CN1086124C - Shuangzuoxing suppository and ointment - Google Patents
Shuangzuoxing suppository and ointment Download PDFInfo
- Publication number
- CN1086124C CN1086124C CN98114284A CN98114284A CN1086124C CN 1086124 C CN1086124 C CN 1086124C CN 98114284 A CN98114284 A CN 98114284A CN 98114284 A CN98114284 A CN 98114284A CN 1086124 C CN1086124 C CN 1086124C
- Authority
- CN
- China
- Prior art keywords
- grams
- suppository
- gram
- ointment
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000829 suppository Substances 0.000 title claims abstract description 10
- 239000002674 ointment Substances 0.000 title abstract 4
- 229960000282 metronidazole Drugs 0.000 claims abstract description 11
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960004022 clotrimazole Drugs 0.000 claims abstract description 10
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims abstract description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 21
- NRBJWZSFNGZBFQ-UHFFFAOYSA-N 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 NRBJWZSFNGZBFQ-UHFFFAOYSA-N 0.000 claims description 9
- 229960004055 ciprofloxacin lactate Drugs 0.000 claims description 9
- 229940093430 polyethylene glycol 1500 Drugs 0.000 claims description 6
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 230000002538 fungal effect Effects 0.000 abstract 2
- 241000224526 Trichomonas Species 0.000 abstract 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 abstract 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 abstract 1
- 206010046914 Vaginal infection Diseases 0.000 abstract 1
- 201000008100 Vaginitis Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 229960002152 chlorhexidine acetate Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 208000011833 infective vaginitis Diseases 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 2
- 239000002511 suppository base Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a suppository and an ointment of shaung zuo xing for treating bacillary, fungal and trichomonas vaginitis and improving treating effects on bacillary, the fungal and trichomonas and mixing infectious vaginitis. The suppository or the ointment of shaung zuo xing is composed of 100 to 300 grams of metronidazole, 100 to 300 grams of clotrimazole, 80 to 240 grams of antibacterial agent of quinolone, and base material of the suppository or the ointment as the rest.
Description
The present invention is the colpitic medicine of treatment, particularly a kind of Shuangzuoxing suppository.
The colpitic medicine of treatment is a lot, wherein comparatively outstanding with " metronidazole,clotrimazole and chlorhexidine acetate suppositories " at present.Said medicine is made up of metronidazole, clotrimazole and chlorhexidine acetate and suppository base, because the toxicity of chlorhexidine acetate is higher, corresponding adding dosage is less, and is therefore, undesirable to bacterial vaginitis and mixed infective vaginitis curative effect.
The object of the present invention is to provide a kind of Shuangzuoxing suppository for the treatment of bacillary, mycotic, trichomonal vaginitis and can improve bacterial vaginitis and mixed infective vaginitis curative effect.
The present invention is achieved in that
It is by metronidazole 100-300 gram, and clotrimazole 100-300 gram, ciprofloxacin lactate 80-240 gram, polyethylene glycol 6000 1165-1500 gram, polyethylene glycol 1500 1000-1145 gram and propylene glycol 5-15 gram are formed.
Advantage of the present invention is: because the toxicity of ciprofloxacin lactate is low, therefore can increase dosage, thereby improve the curative effect to bacterial vaginitis and mixed infective vaginitis.Adopt water miscible Polyethylene Glycol and propylene glycol can improve fusing point again, prevent the suppository fusing, be convenient to transportation and storage, and bring into play drug effect more fully.
Embodiments of the invention are provided below:
Embodiment 1:
Get metronidazole 100 grams, clotrimazole 100 grams, ciprofloxacin lactate 80 grams, polyethylene glycol 6000 1165 grams, polyethylene glycol 1500 1000 grams, propylene glycol 5 grams, full dose 2500 grams.
Embodiment 2:
Get metronidazole 300 grams, clotrimazole 300 grams, ciprofloxacin lactate 240 grams, polyethylene glycol 6000 1500 grams, polyethylene glycol 1500 1145 grams, propylene glycol 15 grams, full dose 3500 grams.
Embodiment 3:
Get metronidazole 200 gram clotrimazoles 200 gram ciprofloxacin lactate 160 gram polyethylene glycol 6000s 1430 gram polyethylene glycol 1500s 1000 gram propylene glycol 10 grams, full dose 3000 grams.
Preparation process is as follows:
1, with metronidazole, clotrimazole, ciprofloxacin lactate, pulverize separately, mistake 100-120 mesh sieve, standby;
2, polyethylene glycol 6000 is heated to 60-70 ℃, complete molten after, clotrimazole, the metronidazole that sieves added wherein, stir, standby;
3, polyethylene glycol 1500 is heated to 50-60 ℃, complete molten after, the ciprofloxacin lactate after sieving is added wherein, stir, standby;
4, the polyethylene glycol 6000 medicinal liquid is added in the polyethylene glycol 1500 medicinal liquid, stir, and add propylene glycol, temperature remains on 60-70 ℃, crosses 100 mesh sieves, places 1-2 hour;
5, fill, 0-5 ℃ of cooling is after 20 minutes, and die sinking is got it filled.
6, packing promptly.
Embodiment 4:
Suppository base adopts semi-synthetic or natural acid ester, and the dosage of metronidazole, clotrimazole, ciprofloxacin lactate is with embodiment 1-4, and addition semi-synthetic or natural acid ester is 2000 grams.
Embodiment 5: addition semi-synthetic or natural acid ester is 4000 grams, and other is with embodiment 4.
Embodiment 6: addition semi-synthetic or natural acid ester is 3000 grams, and other is the same.
Claims (1)
1, a kind of Shuangzuoxing suppository is characterized in that, it is made up of metronidazole 100-300 gram, clotrimazole 100-300 gram, ciprofloxacin lactate 80-240 gram, polyethylene glycol 6000 1165-2645 gram, polyethylene glycol 1500 1000-1145 gram and propylene glycol 5-15 gram.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98114284A CN1086124C (en) | 1998-09-01 | 1998-09-01 | Shuangzuoxing suppository and ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98114284A CN1086124C (en) | 1998-09-01 | 1998-09-01 | Shuangzuoxing suppository and ointment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1206590A CN1206590A (en) | 1999-02-03 |
| CN1086124C true CN1086124C (en) | 2002-06-12 |
Family
ID=5223955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98114284A Expired - Fee Related CN1086124C (en) | 1998-09-01 | 1998-09-01 | Shuangzuoxing suppository and ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1086124C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060379A2 (en) * | 2003-01-03 | 2004-07-22 | Milankovits Marton | Pharmaceutical compositions comprising an antibacterial agent nd antifungal agent and a nitroimidazole for the treatment and prevention of genitourinary infections and their extragenital complications |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228303A (en) * | 1998-03-09 | 1999-09-15 | 锦州市制药五厂 | Drug composition for curing gynaecological vaginitis |
-
1998
- 1998-09-01 CN CN98114284A patent/CN1086124C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228303A (en) * | 1998-03-09 | 1999-09-15 | 锦州市制药五厂 | Drug composition for curing gynaecological vaginitis |
Non-Patent Citations (3)
| Title |
|---|
| 《第一军医大学学报》1995,15(2) 1995.4.1 庄志铨等，"阴泰栓剂的制备及其疗效观察";《西北药学杂志》1996,11(5) 1996.6.1 陈洪轩，"乳酸环丙沙星阴道泡腾片的研制" * |
| 《第一军医大学学报》1995,15(2) 1995.4.1 庄志铨等，"阴泰栓剂的制备及其疗效观察" * |
| 《西北药学杂志》1996,11(5) 1996.6.1 陈洪轩，"乳酸环丙沙星阴道泡腾片的研制" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1206590A (en) | 1999-02-03 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |