CN107712357A - A kind of complex compound of secondary Complexing Iron and preparation method thereof - Google Patents
A kind of complex compound of secondary Complexing Iron and preparation method thereof Download PDFInfo
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- CN107712357A CN107712357A CN201711166052.6A CN201711166052A CN107712357A CN 107712357 A CN107712357 A CN 107712357A CN 201711166052 A CN201711166052 A CN 201711166052A CN 107712357 A CN107712357 A CN 107712357A
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- Prior art keywords
- iron
- complex compound
- maltose
- complex
- secondary complexing
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 217
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 109
- 230000000536 complexating effect Effects 0.000 title claims abstract description 56
- 150000001875 compounds Chemical class 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 150000001413 amino acids Chemical class 0.000 claims abstract description 49
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims abstract description 43
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims abstract description 43
- 238000006243 chemical reaction Methods 0.000 claims abstract description 27
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 239000002699 waste material Substances 0.000 claims abstract description 9
- 229910001448 ferrous ion Inorganic materials 0.000 claims abstract description 7
- 235000019730 animal feed additive Nutrition 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 42
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 19
- 239000000047 product Substances 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 7
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 5
- WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical compound [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 claims description 5
- 230000033228 biological regulation Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 229910001437 manganese ion Inorganic materials 0.000 claims description 5
- 229930182817 methionine Natural products 0.000 claims description 5
- 239000012452 mother liquor Substances 0.000 claims description 5
- 230000001376 precipitating effect Effects 0.000 claims description 5
- 230000035484 reaction time Effects 0.000 claims description 5
- 238000011084 recovery Methods 0.000 claims description 5
- 230000004044 response Effects 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 239000002351 wastewater Substances 0.000 claims description 5
- 239000004277 Ferrous carbonate Substances 0.000 claims description 4
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 claims description 4
- 235000019268 ferrous carbonate Nutrition 0.000 claims description 4
- 229960004652 ferrous carbonate Drugs 0.000 claims description 4
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 claims description 4
- 229910000015 iron(II) carbonate Inorganic materials 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 3
- 229960003067 cystine Drugs 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
- 238000005984 hydrogenation reaction Methods 0.000 claims description 2
- 239000002893 slag Substances 0.000 claims description 2
- 238000000967 suction filtration Methods 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 8
- 235000019629 palatability Nutrition 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- 239000011790 ferrous sulphate Substances 0.000 description 13
- 235000003891 ferrous sulphate Nutrition 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 11
- 241000282887 Suidae Species 0.000 description 7
- 230000006651 lactation Effects 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 5
- 230000037213 diet Effects 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 235000011121 sodium hydroxide Nutrition 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000011573 trace mineral Substances 0.000 description 5
- 235000013619 trace mineral Nutrition 0.000 description 5
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 230000008485 antagonism Effects 0.000 description 4
- 239000013522 chelant Substances 0.000 description 4
- -1 ferrodextranum Chemical compound 0.000 description 4
- 150000004698 iron complex Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000002366 mineral element Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 4
- 229910001948 sodium oxide Inorganic materials 0.000 description 4
- 208000007502 anemia Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- JKQOBWVOAYFWKG-UHFFFAOYSA-N molybdenum trioxide Chemical compound O=[Mo](=O)=O JKQOBWVOAYFWKG-UHFFFAOYSA-N 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 230000035935 pregnancy Effects 0.000 description 3
- YNVZDODIHZTHOZ-UHFFFAOYSA-K 2-hydroxypropanoate;iron(3+) Chemical compound [Fe+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YNVZDODIHZTHOZ-UHFFFAOYSA-K 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000011640 ferrous citrate Substances 0.000 description 2
- 235000019850 ferrous citrate Nutrition 0.000 description 2
- APVZWAOKZPNDNR-UHFFFAOYSA-L iron(ii) citrate Chemical compound [Fe+2].OC(=O)CC(O)(C([O-])=O)CC([O-])=O APVZWAOKZPNDNR-UHFFFAOYSA-L 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- OOPLWEDSEDELIX-TYYBGVCCSA-N (e)-but-2-enedioic acid;iron Chemical compound [Fe].OC(=O)\C=C\C(O)=O OOPLWEDSEDELIX-TYYBGVCCSA-N 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 150000001576 beta-amino acids Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 229940108967 ferrous sulfate 200 mg Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 150000003278 haem Chemical group 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 239000002440 industrial waste Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
Abstract
The present invention relates to a kind of complex compound, the particularly a kind of complex compound of secondary Complexing Iron, preparation method and its purposes in animal feed additive.A kind of complex compound of secondary Complexing Iron, first by maltose Complexing Iron, then ensure that iron reaction is complete, finally again by maltose iron product and iron-amino acid complex product mix with the ferrous ion in amino-acid complex waste liquid and filter residue again.The complex compound of the secondary Complexing Iron of the present invention had both possessed maltose Complexing Iron low cost, growth promoting function clear advantage, but also with the advantages of iron-amino acid complex biological value is high, chemical property is stable, palatability is good, compared with the cost used in Amino acids complex merely, present invention reduces 30 40% use cost.
Description
Technical field
The present invention relates to a kind of complex compound, particularly a kind of complex compound of secondary Complexing Iron, preparation method and its in animal
Purposes in feed addictive.
Background technology
Application of the iron additive on animal productiong：The iron additive used at present in feed experienced three development ranks
Section, first generation product is inorganic iron：Ferrous sulfate, ferrous carbonate, ferric oxide, iron chloride, frerrous chloride etc.；Second generation product
That is organic salt iron：Ferric lactate, ferrodextranum, ferrous citrate, fumaric acid iron etc.；The third generation is protein sources or chelating amino acids
Iron：Ferrous methionine chelate, threonine chelated iron etc..Inorganic iron：Ferrous sulfate is good inorganic source of iron, especially seven water sulphur
Sour ferrous salt is most widely used in current feed industry.Japanese scholars (1993) research shows, in the food stuff for chicken laying of laying period
Middle mix 100mg FeSO4 powder feeds, the hypoferric anemia of hen can be prevented, and then improve laying rate more than 25%.Due to
Ferrous sulfate dissolubility is good and can be used as effective heme moiety, so be often used in mending iron to piglet, it is typically, young for prevention
Blows or bacterial infection toxin, it is ensured that normal growth, 2-3 ages in days should just mend iron.The mode of supplement chalybeate has directly to piglet
Mend iron and mend two kinds of iron indirectly by parent, such as sow is fed with ferrous sulfate 200mg iron, containing for iron in pig manure can be improved
Amount, makes piglet eat sow excrement 50-80g daily, can obtain the iron of prevention anaemia enough.
Organic Iron：The organic salt such as ferrodextranum, ferrous citrate, ferric lactate dissolubility is good, it is easy absorb, biological value compared with
High, stability is also compared with inorganic salts height.Organic salt iron is main in Production of Livestock and Poultry to be played nutrition and is immunized.(1) in terms of nutrition：
Organic Iron, organic cobalt and vitamin optimum organization, it is rapid to mend iron positive effect.The reproductive performance of sow can be improved, is improved young
Pig survival rate, birth weight.Can improve egg fowl lay eggs quality, reduce shell-breaking rate, deepen yolk color, reduce stress.(2) it is immunized
Aspect：Piglet anaemia is effectively prevented, suppresses cub diarrhoea, piglet white scour.
Amino acid chelated iron：Amino acid chelated iron is a kind of ligand (amino acid) same metal ion species (trace element)
A kind of complex compound of the cyclic structure formed.Common chelate ring has five-membered ring and hexatomic ring, and wherein a-amino acid chelated iron is
Five-membered ring, beta-amino acids chelated iron are hexatomic ring.Trace element after chelating amino acids, is generated the moderate chelating of stability constant
Thing, these chelates utilize Amino Acid Absorption passage in small intestine, avoid with being operated by mineral element Ions Absorption passage
Other mineral elements competition and antagonism.The biochemical property of other chelate is more stable, effectively resists other in daily ration and supports
Divide and adverse effect occurs therewith.Chelate solubility property in body is good, it is easy absorb, utilization rate it is high.In addition, amino acid chelated iron
Also there is certain sterilization and immunologic function.It is believed that chelated microelements are in particular organization, target organ or functional site
Play specific function.
At present, iron is added in internal feed still based on inorganic iron (ferrous sulfate).Its cost is low, and processing technology is simple,
Wide material sources, and growth to livestock and poultry, breeding, production, immune etc. have preferable facilitation.But the iron ion in inorganic iron
Easily with other mineral ion antagonisms, compete, cause utilization rate to decline, food consumption increase, can not increasingly meet modern production
Demand.Organic acid iron is better than inorganic iron stability, and biological value is high, and growth promoting function is obvious, but still can not solve mineral element
Antagonism and race problem between ion.The appearance of amino acid chelated iron, effectively alleviate this interionic interaction.
At present, biological value highest is amino acid chelated iron, and it has following particular advantages：1. in terms of nutrition：1st, it is raw
Thing potency highest, stability are good；2nd, the antagonism between mineral element is effectively alleviated；3rd, it is not only that body provides trace element, and
And also provide essential amino acid；4th, palatability is good, avoids unnecessary waste.2. process aspect：In amino acid chelated iron
Origin of amino acid is in the enzymolysis of protein sources.For example some puffed soybeans of current many protein sources, keratoprotein, industrial waste, industry
Waste residue, liquid, quantity is big, is but difficult by, and causes the very big wasting of resources.High-quality cheap ammonia caused by these protein sources enzymolysis
Base acid is used for producing amino acid chelated iron, kills two birds with one stone.
However, amino-acid complex (chelating) trace element with synthesis such as the higher lysine of price, methionine, glycine
Although biological value is higher, its use cost is also of a relatively high, especially under current feed market environment with keen competition, drop
The demand of low use cost increasingly highlights.
Therefore, inventor the iron then not reacted completely with amino-acid complex again, is both reduced into maltose Complexing Iron
This, moreover it is possible to keep certain biological value.
The information for being disclosed in the background section is merely intended to understanding of the increase to the general background of the present invention, without answering
It has been the prior art well known to persons skilled in the art when being considered as recognizing or implying the information structure in any form.
The content of the invention
For deficiencies of the prior art, the present invention, which provides one kind, both to have been possessed maltose Complexing Iron low cost, had promoted
Growth clear advantage, but also with the advantages of iron-amino acid complex biological value is high, chemical property is stable, palatability is good
Complex compound of secondary Complexing Iron and preparation method thereof.
To achieve the above object, technical scheme provided by the invention is as follows：
A kind of complex compound of secondary Complexing Iron, it is made up of maltose, soluble ferrous salt and amino acid.
Present invention also offers the preparation method of the complex compound of described secondary Complexing Iron, comprise the following steps：
(1) toward in reactor plus 25-32 parts by weight maltose, after adding the water of 50-55 parts by weight to dissolve maltose, hydrogenation
Aqueous solution of sodium oxide alkalizes, and adjusts the pH 11-12 of solution, heating response kettle, keeps temperature in the kettle between 70-80 DEG C, then add
Enter the soluble ferrous salt of 30-35 parts by weight and carry out complex reaction 1-2h, course of reaction is stirred continuously, and generation maltose iron is molten
Liquid, it is separated by filtration, obtains filter residue and filtrate, 75% ethanol solution will be added in filtrate and is precipitated, centrifuges and take out after precipitating completely
Filter, vacuum drying drying, screening, detection, that is, obtain maltose iron product；
(2) step (1) is centrifuged into filtered waste water evaporation recovery ethanol, and remaining waste liquid is obtained with being separated by filtration
Filter residue mixing, obtain mixture, detect mixture ferrous ions concentration, then add amino acid and carry out complex reaction, use
The pH of sodium hydrate aqueous solution regulation system is 6-7, and at 70-80 DEG C, the reaction time is controlled in 60-70min for reaction temperature control,
After reaction terminates, concentration, dry, then crushed with pulverizer, then sieved, detected, that is, obtain amino-acid complex Asia
Iron；
(3) by maltose iron product and amino-acid complex ferrous iron product mix, that is, the complex compound of secondary Complexing Iron is obtained.
Preferably, the soluble ferrous salt described in step (1) is ferrous sulfate heptahydrate, iron chloride, ferrous carbonate
Any of.
Preferably, the weight ratio of filtrate and 75% ethanol solution is 1: 2 in step (1).
Preferably, the filtrate described in step (1) can return to the mother liquor as dissolving maltose.
Preferably, the amino acid described in step (2) is any of methionine, cystine, glycine.
Preferably, the mol ratio of the amino acid and manganese ion described in step (2) is 2:1.
Present invention also offers purposes of the complex compound of described secondary Complexing Iron in animal feed additive.
The application method of complex compound of the secondary Complexing Iron of the present invention is：After being well mixed with feed, for pig, chicken, duck,
Ox and the feeding of sheep, addition are 200g/ ton feeds.
Compared with prior art, the present invention has the advantages that：
(1) complex compound of secondary Complexing Iron of the invention, first by maltose Complexing Iron, then uses amino-acid complex again
Ferrous ion in waste liquid and filter residue, ensure that iron reaction is complete, finally again produce maltose iron product and amino-acid complex ferrous iron
Product mix.The mixture had both possessed maltose Complexing Iron low cost, growth promoting function clear advantage.
(2) complex compound of secondary Complexing Iron of the invention possesses iron-amino acid complex biological value height, chemical property is stablized,
The advantages of palatability is good, compared with the cost used in amino-acid complex (chelating) trace element merely, present invention reduces
30-40% use cost.
Embodiment
With reference to specific embodiment, the embodiment of the present invention is described in detail, it is to be understood that this hair
Bright protection domain is not limited by embodiment.
Embodiment 1：
A kind of complex compound of secondary Complexing Iron, it is made up of maltose, soluble ferrous salt and amino acid.
The preparation method of the complex compound of described secondary Complexing Iron, comprises the following steps：
(1) toward in reactor plus 25 parts by weight maltose, after adding the water of 50 parts by weight to dissolve maltose, be hydrogenated with sodium oxide molybdena
It is water-soluble basified, the pH 11 of solution is adjusted, heating response kettle, keeping temperature in the kettle, adding 30 parts by weight can between 70 DEG C
The ferrous salt of dissolubility carries out complex reaction 1h, and course of reaction is stirred continuously, and generates maltose ferrous solution, is separated by filtration, is filtered
Slag and filtrate, 75% ethanol solution will be added in filtrate and is precipitated, centrifugation suction filtration after precipitating completely, vacuum drying drying, sieve
Divide, detection, that is, obtain maltose iron product；Described soluble ferrous salt is ferrous sulfate heptahydrate；Filtrate and 75% ethanol
The weight ratio of solution is 1: 2；Described filtrate can return to the mother liquor as dissolving maltose；
(2) step (1) is centrifuged into filtered waste water evaporation recovery ethanol, and remaining waste liquid is obtained with being separated by filtration
Filter residue mixing, obtain mixture, detect mixture ferrous ions concentration, then add amino acid and carry out complex reaction, use
The pH of sodium hydrate aqueous solution regulation system is 6, and reaction temperature is controlled at 70 DEG C, and reaction time control terminates in 60min, reaction
Afterwards, concentrate, dry, then crushed with pulverizer, then sieved, detected, that is, obtain amino-acid complex ferrous iron；Described
Amino acid is methionine；Described amino acid and the mol ratio of manganese ion are 2:1；
(3) by maltose iron product and amino-acid complex ferrous iron product mix, that is, the complex compound of secondary Complexing Iron is obtained.
Embodiment 2：
A kind of complex compound of secondary Complexing Iron, it is made up of maltose, soluble ferrous salt and amino acid.
The preparation method of the complex compound of described secondary Complexing Iron, comprises the following steps：
(1) toward in reactor plus 32 parts by weight maltose, after adding the water of 55 parts by weight to dissolve maltose, be hydrogenated with sodium oxide molybdena
It is water-soluble basified, the pH 12 of solution is adjusted, heating response kettle, keeps temperature in the kettle to add 30-35 weight between 80 DEG C
The soluble ferrous salt of part carries out complex reaction 2h, and course of reaction is stirred continuously, and generates maltose ferrous solution, is separated by filtration, obtains
To filter residue and filtrate, 75% ethanol solution will be added in filtrate and is precipitated, centrifuged and filter after precipitating completely, vacuum drying is dried
It is dry, screening, detection, that is, obtain maltose iron product；Described soluble ferrous salt is iron chloride；Filtrate and 75% ethanol are molten
The weight ratio of liquid is 1: 2；Described filtrate can return to the mother liquor as dissolving maltose；
(2) step (1) is centrifuged into filtered waste water evaporation recovery ethanol, and remaining waste liquid is obtained with being separated by filtration
Filter residue mixing, obtain mixture, detect mixture ferrous ions concentration, then add amino acid and carry out complex reaction, use
The pH of sodium hydrate aqueous solution regulation system is 7, and reaction temperature is controlled at 80 DEG C, and reaction time control terminates in 70min, reaction
Afterwards, concentrate, dry, then crushed with pulverizer, then sieved, detected, that is, obtain amino-acid complex ferrous iron；Described
Amino acid is cystine；Described amino acid and the mol ratio of manganese ion are 2:1；
(3) by maltose iron product and amino-acid complex ferrous iron product mix, that is, the complex compound of secondary Complexing Iron is obtained.
Embodiment 3：
A kind of complex compound of secondary Complexing Iron, it is made up of maltose, soluble ferrous salt and amino acid.
The preparation method of the complex compound of described secondary Complexing Iron, comprises the following steps：
(1) toward in reactor plus 30 parts by weight maltose, after adding the water of 52 parts by weight to dissolve maltose, be hydrogenated with sodium oxide molybdena
It is water-soluble basified, the pH 11.5 of solution is adjusted, heating response kettle, keeps temperature in the kettle to add 33 parts by weight between 75 DEG C
Soluble ferrous salt carries out complex reaction 1.5h, and course of reaction is stirred continuously, and generates maltose ferrous solution, is separated by filtration, obtains
To filter residue and filtrate, 75% ethanol solution will be added in filtrate and is precipitated, centrifuged and filter after precipitating completely, vacuum drying is dried
It is dry, screening, detection, that is, obtain maltose iron product；Described soluble ferrous salt is ferrous carbonate；Filtrate and 75% ethanol
The weight ratio of solution is 1: 2；Described filtrate can return to the mother liquor as dissolving maltose；
(2) step (1) is centrifuged into filtered waste water evaporation recovery ethanol, and remaining waste liquid is obtained with being separated by filtration
Filter residue mixing, obtain mixture, detect mixture ferrous ions concentration, then add amino acid and carry out complex reaction, use
The pH of sodium hydrate aqueous solution regulation system is 6.5, and reaction temperature control is at 75 DEG C, and reaction time control is in 65min, reaction knot
Shu Hou, concentration, dry, then crushed with pulverizer, then sieved, detected, that is, obtain amino-acid complex ferrous iron；It is described
Amino acid be glycine；Described amino acid and the mol ratio of manganese ion are 2:1；
(3) by maltose iron product and amino-acid complex ferrous iron product mix, that is, the complex compound of secondary Complexing Iron is obtained.
Embodiment 4：The application effect of the complex compound of the secondary Complexing Iron of the present invention
4.1 experiments are divided to two groups：The complex compound for the secondary Complexing Iron that test group uses is method system in 1-3 of the embodiment of the present invention
For what is gone out；The inorganic ferrous sulfate that control group uses is that commercial sulfuric acid is ferrous.
4.2 experimental animal：Sow and piglet.
4.3 experimental designs (are shown in Table 1).
The iron added in the feed of table 1 in the complex compound and ferrous sulfate of secondary Complexing Iron
| Project | Secondary complexing iron complex | Ferrous sulfate |
| Sow | 50mg/kg | 50mg/kg |
| Piglet | 100mg/kg | 100mg/kg |
4.4 feeding management：Nursery house uses slatted floor child care equipment, and at 22-25 DEG C, relative humidity controls house temperature control system
In 65-75%.Experiment the last week is cleaned, washed away and sterilized to pig house and various feeding utensils, is sprayed ground with caustic soda, is enclosed
The facilities such as column, trough, colony house ventilation, cleaning are kept during experiment, is dried.
4.5 testing index：The daily gain in each cycle, feed efficiency, feedstuff-meat ratio, feed intake etc..
4.6 result of the test
(1) add respectively in the diet of the latter half of gestation of sow and whole lactation period (before farrowing 7 days to lactation the 26th day)
Add the complex compound and ferrous sulfate of secondary Complexing Iron, test obtained result such as table 2.
Added in the diet of the latter half of gestation of the sow of table 2 and whole lactation period (before farrowing 7 days to lactation the 26th day) secondary
Complexing
The complex compound and ferrous sulfate of iron
(2) 50 sows are divided into two groups, add secondary complexing iron complex and ferrous sulfate, iron respectively in diet and add
Dosage is 50mg/kg.30 days are observed after the sow gestation phase to the 20th day lactation period piglet death rate and nest number pigs weaned, knot
Fruit such as table 3.
Secondary complexing iron complex and the ferrous sulfate piglet death rate and nest number pigs weaned are added in the diet of table 3 respectively
| Project | Nest number pigs weaned/head | The death rate/% |
| Experimental group | 9.6 | 1.32 |
| Control group | 9.1 | 2.41 |
As shown in Table 3, test group and the nest number pigs weaned difference of control group are little, but add secondary Complexing Iron complexing
The piglet death rate of the experimental group of thing substantially reduces, and lower than control group 45.22%.
(3) 50 weanling pigs similar in body weight are randomly assigned into two groups, one group of complex compound (iron for adding secondary Complexing Iron
Addition 100mg/kg), one group adds ferrous sulfate (iron addition is 100mg/kg).
Table 4 adds the production performance of the weanling pig of secondary complexing iron complex group
| Project | Experimental group | Control group |
| Number pigs weaned/head | 25 | 25 |
| Starting weight/kg | 17.67±3.22 | 17.71±3.41 |
| End weight/kg | 55.18±4.52 | 55.32±5.21 |
| Weightening/kg | 37.45±1.21 | 37.76±1.52 |
| Daily gain/g | 601±36.51 | 596±25.68 |
| Total augment weight/kg | 654.6 | 646.7 |
| Total feed consumption weight/kg | 1720.23 | 1782.59 |
| Feed-weight ratio | 2.57 | 2.71 |
As shown in Table 4, the daily gain of experimental group is slightly above control group, but then difference is somewhat big for feed-weight ratio.
(4) 50 weanling pigs and sow similar in body weight are randomly assigned into two groups respectively, one group adds secondary Complexing Iron
Complex compound (iron addition 100mg/kg), one group adds ferrous sulfate (iron addition is 100mg/kg), detects the blood red of pig
Protein concentration, red blood cell number and ferro concentration in serum.
Influence of the 5 two complexing iron complexs of table to sow hemoglobin concentration, red blood cell number, ferro concentration in serum
As can be seen from Table 5, the hemoglobin of experimental group, red blood cell number are higher all than control group, and two groups are present significantly
Difference；When 21 age in days, experimental group Iron in Serum content is higher than control group, it is seen then that secondary Complexing Iron of the invention
Complex compound is more conducive to the growth performance that sow improves sow.
Influence of the 6 two complexing iron complexs of table to piglet hemoglobin concentration, red blood cell number, ferro concentration in serum
As shown in Table 6,7 age in days piglets of experimental group and hemoglobin, red blood cell number and the serum levels of iron of 21 age in days piglets contain
Amount is above control group.
In summary, the complex compound of the secondary Complexing Iron of the present invention is added in the diet of in-pig to be effectively reduced
Birth piglet and the death rate of weanling pig, piglet weightening is improved, reduces the death rate, increase weanling pig head number, reduce and adopt
Appetite, the effect for shortening lactation period；The complex compound of secondary Complexing Iron is added in weanling pig, then can reduce the material meat of piglet
Than improving the growth performance of piglet.
The description of the foregoing specific illustrative embodiment to the present invention is to illustrate and the purpose of illustration.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can be much changed
And change.The purpose of selecting and describing the exemplary embodiment is that explain that the certain principles of the present invention and its reality should
With so that those skilled in the art can realize and utilize the present invention a variety of exemplaries and
Various chooses and changes.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (8)
1. a kind of complex compound of secondary Complexing Iron, it is characterised in that it is by maltose, soluble ferrous salt and amino acid system
Into.
2. the preparation method of the complex compound of secondary Complexing Iron according to claim 1, it is characterised in that including following step
Suddenly：
(1) toward in reactor plus 25-32 parts by weight maltose, after adding the water of 50-55 parts by weight to dissolve maltose, hydrogenation oxidation
Sodium water solution alkalizes, and adjusts the pH 11-12 of solution, heating response kettle, keeps temperature in the kettle to be added between 70-80 DEG C
The soluble ferrous salt of 30-35 parts by weight carries out complex reaction 1-2h, and course of reaction is stirred continuously, and generates maltose ferrous solution,
It is separated by filtration, obtains filter residue and filtrate, 75% ethanol solution will be added in filtrate and is precipitated, centrifugation suction filtration after precipitating completely,
Vacuum drying drying, screening, detection, that is, obtain maltose iron product；
(2) step (1) is centrifuged into filtered waste water evaporation recovery ethanol, and by remaining waste liquid and is separated by filtration obtained filter
Slag mixes, and obtains mixture, detects mixture ferrous ions concentration, then adds amino acid and carries out complex reaction, uses hydrogen-oxygen
The pH for changing sodium water solution regulation system is 6-7, and reaction temperature control is at 70-80 DEG C, and reaction time control is in 60-70min, reaction
After end, concentration, dry, then crushed with pulverizer, then sieved, detected, that is, obtain amino-acid complex ferrous iron；
(3) by maltose iron product and amino-acid complex ferrous iron product mix, that is, the complex compound of secondary Complexing Iron is obtained.
3. the preparation method of the complex compound of secondary Complexing Iron according to claim 2, it is characterised in that institute in step (1)
The soluble ferrous salt stated is any of ferrous sulfate heptahydrate, iron chloride, ferrous carbonate.
4. the preparation method of the complex compound of secondary Complexing Iron according to claim 2, it is characterised in that filtered in step (1)
The weight of liquid and 75% ethanol solution ratio is 1: 2.
5. the preparation method of the complex compound of secondary Complexing Iron according to claim 2, it is characterised in that institute in step (1)
The filtrate stated can return to the mother liquor as dissolving maltose.
6. the preparation method of the complex compound of secondary Complexing Iron according to claim 2, it is characterised in that institute in step (2)
The amino acid stated is any of methionine, cystine, glycine.
7. the preparation method of the complex compound of secondary Complexing Iron according to claim 2, it is characterised in that institute in step (2)
The amino acid and the mol ratio of manganese ion stated are 2:1.
8. according to purposes of the complex compound of any described secondary Complexing Iron of claim 1 in animal feed additive.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114287519A (en) * | 2021-11-23 | 2022-04-08 | 江西正邦农业科学院 | Preparation method and application of oligosaccharide chelate |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821192A (en) * | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| CN101215338A (en) * | 2007-01-05 | 2008-07-09 | 庄茅 | Iron isomaltum oligosaccharide and preparing method thereof |
| CN106243162A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose complex |
| CN107319164A (en) * | 2017-08-22 | 2017-11-07 | 南宁市泽威尔饲料有限责任公司 | A kind of complex compound of secondary Complexing Iron and its production and use |
-
2017
- 2017-11-21 CN CN201711166052.6A patent/CN107712357A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821192A (en) * | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| CN101215338A (en) * | 2007-01-05 | 2008-07-09 | 庄茅 | Iron isomaltum oligosaccharide and preparing method thereof |
| CN106243162A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose complex |
| CN107319164A (en) * | 2017-08-22 | 2017-11-07 | 南宁市泽威尔饲料有限责任公司 | A kind of complex compound of secondary Complexing Iron and its production and use |
Non-Patent Citations (1)
| Title |
|---|
| 谢步云等: "糖基配合物的结构与配位模式", 《赣南师范学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114287519A (en) * | 2021-11-23 | 2022-04-08 | 江西正邦农业科学院 | Preparation method and application of oligosaccharide chelate |
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