotating bar 4, form nothing
Advise structure；Excessive distance can cause nanofiber to be pulled off when winding collection in rotating bar.By testing, preferably 30 ~
100mm。
It will be appreciated by those skilled in the art that ground, the operating voltage for the high voltage power supply being connected with syringe needle can be other models
It encloses, accordingly, the length of the first reception bar 1 and third reception bar 3 can also be other ranges, and the present invention couple is connected with syringe needle
The operating voltage range of high voltage power supply and the first reception bar and third receive the length of bar（That is third holder 71 and first support
The distance between 61, the distance between the 4th holder 72 and second support 62）It is not limited.
Electrostatic spinning reception device can also include governor 11, and in the present embodiment, the governor 11 is installed on first
The bottom of driving unit 5, the governor 11 can connect the first driving unit 5 and can be to the rotations of the first driving unit 5
Rotary speed is adjusted.Governor 11 can also connect the second driving unit 10, to adjust third holder 71, the 4th holder 72
Translational velocity and translation direction.Governor 11 carries out insulation processing.
It is orientated the preparation of tubular bracket or the preparation of the tubular bracket of a certain angle-fiber orientation when needing progress multipole
When, the second driving unit 10 can move back and forth or translate a certain angle to a direction to realize for different spinning
The needs in direction.
The voltage output range of the voltage allocation unit is -4 ~ 4kV.The voltage strength of voltage allocation unit output is held
Continuous time, voltage waveform are adjustable, to obtain the high-voltage electrostatic field of different distributions, promote the directional collecting of nanofiber.
Embodiment five：
What Fig. 6 showed the PLA nano-fiber tubular scaffolds of axial orientation prepares schematic diagram：
S1. by 0.8g polylactic acid（PLA）It is added in the hexafluoroisopropanol solution of 10mL, stirring at normal temperature is made 8% until dissolving
（w/v）Spinning solution；Spinning solution is added in syringe, front end of the syringe needle is plus extension tube and connects the syringe needle that specification is 20G,
Syringe is positioned on micro-injection pump, and syringe needle receives rod grounded perpendicular to receiving plane；
S2. third holder 71 and the 4th holder 72 are moved, makes to form a rectangle between 3 reception bars and rotating bar；Pass through electricity
The adjusting for pressing allocation unit makes the first reception bar 1, third receive the voltage that bar 3 takes -4kv, the second reception bar 2 is made to take 4kv
Voltage；
S3. setting syringe pump rate be 6ml/h, wait have spinning solution from syringe needle from spray when, on syringe needle apply 22kv electricity
Pressure, has nanofiber to be sprayed from syringe needle at this time, is received bar 3 by the first reception bar 1, third and is collected, forms the Nanowire of orientation
Net is tieed up, and has a small amount of nanofiber to be deposited in rotating bar 4；
S4. the voltage for adjusting rotating bar 4 is 4kv, prevents nanofiber continuation from being deposited in rotating bar 4, and adjust rotating bar 4
Rotating speed be 100rpm, the first reception 1 third of bar, which receives the oriented nanofibers net collected between bar 3 and turned around, at this time is collected into
In rotating bar 4；Persistently process, until obtaining the axial orientation tubular bracket of suitable thickness.
The PLA nano-fiber tubular scaffolds of gained axial orientation, pattern photo are as shown in Figure 3；Wherein, PLA nanofibers
Average diameter be 452 ± 43nm, aperture be 2.5 ± 0.8 μm.
Embodiment six：
What Fig. 7 showed radial oriented PCL nano-fiber tubular scaffolds prepares schematic diagram：
S1. 0.6g polycaprolactones are added in the hexafluoroisopropanol solution of 10mL, stirring at normal temperature is made 6% until dissolving（w/v）
Spinning solution；Spinning solution is added in syringe, front end of the syringe needle is plus extension tube and connects the syringe needle that specification is 23G, injection
Device is positioned on micro-injection pump, and syringe needle receives rod grounded perpendicular to bar is received；
S2. third holder 71 and the 4th holder 72 are moved, makes to form a rectangle between 3 reception bars and rotating bar；Pass through electricity
The adjusting for pressing distribution system makes the first reception bar 1 and third receive the voltage that bar 3 takes 4kv, make the second reception bar 2 take-
The voltage of 4kv；
S3. setting syringe pump rate be 5ml/h, wait have spinning solution from syringe needle from spray when, on syringe needle apply 25kv electricity
Pressure, has nanofiber to be sprayed from syringe needle at this time, is collected by the second reception bar 2 and rotating bar 4, forms the nanofiber of orientation
Net；
S4. the rotating speed for adjusting rotating bar 4 is 50rpm, and the orientation nano collected between the second reception bar 2 and rotating bar 4 at this time is fine
Dimension net, which is turned around, to be collected into rotating bar 4；Persistently process, until obtaining the radial oriented tubular bracket of suitable thickness.
The radial oriented PCL nano-fiber tubular scaffolds of gained, pattern photo are as shown in Figure 4；Wherein, PCL nanofibers
Average diameter be 652 ± 98 nm, aperture be 5.4 ± 0.3 μm.
Embodiment seven：
The preparation for the gelatine nano fiber tubular bracket that multipole is orientated：
S1. 1.5g gelatin is added in the trifluoroethanol solution of 10mL, stirring at normal temperature is made 15% until dissolving（w/v）Spinning
Liquid；Spinning solution is added in syringe, front end of the syringe needle is plus extension tube and connects the syringe needle that specification is 25G, and syringe is placed
In on micro-injection pump, syringe needle receives rod grounded perpendicular to bar is received；
S2. by the adjusting of potential distribution system, so that the first reception bar 1 and third is received the voltage that bar 3 takes 4kv, make second
Receive the voltage that bar 2 takes -4kv；
S3. the rate of setting syringe pump is 5ml/h, when having spinning solution from syringe needle except spraying, applies the electricity of 32kv on syringe needle
Pressure, has nanofiber to be sprayed from syringe needle at this time, is collected by the second reception bar 2 and rotating bar 4, forms the nanofiber of orientation
Net；
S4. the rotating speed for adjusting rotating bar 4 is 50rpm, and the orientation nano collected between the second reception bar 2 and rotating bar 4 at this time is fine
Dimension net, which is turned around, to be collected into rotating bar 4；Third holder 71 is adjusted to move back and forth along synchronous control of guide rail 9 with the 4th holder 72；
Persistently process, until the multipole for obtaining suitable thickness is orientated tubular bracket.
The gelatine nano fiber tubular bracket of the netted double orientation of gained, pattern photo are as shown in Figure 5；Wherein, gelatin is received
The average diameter of rice fiber is 354 ± 43 nm, and aperture is 1.5 ± 0.9 μm.
Embodiment eight：
A kind of tubular bracket, the tubular bracket are integrally formed by monopole or multipole oriented nanofibers.The nanofiber is straight
Diameter is 0.1 ~ 2 μm, preferably 0.3 ~ 1.5 μm.The aperture of the micropore formed between the nanofiber be 1 ~ 10 μm, preferably 2 ~
5μm.The nanofiber porosity of the tubular bracket is 85% ~ 90%.
The reception device for preparing the tubular bracket can be the reception device in embodiment one to example IV.The tubulose branch
Frame can be prepared using the method for embodiment five to embodiment seven.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
All any modification, equivalent and improvement etc., should be included in the claims in the present invention made by within the spirit and principle of invention
Protection domain within.
Claims (15)
1. a kind of electrostatic spinning reception device, which is characterized in that including receiving plane, the first driving unit（5）It is distributed with high pressure single
Member, the receiving plane receive bar by first（1）, second receive bar（2）, third receive bar（3）And rotating bar（4）Head and the tail successively
Connect the parallelogram region to be formed composition, first driving unit and rotating bar（4）It is connected, and drives rotating bar（4）
It rotates along central shaft；The high pressure allocation unit control first receives bar（1）, second receive bar（2）, third receive bar
（3）And rotating bar（4）Voltage.
2. electrostatic spinning reception device according to claim 1, which is characterized in that described second receives bar（2）With turn
Lever（4）Between can make relative translation motion along the axial direction of the two.
3. electrostatic spinning reception device according to claim 2, which is characterized in that the device further includes accepting the reception
The first support in face（61）, second support（62）, third holder（71）With the 4th holder（72）；
The rotating bar（4）Both ends respectively with first support（61）, second support（62）The connection of upper end bearing；Described first
Receive bar（1）Both ends respectively with first support（61）, third holder（71）The universal connection in upper end；Described second receives bar
（2）Both ends respectively with third holder（71）, the 4th holder（72）The universal connection in upper end；The third receives bar（3）Both ends
Respectively with second support（62）, the 4th holder（72）The universal connection in upper end；
The third holder（71）, the 4th holder（72）Described second can be made to receive bar by synchronizing moving on its line direction
（2）With rotating bar（4）Between can make relative translation motion along the axial direction of the two.
4. electrostatic spinning reception device according to claim 3, which is characterized in that the device further includes pedestal（8）；It is described
Pedestal（8）Third holder described in upper edge（71）, the 4th holder（72）It is provided with guide rail on the direction of line（9）, described
Three holders（71）With the 4th holder（72）Lower end be installed on the guide rail（9）It is interior and can be along guide rail（9）Synchronizing moving；Institute
The first support stated（61）, second support（62）Lower end be fixed on pedestal（8）On.
5. electrostatic spinning reception device according to claim 4, which is characterized in that the device further includes being set to pedestal
（8）Second driving unit of lower section（10）, second driving unit（10）Third holder can be driven（71）With the 4th
Frame（72）Along guide rail（9）It moves back and forth.
6. the electrostatic spinning reception device according to claim 1 ~ 5 any one, which is characterized in that the device further includes adjusting
Fast device（11）, the governor（11）Connect the first driving unit（5）, the governor（11）It can be single to the first driving
Member（5）Rotary speed be adjusted.
7. a kind of using orientation tubulose branch of the electrostatic spinning reception device as reception device described in claim 1 ~ 6 any one
The preparation method of frame, which is characterized in that include the following steps：
S1：Electrospun material is dissolved in corresponding solvent, spinning solution is configured to and is transferred to spinning syringe；
S2：Syringe pump is opened, wait having spinning solution after spinning syringe needle squeezes out, opens the high voltage power supply being connected with syringe needle,
Nanofiber is set to be sprayed from syringe needle；
S3：The high pressure allocation unit in reception device is opened to rotating bar and/or receives bar application voltage, it is fine to form orientation nano
Tie up net；
S4：Control rotating bar starts rotation to collect oriented nanofibers net, obtains and is orientated tubular bracket.
8. the preparation method according to claim 7 for being orientated tubular bracket, which is characterized in that also wrapped before the step S3
It includes：
The second reception bar and rotating bar of control along both axial direction make relative translation motion, first receive bar, second receive bar,
When the receiving plane that third reception bar and rotating bar are constituted is rectangular area, stop relatively flat between the second reception bar and rotating bar
Shifting movement.
9. the preparation method according to claim 7 for being orientated tubular bracket, which is characterized in that the step S4 is specifically wrapped
It includes：
After rotating bar rotation, the second reception bar of control and the axial direction on both rotating bar edges make reciprocal relative translation motion, obtain
Multipole is orientated tubular bracket.
10. the preparation method according to claim 7 for being orientated tubular bracket, which is characterized in that electrostatic described in step S1
Spinning material is the copolymer of polylactic acid, poly-epsilon-caprolactone, fibroin, polylactic acid and polyglycolic acid, polylactic acid-polyglycol copolymerization
The copolymer of object, poly-epsilon-caprolactone and polylactic acid or polyethylene glycol, polydioxanone, polyanhydride, gelatin, collagen, hyalomitome
Acid, chitosan, fibrin, pectin, starch and its derivative, cellulose and its etherate, polyvinyl alcohol, gather polyoxyethylene
Any one or a few mixture in ethylene glycol, Kynoar, polyurethane.
11. the preparation method according to claim 7 for being orientated tubular bracket, which is characterized in that solvent described in step S1
For ethyl alcohol, methanol, hexafluoroisopropanol, acetone, tetrahydrofuran, dimethylformamide, chloroform, dichloromethane, formic acid, acetic acid, two
Any one or a few mixed solution in six ring of oxygen, trifluoroacetic acid.
12. a kind of tubular bracket prepared by the preparation method for being orientated tubular bracket described in claim 7 ~ 11 any one, institute
Tubular bracket is stated to be integrally formed by monopole or multipole oriented nanofibers.
