CN107684070A - A kind of sobering-up composition and preparation method thereof and alcohol-decomposing beverage - Google Patents

Abstract

The present invention relates to health product technology field, more particularly to a kind of sobering-up composition and preparation method thereof and alcohol-decomposing beverage.The sobering-up composition is made up of the root of kudzu vine, lophatherum gracile, chrysanthemum, honey.In inventive formulation four taste raw materials be well-chosen and the scientific and effective integration of drinking and medicinal herbs composition that goes out, sobering-up composition of the present invention is made by reasonably combined, said composition and the beverage made prove through effect experiment, confirmation can reduce drunk rate, extend Sleep latency, shorten the drunk length of one's sleep, promote alcohol levels in blood samples metabolism, with significant sober-up function, positive effect is better than single dose.

Description

A kind of hangover composition and its preparation method and hangover drink

technical field

The invention relates to the technical field of health care products, in particular to a hangover-relief composition, a preparation method thereof and a hangover-relief drink.

Background technique

Alcohol is an important part of Chinese culture, and it is inevitable for people to drink alcohol in their daily life and in the process of interacting with people. Drinking alcohol can cause serious damage to the liver and stomach. Long-term heavy drinking can easily lead to fat accumulation in the liver, causing fatty liver, and may also cause gastric ulcer or gastric bleeding, which can be life-threatening. Long-term heavy drinking can also cause damage to the nervous system and atrophy of the cerebral cortex. Drunkenness is also extremely harmful to the human body. Alcohol can inhibit the respiratory center of the medulla oblongata, causing respiratory arrest. In addition, a drop in blood sugar may also be a fatal factor; heavy drinking can also cause various vitamin deficiencies, which indirectly lead to various nervous system injuries. . Therefore, hangover medicine more and more causes people's attention.

Anti-alcoholic drugs are divided into three types: chemical drugs, traditional Chinese medicine preparations and health products. Chemicals, while relieving hangovers, will cause metabolic burdens on the liver and kidneys and cause varying degrees of damage. Therefore, chemical drugs for hangovers are gradually fading out of the sight of consumers. Traditional Chinese medicine preparations and health products with anti-alcoholic effects are more favored by consumers because of their safety. There are chrysanthemum, sophora flavescens, grass fruit, white lentils, Hovenia dulcis, nutmeg, galangal, etc., which have the effect of relieving hangover, and the compound Chinese medicine preparation with better effect of relieving hangover has become a research hotspot.

For example, the patent with the publication number CN101496854A discloses a Chinese medicine anti-alcohol composition, which is composed of pueraria root, licorice, red dates, wolfberry, chrysanthemum, and tangerine peel. Another example is that the patent of publication number CN1582990 discloses a kind of Chinese medicine anti-alcoholic drink, which consists of 10-30g of kudzu root, 10-30g of kudzu flower, 10-30g of Hovenia dulcis fruit, 10-15g of Acanthopanax, 10-20g of Eucommia, wolfberry Made from 10-30g cinnamon bark, 10-20g cinnamon bark, 10-30g Hovenia dulcis bark, 10-20g lacquer bark, 10-20g linden bark, 10-20g white birch bark, and 100mg Vc, it has anti-alcohol and anti-alcohol effects , and can effectively protect the liver, nourish the kidney and nourish the stomach. Another example is that the patent with the publication number CN103055190A discloses a Chinese medicine preparation for protecting the liver and relieving alcoholism, which consists of 20-30 parts of corn silk, 20-30 parts of Chinese yam, 10-20 parts of Schisandra chinensis, 10-20 parts of cassia twig, 5 parts of Bupleuri. -10 parts, 10-20 parts of hawthorn, 5-10 parts of Prunella vulgaris, 5-10 parts of ground beetle, 3-8 parts of rhubarb, and 3-8 parts of licorice. It has the advantages of quick effect, safety and no side effects of hangover.

However, there is still a demand for compound Chinese medicinal preparations or health products thereof that are simpler in composition and have a significant anti-alcoholic effect.

Contents of the invention

In view of this, the present invention provides a hangover composition, a preparation method thereof and a hangover drink. The anti-alcoholic composition and the prepared beverage have been proved by drug efficacy experiments to reduce the rate of drunkenness, prolong the sleep latency period, shorten the time of drunken sleep, promote blood alcohol metabolism, and have significant anti-alcoholic effect.

In order to achieve the above-mentioned purpose of the invention, the present invention provides the following technical solutions:

The invention provides an anti-alcohol composition, which is made of kudzu root, light bamboo leaves, chrysanthemum and honey.

The formula of the present invention is composed of kudzu root, light bamboo leaves, chrysanthemum, and honey, and these four components all belong to the same source of traditional medicine and food, so it is safe to eat.

Radix Puerariae, flat in nature, sweet and pungent in taste, has the effects of relieving muscle and reducing fever, promoting body fluid and quenching thirst, clearing rash, promoting yang and stopping diarrhea, dredging meridian and activating collaterals, and relieving alcohol poisoning. Pueraria lobata contains 12% flavonoids, which can promote metabolism, strengthen liver detoxification function, and prevent liver damage caused by alcohol. Modern medical research shows that kudzu root has good functions of anti-oxidation, lowering blood sugar, lowering blood fat, lowering blood pressure, antipyretic, hangover and enhancing immunity.

Bamboo leaves, sweet, light, cold in nature; Guixin, lung, stomach, bladder meridian; body light and oozing, has the effect of clearing away heat and restlessness, inducing diuresis and treating stranguria. Folks mostly use its stems and leaves to make herbal tea for cooling off in summer. It can effectively reduce the dryness and boredom after drinking.

Chrysanthemum, a perennial herb of Compositae, is one of the traditional Chinese medicinal materials commonly used in my country. According to ancient records, chrysanthemum is sweet and bitter in taste and slightly cold in nature. It has a certain curative effect on diseases such as dry mouth, excessive fire, astringent eyes, or limb pain and numbness caused by wind, cold, and dampness. It is mainly used to treat colds, wind-heat, headaches, sores, etc. It can prevent and treat dizziness, headaches, and tinnitus. If it is consumed for a long time, it also has the effect of "reinforcing blood, lightening body, and prolonging life".

Honey, sweet in taste and flat in nature, has been used as a food with the same source of medicine and food since ancient times. It has the functions of protecting the liver, gastrointestinal tract, cardiovascular system, antibacterial and anti-inflammatory, moisturizing the lungs and eliminating phlegm, protecting wounds, and anti-tumor. It has been reported in the literature that honey can promote the catabolism of alcohol and relieve the headache symptoms caused by drinking alcohol. degree of mucosal damage. Studies have also found that honey can protect the liver by reducing the degree of mitochondrial membrane lipid peroxidation.

To sum up, the four ingredients in the formula of the present invention are carefully selected scientifically effective homologous compositions of medicine and food. After reasonable matching and processing by modern food technology, the hangover-relief composition of the present invention is made. The anti-alcoholic composition and the drink made by it have been proved by drug efficacy experiments that it can reduce the rate of drunkenness, prolong the sleep latency period, shorten the time of drunken sleep, and promote the metabolism of alcohol in the blood. .

As preferably, in parts by weight, each raw material consumption is:

Preferably, in parts by weight, the amount of each raw material is:

Preferably, in parts by weight, the amount of each raw material is:

Preferably, in parts by weight, the amount of each raw material is:

Preferably, in parts by weight, the amount of each raw material is:

The invention also provides a preparation method of the hangover-relief composition, which comprises: mixing kudzu root, light bamboo leaves and chrysanthemum, adding water to decoct to obtain an extract; mixing honey with the extract to obtain a hangover-relief composition.

As preferably, the consumption of water is 5～15 times of the total weight of kudzu root, light bamboo leaf and chrysanthemum.

In the embodiment provided by the present invention, the consumption of water is 10 times of the total weight of kudzu root, light bamboo leaf and chrysanthemum.

Preferably, the number of decoctions is 2-4 times, and the time for each decoction is 0.5-1.5 h.

In the embodiment provided by the present invention, the number of times of decocting is 2 times, and the time of decocting each time is 1 h.

The present invention also provides a hangover drink, which comprises the hangover composition provided by the present invention and food acceptable auxiliary materials.

Preferably, the food acceptable auxiliary material is one or more of white granulated sugar, potassium sorbate, lactose, sucrose, mannitol, sorbitol, steviol glycoside, gelatin, tragacanth, xanthan gum, carrageenan or konjac gum Several kinds. However, the types of food-acceptable auxiliary materials in the present invention are not limited thereto, and the types of auxiliary materials recognized by those skilled in the art are all within the protection scope of the present invention.

Preferably, in parts by weight, the hangover drink is made from the following raw materials:

The present invention also provides a preparation method of the hangover drink, comprising:

Mix kudzu root, light bamboo leaves, and chrysanthemum, add water to decoct, and obtain an extract;

Mix honey, white granulated sugar, potassium sorbate, extract and water, filter, homogenize and sterilize to obtain hangover drink.

The invention provides an anti-alcohol composition. The anti-alcohol composition is made of kudzu root, light bamboo leaves, chrysanthemum and honey. The present invention has at least one of the following beneficial effects:

1. The formula of the present invention is composed of kudzu root, light bamboo leaves, chrysanthemum, and honey. These four components all belong to the same source of traditional medicine and food, so it is safe to eat;

2. The four raw materials in the formula of the present invention are carefully selected, reasonably matched, and scientifically effective homologous compositions of medicine and food. The composition and the beverage made by it have been proved by drug efficacy experiments that it can reduce the rate of drunkenness and prolong the latency period of sleep , shorten the sleep time of drunkenness, promote the metabolism of alcohol in the blood, and have a significant anti-alcoholic effect, and the effect is obviously better than that of a single dose.

detailed description

The invention discloses a hangover-relief composition, a preparation method thereof and a hangover-relief beverage. Those skilled in the art can learn from the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and the relevant personnel can obviously make changes or appropriate changes and combinations to the method and application described herein without departing from the content, spirit and scope of the present invention to realize and Apply the technology of the present invention.

The hangover-relief composition provided by the present invention, its preparation method and the raw materials or auxiliary materials used in the hangover-relief beverage can all be purchased from the market.

Below in conjunction with embodiment, further set forth the present invention:

The preparation of embodiment 1 Chinese medicine composition

The anti-alcoholic Chinese medicine composition of this embodiment is prepared from the following raw materials in parts by weight:

120 parts of kudzu root, 60 parts of light bamboo leaves, 60 parts of chrysanthemum, 5 parts of honey.

The preparation method is as follows:

(1) Extraction: Take 120 parts of Pueraria lobata root, 60 parts of Danzhu leaves, and 60 parts of chrysanthemum respectively, add pure water 10 times the total weight of raw materials, boil and extract twice, each time for 1 hour, filter through 100 mesh, and combine the two extractions liquid.

(2) Preparation: add 5 parts of honey to the extract, stir and mix evenly, and fine filter with 200 meshes to obtain the traditional Chinese medicine composition.

The preparation of embodiment 2 Chinese medicine composition

The anti-alcoholic Chinese medicine composition of this embodiment is prepared from the following raw materials in parts by weight:

100 parts of kudzu root, 100 parts of light bamboo leaves, 50 parts of chrysanthemum, and 10 parts of honey.

The preparation method is as follows:

(1) Extraction: Take 100 parts of Pueraria lobata root, 100 parts of Danzhu leaves, and 50 parts of chrysanthemum respectively, add pure water 10 times the total weight of raw materials, boil and extract twice, each time for 1 hour, filter through 100 mesh, and combine the two extractions liquid.

(2) Preparation: add 10 parts of honey to the extract, stir and mix evenly, and filter through 200 meshes to obtain the traditional Chinese medicine composition.

The preparation of embodiment 3 Chinese medicine composition

The anti-alcoholic Chinese medicine composition of this embodiment is prepared from the following raw materials in parts by weight:

200 parts of kudzu root, 50 parts of light bamboo leaves, 100 parts of chrysanthemum, 1 part of honey.

The preparation method is as follows:

(1) Extraction: Take 200 parts of Pueraria lobata root, 50 parts of Danzhu leaves, and 100 parts of chrysanthemum respectively, add pure water 10 times the total weight of raw materials, boil and extract twice, each time for 1 hour, filter through 100 mesh, and combine the two extractions liquid.

(2) Preparation: add 1 portion of honey to the extract, stir and mix evenly, and filter through 200 meshes to obtain the traditional Chinese medicine composition.

Example 4 Preparation of hangover drink

The anti-alcoholic drink of this embodiment is prepared from the following raw materials in parts by weight:

120 parts of kudzu root, 60 parts of light bamboo leaves, 60 parts of chrysanthemum, and 8 parts of honey.

The preparation method is as follows:

(1) Extraction: Take 120 parts of Pueraria lobata root, 60 parts of Danzhu leaves, and 600 parts of chrysanthemum respectively, add pure water 10 times the total amount of raw materials, boil and extract twice, each time for 1 hour, filter through 100 mesh, and combine the two extractions liquid.

(2) Preparation: After adding equal volumes of pure water to the extract, add 8 parts of honey, 5% white granulated sugar, and 0.05% potassium sorbate respectively, stir and mix, and filter through 200 meshes to obtain a preparation.

(3) Homogenization: The prepared liquid is poured into a homogenizer for homogenization, and the crushing particle size is 0.1-0.5 micron in a high-pressure homogenizer, and the pressure of the homogenizer is 60-120Mpa.

(4) One-time sterilization: the homogenized liquid is sterilized instantaneously by ultra-high temperature, 140° C., for 5 seconds.

(5) Filling: filling and capping by vacuum filling machine.

(6) Secondary sterilization: use a sterilizer to sterilize at 80°C for 20 minutes.

Example 5 Anti-alcoholic efficacy test

In order to further demonstrate the performance of the hangover Chinese medicine composition and hangover drink provided by the present invention, take the hangover Chinese medicine composition and hangover drink in Examples 1 to 4 as examples, test it, test method, test data and related analysis As follows.

1. Experimental materials

1.1 Animals

ICR mice, clean grade, 18-22g, male, were purchased from the Comparative Medicine Center of Yangzhou University, certificate number: SCXK (Su) 2012-0004.

1.2 Drugs and reagents

RU-21, Spirit Science USA, Inc., lot number: 25752;

The hangover drink prepared in Examples 1-4, concentration 0.067g/mL;

Ethanol solution, prepared to 50% (v/v) concentration, for later use.

2. Experimental method

2.1 Grouping and dose setting

Normal group: intragastric administration of normal saline;

Model group: first give normal saline orally;

Positive drug group: RU-21 was administered orally, and the dose of mice was 0.33g/kg;

Example 1 group: given the traditional Chinese medicine composition of Example 1 orally, and the dosage of mice was 0.33g/kg;

Example 2 group: given the traditional Chinese medicine composition of Example 2 orally, and the dosage of mice was 0.33g/kg;

Example 3 group: give the traditional Chinese medicine composition of Example 3 orally, and the dosage of mice is 0.33g/kg;

Example 4 group: give the traditional Chinese medicine composition of Example 4 orally, and the dosage of mice is 0.33g/kg;

Pueraria root single-dose group: give the Pueraria root extract orally, and the mouse administration dose is 0.33g/kg;

Danzhu leaf single-dose group: give the extract of Danzhu leaf orally, and the dosage of mice is 0.33g/kg;

Chrysanthemum single-dose group: intragastric administration of chrysanthemum extract, and the dosage of mice was 0.33g/kg;

Honey single-dose group: honey was administered into the stomach, and the dosage of mice was 0.33g/kg;

The volume of normal saline gavage is calculated according to 10mL/kg body weight.

The preparation method of the traditional Chinese medicine extract in each single-dose group: take one of the clean kudzu root, light bamboo leaf, and chrysanthemum, add pure water 10 times the total amount of raw materials, boil and extract twice, each time for 1 hour, filter through 200 mesh , combined the two extracts.

2.2 Mouse hangover test

Take mice, males. After raising in the laboratory for 3 days, then fasting for 5 hours, select (25 ± 1) g of healthy mice, weigh and mark, and then randomly group them into groups of 12 mice in the model group, normal group, positive drug group, and embodiment 1 group ~Example 4 groups, each single-dose group, each group has 10 rats. Accurately weigh each mouse, and calculate the gavage amount of each mouse according to the pre-test intoxication amount (0.13mL/kg body weight). The normal group and the model group were intragastrically administered normal saline, and the other groups were intragastrically administered different doses of the test drugs in turn. After 0.5h, except for the normal group, each group was administered ethanol solution (50% v/v ethanol) according to the intoxicating amount, and the time for the disappearance and recovery of the righting reflex of the mice in each group was recorded, and blood was taken after 3 hours to detect serum ethanol concentration.

2.3 Data processing

Generally, analysis of variance is used, but the homogeneity of variance test needs to be carried out according to the procedure of analysis of variance. The variance is homogeneous, and the F value is calculated. The F value is <F0.05. The conclusion: there is no significant difference between the means of each group; the F value≥F0. 05, P<0.05, use the pairwise comparison method between multiple experimental groups and a model group for statistics; perform appropriate variable transformation on non-normal or heterogeneous variance data, to meet the requirements of normality or homogeneous variance Finally, use the converted data for statistics; if the variable is still not normal or the variance is equal after conversion, use the rank sum test for statistics.

3. Experimental results

3.1 Effect on the number of drunk animals

The results of the prevention of drunkenness test are shown in Table 1. It can be seen from Table 1 that the drunk rate of mice in the model group was 83.3%, and no animal died of drunkenness was found in each group; compared with the model group, the drunk rate of the positive group and the compound group decreased significantly, and the effect of the positive group was slightly better than that of the model group. 4 compound groups. The effect of the compound group was significantly better than that of the single-dose group.

Table 1 The impact of tested samples on the number of intoxicated mice

3.2 Influence on drunk time

The test results are shown in Table 2. As can be seen from Table 2, in several tested sample groups, the sleep latency of the mice in Example 4 group is the longest, and the sleep time is the shortest; the compound group is compared with the model group, and the sleep latency and sleep time are significantly different; the compound group The effects were better than those of the active drug RU-21 group, and the effect of the compound group was better than that of the single-dose group.

Table 2 The impact of test samples on the drunken time of mice

Note: Compared with the model group, *: p≤<0.05, **: p<0.01.

3.3 Effects on serum ethanol content of mice

The test results are shown in Table 3. As can be seen from Table 3, the ethanol content in the blood of the mice in the normal group was very low. After gavage with ethanol for 3 hours, the ethanol content in the serum of the model group and each drug administration group all increased significantly; The level of ethanol in the serum of mice in the positive group was relatively the lowest. The content of ethanol in the serum of the compound group was significantly lower than that of the model group, and the effect of the compound group was better than that of the single-dose group.

Table 3 The impact of test samples on ethanol in mouse serum

Note: Compared with the model group, *: p<0.05, **: p<0.01;

Compared with the normal group, #: p<0.05, ##: p<0.01.

4 Conclusion

In this research protocol, the test sample can be judged to have the effect of preventing drunkenness only when the drunken rate, sleep latency, sleep time, serum ethanol content and other indicators of the tested sample are statistically different from the model group. According to the above-mentioned experimental results, compared with the model group, the tested sample group has significant differences; the effect of the compound group is significantly better than that of the single group, indicating that the composition formula has a synergistic effect; Shortening sleep time, promoting blood ethanol metabolism and other aspects have a certain improvement effect, and in prolonging sleep latency and shortening sleep time, the drug effect is better than positive medicine.

The above is only a preferred embodiment of the present invention, it should be pointed out that, for those of ordinary skill in the art, without departing from the principle of the present invention, some improvements and modifications can also be made, and these improvements and modifications can also be made. It should be regarded as the protection scope of the present invention.

Claims (10)

1. a hangover composition, is characterized in that, is made of Radix Puerariae Radix Puerariae, leaf of light bamboo, chrysanthemum, honey. 2. hangover composition according to claim 1, is characterized in that, by weight, each raw material consumption is: 3. according to claim 1 or 2 described compositions for relieving hangover, it is characterized in that, by weight, each raw material consumption is: 4. The preparation method of the anti-alcoholic composition according to any one of claims 1 to 3, characterized in that, comprising: mixing kudzu root, light bamboo leaves, and chrysanthemum, adding water and decocting to obtain an extract; mixing honey with The extracts are mixed to obtain the anti-alcohol composition. 5. The preparation method according to claim 4, characterized in that, the consumption of the water is 5 to 15 times of the total weight of the kudzu root, the leaves of the bamboo and the chrysanthemum. 6. The preparation method according to claim 4 or 5, characterized in that, the number of decocting is 2-4 times, and the time of each decocting is 0.5-1.5 h. 7. A hangover drink, characterized in that it comprises the hangover composition according to any one of claims 1 to 3 and food acceptable auxiliary materials. 8. The drink for relieving hangover according to claim 7, wherein the food acceptable auxiliary materials are white granulated sugar, potassium sorbate, lactose, sucrose, mannitol, sorbitol, steviol glycosides, gelatin, tragacanth, One or more of xanthan gum, carrageenan or konjac gum. 9. The hangover drink according to claim 7, characterized in that, in parts by weight, the hangover drink is made of the following raw materials: 10. The method for preparing the hangover drink according to any one of claims 7 to 9, characterized in that, comprising: Mix kudzu root, light bamboo leaves, and chrysanthemum, add water to decoct, and obtain an extract; Mix honey, white granulated sugar, potassium sorbate, the extract and water, filter, homogenize and sterilize to obtain the hangover drink.