CN108288427A - A kind of production method of 3 D-printing transtracheal mirror lymph node puncture training pattern - Google Patents
A kind of production method of 3 D-printing transtracheal mirror lymph node puncture training pattern Download PDFInfo
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- 238000012549 training Methods 0.000 title claims abstract description 36
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Abstract
本发明提供了一种三维打印经气管镜淋巴结穿刺训练模型的制作方法,步骤为:先通过CT断层扫描及三维重建技术采集不同人的喉部、气管、支气管的结构信息,应用三维打印技术制作出多个符合临床真实解剖结构的气道模型,然后制作粘在支气管外侧壁相应位置的模拟淋巴结,仿真颌模型以及用于遮挡和固定支气管模型的壳体,最后将各部件按解剖位置组装,最外层用壳体覆盖;本发明的制作经气管镜淋巴结穿刺训练模型的方法使得训练模型的气道结构与真实病例的结构高度近似,训练模型中多个气道模型的结构和难易程度各不相同,从而使得训练过程更加接近临床真实操作环境,训练过程由易到难,提高了训练效果。
The invention provides a method for making a three-dimensionally printed lymph node puncture training model through bronchoscopy. Create a number of airway models that conform to the clinical real anatomical structure, then make simulated lymph nodes glued to the corresponding positions on the lateral wall of the bronchus, simulate the jaw model, and the shell used to block and fix the bronchial model, and finally assemble the components according to the anatomical position, The outermost layer is covered with a shell; the method for making a training model of lymph node puncture through bronchoscopy of the present invention makes the airway structure of the training model highly similar to the structure of real cases, and the structure and degree of difficulty of multiple airway models in the training model Each is different, so that the training process is closer to the actual clinical operating environment, and the training process is from easy to difficult, which improves the training effect.
Description
技术领域technical field
本发明涉及一种支气管镜的训练模型,具体涉及一种三维打印经气管镜淋巴结穿刺训练模型的制作方法。The invention relates to a bronchoscope training model, in particular to a method for making a three-dimensionally printed transbronchoscope lymph node puncture training model.
背景技术Background technique
经支气管镜针吸活检术是应用一种特制的带有可弯曲导管的穿刺针,通过纤维支气管镜的活检孔道送入气道内,然后穿透气道壁对气管、支气管腔外病变,如结节、肿块、肿大的淋巴结以及肺部的病灶进行针刺吸引,获取细胞或组织标本进行细胞学和病理学检查的一种新技术。经支气管镜针吸活检术广泛应用于紧贴气管、支气管周围病灶的定性诊断,并使支气管镜技术参与到恶性肿瘤的临床分期,但在对该项技术熟练掌握之前,不允许在病人身体直接操作。而目前训练多为虚拟支气管镜模拟技术和纤维支气管镜训练箱,这些现有技术虽可以进行操作训练,但是呼吸系统各个组织、器官模型具体形态和真实的还有差距,相对空间位置和毗邻结构不够确切,材料的选择还不合理,且训练模型支气管结构千篇一律,没有难度差别,所以不能很好的达到临床实际要求,训练者不能熟练掌握经支气管镜针吸活检术操作的流程、技巧和手法。Needle aspiration biopsy through bronchoscope is a special puncture needle with a flexible catheter, which is sent into the airway through the biopsy channel of the fiberoptic bronchoscope, and then penetrates the wall of the airway to treat tracheal and bronchial lesions, such as knots. It is a new technology for acupuncture suction of nodules, masses, enlarged lymph nodes and lung lesions, and to obtain cell or tissue samples for cytological and pathological examination. Needle aspiration biopsy via bronchoscope is widely used in the qualitative diagnosis of lesions close to the trachea and peribronchus, and allows bronchoscopic techniques to participate in the clinical staging of malignant tumors. operate. At present, most of the training is virtual bronchoscopic simulation technology and fiberoptic bronchoscope training box. Although these existing technologies can be used for operational training, there is still a gap between the specific shape of each tissue and organ model of the respiratory system and the real one, relative spatial position and adjacent structure. It is not accurate enough, the choice of materials is not reasonable, and the bronchial structure of the training model is the same, there is no difference in difficulty, so it cannot meet the actual clinical requirements well, and the trainers cannot master the process, skills and techniques of transbronchial needle aspiration biopsy .
三维扫描主要用于对物体空间外形和结构及色彩进行扫描,以获得物体表面的空间坐标,搜集到的数据可被用来进行三维重建计算,创建实际物体的数字模型文件,具有高效率、高精度的特征。三维打印技术以数字模型文件为基础,运用粉末状金属或塑料等可粘合材料,通过逐层打印的方式来构造物体。Three-dimensional scanning is mainly used to scan the shape, structure and color of the object space to obtain the spatial coordinates of the object surface. The collected data can be used for three-dimensional reconstruction calculations to create digital model files of the actual object, which has high efficiency and high efficiency. characteristics of precision. Based on digital model files, 3D printing technology uses bondable materials such as powdered metal or plastic to construct objects by layer-by-layer printing.
发明内容Contents of the invention
为了解决现有技术中存在的问题,本发明提供了一种三维打印经气管镜淋巴结穿刺训练模型的制作方法,使得训练模型的支气管结构更接近真实病例的解剖结构,训练过程中有难易程度不等的多个模型可供选择,提高了训练效果。In order to solve the problems existing in the prior art, the present invention provides a method for making a three-dimensionally printed lymph node puncture training model through bronchoscopy, so that the bronchial structure of the training model is closer to the anatomical structure of the real case, and there is a degree of difficulty in the training process There are multiple models to choose from, which improves the training effect.
本发明解决上述问题的技术方案为:一种三维打印经气管镜淋巴结穿刺训练模型的制作方法,其具体包括以下步骤:The technical solution of the present invention to solve the above problems is: a method for making a three-dimensionally printed lymph node puncture training model through bronchoscopy, which specifically includes the following steps:
步骤1:选取低难度、中难度、高难度病人各五个,通过CT断层扫描及三维重建技术采集他们的喉部、气管、支气管的结构信息,得到三维模型数据;Step 1: Select five low-difficulty, medium-difficulty, and high-difficulty patients, and collect structural information of their larynx, trachea, and bronchus through CT tomography and 3D reconstruction technology to obtain 3D model data;
步骤2:使用计算机软件读取步骤1中得到的三维模型数据,进行还原和修复,据此生成气道模型的三维模型;Step 2: use computer software to read the 3D model data obtained in Step 1, restore and repair, and generate a 3D model of the airway model accordingly;
步骤3:使用三维打印机,将各气道模型的三维模型打印成型,从而得到多个既高度符合真实解剖结构又个体化的气道模型,气道模型的气管环部分采用树脂材料,气管壁柔软部分采用硅胶材料,气道模型包括由上而下包括模拟喉部、模拟气管部和模拟支气管部;Step 3: Use a 3D printer to print the 3D models of each airway model, so as to obtain multiple airway models that are highly consistent with the real anatomical structure and individualized. The tracheal ring part of the airway model is made of resin material, and the tracheal wall is soft Partially made of silicone material, the airway model includes simulated larynx, simulated trachea and simulated bronchi from top to bottom;
步骤4:采用硅胶材质制作模拟淋巴结,模拟淋巴结的形状为直径5mm~10mm的中空球形,内部充填软组织,所述软组织为橡皮泥或甘油或石蜡油,多次使用后可以更换;Step 4: The simulated lymph node is made of silica gel. The simulated lymph node is hollow spherical with a diameter of 5 mm to 10 mm, and the interior is filled with soft tissue. The soft tissue is plasticine or glycerin or paraffin oil, which can be replaced after multiple uses;
步骤5:使用硅胶、金属材料制作颌模型,该颌模型是在插入支气管镜时作为插入口的部位,外形为真实颌的仿真模型,以针对人体实施时的情况从而提高训练效果,在颌模型中设有喉头部,该喉头部的末端与气道模型的模拟喉部相连,可根据需要将气道模型整体替换;Step 5: Use silica gel and metal materials to make a jaw model. This jaw model is used as the insertion port when inserting a bronchoscope. There is a larynx in the middle, and the end of the larynx is connected to the simulated larynx of the airway model, and the airway model can be replaced as a whole according to needs;
步骤6:选用透明塑料材质制作壳体,并在壳体外侧面选择性覆盖不透明遮挡,壳体用于收容气道模型,其正面侧可以打开,壳体内设有气道模型安装件,气道模型通过气道模型安装件安装在壳体内,将颌模型的喉头部与气道模型的模拟喉部连接组装,颌模型设置在壳体外,将模拟淋巴结粘在真实淋巴结位置处,可以在穿刺训练结束后打开壳体正面观察是否穿刺到淋巴结;Step 6: Choose a transparent plastic material to make the shell, and selectively cover the outer surface of the shell with opaque shielding. The shell is used to accommodate the airway model, and its front side can be opened. The airway model mounting parts are installed in the shell, and the throat of the jaw model is connected to the simulated throat of the airway model. The jaw model is set outside the shell, and the simulated lymph nodes are glued to the real lymph nodes, which can be completed at the end of the puncture training. Finally, open the front of the shell to observe whether the lymph node is punctured;
进一步的,步骤1中病人难度根据气道通畅程度、气道变异情况、病变部位的位置、大小、形状判断,气道通畅程度低难度高,气道变异大难度高,病变部位位于气道深部、比较小、形状难以抓取难度高,同时根据在对病人进行气管镜标准操作的总时间以及活检阳性率,费时长、活检阳性率低的气道标本难度高;Further, in step 1, the difficulty of the patient is judged according to the degree of airway patency, airway variation, and the location, size, and shape of the lesion. If the airway is low, the difficulty is high, and if the airway variation is large, the difficulty is high, and the lesion is located in the deep part of the airway. , relatively small, difficult to grasp, and difficult to grasp. At the same time, according to the total time of bronchoscopy standard operation on the patient and the positive rate of biopsy, the airway specimens that take a long time and have a low positive rate of biopsy are difficult;
进一步的,步骤2中使用计算机软件读取步骤1中得到的三维模型数据,其具体步骤为,第一步:读取图像,利用图像导入功能将CT图像导入Mimics软件中,自动定义前后左右四个方向,手动定义图像的上下两个方向,软件将根据横断面图像自动生成矢状面和冠状面图像;第二步:提取轮廓,进入三视图可编辑操作界面,利用阈值设定工具提取轮廓,在保证重建组织被选取的情况下,尽量不使重建组织以外的结构出现轮廓阴影,界定阈值在合适的范围,形成蒙面;第三步:选择热区,利用软件中的区域增长工具进行热区选择,如果需要重建结构与周围组织灰度值相近,提取时则需采取人工识别的方法,对每层图像都要进行边缘分割、去除冗余数据、选择性编辑及补洞处理,第四步:生成三维模型,基于3D插补法,利用软件的三维计算工具—分割菜单中的Calculate 3D可将二维图像直接转化成三维模型,重建的模型外形逼真,可平移、缩放、任意平面切割、任意角度旋转,直接清楚地再现喉部、气管、支气管的三维立体形态,将重建好的三维模型以SLT格式输出保存,即可得到重建的三维可视化模型。Further, in step 2, computer software is used to read the three-dimensional model data obtained in step 1. The specific steps are as follows: the first step: read the image, use the image import function to import the CT image into the Mimics software, and automatically define the front, rear, left, and right sides Manually define the upper and lower directions of the image, and the software will automatically generate sagittal and coronal images based on the cross-sectional image; the second step: extract the contour, enter the three-view editable operation interface, and use the threshold setting tool to extract the contour , in the case of ensuring that the reconstructed tissue is selected, try not to make the contour shadow of the structure other than the reconstructed tissue appear, and define the threshold in an appropriate range to form a mask; the third step: select the hot area, and use the region growth tool in the software to perform Hot area selection, if the reconstruction structure needs to be similar to the gray value of the surrounding tissue, manual recognition is required for extraction, and edge segmentation, redundant data removal, selective editing and hole filling must be performed on each layer of image. Step 4: Generate a 3D model. Based on the 3D interpolation method, use the 3D calculation tool of the software - Calculate 3D in the segmentation menu to directly convert the 2D image into a 3D model. The reconstructed model has a realistic appearance and can be translated, zoomed, and any plane Cut, rotate at any angle, directly and clearly reproduce the three-dimensional shape of the larynx, trachea, and bronchi, and save the reconstructed three-dimensional model in SLT format to obtain the reconstructed three-dimensional visualization model.
本发明具有有益效果:The present invention has beneficial effects:
本发明能够进行在现有穿刺训练模型中无法实施的、从气管或支气管内侧对靠近气管或支气管的淋巴结进行穿刺的穿刺技术的训练;本发明采用三维打印技术制作气道模型,其结构与真实解剖结构更为接近,从而使训练过程更接近临床;本发明通过扫描不同病人的支气管结构,根据支气管镜淋巴结穿刺的操作的难易程度,可以制作出不同难度的训练模型,从而使得训练循序渐进,有助于提高施术者的穿刺技术。The present invention can carry out the training of the puncture technique of puncturing the lymph nodes close to the trachea or bronchi from the inner side of the trachea or bronchi, which cannot be implemented in the existing puncture training models; The anatomical structure is closer, so that the training process is closer to the clinic; the present invention scans the bronchial structure of different patients, and according to the difficulty of bronchoscopic lymph node puncture, it can make training models with different difficulties, so that the training can be done step by step. Helps improve the operator's piercing technique.
附图说明Description of drawings
图1为穿刺模型的结构示意图;Fig. 1 is the structural representation of puncture model;
图中:1-模拟喉部,2-模拟气管部,3-模拟支气管部,4-颌模型,5-喉头部,6-壳体,7-气道模型安装件。In the figure: 1-simulated larynx, 2-simulated trachea, 3-simulated bronchi, 4-jaw model, 5-larynx, 6-shell, 7-airway model mounting parts.
具体实施方式Detailed ways
下面结合附图及具体实施方式对本发明作进一步的说明。The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.
如图所示,一种三维打印经气管镜淋巴结穿刺训练模型的制作方法,其具体包括以下步骤:As shown in the figure, a method for making a three-dimensionally printed lymph node puncture training model through bronchoscopy, which specifically includes the following steps:
步骤1:选取低难度、中难度、高难度病人各五个,通过CT断层扫描及三维重建技术采集他们的喉部、气管、支气管的结构信息,得到三维模型数据;Step 1: Select five low-difficulty, medium-difficulty, and high-difficulty patients, and collect structural information of their larynx, trachea, and bronchus through CT tomography and 3D reconstruction technology to obtain 3D model data;
步骤2:使用计算机软件读取步骤1中得到的三维模型数据,进行还原和修复,据此生成气道模型的三维模型;Step 2: use computer software to read the 3D model data obtained in Step 1, restore and repair, and generate a 3D model of the airway model accordingly;
步骤3:使用三维打印机,将各气道模型的三维模型打印成型,从而得到多个既高度符合真实解剖结构又个体化的气道模型,气道模型的气管环部分采用树脂材料,气管壁柔软部分采用硅胶材料,气道模型包括由上而下包括模拟喉部、模拟气管部和模拟支气管部;Step 3: Use a 3D printer to print the 3D models of each airway model, so as to obtain multiple airway models that are highly consistent with the real anatomical structure and individualized. The tracheal ring part of the airway model is made of resin material, and the tracheal wall is soft Partially made of silicone material, the airway model includes simulated larynx, simulated trachea and simulated bronchi from top to bottom;
步骤4:采用硅胶材质制作模拟淋巴结,模拟淋巴结的形状为直径5mm~10mm的中空球形,内部充填软组织,所述软组织为橡皮泥或甘油或石蜡油,多次使用后可以更换;Step 4: The simulated lymph node is made of silica gel. The simulated lymph node is hollow spherical with a diameter of 5 mm to 10 mm, and the interior is filled with soft tissue. The soft tissue is plasticine or glycerin or paraffin oil, which can be replaced after multiple uses;
步骤5:使用硅胶、金属材料制作颌模型,该颌模型是在插入支气管镜时作为插入口的部位,外形为真实颌的仿真模型,以针对人体实施时的情况从而提高训练效果,在颌模型中设有喉头部,该喉头部的末端与气道模型的模拟喉部相连,可根据需要将气道模型整体替换;Step 5: Use silica gel and metal materials to make a jaw model. This jaw model is used as the insertion port when inserting a bronchoscope. There is a larynx in the middle, and the end of the larynx is connected to the simulated larynx of the airway model, and the airway model can be replaced as a whole according to needs;
步骤6:选用透明塑料材质制作壳体,并在壳体外侧面选择性覆盖不透明遮挡,壳体用于收容气道模型,其正面侧可以打开,壳体内设有气道模型安装件,气道模型通过气道模型安装件安装在壳体内,将颌模型的喉头部与气道模型的模拟喉部连接组装,颌模型设置在壳体外,将模拟淋巴结粘在真实淋巴结位置处,可以在穿刺训练结束后打开壳体正面观察是否穿刺到淋巴结,因此有助于提高本训练模型的评价效果;Step 6: Choose a transparent plastic material to make the shell, and selectively cover the outer surface of the shell with opaque shielding. The shell is used to accommodate the airway model, and its front side can be opened. The airway model mounting parts are installed in the shell, and the throat of the jaw model is connected to the simulated throat of the airway model. The jaw model is set outside the shell, and the simulated lymph nodes are glued to the real lymph nodes, which can be completed at the end of the puncture training. Finally, open the front of the shell to observe whether the lymph node is punctured, so it is helpful to improve the evaluation effect of this training model;
进一步的,步骤1中病人难度根据气道通畅程度、气道变异情况、病变部位的位置、大小、形状判断,气道通畅程度低难度高,气道变异大难度高,病变部位位于气道深部、比较小、形状难以抓取难度高,同时根据在对病人进行气管镜标准操作的总时间以及活检阳性率,费时长、活检阳性率低的气道标本难度高;Further, in step 1, the difficulty of the patient is judged according to the degree of airway patency, airway variation, and the location, size, and shape of the lesion. If the airway is low, the difficulty is high, and if the airway variation is large, the difficulty is high, and the lesion is located in the deep part of the airway. , relatively small, difficult to grasp, and difficult to grasp. At the same time, according to the total time of bronchoscopy standard operation on the patient and the positive rate of biopsy, the airway specimens that take a long time and have a low positive rate of biopsy are difficult;
进一步的,步骤2中使用计算机软件读取步骤1中得到的三维模型数据,其具体步骤为,第一步:读取图像,利用图像导入功能将CT图像导入Mimics软件中,自动定义前后左右四个方向,手动定义图像的上下两个方向,软件将根据横断面图像自动生成矢状面和冠状面图像;第二步:提取轮廓,进入三视图可编辑操作界面,利用阈值设定工具提取轮廓,在保证重建组织被选取的情况下,尽量不使重建组织以外的结构出现轮廓阴影,界定阈值在合适的范围,形成蒙面;第三步:选择热区,利用软件中的区域增长工具进行热区选择,如果需要重建结构与周围组织灰度值相近,提取时则需采取人工识别的方法,对每层图像都要进行边缘分割、去除冗余数据、选择性编辑及补洞处理,第四步:生成三维模型,基于3D插补法,利用软件的三维计算工具—分割菜单中的Calculate 3D可将二维图像直接转化成三维模型,重建的模型外形逼真,可平移、缩放、任意平面切割、任意角度旋转,直接清楚地再现喉部、气管、支气管的三维立体形态。将重建好的三维模型以SLT格式输出保存,即可得到重建的三维可视化模型。Further, in step 2, computer software is used to read the three-dimensional model data obtained in step 1. The specific steps are as follows: the first step: read the image, use the image import function to import the CT image into the Mimics software, and automatically define the front, rear, left, and right sides Manually define the upper and lower directions of the image, and the software will automatically generate sagittal and coronal images based on the cross-sectional image; the second step: extract the contour, enter the three-view editable operation interface, and use the threshold setting tool to extract the contour , in the case of ensuring that the reconstructed tissue is selected, try not to make the contour shadow of the structure other than the reconstructed tissue appear, and define the threshold in an appropriate range to form a mask; the third step: select the hot area, and use the region growth tool in the software to perform Hot area selection, if the reconstruction structure needs to be similar to the gray value of the surrounding tissue, manual recognition is required for extraction, and edge segmentation, redundant data removal, selective editing and hole filling must be performed on each layer of image. Step 4: Generate a 3D model. Based on the 3D interpolation method, use the 3D calculation tool of the software - Calculate 3D in the segmentation menu to directly convert the 2D image into a 3D model. The reconstructed model has a realistic appearance and can be translated, zoomed, and any plane Cut and rotate at any angle, directly and clearly reproduce the three-dimensional shape of the larynx, trachea, and bronchi. Export and save the reconstructed 3D model in SLT format to obtain a reconstructed 3D visualization model.
进行穿刺训练时,训练者依次使用低难度、中难度、高难度组的支气管模型训练,使用时,训练者将支气管镜从颌模型插入,经颌模型的喉头部到达气道模型的模拟气管部或模拟支气管部,并使用穿刺针穿过气管或支气管软骨环间隙的气管壁软组织,对气管或支气管旁的模拟淋巴结进行穿刺吸引,当吸引到模拟淋巴结中的软组织时,表示穿刺成功,也可以在穿刺后打开壳体的正面侧,直接观察是否穿刺成功。训练者由较低难度开始训练,只有当较低难度考核通过后,才可以进行下一难度的训练,因此本发明实施方式可显著提高经支气管镜淋巴结穿刺的训练效果。During the puncture training, the trainer uses the bronchial models of the low-difficulty, medium-difficulty, and high-difficulty groups in turn for training. When in use, the trainer inserts the bronchoscope from the jaw model, through the larynx of the jaw model to the simulated trachea of the airway model Or simulate the bronchi, and use the puncture needle to pass through the soft tissue of the trachea wall in the gap between the trachea or bronchial cartilage ring, and puncture and aspirate the simulated lymph nodes next to the trachea or bronchi. When the soft tissue in the simulated lymph nodes is attracted, it means that the puncture is successful. After the puncture, open the front side of the housing to directly observe whether the puncture is successful. The trainer starts training with a lower difficulty level, and only after the lower difficulty level is passed, can the next level of difficulty training be performed. Therefore, the embodiment of the present invention can significantly improve the training effect of bronchoscopic lymph node puncture.
以上所述,仅是本发明的较佳实施例而已,并非是对本发明作其它形式的限制,任何熟悉本专业的技术人员可能利用上述揭示的技术内容加以变更或改型为等同变化的等效实施例应用于其它领域,但是凡是未脱离本发明技术方案内容,依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与改型,仍属于本发明技术方案的保护范围。The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention to other forms. Any skilled person who is familiar with this profession may use the technical content disclosed above to change or modify the equivalent of equivalent changes. The embodiments are applied to other fields, but any simple modifications, equivalent changes and modifications made to the above embodiments according to the technical essence of the present invention still belong to the protection scope of the technical solutions of the present invention without departing from the content of the technical solutions of the present invention.
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