13. tubular bracket according to claim 12, which is characterized in that the nanofiber diameter is 0.1 ~ 2 μm, preferably
It is 0.3 ~ 1.5 μm.
14. tubular bracket according to claim 12, which is characterized in that the hole of the micropore formed between the nanofiber
Diameter is 1 ~ 10 μm, preferably 2 ~ 5 μm.
15. tubular bracket according to claim 12, which is characterized in that the nanofiber porosity of the tubular bracket is
85%~90%。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810508682.5A CN108754634B (en) | 2018-05-24 | 2018-05-24 | Electrostatic spinning receiving device, method for preparing oriented electrostatic spinning tubular support and tubular support |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810508682.5A CN108754634B (en) | 2018-05-24 | 2018-05-24 | Electrostatic spinning receiving device, method for preparing oriented electrostatic spinning tubular support and tubular support |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108754634A true CN108754634A (en) | 2018-11-06 |
| CN108754634B CN108754634B (en) | 2021-05-18 |
Family
ID=64005487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810508682.5A Active CN108754634B (en) | 2018-05-24 | 2018-05-24 | Electrostatic spinning receiving device, method for preparing oriented electrostatic spinning tubular support and tubular support |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108754634B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111321475A (en) * | 2020-04-17 | 2020-06-23 | 中广核达胜加速器技术有限公司 | Inorganic fiber precursor spinning system and spinning method thereof |
| CN112981556A (en) * | 2021-02-08 | 2021-06-18 | 华南理工大学 | Electrostatic spinning fiber collecting device and method for preparing nanofiber membrane with radial orientation structure |
| CN113046844A (en) * | 2021-04-20 | 2021-06-29 | 华南理工大学 | Method and device for preparing thick-layer oriented nanofiber |
| CN115323612A (en) * | 2022-08-19 | 2022-11-11 | 佛山清立新材料科技有限公司 | High-thermal-conductivity composite material and preparation method thereof |
| US20230082048A1 (en) * | 2021-09-15 | 2023-03-16 | Shaanxi Environmental Protection Research Institute | Electrospun nanofiber membrane and method for preparing electrospun nanofiber membrane |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876901A (en) * | 2006-07-10 | 2006-12-13 | 南开大学 | Receiver for collecting electrospun polymer fiber tube |
| CN101532183A (en) * | 2009-04-22 | 2009-09-16 | 南开大学 | Receiving device for bilaterally collecting electric spinning polymer fiber tubes |
| US20120040461A1 (en) * | 2009-02-23 | 2012-02-16 | Beachley Vince Z | Fabrication of nanofiber reinforced structures for tissue engineering |
| CN104313706A (en) * | 2014-09-29 | 2015-01-28 | 中鸿纳米纤维技术丹阳有限公司 | Novel high-efficiency nanofiber electrostatic spinning equipment |
| CN105671657A (en) * | 2016-04-01 | 2016-06-15 | 重庆大学 | Small-aperture artificial blood vessel preparation device based on electrostatic spinning |
| CN108103598A (en) * | 2018-02-09 | 2018-06-01 | 郑州大学 | A kind of electrostatic spinning reception device for preparing axial orientation tubular tissue engineering material |
| KR101897516B1 (en) * | 2017-11-20 | 2018-09-12 | 전북대학교산학협력단 | Apparatus and method for manufacturing grid aligned nano fiber structure |
-
2018
- 2018-05-24 CN CN201810508682.5A patent/CN108754634B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876901A (en) * | 2006-07-10 | 2006-12-13 | 南开大学 | Receiver for collecting electrospun polymer fiber tube |
| US20120040461A1 (en) * | 2009-02-23 | 2012-02-16 | Beachley Vince Z | Fabrication of nanofiber reinforced structures for tissue engineering |
| CN101532183A (en) * | 2009-04-22 | 2009-09-16 | 南开大学 | Receiving device for bilaterally collecting electric spinning polymer fiber tubes |
| CN104313706A (en) * | 2014-09-29 | 2015-01-28 | 中鸿纳米纤维技术丹阳有限公司 | Novel high-efficiency nanofiber electrostatic spinning equipment |
| CN105671657A (en) * | 2016-04-01 | 2016-06-15 | 重庆大学 | Small-aperture artificial blood vessel preparation device based on electrostatic spinning |
| KR101897516B1 (en) * | 2017-11-20 | 2018-09-12 | 전북대학교산학협력단 | Apparatus and method for manufacturing grid aligned nano fiber structure |
