CN1080864A - A kind of alcohol-decomposing powder and preparation method thereof - Google Patents
A kind of alcohol-decomposing powder and preparation method thereof Download PDFInfo
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- CN1080864A CN1080864A CN 93107383 CN93107383A CN1080864A CN 1080864 A CN1080864 A CN 1080864A CN 93107383 CN93107383 CN 93107383 CN 93107383 A CN93107383 A CN 93107383A CN 1080864 A CN1080864 A CN 1080864A
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- alcohol
- ethanol
- radix ginseng
- sucrose
- citric acid
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- 239000000843 powder Substances 0.000 title claims abstract 6
- 238000002360 preparation method Methods 0.000 title abstract description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000008434 ginseng Nutrition 0.000 claims abstract description 14
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 13
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 13
- 241000229143 Hippophae Species 0.000 claims abstract description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 8
- 229930006000 Sucrose Natural products 0.000 claims abstract description 8
- 239000005720 sucrose Substances 0.000 claims abstract description 8
- 241000208340 Araliaceae Species 0.000 claims abstract 6
- 241000628997 Flos Species 0.000 claims abstract 4
- 235000003935 Hippophae Nutrition 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 239000008187 granular material Substances 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 6
- 239000000469 ethanolic extract Substances 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 229930182490 saponin Natural products 0.000 claims description 3
- 150000007949 saponins Chemical class 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 230000006837 decompression Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 239000000686 essence Substances 0.000 abstract 1
- 240000004371 Panax ginseng Species 0.000 description 8
- 206010019133 Hangover Diseases 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 235000003145 Hippophae rhamnoides Nutrition 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 241000202807 Glycyrrhiza Species 0.000 description 4
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 4
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940010454 licorice Drugs 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000035622 drinking Effects 0.000 description 3
- 208000007848 Alcoholism Diseases 0.000 description 2
- 244000228451 Stevia rebaudiana Species 0.000 description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 2
- 201000007930 alcohol dependence Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229930182494 ginsenoside Natural products 0.000 description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 229940013618 stevioside Drugs 0.000 description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 2
- 235000019202 steviosides Nutrition 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 240000000950 Hippophae rhamnoides Species 0.000 description 1
- 206010021639 Incontinence Diseases 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 208000010476 Respiratory Paralysis Diseases 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- 230000002075 anti-alcohol Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
本发明是一种用于解酒、醒酒的药物组合物，它是以中草药为原料，经特定加工工艺制成的中药制剂，具有解酒、保健功效，属于中药制剂领域。The invention relates to a medicinal composition for hangover and sobering up, which is a traditional Chinese medicine preparation made from Chinese herbal medicines through specific processing technology, has functions of hangover and health care, and belongs to the field of traditional Chinese medicine preparations.
饮酒是多数人的一种嗜好，但是过量饮酒会对人体带来严重的损伤。酒进入人体后，酒精被吸收入血，随饮酒量的增加血中酒精浓度也相应增加，当血中酒精浓度达到0.5%以上时，可出现高度抑制、昏睡、意识障碍、大小便失禁，如果不进行及时抢救，可因呼吸麻痹而死亡。因此对于饮酒过度的人来说，非常需要有一种解酒，醒酒的保健药物，来缓解和治疗其酒精中毒，保护脏器免受损伤。目前临床上尚没有一种疗效确切的解酒药供医选择使用。Drinking is a hobby of most people, but excessive drinking can cause serious damage to the human body. After alcohol enters the human body, the alcohol is absorbed into the blood, and the alcohol concentration in the blood also increases correspondingly with the increase of the amount of alcohol consumed. When the alcohol concentration in the blood reaches 0.5%, high depression, lethargy, disturbance of consciousness, and incontinence may occur. If timely rescue is not carried out, death may occur due to respiratory paralysis. Therefore, for people who drink excessively, it is very necessary to have a hangover, a health-care medicine for sobering up, to alleviate and treat its alcoholism, and to protect organs from damage. At present, there is not yet a kind of definite anti-alcoholic drug for doctors to choose to use clinically.
本发明目的是提供一种解酒药物组合物。The object of the present invention is to provide a drug composition for anti-alcoholism.
本发明另一个目的是提供一种醒酒冲剂及其制备方法。Another object of the present invention is to provide a hangover granule and a preparation method thereof.
