CN1076112A - Change quiet notes lentinan powder pin into liquid drugs injection - Google Patents
Change quiet notes lentinan powder pin into liquid drugs injection Download PDFInfo
- Publication number
- CN1076112A CN1076112A CN 92101531 CN92101531A CN1076112A CN 1076112 A CN1076112 A CN 1076112A CN 92101531 CN92101531 CN 92101531 CN 92101531 A CN92101531 A CN 92101531A CN 1076112 A CN1076112 A CN 1076112A
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- CN
- China
- Prior art keywords
- lentinan
- powder pin
- injection
- liquid drugs
- cosolvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of ethanol, Polyethylene Glycol, propylene glycol, glycerol etc. used as cosolvent, change intravenous injection lentinan powder pin into liquid drugs injection, save the pork barrel of super cleaning shop, reduce cost greatly, make extensive patients afford to use this medicine economically, and with inexpensive competition in the world.
Description
Lentinan has been to be known as the new drug that improves immunologic function in the world, of many uses, the lentinan tablet has been produced for many years in China Kaifeng pharmaceutical factory, and central Ministry of Public Health approval Meifeng Pharmaceutical Factory Fuzhou City produced the intramuscular injection lentinan in 89 years, applied gradually.
Since 88 years, China was the powder pin from Japanese import intravenous injection lentinan every year, 1 milligram every, and 36 dollars, owing to cost an arm and a leg.20,000 of annual limiting inlets use for especial patient.Domestic a lot of units are at development intravenous injection lentinan, because of its curative effect the best at present.China is also with mass production from now on, but produce comparatively difficulty of powder pin, very strict to the requirement of plant and equipment, need build up super cleaning shop, essential strict aseptic, after making the powder pin, can not sterilize by heat sterilization, build up such ultra-clean workshop, need 1,000,000 dollars approximately, go up the Matthew difficulty like this, and cost is too high, and patient is also with not playing this medicine, and is also nocompetitive in the world.
Lentinan is a macromolecule mixture, when the heated in water solution sterilization, understand polymerization and separate out precipitate, so can not a water as solvent, organic chemistry principle according to its dissolubility increase of the identical person of structure, lentinan contains the volume hydroxyl, so courageously imagination ethanol, glycerol, propylene glycol, Polyethylene Glycol etc. are as cosolvent, thereby and utilize its viscosity and prevent to separate out precipitate and be mixed with qualified liquid drugs injection, succeed through preliminary test, compare with existing powder pin technology, because of sterilizing by heat sterilization, so the present invention has following advantage:
1, do not need strict aseptic Factory Building;
2, do not need strict aseptic equipment;
3, simplify procedures greatly, use manpower and material resources sparingly;
4, reduce cost greatly, extensive patients is all afforded to use this medicine, and competition in the world.
Hereinafter give several embodiment of this process:
1, the intravenous injection lentinan is added the injection water and be made into about 1～4 milligram every milliliter, be filtered to clarification, add an amount of propylene glycol and water for injection and be mixed with 1 milligram every, embedding, sterilization wrap, promptly.
2, the intravenous injection lentinan is added the injection water and be mixed with about 1～4 milligram every milliliter, be filtered to clarification, add an amount of ethanol or glycerol or Polyethylene Glycol and water for injection, be mixed with 1 milligram every, embedding, sterilization, packing, promptly.
3, the intravenous injection lentinan being added the injection water is mixed with about 1～4 milligram every milliliter, be filtered to clarification, add an amount of ethanol, propylene glycol, Polyethylene Glycol, glycerol mixture solvent and water for injection, be mixed with 1 milligram every, embedding, sterilization, packing, promptly.
4, the intravenous injection lentinan is added the injection water and be mixed with about 1～4 milligram every milliliter, be filtered to clarification, add the mixed solvent and the water for injection of above two kinds or three kinds, be mixed with 1 milligram every, embedding, sterilization, packing, promptly.
After above-mentioned operation preparation, select the best prescription of stability, produce and declaration.
Claims (4)
1, a kind of by the operation that adds cosolvent, change intravenous injection lentinan powder pin the preparation method of liquid drugs injection into, it is characterized in that: add ethanol, Polyethylene Glycol, propylene glycol, glycerol as cosolvent.
2, the method for claim 1, its feature also is: use any as cosolvent in above-mentioned four kinds.
3, the method for claim 1, its feature also is: use propylene glycol as cosolvent.
4, the method for claim 1 is selected wherein two kinds for use, or three kinds or four kinds are used as cosolvent entirely.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92101531 CN1076112A (en) | 1992-03-08 | 1992-03-08 | Change quiet notes lentinan powder pin into liquid drugs injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92101531 CN1076112A (en) | 1992-03-08 | 1992-03-08 | Change quiet notes lentinan powder pin into liquid drugs injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1076112A true CN1076112A (en) | 1993-09-15 |
Family
ID=4939168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92101531 Pending CN1076112A (en) | 1992-03-08 | 1992-03-08 | Change quiet notes lentinan powder pin into liquid drugs injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1076112A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002007708A1 (en) * | 2000-07-19 | 2002-01-31 | Nanjing New@High Technology Industry Developing Zone | Lyophilized powder of lentinan and the process of preparation thereof |
| CN1087610C (en) * | 1996-03-28 | 2002-07-17 | 中国科学院上海药物研究所 | Lentinus edodes polysaccharide injecta and its preparation |
| CN116139051A (en) * | 2021-11-22 | 2023-05-23 | 中国科学院植物研究所 | A kind of peony flower extract and preparation method thereof |
-
1992
- 1992-03-08 CN CN 92101531 patent/CN1076112A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087610C (en) * | 1996-03-28 | 2002-07-17 | 中国科学院上海药物研究所 | Lentinus edodes polysaccharide injecta and its preparation |
| WO2002007708A1 (en) * | 2000-07-19 | 2002-01-31 | Nanjing New@High Technology Industry Developing Zone | Lyophilized powder of lentinan and the process of preparation thereof |
| US7091336B2 (en) | 2000-07-19 | 2006-08-15 | Nanjing Zhenzhong Bioengineering Co., Ltd. | Lyophilized powder of lentinan and the process of preparation thereof |
| RU2303978C2 (en) * | 2000-07-19 | 2007-08-10 | Нанджинг Зензонг Биоинджиниринг Компани Лтд. | Lentinane lyophilized powder and process for its preparing |
| CN116139051A (en) * | 2021-11-22 | 2023-05-23 | 中国科学院植物研究所 | A kind of peony flower extract and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |