CN108653701A - A kind of herbal mixture essential oil composition of analgesic and its preparation method of preparation - Google Patents
A kind of herbal mixture essential oil composition of analgesic and its preparation method of preparation Download PDFInfo
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- CN108653701A CN108653701A CN201810705477.8A CN201810705477A CN108653701A CN 108653701 A CN108653701 A CN 108653701A CN 201810705477 A CN201810705477 A CN 201810705477A CN 108653701 A CN108653701 A CN 108653701A
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- 239000000341 volatile oil Substances 0.000 title claims abstract description 387
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 230000000202 analgesic effect Effects 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 44
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- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims 1
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 30
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- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
- 208000000114 Pain Threshold Diseases 0.000 description 1
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
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- ZDGGJQMSELMHLK-UHFFFAOYSA-N m-Trifluoromethylhippuric acid Chemical compound OC(=O)CNC(=O)C1=CC=CC(C(F)(F)F)=C1 ZDGGJQMSELMHLK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Birds (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
技术领域technical field
本发明属于药物制剂技术领域，具体涉及一种止痛的复方中药精油组合物和该组合物止痛乳膏的制备方法。The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pain-relieving compound traditional Chinese medicine essential oil composition and a preparation method of the composition pain-relieving cream.
背景技术Background technique
疼痛是临床常见的症状和疾病，严重影响了患者的生存质量，越来越引起医务人员和大众的重视。国际疼痛学会(international association for the study of pain，IASP)将疼痛定义为：疼痛是具有感觉、情绪、认知和社会层面的实际或潜在组织损伤所引起的痛苦体验。其不仅是临床最常见的症状之一，而且慢性疼痛已被公认为一类疾病。在美国，对5646个初级医疗保健机构调研发现：每就诊5名患者，就有2名患者是以疼痛作为主诉；其中30％在日后会转为慢性疼痛。目前，全世界至少有3.2亿人口正在受到慢性疼痛的折磨。这些患者伴随睡眠障碍、焦虑和抑郁等情绪障碍，严重影响患者的生活质量。急性疼痛有积极的作用，警告机体组织器官可能有潜在的危险。然而在有中枢机制参与的慢性疼痛中，疼痛的持续存在却超越了它的生物有效性，并使患者的生存质量大打折扣。并且，疼痛性质常难以描述，没有特异性指标，主要依靠患者主诉，尚无明确客观的分类诊断标准，疼痛治疗多种多样且缺乏规范。Pain is a common clinical symptom and disease, which seriously affects the quality of life of patients, and has attracted more and more attention from medical staff and the public. The International Association for the Study of Pain (IASP) defines pain as: Pain is a painful experience caused by actual or potential tissue damage with sensory, emotional, cognitive, and social dimensions. It is not only one of the most common clinical symptoms, but chronic pain has been recognized as a class of diseases. In the United States, a survey of 5,646 primary health care institutions found that for every 5 patients who visit a doctor, 2 patients complain of pain; 30% of them will turn into chronic pain in the future. At present, at least 320 million people in the world are suffering from chronic pain. These patients are accompanied by emotional disorders such as sleep disorders, anxiety and depression, which seriously affect the quality of life of patients. Acute pain has a positive effect, alerting the body to potentially dangerous tissues and organs. However, in chronic pain involving central mechanisms, the persistence of pain exceeds its biological effectiveness and greatly reduces the quality of life of patients. Moreover, the nature of pain is often difficult to describe, there is no specific index, it mainly depends on the patient's complaint, there is no clear and objective classification and diagnosis standard, and pain treatment is diverse and lacks standardization.
现有镇痛药物种类多样，但有效性较低，副作用较大。疼痛治疗的目的是抑制伤害性刺激，达到最大的镇痛、最小的不良反应、最大的功能和最高的生活质量。美国的医疗门诊数据显示，镇痛药物位于处方药物的前5位。然而，在常规的临床工作中，经镇痛药物治疗后，依然有多达50％的患者疼痛未得到充分缓解，或者由于药物的副作用患者停药，因此疼痛治疗结果通常大打折扣。常用镇痛药物包括抗抑郁药物、抗惊厥药物、苯二氮卓类药物、NMDA拮抗剂、非甾体抗炎药物、阿片类药物、肌松药物、外用药物等。其中阿片类药物的镇痛作用最强，对各种疼痛均有良好的治疗效果，但由于严重的副作用，在临床上不被视为一线镇痛药物。Existing analgesic drugs are of various types, but their effectiveness is low and their side effects are relatively large. The goal of pain therapy is to suppress noxious stimuli to achieve maximum analgesia, minimum adverse reactions, maximum function, and the highest quality of life. According to the medical outpatient data in the United States, analgesics are among the top five prescription drugs. However, in routine clinical work, as many as 50% of patients still have insufficient pain relief after analgesic drug treatment, or patients stop taking drugs due to side effects of drugs, so the pain treatment results are usually greatly reduced. Commonly used analgesic drugs include antidepressants, anticonvulsants, benzodiazepines, NMDA antagonists, non-steroidal anti-inflammatory drugs, opioids, muscle relaxants, and topical drugs. Among them, opioids have the strongest analgesic effect and have good therapeutic effects on various pains, but they are not considered as first-line analgesics in clinical practice due to serious side effects.
疼痛在我国传统中医药的治疗中属于“痹证”的范畴。我国在治疗痹症中积累了丰富的经验，早在《金匮要略》就出现了对疼痛的论述，认为引起疼痛的主要病机病因是风、寒、湿、邪侵袭机体，芳香中药对痹症疼痛尤其是慢性疼痛具有独特的疗效。芳香中药的有效成分大多为其挥发油，中药精油是从药材的花、叶、茎、根或果实中提炼萃取出来的挥发性芳香物质，传承自中国中医养生，在较多中药里发挥重要的治疗作用，是不可缺少的有效成分。中药精油具有高渗透性，将其制成外用乳膏制剂能使药物在特定部位透过皮肤直达疼痛部位，有利于提高局部药物浓度，与口服给药比较，可有效地避免肝脏的首过效应，提高生物利用度，更有利于发挥药效。Pain belongs to the category of "bi syndrome" in the treatment of traditional Chinese medicine in my country. my country has accumulated rich experience in the treatment of arthralgia. As early as in "Synopsis of the Golden Chamber", there was a discussion on pain. It was believed that the main pathogenesis and cause of pain were wind, cold, dampness, and evil invasion of the body. Especially chronic pain has a unique curative effect. Most of the active ingredients of aromatic traditional Chinese medicine are volatile oils. Chinese medicinal essential oils are volatile aromatic substances extracted from the flowers, leaves, stems, roots or fruits of medicinal materials. They are inherited from Chinese traditional Chinese medicine and play an important role in many traditional Chinese medicines. It is an indispensable active ingredient. The essential oil of traditional Chinese medicine has high permeability, and it can be made into cream preparation for external use, so that the drug can penetrate the skin directly to the pain site at a specific part, which is beneficial to increase the local drug concentration. Compared with oral administration, it can effectively avoid the first-pass effect of the liver , improve bioavailability, more conducive to play a drug effect.
发明内容Contents of the invention
本发明的目的在于提供一种止痛的复方中药精油组合物。The object of the present invention is to provide a compound traditional Chinese medicine essential oil composition for relieving pain.
本发明的另一个目的在于提供一种止痛中药精油乳膏、喷雾剂、软膏的制备方法。Another object of the present invention is to provide a preparation method of analgesic traditional Chinese medicine essential oil cream, spray and ointment.
本发明通过下述技术方案来实现：一种止痛的复方中药精油组合物，其包含如下重量配比的组分：乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份。The present invention is realized through the following technical scheme: a compound traditional Chinese medicine essential oil composition for relieving pain, which comprises the following components in weight ratio: 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil 5-10 parts of asarum essential oil, 12-25 parts of dried ginger essential oil, 5-12 parts of peppermint essential oil, 5-10 parts of wintergreen essential oil, and 15-30 parts of geranium essential oil.
优选地，所述复方中药精油组合物由如下重量配比的组分组成：Preferably, the compound traditional Chinese medicine essential oil composition is composed of the following components by weight:
乳香精油7.5份、没药精油9.5份、艾叶精油15份、细辛精油8.5份、干姜精油18份、薄荷精油8份、冬青精油10份、天竺葵精油20份。7.5 parts of frankincense essential oil, 9.5 parts of myrrh essential oil, 15 parts of mugwort essential oil, 8.5 parts of asarum essential oil, 18 parts of dried ginger essential oil, 8 parts of peppermint essential oil, 10 parts of wintergreen essential oil, and 20 parts of geranium essential oil.
其中，所述乳香精油、没药精油、艾叶精油、细辛精油、干姜精油、天竺葵精油是分别以乳香、没药、艾叶、细辛、干姜、天竺葵为原料，采用水蒸气蒸馏法萃取法制备得到的挥发油。Wherein, the frankincense essential oil, myrrh essential oil, mugwort essential oil, asarum essential oil, dried ginger essential oil, and geranium essential oil are respectively made of frankincense, myrrh, mugwort leaves, asarum, dried ginger, and geranium as raw materials, and are extracted by steam distillation. The volatile oil prepared by the method.
其中，复方精油的每种组分的纯度均大于99％。Wherein, the purity of each component of the compound essential oil is greater than 99%.
本发明还提供了前述的复方中药精油组合物在制备具有止痛功效的剂型、日化用品中的用途。The present invention also provides the application of the aforementioned compound traditional Chinese medicine essential oil composition in preparing dosage forms and daily chemical products with analgesic effect.
本发明提供了一种具有止痛功效的乳膏的制备方法，将前述复方中药精油组合物加入油相助剂中制备得到油相，并水相助剂与水混合得到水相，同一方向搅拌条件下，将油相加入到水相，加入过程中控制温度为60-85℃，继续搅拌至完全乳化，乳化放冷后将其用高速剪切机剪切，得到止痛乳膏成品。有效成分复方中药精油组合物的加入量可以根据止痛等级不同选择不同的加入量，油相助剂可以选择现有技术乳膏制备中的常用组分，如蜂蜡、硬脂酸、单甘脂、蓖麻油、十六十八醇、癸酸甘油三酯等，水相助剂可选择甘油、丙二醇，当然也可旋转现有技术中常用的水相助剂。The present invention provides a method for preparing a cream with analgesic effect. The above-mentioned compound Chinese medicine essential oil composition is added to an oil phase auxiliary to prepare an oil phase, and the water phase auxiliary is mixed with water to obtain a water phase. Stirring in the same direction, Add the oil phase to the water phase, control the temperature at 60-85°C during the addition process, continue to stir until it is completely emulsified, let it cool after emulsification, and cut it with a high-speed shear to obtain the finished pain relief cream. The addition amount of active ingredient compound traditional Chinese medicine essential oil composition can be selected different addition amount according to the difference of analgesic level, and oil phase auxiliary agent can choose the commonly used component in the cream preparation of prior art, as beeswax, stearic acid, monoglyceride, castor Sesame oil, cetostearyl alcohol, capric triglyceride, etc., glycerin and propylene glycol can be selected as water phase additives, and of course, water phase additives commonly used in the prior art can also be rotated.
更特别的，本发明提供了一种具有止痛功效的乳膏的制备方法，包括油相制备、水相制备、乳膏制备，其中：More particularly, the present invention provides a method for preparing a cream with analgesic effect, including oil phase preparation, water phase preparation, and cream preparation, wherein:
a、中药精油止痛乳膏的原料组成为：乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份，蜂蜡5-15份、硬脂酸5-10份、单甘脂10-15份、蓖麻油10-18份、十六十八醇15-25份、癸酸甘油三酯10-18份，甘油3-7份、丙二醇5-10份、水30-50份。a. The raw materials of traditional Chinese medicine essential oil analgesic cream consist of: 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of Asarum essential oil, 12-25 parts of dried ginger essential oil, 5-12 parts of peppermint essential oil, 5-10 parts of wintergreen essential oil, 15-30 parts of geranium essential oil, 5-15 parts of beeswax, 5-10 parts of stearic acid, 10-15 parts of monoglyceride, 10-18 parts of castor oil, Cetostearyl alcohol 15-25 parts, capric triglyceride 10-18 parts, glycerin 3-7 parts, propylene glycol 5-10 parts, water 30-50 parts.
b、油相制备：按照中药精油止痛乳膏的原料组成准备各种原料，首先将蜂蜡、硬脂酸、单甘脂、蓖麻油、十六十八醇、癸酸甘油三酯混合，并加热至60～85℃进行充分溶解，溶解后快速加入乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份所组成的复方中药精油组合物，得到油相。b. Oil phase preparation: Prepare various raw materials according to the composition of the raw materials of traditional Chinese medicine essential oil analgesic cream, first mix beeswax, stearic acid, monoglyceride, castor oil, cetostearyl alcohol, capric triglyceride, and heat Fully dissolve at 60-85°C, quickly add 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of Asarum essential oil, 12-25 parts of dried ginger essential oil , 5-12 parts of peppermint essential oil, 5-10 parts of wintergreen essential oil and 15-30 parts of geranium essential oil form the compound traditional Chinese medicine essential oil composition to obtain an oil phase.
c、水相制备：将准备的甘油和丙二醇加入到水中，并保持在60～85℃温度下加热混匀，得到水相，备用。c. Water phase preparation: add the prepared glycerin and propylene glycol into water, and keep heating and mixing at a temperature of 60-85° C. to obtain a water phase for later use.
d、止痛乳膏制备：同一方向搅拌条件下，将油相加入到水相，加入过程中控制温度为60-85℃，继续搅拌至完全乳化。乳化放冷后将其用高速剪切机进行30-60min的剪切，得到止痛乳膏成品。d. Preparation of analgesic cream: Add the oil phase to the water phase under stirring in the same direction, control the temperature at 60-85°C during the addition, and continue stirring until complete emulsification. After the emulsification is allowed to cool, it is sheared for 30-60 minutes with a high-speed shearing machine to obtain a finished pain-relieving cream.
一种具有止痛功效的软膏的制备方法，将前述复方中药精油组合物与软膏助剂混合，研磨搅匀，分装即得软膏，软膏助剂可以选择现有技术中的制备软膏的常用助剂，例如石蜡、白凡士林。复方中药精油组合物的加入量可根据有效成分需要量确定。A method for preparing an ointment with analgesic effect. The aforementioned compound Chinese medicine essential oil composition is mixed with an ointment auxiliary, ground and stirred evenly, and then packaged to obtain an ointment. The ointment auxiliary can be selected from the commonly used auxiliary agents for preparing ointment in the prior art. , such as paraffin, white petrolatum. The addition amount of the compound traditional Chinese medicine essential oil composition can be determined according to the required amount of active ingredients.
更特别的是，本发明提供了一种具有止痛功效的软膏的制备方法，其特征在于包括以下步骤：More particularly, the present invention provides a kind of preparation method of the ointment with analgesic effect, it is characterized in that comprising the following steps:
a、中药精油止痛软膏的原料组成为：乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份，石蜡40-60份，白凡士林5-15份。a. The raw materials of traditional Chinese medicine essential oil analgesic ointment are: 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of Asarum essential oil, 12-25 parts of dried ginger essential oil, peppermint 5-12 parts of essential oil, 5-10 parts of wintergreen essential oil, 15-30 parts of geranium essential oil, 40-60 parts of paraffin, 5-15 parts of white petrolatum.
b、止痛软膏制备：按照上述原料，首先加入石蜡和白凡士林于烧杯中在水浴锅中加热熔融，搅匀，放冷至60℃，再加入乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份所组成的复方中药精油组合物，研磨搅匀，分装即得。b. Preparation of analgesic ointment: According to the above raw materials, first add paraffin wax and white vaseline in a beaker, heat and melt in a water bath, stir well, let cool to 60°C, then add 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil A compound Chinese medicine consisting of 10-18 parts of mugwort essential oil, 5-10 parts of asarum essential oil, 12-25 parts of dried ginger essential oil, 5-12 parts of peppermint essential oil, 5-10 parts of wintergreen essential oil, and 15-30 parts of geranium essential oil Essential oil composition, grind and stir well, then pack and get.
本发明还提供了一种具有止痛功效的喷雾的制备方法，将前述复方中药精油组合物与表面活性剂混合，加入水，搅拌得到喷雾剂。复方中药精油组合物的加入量可根据浓度需要量确定。The present invention also provides a method for preparing a spray with analgesic effect. The above-mentioned compound Chinese medicine essential oil composition is mixed with a surfactant, added with water, and stirred to obtain a spray. The addition amount of the compound traditional Chinese medicine essential oil composition can be determined according to the required concentration.
本发明还提供了一种具有止痛功效的喷雾的制备方法，其特征在于包括以下步骤：The present invention also provides a preparation method of the spray with analgesic effect, which is characterized in that it comprises the following steps:
a、中药精油止痛喷雾的原料组成为：乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份，PEG-40060-90份，EL-40220-380份，水3000-5000份。a. The raw materials of traditional Chinese medicine essential oil pain relief spray are: 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of asarum essential oil, 12-25 parts of dried ginger essential oil, peppermint 5-12 parts of essential oil, 5-10 parts of wintergreen essential oil, 15-30 parts of geranium essential oil, PEG-40060-90 parts, EL-40220-380 parts, water 3000-5000 parts.
b、止痛功效的喷雾的制备：按照上述原料，首先将乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份所组成的复方中药精油组合物加入烧杯中混匀，再加入表面活性剂EL-40和助表面活性剂PEG-400于烧杯中，在磁力搅拌器的作用下，让其先混匀，最后在磁力搅拌器的作用下缓缓加入水，直接加到有乳光，即得喷雾剂的成品。b. Preparation of spray with analgesic effect: According to the above raw materials, firstly mix 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of Asarum essential oil, 12-12 parts of dried ginger essential oil The compound Chinese medicine essential oil composition composed of 25 parts, 5-12 parts of peppermint essential oil, 5-10 parts of wintergreen essential oil, and 15-30 parts of geranium essential oil is put into a beaker and mixed well, then add surfactant EL-40 and co-surfactant Put PEG-400 in a beaker, under the action of a magnetic stirrer, let it mix first, and finally add water slowly under the action of a magnetic stirrer, and directly add it until there is opalescence, and the finished spray is obtained.
具体实施方式Detailed ways
显然，根据本发明的上述内容，按照本领域的普通技术知识和惯用手段，在不脱离本发明上述基本技术思想前提下，还可以做出其它多种形式的修改、替换或变更。Apparently, according to the above content of the present invention, according to common technical knowledge and conventional means in this field, without departing from the above basic technical idea of the present invention, other various forms of modification, replacement or change can also be made.
以下通过实施例形式的具体实施方式，对本发明的上述内容再作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实例。凡基于本发明上述内容所实现的技术均属于本发明的范围。The above-mentioned content of the present invention will be further described in detail below through specific implementation in the form of examples. However, this should not be construed as limiting the scope of the above-mentioned subject matter of the present invention to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.
复方中药精油组合物的制备Preparation of Compound Traditional Chinese Medicine Essential Oil Composition
分别取乳香精油、没药精油、艾叶精油、细辛精油、干姜精油、薄荷精油、冬青精油、天竺葵精油用水蒸气蒸馏法进行提取，具体步骤如下：分别将各原料处理干净并适当粉碎后，放入水蒸气提取罐中，通入蒸汽，提取至油量不再增加后收集所得精油，用无水硫酸钠干燥后进行过滤，经精制后得到各原料的精油。所述乳香精油、没药精油、艾叶精油、细辛精油、干姜精油、天竺葵精油是分别以乳香、没药、艾叶、细辛、干姜、天竺葵为原料，采用水蒸气蒸馏法萃取法制备得到的挥发油。Extract frankincense essential oil, myrrh essential oil, mugwort essential oil, asarum essential oil, dried ginger essential oil, peppermint essential oil, wintergreen essential oil, and geranium essential oil by steam distillation. Put it into a water vapor extraction tank, pass in steam, extract until the oil volume does not increase, collect the obtained essential oil, dry it with anhydrous sodium sulfate, filter it, and obtain the essential oil of each raw material after refining. The frankincense essential oil, myrrh essential oil, mugwort essential oil, asarum essential oil, dried ginger essential oil, and geranium essential oil are prepared from frankincense, myrrh, mugwort leaf, asarum, dried ginger, and geranium as raw materials respectively, and are prepared by steam distillation extraction method The obtained volatile oil.
其中，复方精油的每种组分的纯度均大于99％。Wherein, the purity of each component of the compound essential oil is greater than 99%.
本发明各种精油也可以直接采取购买的方式获得。Various essential oils of the present invention can also be obtained directly by purchasing.
取上述精油，按照以下重量份“乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份”进行组方，混合，即得到本发明所述的止痛的复方中药精油。Take the above-mentioned essential oils, according to the following parts by weight: "5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of Asarum essential oil, 12-25 parts of dried ginger essential oil, 5 parts of peppermint essential oil -12 parts, 5-10 parts of wintergreen essential oil, 15-30 parts of geranium essential oil " carry out prescription, mix, promptly obtain the compound traditional Chinese medicine essential oil of the pain relief of the present invention.
实施例1Example 1
乳香精油：乳香精油7.5g、没药精油9.5g、艾叶精油15g、细辛精油8.5g、干姜精油18g、薄荷精油8g、冬青精油10g、天竺葵精油20g。Frankincense essential oil: 7.5g frankincense essential oil, 9.5g myrrh essential oil, 15g mugwort essential oil, 8.5g asarum essential oil, 18g dried ginger essential oil, 8g peppermint essential oil, 10g wintergreen essential oil, 20g geranium essential oil.
实施例2：乳香精油5g、没药精油9g、艾叶精油15g、细辛精油9g、干姜精油18g、薄荷精油8g、冬青精油10g、天竺葵精油20g。Example 2: 5g of frankincense essential oil, 9g of myrrh essential oil, 15g of mugwort essential oil, 9g of asarum essential oil, 18g of dry ginger essential oil, 8g of peppermint essential oil, 10g of wintergreen essential oil, and 20g of geranium essential oil.
实施例3：乳香精油10g、没药精油15g、艾叶精油18g、细辛精油5g、干姜精油20g、薄荷精油5g、冬青精油8g、天竺葵精油30g。Example 3: 10g of frankincense essential oil, 15g of myrrh essential oil, 18g of mugwort essential oil, 5g of asarum essential oil, 20g of dried ginger essential oil, 5g of peppermint essential oil, 8g of wintergreen essential oil, and 30g of geranium essential oil.
实施例4：乳香精油10g、没药精油15g、艾叶精油15g、细辛精油10g、干姜精油15g、薄荷精油12g、冬青精油5g、天竺葵精油18g。Example 4: 10g of frankincense essential oil, 15g of myrrh essential oil, 15g of mugwort essential oil, 10g of Asarum essential oil, 15g of dried ginger essential oil, 12g of peppermint essential oil, 5g of wintergreen essential oil, and 18g of geranium essential oil.
实施例5：乳香精油8g、没药精油5g、艾叶精油16g、细辛精油6g、干姜精油20g、薄荷精油10g、冬青精油5g、天竺葵精油25g。Example 5: 8 g of frankincense essential oil, 5 g of myrrh essential oil, 16 g of mugwort essential oil, 6 g of asarum essential oil, 20 g of dried ginger essential oil, 10 g of peppermint essential oil, 5 g of wintergreen essential oil, and 25 g of geranium essential oil.
实施例6：乳香精油8g、没药精油8g、艾叶精油10g、细辛精油9g、干姜精油12g、薄荷精油7g、冬青精油6g、天竺葵精油22g。Example 6: 8g of frankincense essential oil, 8g of myrrh essential oil, 10g of mugwort essential oil, 9g of asarum essential oil, 12g of dry ginger essential oil, 7g of peppermint essential oil, 6g of wintergreen essential oil, and 22g of geranium essential oil.
实施例7：乳香精油10g、没药精油10g、艾叶精油18g、细辛精油7g、干姜精油22g、薄荷精油6g、冬青精油10g、天竺葵精油30g。Example 7: 10g of frankincense essential oil, 10g of myrrh essential oil, 18g of mugwort essential oil, 7g of Asarum essential oil, 22g of dried ginger essential oil, 6g of peppermint essential oil, 10g of wintergreen essential oil, and 30g of geranium essential oil.
实施例8：乳香精油8g、没药精油12g、艾叶精油10g、细辛精油10g、干姜精油25g、薄荷精油15g、冬青精油5g、天竺葵精油20g。Example 8: 8g of frankincense essential oil, 12g of myrrh essential oil, 10g of mugwort essential oil, 10g of Asarum essential oil, 25g of dried ginger essential oil, 15g of peppermint essential oil, 5g of wintergreen essential oil, and 20g of geranium essential oil.
实施例9：乳香精油7g、没药精油13g、艾叶精油12g、细辛精油5g、干姜精油12g、薄荷精油11g、冬青精油6g、天竺葵精油18g。Example 9: 7g of frankincense essential oil, 13g of myrrh essential oil, 12g of mugwort essential oil, 5g of Asarum essential oil, 12g of dried ginger essential oil, 11g of peppermint essential oil, 6g of wintergreen essential oil, and 18g of geranium essential oil.
实施例10：乳香精油10g、没药精油15g、艾叶精油18g、细辛精油7g、干姜精油25g、薄荷精油12g、冬青精油7g、天竺葵精油15g。Example 10: 10g of frankincense essential oil, 15g of myrrh essential oil, 18g of mugwort essential oil, 7g of asarum essential oil, 25g of dried ginger essential oil, 12g of peppermint essential oil, 7g of wintergreen essential oil, and 15g of geranium essential oil.
实施例11：止痛乳膏的制备Example 11: Preparation of Pain Relief Cream
一种具有止痛功效的乳膏的制备方法，包括油相制备、水相制备、乳膏制备，其详细制备过程为：A method for preparing a cream with analgesic effect, comprising oil phase preparation, water phase preparation, and cream preparation, the detailed preparation process is as follows:
a、中药精油止痛乳膏的原料组成为：乳香精油：7.5g、没药精油：9.5g、艾叶精油：15g、细辛精油：8.5g、干姜精油：18g、薄荷精油：8g、冬青精油：5g、天竺葵精油：20g，蜂蜡：10g、硬脂酸：6g、单甘脂：12g、蓖麻油：15g、十六十八醇：20g、癸酸甘油三酯：15g，甘油：5g、丙二醇：8g、水：40g。a. The raw materials of traditional Chinese medicine essential oil pain relief cream are: frankincense essential oil: 7.5g, myrrh essential oil: 9.5g, mugwort essential oil: 15g, asarum essential oil: 8.5g, dried ginger essential oil: 18g, peppermint essential oil: 8g, wintergreen essential oil : 5g, Geranium Essential Oil: 20g, Beeswax: 10g, Stearic Acid: 6g, Monoglyceride: 12g, Castor Oil: 15g, Cetearyl Alcohol: 20g, Capric Triglyceride: 15g, Glycerin: 5g, Propylene Glycol : 8g, water: 40g.