本发明醒酒冲剂的组成及制备工艺是：The composition and preparation process of the hangover granule of the present invention are:
处方组成：沙棘果 40-50%Prescription composition: sea buckthorn fruit 40-50%
鲜桔皮 8-12%Fresh orange peel 8-12%
甘草 3-8%Licorice 3-8%
人参 0.5-2%Ginseng 0.5-2%
甜菊精 1-2%Stevia 1-2%
蔗糖 25-30%Sucrose 25-30%
柠檬酸 8-15%Citric acid 8-15%
以上用量为重量百分比，各组份的优选重量百分比为：Above consumption is percentage by weight, and the preferred percentage by weight of each component is:
沙棘果 46%Sea buckthorn fruit 46%
鲜桔皮 9%Fresh orange peel 9%
甘草 4%Licorice 4%
人参 1%Ginseng 1%
甜菊精 1%Stevia 1%
蔗糖 29%Sucrose 29%
柠檬酸 10%Citric acid 10%
上述处方中的人参可以是人参茎叶皂甙（人参茎叶皂甙的标准应符合辽卫药准字（84）942-66号《关于人参皂甙暂行质量标准的批复》批文的质量要求）。人参也可以是人参的水提取物或醇提取物。沙棘果、鲜桔皮、甘草提取物的提取方法在本发明的药物制剂工艺中有具体描述。The ginseng in the above prescription can be ginseng stem and leaf saponins (the standard of ginseng stem and leaf saponins should meet the quality requirements of Liaowei Yaozhunzi No. (84) 942-66 "Approval on Interim Quality Standards for Ginsenosides"). Ginseng can also be an aqueous or alcoholic extract of Panax ginseng. The extraction methods of seabuckthorn fruit, fresh orange peel and licorice extract are specifically described in the pharmaceutical preparation process of the present invention.
本发明药物的制备方法是：The preparation method of medicine of the present invention is:
取处方量的桔皮、甘草、沙棘果、人参用乙醇3倍量，加热回流1小时，抽滤，滤液备用。残渣加50%乙醇5倍量回流两次，每次1小时，抽滤合并两次乙醇提取液，减压回收乙醇至膏状。80℃减压真空成干浸膏，粉碎，过80目筛，然后加入粉碎并过80目筛的柠檬酸、甜菊精、蔗糖。搅拌均匀后，用桔皮乙醇的提取液湿润，制成软材，过16目筛制粒，低温干燥，16目筛整粒，包装。Take the prescribed amount of orange peel, licorice, sea buckthorn fruit, and 3 times the amount of ethanol used for ginseng, heat and reflux for 1 hour, filter with suction, and use the filtrate for later use. Add 5 times the amount of 50% ethanol to the residue and reflux twice, each time for 1 hour, combine the two ethanol extracts by suction filtration, and recover the ethanol under reduced pressure until it becomes a paste. 80 DEG C reduced pressure and vacuum into a dry extract, crushed, passed through an 80-mesh sieve, and then added citric acid, stevioside, and sucrose that were crushed and passed through an 80-mesh sieve. After stirring evenly, moisten with ethanol extract of orange peel to make soft material, granulate through 16-mesh sieve, dry at low temperature, granulate with 16-mesh sieve, and pack.
本发明的药物组合物经过滚棒法实验观察其抗醉和醒酒效果，其抗醉能力效果显著，醒酒效果也很明显。如饮酒前半小时温开水送服一剂后，再饮酒间加服，则抗醉效果更佳。临床观察实验结果表明服用醒酒灵冲剂能加速乙醇在体内代谢，并且可使饮酒者血中乙醇浓度下降。具有良好的解酒作用。另外，本发明的解酒冲剂还具有保肝、健脑、护胃提神的功效。The anti-drunk and sobering effects of the pharmaceutical composition of the present invention are observed through a rolling rod test, and the anti-drunk ability and the sobering effect are obvious. If you take one dose with warm water half an hour before drinking, and then take it again between drinking, the anti-drunk effect will be better. Clinical observation and experimental results show that taking Xingjiuling Granules can accelerate the metabolism of ethanol in the body, and can reduce the alcohol concentration in the blood of drinkers. Has a good hangover effect. In addition, the hangover granule of the present invention also has the effects of protecting the liver, strengthening the brain, protecting the stomach and refreshing the mind.
实施例1Example 1
取沙棘果460g、甘草40g、鲜桔皮90g，加3倍量95%乙醇，加热回流1小时，抽滤，滤液备用。残渣加50%乙醇5倍量回流两次，每次1小时，抽滤合并两次乙醇提取液，减压回收乙醇至膏状，80℃减压真空成干浸膏，粉碎，过80目筛，然后加入粉碎并过80目筛的柠檬酸100g，甜菊精10g，蔗糖290g和人参茎叶皂甙50g。搅拌均匀后，用桔皮乙醇的提取液湿润，制成软材，过16目筛制粒，低温干燥，16目筛整粒包装。Take 460g of seabuckthorn fruit, 40g of licorice, and 90g of fresh orange peel, add 3 times the amount of 95% ethanol, heat and reflux for 1 hour, filter with suction, and use the filtrate for later use. Add 50% ethanol to the residue and reflux twice, each time for 1 hour, combine the two ethanol extracts by suction filtration, recover the ethanol under reduced pressure until it becomes a paste, turn it into a dry extract under reduced pressure at 80°C, crush it, and pass through an 80-mesh sieve , then add pulverized citric acid 100g and 80 mesh sieves, stevioside 10g, sucrose 290g and ginsenosides 50g. After stirring evenly, it is moistened with ethanol extract of orange peel to make a soft material, granulated through a 16-mesh sieve, dried at low temperature, granulated and packaged through a 16-mesh sieve.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93107383 CN1080864A (en) | 1993-06-28 | 1993-06-28 | A kind of alcohol-decomposing powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93107383 CN1080864A (en) | 1993-06-28 | 1993-06-28 | A kind of alcohol-decomposing powder and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1080864A true CN1080864A (en) | 1994-01-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93107383 Pending CN1080864A (en) | 1993-06-28 | 1993-06-28 | A kind of alcohol-decomposing powder and preparation method thereof |
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| Country | Link |
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| CN (1) | CN1080864A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0868917A1 (en) * | 1997-03-31 | 1998-10-07 | Naohiko Sato | Use of stevia extracts for the manufacture of an antihistaminic composition |
| US6156318A (en) * | 1997-03-31 | 2000-12-05 | Naohiko Sato | Method of counteracting harmful effects of histamine |
| US6399072B1 (en) * | 1996-03-13 | 2002-06-04 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of alcoholism |
| US6509381B2 (en) * | 1996-03-13 | 2003-01-21 | Archer Daniels Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of neurological conditions |
| CN103461871A (en) * | 2013-07-29 | 2013-12-25 | 安徽燕之坊食品有限公司 | Sobering-up foodstuff and preparation method thereof |
| CN108271963A (en) * | 2018-04-23 | 2018-07-13 | 浙江民生健康科技有限公司 | A kind of herbal beverage and preparation method thereof with antialcoholism action |
| CN113797252A (en) * | 2021-10-29 | 2021-12-17 | 上海纳米技术及应用国家工程研究中心有限公司 | Formula for relieving alcoholism and preparation process thereof |
| CN118403103A (en) * | 2024-05-06 | 2024-07-30 | 陕西省中医药研究院 | A Chinese medicine composition for treating non-alcoholic fatty liver disease and its preparation method |
-
1993
- 1993-06-28 CN CN 93107383 patent/CN1080864A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6900240B2 (en) | 1996-03-13 | 2005-05-31 | Archer-Daniels-Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of cancer |
| US6399072B1 (en) * | 1996-03-13 | 2002-06-04 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of alcoholism |
| US6509381B2 (en) * | 1996-03-13 | 2003-01-21 | Archer Daniels Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of neurological conditions |
| US6518319B1 (en) * | 1996-03-13 | 2003-02-11 | Archer Daniels Midland Company | Method of preparing and using compositions extracted from vegetable matter for the treatment of female symptoms |
| US5958419A (en) * | 1997-03-31 | 1999-09-28 | Naohiko Sato | Antihistaminic substance of stevia origin |
| US6156318A (en) * | 1997-03-31 | 2000-12-05 | Naohiko Sato | Method of counteracting harmful effects of histamine |
| EP0868917A1 (en) * | 1997-03-31 | 1998-10-07 | Naohiko Sato | Use of stevia extracts for the manufacture of an antihistaminic composition |
| CN103461871A (en) * | 2013-07-29 | 2013-12-25 | 安徽燕之坊食品有限公司 | Sobering-up foodstuff and preparation method thereof |
| CN108271963A (en) * | 2018-04-23 | 2018-07-13 | 浙江民生健康科技有限公司 | A kind of herbal beverage and preparation method thereof with antialcoholism action |
| CN108271963B (en) * | 2018-04-23 | 2021-06-15 | 浙江民生健康科技有限公司 | A kind of herbal beverage with hangover effect and preparation method thereof |
| CN113797252A (en) * | 2021-10-29 | 2021-12-17 | 上海纳米技术及应用国家工程研究中心有限公司 | Formula for relieving alcoholism and preparation process thereof |
| CN118403103A (en) * | 2024-05-06 | 2024-07-30 | 陕西省中医药研究院 | A Chinese medicine composition for treating non-alcoholic fatty liver disease and its preparation method |
| CN118403103B (en) * | 2024-05-06 | 2025-11-25 | 陕西省中医药研究院 | A traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and its preparation method |
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