| CN108103598A (en) * | 2018-02-09 | 2018-06-01 | 郑州大学 | A kind of electrostatic spinning reception device for preparing axial orientation tubular tissue engineering material |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111321475A (en) * | 2020-04-17 | 2020-06-23 | 中广核达胜加速器技术有限公司 | Inorganic fiber precursor spinning system and spinning method thereof |
| CN112981556A (en) * | 2021-02-08 | 2021-06-18 | 华南理工大学 | Electrostatic spinning fiber collecting device and method for preparing nanofiber membrane with radial orientation structure |
| CN112981556B (en) * | 2021-02-08 | 2022-05-17 | 华南理工大学 | Electrospinning fiber collection device and method for preparing nanofiber membrane with radially oriented structure |
| CN113046844A (en) * | 2021-04-20 | 2021-06-29 | 华南理工大学 | Method and device for preparing thick-layer oriented nanofiber |
| US20230082048A1 (en) * | 2021-09-15 | 2023-03-16 | Shaanxi Environmental Protection Research Institute | Electrospun nanofiber membrane and method for preparing electrospun nanofiber membrane |
| US11629435B2 (en) * | 2021-09-15 | 2023-04-18 | Shaanxi Environmental Protection Research Inst. | Electrospun nanofiber membrane and method for preparing electrospun nanofiber membrane |
| CN115323612A (en) * | 2022-08-19 | 2022-11-11 | 佛山清立新材料科技有限公司 | High-thermal-conductivity composite material and preparation method thereof |
| CN115323612B (en) * | 2022-08-19 | 2024-06-07 | 佛山清立新材料科技有限公司 | High-heat-conductivity composite material and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108754634B (en) | 2021-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108754634A (en) | Electrostatic spinning reception device prepares the method and tubular bracket for being orientated electrostatic spinning tubular bracket | |
| Garg et al. | Electrospinning jets and nanofibrous structures | |
| EP3183382B1 (en) | Method and apparatus for controlled alignment and deposition of branched electrospun fiber | |
| US11007297B2 (en) | Process for making aligned or twisted electrospun fibers | |
| Zhu et al. | Electrospinning and rheology of regenerated Bombyx mori silk fibroin aqueous solutions: The effects of pH and concentration | |
| US20100047310A1 (en) | Bio-acceptable conduits and method providing the same | |
| CN102430157B (en) | A kind of medical stent with inner coating and preparation method thereof | |
| CN102817105A (en) | Preparation method of core-shell structured synthetic polymer-natural polymer composite fiber | |
| CN106480518B (en) | A kind of electrospinning collection device and preparation method of nanofiber with gradient orientation structure | |
| CN105209678A (en) | Biocompatible fiber textiles for implantation | |
| CN106492277B (en) | A kind of biomimetic artificial bone bracket and preparation method thereof | |
| WO2016192733A1 (en) | Conduit for regeneration of biological material | |
| CN101417150B (en) | Preparation method of aliphatic polyester-chitosan composite fiber tissue repair bracket | |
| CN101280468A (en) | Multi-needle V-groove drum electrospinning system and method for preparing nanofiber bundles | |
| CN104027842A (en) | Preparation method of axially oriented nanofiber nerve conduit | |
| CN108642719B (en) | A kind of preparation method of integrated small-caliber artificial blood vessel stent | |
| KR101501383B1 (en) | Nanofiber scaffold with an aligned structure and method thereof | |
| CN117626527A (en) | Micro-nano fiber composite biofilm based on electrospinning technology and its preparation method and application | |
| Oprea et al. | Electrospun nanofibers for tissue engineering applications | |
| CN109457309A (en) | A kind of polyglycolic acid oriented nanofibers beam and preparation method thereof | |
| CN110124109B (en) | Artificial blood vessel stent and preparation method and application thereof | |
| Castaño et al. | Electrospinning technology in tissue regeneration | |
| CN102828261A (en) | Spinneret-free electrostatic spinning device and method for preparation of nano-fiber pipes | |
| EP2376692B1 (en) | Biomimetic nanofiber web and method and device to manufacture the same | |
| CN105688277B (en) | Compound calcium phosphate artificial bone and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |