CN1084185C - Liquid spray for treating oral and throat diseases and its preparing process - Google Patents
Liquid spray for treating oral and throat diseases and its preparing process Download PDFInfo
- Publication number
- CN1084185C CN1084185C CN98112092A CN98112092A CN1084185C CN 1084185 C CN1084185 C CN 1084185C CN 98112092 A CN98112092 A CN 98112092A CN 98112092 A CN98112092 A CN 98112092A CN 1084185 C CN1084185 C CN 1084185C
- Authority
- CN
- China
- Prior art keywords
- parts
- distilled water
- oil
- glycyrrhetate
- liquid spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 39
- 201000010099 disease Diseases 0.000 title claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 13
- 239000007921 spray Substances 0.000 title claims description 19
- 238000000034 method Methods 0.000 title abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000012153 distilled water Substances 0.000 claims abstract description 20
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- 210000000214 mouth Anatomy 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 241000209094 Oryza Species 0.000 claims description 20
- 235000007164 Oryza sativa Nutrition 0.000 claims description 20
- 235000009566 rice Nutrition 0.000 claims description 20
- 239000003814 drug Substances 0.000 abstract description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 238000005507 spraying Methods 0.000 abstract description 4
- 238000001256 steam distillation Methods 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 2
- 241001252601 Blumea Species 0.000 abstract 2
- 229940116229 borneol Drugs 0.000 abstract 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 2
- 229940041616 menthol Drugs 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229940060184 oil ingredients Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000008187 granular material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 229940098458 powder spray Drugs 0.000 description 3
- 206010018286 Gingival pain Diseases 0.000 description 2
- 206010018291 Gingival swelling Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 206010044008 tonsillitis Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a liquid spraying agent for treating the disease of an oral cavity and a throat, which is characterized in that the liquid spraying agent is prepared from the raw materials of blumea oil, bran oil, borneol, menthol, glycyrrhetate, alcohol, distilled water, etc. The liquid spraying agent has the preparation method that the bran oil is obtained by a steam distillation and extraction method; the bran oil, the blumea oil, the borneol and the menthol are dissolved into the alcohol; the glycyrrhetate is completely dissolved into the distilled water by a heating method; an alcohol solution and a water solution are mixed; the distilled water is continuously added to be uniformly stirred, and a finished product medicament is obtained. The present invention has the characteristics of easy absorption, rapid medicine effect exert and high therapeutic effect, and is easy for patients to accept and use. The present invention is an ideal medicament for treating the disease of an oral cavity and a throat.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of liquid spray for the treatment of oral cavity and laryngopharyngeal diseases.
Oral cavity and laryngopharyngeal diseases are more common diseases as gingival swelling and pain, oral ulcer, pharyngitis, tonsillitis etc.This class curative effect of disease of treatment is relatively good at present, and what the use means were more convenient is the powder spray, and it is sprayed directly on to diseased region with medicine, and the drug effect of medicine is brought into play preferably.But the used drug regimen of this class spray though curative effect is better, but still has much room for improvement at present.The powder spray has certain zest to the throat when spraying in addition, so that many patients are reluctant to use.
The objective of the invention is to: a kind of liquid spray for the treatment of oral cavity and laryngopharyngeal diseases is provided, and it is than existing powder spray better efficacy, and throat is not stimulated, and the patient can not choke in use and cough, and is easilier accepted use by the patient.
Implementation of the present invention is,
Liquid spray of the present invention is (consumption is a weight portion) of being made by the conventional liquid spray preparation method of raw material employing of following component:
9～29 parts of 5～16 parts of rice original texts of Oleum Blumeae Balsamiferae oil
25～75 parts of 20～60 parts of Mentholums of Borneolum Syntheticum
4250～12750 parts of 35～105 parts of ethanol of glycyrrhetate
4400～13320 parts of distilled water
The formula optimization weight proportion scope of preparation liquid spray of the present invention is:
15～23 parts of 8～13 parts of rice original texts of Oleum Blumeae Balsamiferae oil
40～60 parts of 32～48 parts of Mentholums of Borneolum Syntheticum
7650～9350 parts of 56～84 parts of ethanol of glycyrrhetate
8000～9770 parts of distilled water
The optimum weight proportioning of preparation liquid spray of the present invention is:
18.9 parts of 10.4 parts of rice original text oil of Oleum Blumeae Balsamiferae
50 parts of 40 parts of Mentholums of Borneolum Syntheticum
8500 parts of 70 parts of ethanol of glycyrrhetate
8880 parts of distilled water
The manufacture method that above-mentioned each component is made liquid spray of the present invention is:
1. the rice original text is ground into the granule of 0.5～3cm, obtains a meter original text oil with water vapour distillation;
2. rice original text oil, Oleum Blumeae Balsamiferae, Borneolum Syntheticum, Mentholum are dissolved in the ethanol of 95% concentration A liquid;
3. glycyrrhetate is heated to 70～100 ℃ with 5～10 times distilled water, it is dissolved fully, B liquid;
4. A, B liquid are mixed, continue to add distilled water, and stir, get the finished product medicament.
Compared with the prior art, the present invention adopts new drug regimen, and is made into liquid spray, makes its better efficacy, and total effective rate can reach 86.8%, and is easy to be accepted use by the patient.Have be easy to absorb, the performance drug effect is rapid, the curative effect height, patient and in the characteristics of accepting to use is treatment oral cavity and the comparatively ideal medicine of laryngopharyngeal diseases.
Below the specific embodiment of the present invention is described in further detail.
Embodiment 1: press 8 parts of Oleum Blumeae Balsamiferaes, 15 parts of rice original text oil, 32 parts of Borneolum Syntheticums, 40 parts of Mentholums, 56 parts of glycyrrhetates, 7650 parts of the ethanol of 95% concentration, the weight ratio configuration raw material that distilled water is 9770 parts.Rice original text oil adopt with the rice original text be ground into 0.5～3cm all can granule, extract and get with steam distillation then.Oleum Blumeae Balsamiferae, rice original text oil, Borneolum Syntheticum, Mentholum are dissolved in the ethanol, get A liquid; With 500 parts of distilled water glycyrrhetate is heated to 80 ℃ in addition, glycyrrhetate is dissolved fully, get B liquid; A, B liquid are mixed, be added to the distilled water of capacity, get the finished product medicinal liquid after stirring,, can get liquid spray of the present invention the bottling of finished product medicinal liquid.
Embodiment 2: press 10.4 parts of Oleum Blumeae Balsamiferaes, 18.9 parts of rice original text oil, 40 parts of Borneolum Syntheticums, 50 parts of Mentholums, 70 parts of glycyrrhetates, 8500 parts of the ethanol of 95% concentration, the weight ratio configuration raw material that distilled water is 8880 parts.Rice original text oil adopt with the rice original text be ground into 0.5～3cm all can granule, extract and get with steam distillation then.Oleum Blumeae Balsamiferae, rice original text oil, Borneolum Syntheticum, Mentholum are dissolved in the ethanol, get A liquid; With 400 parts of distilled water glycyrrhetate is heated to 100 ℃ in addition, glycyrrhetate is dissolved fully, get B liquid; A, B liquid are mixed, be added to the distilled water of capacity, get the finished product medicinal liquid after stirring,, can get liquid spray of the present invention the bottling of finished product medicinal liquid.
Embodiment 3: press 13 parts of Oleum Blumeae Balsamiferaes, 23 parts of rice original text oil, 48 parts of Borneolum Syntheticums, 60 parts of Mentholums, 84 parts of glycyrrhetates, 9350 parts of the ethanol of 95% concentration, the weight ratio configuration raw material that distilled water is 8000 parts.Rice original text oil adopt with the rice original text be ground into 0.5～3cm all can granule, extract and get with steam distillation then.Oleum Blumeae Balsamiferae, rice original text oil, Borneolum Syntheticum, Mentholum are dissolved in the ethanol, get A liquid; With 600 parts of distilled water glycyrrhetate is heated to 90 ℃ in addition, glycyrrhetate is dissolved fully, get B liquid; A, B liquid are mixed, be added to the distilled water of capacity, get the finished product medicinal liquid after stirring,, can get liquid spray of the present invention the bottling of finished product medicinal liquid.
Liquid spray of the present invention has the function of the detoxifcation of dispeling the wind, reducing swelling and alleviating pain, throat-benefiting.Can be used for acute and chronic pharyngitis.Tonsillitis, laryngopharynx swelling and pain, gingival swelling and pain, aphtha of the mouth and tongue.Usage is to be sprayed directly on to the affected part, and is each an amount of, and one for several times.
Claims (3)
1, a kind of liquid spray for the treatment of oral cavity and laryngopharyngeal diseases is characterized in that: it is to adopt conventional liquid spray preparation method to make by the following weight proportion raw material:
9～29 parts of 5～16 parts of rice original texts of Oleum Blumeae Balsamiferae oil
25～75 parts of 20～60 parts of Mentholums of Borneolum Syntheticum
4250～12750 parts of 35～105 parts of ethanol of glycyrrhetate
4400～13320 parts of distilled water.
2, a kind of liquid spray for the treatment of oral cavity and laryngopharyngeal diseases according to claim 1, it is characterized in that: described weight proportion is:
15～23 parts of 8～13 parts of rice original texts of Oleum Blumeae Balsamiferae oil
40～60 parts of 32～48 parts of Mentholums of Borneolum Syntheticum
7650～9350 parts of 56～84 parts of ethanol of glycyrrhetate
8000～9770 parts of distilled water.
3, a kind of liquid spray for the treatment of oral cavity and laryngopharyngeal diseases according to claim 2, it is characterized in that: described weight proportion is:
18.9 parts of 10.4 parts of rice original text oil of Oleum Blumeae Balsamiferae
50 parts of 40 parts of Mentholums of Borneolum Syntheticum
8500 parts of 70 parts of ethanol of glycyrrhetate
8880 parts of distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112092A CN1084185C (en) | 1998-06-15 | 1998-06-15 | Liquid spray for treating oral and throat diseases and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112092A CN1084185C (en) | 1998-06-15 | 1998-06-15 | Liquid spray for treating oral and throat diseases and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1238946A CN1238946A (en) | 1999-12-22 |
| CN1084185C true CN1084185C (en) | 2002-05-08 |
Family
ID=5221971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98112092A Expired - Lifetime CN1084185C (en) | 1998-06-15 | 1998-06-15 | Liquid spray for treating oral and throat diseases and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1084185C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427079C (en) * | 2006-03-10 | 2008-10-22 | 贵州宏宇药业有限公司 | Vaginal foam preparation of chlorhexidine acetate and its preparing process |
| CN108904644A (en) * | 2018-10-08 | 2018-11-30 | 广东云瑶生物医药科技有限公司 | Borneol larynx nose is logical and preparation method thereof |
| CN113209160A (en) * | 2021-05-14 | 2021-08-06 | 云南昭药健康产业有限公司 | Oral ulcer gel and preparation method thereof |
-
1998
- 1998-06-15 CN CN98112092A patent/CN1084185C/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 贵阳中医学院学报.1998年，20卷，1期 1998.3.1 柴木等.金喉健喷雾剂治疗急性咽炎闻效观察 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1238946A (en) | 1999-12-22 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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Granted publication date: 20020508 |
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| CX01 | Expiry of patent term |