b、油相制备：按照中药精油止痛乳膏的原料组成准备各种原料，首先将蜂蜡、硬脂酸、单甘脂、蓖麻油、十六十八醇、癸酸甘油三酯混合，并加热至70℃进行充分溶解，溶解后快速加入乳香精油、没药精油、艾叶精油、细辛精油、干姜精油、薄荷精油、冬青精油、天竺葵精油所组成的复方中药精油组合物，得到油相。b. Oil phase preparation: Prepare various raw materials according to the composition of the raw materials of traditional Chinese medicine essential oil analgesic cream, first mix beeswax, stearic acid, monoglyceride, castor oil, cetostearyl alcohol, capric triglyceride, and heat Fully dissolve at 70°C, and quickly add the compound Chinese medicine essential oil composition composed of frankincense essential oil, myrrh essential oil, mugwort essential oil, asarum essential oil, dried ginger essential oil, peppermint essential oil, wintergreen essential oil, and geranium essential oil to obtain an oil phase.
c、水相制备：按照中药精油止痛乳膏的原料组成准备各种原料，将准备的甘油和丙二醇加入到水中，并保持在65℃温度下加热混匀，得到水相，备用。c. Water phase preparation: prepare various raw materials according to the raw material composition of traditional Chinese medicine essential oil analgesic cream, add the prepared glycerin and propylene glycol into water, keep heating and mixing at a temperature of 65°C to obtain the water phase, and set aside.
d、止痛乳膏制备：同一方向搅拌条件下，将油相加入到水相，加入过程中控制温度为60℃，搅拌时间为1h，搅拌速度为250r/min。停止加热，继续边搅拌边降温，搅拌速度为250r/min，降至室温并完全乳化。乳化放冷后将其用高速剪切机进行30-60min的剪切，得到止痛乳膏成品。d. Preparation of analgesic cream: under the condition of stirring in the same direction, add the oil phase to the water phase, control the temperature at 60°C during the addition process, stir for 1 hour, and stir at a speed of 250r/min. Stop heating, continue cooling while stirring, the stirring speed is 250r/min, drop to room temperature and emulsify completely. After the emulsification is allowed to cool, it is sheared for 30-60 minutes with a high-speed shearing machine to obtain a finished pain-relieving cream.
需要说明的是，止痛乳膏各组分的用量可以在“乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份，蜂蜡5-15份、硬脂酸5-10份、单甘脂10-15份、蓖麻油10-18份、十六十八醇15-25份、癸酸甘油三酯10-18份，甘油3-7份、丙二醇5-10份、水30-50份”内选择，本发明不再罗列类似实施例。It should be noted that the dosage of each component of the analgesic cream can be in the range of "5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of asarum essential oil, 12 parts of dried ginger essential oil. -25 parts, peppermint essential oil 5-12 parts, wintergreen essential oil 5-10 parts, geranium essential oil 15-30 parts, beeswax 5-15 parts, stearic acid 5-10 parts, monoglyceride 10-15 parts, castor oil 10 parts -18 parts, 15-25 parts of cetostearyl alcohol, 10-18 parts of capric triglyceride, 3-7 parts of glycerin, 5-10 parts of propylene glycol, and 30-50 parts of water", which are not listed in the present invention Similar example.
实施例12：本发明涂止痛软膏的制备Embodiment 12: the preparation of the present invention coated with analgesic ointment
具有止痛功效的软膏的制备方法，其详细制备过程为：The preparation method of the ointment with analgesic effect, its detailed preparation process is:
a、中药精油止痛软膏的原料组成为：乳香精油：7.5g、没药精油：9.5g、艾叶精油：15g、细辛精油：8.5g、干姜精油：18g、薄荷精油：8g、冬青精油：5g、天竺葵精油：20g，石蜡：50g，白凡士林：10g。a. The raw materials of traditional Chinese medicine essential oil analgesic ointment are: frankincense essential oil: 7.5g, myrrh essential oil: 9.5g, mugwort essential oil: 15g, asarum essential oil: 8.5g, dried ginger essential oil: 18g, peppermint essential oil: 8g, wintergreen essential oil: 5g, geranium essential oil: 20g, paraffin: 50g, white vaseline: 10g.
b、止痛软膏制备：按照上述原料，首先加入石蜡和白凡士林于烧杯中在水浴锅中加热熔融，搅匀，放冷至60℃，再加入乳香精油、没药精油、艾叶精油、细辛精油、干姜精油、薄荷精油、冬青精油、天竺葵精油所组成的复方中药精油组合物，研磨搅匀，分装即得。b. Preparation of analgesic ointment: According to the above raw materials, first add paraffin and white vaseline in a beaker, heat and melt in a water bath, stir well, let cool to 60°C, then add frankincense essential oil, myrrh essential oil, mugwort essential oil, asarum essential oil , dried ginger essential oil, peppermint essential oil, wintergreen essential oil, and geranium essential oil are compound Chinese medicine essential oil compositions, which are ground, stirred evenly, and then packaged.
中药精油止痛软膏的原料组成可在“乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份，石蜡40-60份，白凡士林5-15份”内选择，步骤与上相同，不在罗列实施例。。The raw material composition of traditional Chinese medicine essential oil analgesic ointment can be in " 5-10 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 10-18 parts of mugwort essential oil, 5-10 parts of Asarum essential oil, 12-25 parts of dried ginger essential oil, 12-25 parts of peppermint essential oil 5-12 parts, 5-10 parts of wintergreen essential oil, 15-30 parts of geranium essential oil, 40-60 parts of paraffin, 5-15 parts of white petroleum jelly", the steps are the same as above, and the examples are not listed. .
实施例13：精油止痛喷雾的制备Example 13: Preparation of Essential Oil Pain Relief Spray
具有止痛功效的喷雾的制备方法，其详细制备过程为：The preparation method of the spray with analgesic effect, its detailed preparation process is:
a、中药精油止痛乳膏的原料组成为：乳香精油：0.75g、没药精油：0.95g、艾叶精油：1.5g、细辛精油：0.85g、干姜精油：1.8g、薄荷精油：0.8g、冬青精油：0.5g、天竺葵精油：2.0g，PEG-400：7.5g、EL-40：30g，水：400g。a. The raw materials of traditional Chinese medicine essential oil analgesic cream are: frankincense essential oil: 0.75g, myrrh essential oil: 0.95g, mugwort essential oil: 1.5g, asarum essential oil: 0.85g, dried ginger essential oil: 1.8g, peppermint essential oil: 0.8g , Wintergreen essential oil: 0.5g, geranium essential oil: 2.0g, PEG-400: 7.5g, EL-40: 30g, water: 400g.
b、按照上述原料，首先加入乳香精油、没药精油、艾叶精油、细辛精油、干姜精油、薄荷精油、冬青精油、天竺葵精油所组成的复方中药精油组合物于烧杯中混匀，再加入表面活性剂EL-40和助表面活性剂PEG-400于烧杯中，在磁力搅拌器的作用下，让其先混匀，最后在磁力搅拌器的作用下缓缓加入水，直接加到有乳光，即得喷雾剂的成品。b. According to the above raw materials, first add the compound Chinese medicine essential oil composition composed of frankincense essential oil, myrrh essential oil, mugwort essential oil, asarum essential oil, dried ginger essential oil, peppermint essential oil, wintergreen essential oil and geranium essential oil in a beaker and mix well, then add Surfactant EL-40 and co-surfactant PEG-400 were placed in a beaker, under the action of a magnetic stirrer, let it mix first, and finally, under the action of a magnetic stirrer, slowly add water, directly added to the milk Light, that is, the finished product of the spray.
需要说明的是，中药精油止痛喷雾的原料在“乳香精油5-10份、没药精油5-15份、艾叶精油10-18份、细辛精油5-10份、干姜精油12-25份、薄荷精油5-12份、冬青精油5-10份、天竺葵精油15-30份，PEG-40060-90份，EL-40220-380份，水3000-5000份”内选择配比，步骤相同，不再罗列实施例。It should be noted that the raw materials of traditional Chinese medicine essential oil pain relief spray are "frankincense essential oil 5-10 parts, myrrh essential oil 5-15 parts, mugwort essential oil 10-18 parts, asarum essential oil 5-10 parts, dried ginger essential oil 12-25 parts , 5-12 parts of peppermint essential oil, 5-10 parts of wintergreen essential oil, 15-30 parts of geranium essential oil, PEG-40060-90 parts, EL-40220-380 parts, water 3000-5000 parts" select the ratio, the steps are the same, Examples are not listed any more.
试验例1耳肿胀试验Test example 1 ear swelling test
试验选用60只小鼠，雌雄各半，随机分为6组，每组10只，即空白组、组合物复方精油(实施例1制备)、止痛乳膏组(实施例11制备)、止痛软膏组(实施例12制备)、止痛喷雾组(实施例13制备)、阳性组(吲哚美辛乳膏)。每日涂抹给药1次，各组小鼠相应药物：(1)空白组不给药物(2)组合物复方精油组涂抹0.1ml依稀的精油，(3)止痛乳膏组给予0.5g止痛乳膏，(4)止痛软膏组给予0.5g止痛软膏，(5)止痛喷雾组给予2ml止痛喷雾，(6)对照组给予0.5g扶他林软膏。连续给药7天，末次给药后30分钟，在小鼠右耳正反两面用微量加样器各滴加10μl二甲苯致炎。末次给药后1小时，将小鼠颈椎脱臼处死，沿耳廓基部剪下两耳，用直径9毫米的打孔器在左右耳的同一部位打下圆形耳片。称同一小鼠左右两耳片的重量，以左右两耳片重量之差表示肿胀度，并比较试验组与对照组间差异的显著性。按下式计算耳增重百分比，并比较试验组和对照组差异的显著性。The test selected 60 mice, half male and half male, randomly divided into 6 groups, 10 in each group, i.e. blank group, composition compound essential oil (prepared in Example 1), analgesic cream group (prepared in Example 11), analgesic ointment group (prepared in Example 12), analgesic spray group (prepared in Example 13), positive group (indomethacin cream). Smear and administer once a day, corresponding drugs for mice in each group: (1) Blank group did not give drugs; (2) Compound essential oil group smeared 0.1ml faint essential oil; (4) pain relief ointment group was given 0.5g pain relief ointment, (5) pain relief spray group was given 2ml pain relief spray, (6) control group was given 0.5g Voltaren ointment. The administration was continued for 7 days, and 30 minutes after the last administration, 10 μl of xylene was dripped on the front and back sides of the mouse's right ear to cause inflammation. One hour after the last administration, the mice were sacrificed by cervical dislocation, and the two ears were cut off along the base of the auricles, and circular ear pieces were punched at the same part of the left and right ears with a puncher with a diameter of 9 mm. The weight of the left and right ears of the same mouse was weighed, and the degree of swelling was expressed as the difference between the weights of the left and right ears, and the significance of the difference between the test group and the control group was compared. Calculate the percentage of ear weight gain according to the following formula, and compare the significance of the difference between the test group and the control group.
耳增重百分比＝耳肿胀度左耳重×100％Ear weight gain percentage = ear swelling left ear weight × 100%
结果如表一所示：The results are shown in Table 1:
表一组合物复方精油及止痛乳膏、软膏和喷雾对二甲苯致小鼠耳肿胀的影响Table 1 Effects of compound essential oils and analgesic creams, ointments and sprays on xylene-induced ear swelling in mice
注：与空白组比较*p＜0.05**p＜0.01***p＜0.001Note: Compared with the blank group *p<0.05**p<0.01***p<0.001
由表1可以看出，与空白组相比，本发明的组合物复方精油及止痛乳膏、软膏和喷雾四个实验组均能明显减轻小鼠耳肿胀的程度，具有良好的抗炎作用，其中，止痛乳膏组的效果最佳。As can be seen from Table 1, compared with the blank group, the composition compound essential oil of the present invention and four experimental groups of pain-relieving cream, ointment and spray can significantly reduce the degree of mouse ear swelling, and have good anti-inflammatory effects. Among them, the analgesic cream group had the best effect.
试验例2醋酸扭体试验Test example 2 Acetic acid writhing test
试验选用60只小鼠(雌雄各半)按基础压痛痛阈值及体重随机分成6组，每组10只，即空白组、组合物复方精油(实施例1制备)、止痛乳膏组(实施例11制备)、对照组(扶他林软膏)。脱毛一天后按组别给予各组小鼠相应药物：(1)空白组不给药物，(2)组合物复方精油组涂抹0.1ml依稀的精油，(3)止痛乳膏组给予0.5g止痛乳膏，(4)止痛软膏组给予0.5g止痛乳膏，(5)止痛喷雾组给予2ml止痛喷雾，(6)对照组给予0.5g扶他林软膏。The test selects 60 mice (half male and half male) to be randomly divided into 6 groups according to the threshold of tenderness pain and body weight, 10 in each group, i.e. blank group, composition compound essential oil (prepared in Example 1), pain-relieving cream group (Example 1). 11 preparation), control group (Voltaren ointment). One day after depilation, the corresponding drugs were given to the mice in each group according to the group: (1) the blank group was not given drugs, (2) the composition compound essential oil group was smeared with 0.1ml of essential oil, (3) the analgesic cream group was given 0.5g analgesic milk (4) pain-relieving ointment group was given 0.5g pain-relieving cream, (5) pain-relieving spray group was given 2ml pain-relieving spray, (6) control group was given 0.5g Voltaren ointment.
各组小鼠每天给药两次，连续给药5天，软膏分别涂于小鼠背部脱毛处并用纱布覆盖再用医用透气胶带固定。第5天在药物去除30min后测试痛阈值，观察ip0.6％冰醋酸溶液后小鼠扭体反应潜伏期(min)及15min内小鼠扭体反应的次数。The mice in each group were administered twice a day for 5 consecutive days. The ointment was applied to the depilated areas on the back of the mice respectively, covered with gauze and fixed with medical air-permeable adhesive tape. On the 5th day, the pain threshold was tested 30 minutes after the drug was removed, and the writhing reaction latency (min) of the mice after ip 0.6% glacial acetic acid solution was observed and the times of the writhing reactions of the mice within 15 minutes.
结果如表二所示：The results are shown in Table 2:
表二组合物复方精油及止痛乳膏、软膏和喷雾对小鼠醋酸刺激痛的影响Table 2 Effects of composition compound essential oil and pain-relieving cream, ointment and spray on acetic acid-stimulated pain in mice
注：与空白组比较*p＜0.05**p＜0.01***p＜0.001Note: Compared with the blank group *p<0.05**p<0.01***p<0.001
由表2可以看出，与空白组相比，本发明的组合物复方精油及止痛乳膏、软膏和喷雾四个实验组均能减轻小鼠小鼠醋酸刺激痛的缓解，都具有良好的镇痛作用。As can be seen from Table 2, compared with the blank group, the composition compound essential oil of the present invention and analgesic cream, ointment and spray four experimental groups can all reduce the relief of acetic acid-stimulated pain in mice, and all have good analgesic effects. pain effect.
综上，本发明研究表明，将乳香精油、没药精油、艾叶精油、细辛精油、薄荷精油、冬青精油、天竺葵精油制备成的乳膏、喷雾剂及软膏剂后，在特定的用量下使用后，能够有效缓解关节疼痛，具有止痛的功效。In summary, the research of the present invention shows that after frankincense essential oil, myrrh essential oil, mugwort essential oil, asarum essential oil, peppermint essential oil, wintergreen essential oil, and geranium essential oil are prepared into cream, spray and ointment, use them in a specific amount Finally, it can effectively relieve joint pain and has analgesic effect.
以上所揭露的仅为本发明一种较佳实施例而已，当然不能以此来限定本发明之权利范围，本领域普通技术人员可以理解实现上述实施例的全部或部分流程，并依本发明权利要求所作的等同变化，仍属于本发明所涵盖的范围。What is disclosed above is only a preferred embodiment of the present invention, and of course it cannot limit the scope of rights of the present invention. Those of ordinary skill in the art can understand all or part of the process for realizing the above embodiments, and according to the rights of the present invention The required equivalent changes still belong to the scope covered by the present invention.
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| CN113082070A (en) * | 2021-04-14 | 2021-07-09 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Compound essential oil and preparation method thereof |
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| CN109432369A (en) * | 2018-12-07 | 2019-03-08 | 广州市香际会生物技术有限公司 | A compound essential oil for soothing shoulder and neck pain |
| CN113082070A (en) * | 2021-04-14 | 2021-07-09 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Compound essential oil and preparation method thereof |
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