CN107496600A - A kind of Reishi sporule powder preparation and preparation method thereof - Google Patents
A kind of Reishi sporule powder preparation and preparation method thereof Download PDFInfo
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- CN107496600A CN107496600A CN201710730266.5A CN201710730266A CN107496600A CN 107496600 A CN107496600 A CN 107496600A CN 201710730266 A CN201710730266 A CN 201710730266A CN 107496600 A CN107496600 A CN 107496600A
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- powder
- lucidum spore
- preparation
- reishi sporule
- spore powder
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- 239000000843 powder Substances 0.000 title claims abstract description 107
- 240000008397 Ganoderma lucidum Species 0.000 title claims abstract description 69
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 45
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 244000194101 Ginkgo biloba Species 0.000 claims abstract description 20
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 14
- 235000005487 catechin Nutrition 0.000 claims abstract description 14
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229950001002 cianidanol Drugs 0.000 claims abstract description 14
- 235000012907 honey Nutrition 0.000 claims abstract description 14
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 13
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 13
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 13
- 235000011477 liquorice Nutrition 0.000 claims abstract description 13
- 239000010446 mirabilite Substances 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000011435 rock Substances 0.000 claims abstract description 13
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 10
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 10
- 241000239370 Euphausia superba Species 0.000 claims abstract description 9
- 230000001954 sterilising effect Effects 0.000 claims description 28
- 238000001035 drying Methods 0.000 claims description 25
- 241000222336 Ganoderma Species 0.000 claims description 15
- 238000007873 sieving Methods 0.000 claims description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 238000009472 formulation Methods 0.000 claims description 13
- 239000008213 purified water Substances 0.000 claims description 13
- 235000011201 Ginkgo Nutrition 0.000 claims description 11
- 241000218628 Ginkgo Species 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 11
- 238000005057 refrigeration Methods 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 10
- 238000004321 preservation Methods 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- 239000012535 impurity Substances 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 3
- 241000239366 Euphausiacea Species 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 206010011224 Cough Diseases 0.000 abstract description 23
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 9
- 208000026435 phlegm Diseases 0.000 abstract description 9
- 208000024891 symptom Diseases 0.000 abstract description 8
- 206010036790 Productive cough Diseases 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 210000004072 lung Anatomy 0.000 description 13
- 241000143060 Americamysis bahia Species 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000000465 moulding Methods 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241000220287 Sedum rubrotinctum Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 210000004081 cilia Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- -1 terpene lactone compound Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/612—Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
A kind of Reishi sporule powder preparation and preparation method thereof, the Reishi sporule powder preparation are made up of the raw material of following weight parts：6~8 parts of lucidum spore powder, 0.5~0.7 part of catechin, 0.4~1.0 part of honey, 0.8~1.2 part of ginkgo biloba p.e, 0.3~0.5 part of rock sugar, 0.2~0.4 part of Tea Polyphenols, 0.1~0.3 part of euphausia superba powder, 0.2~0.4 part of B B-complex, 0.3~0.7 part of pearl powder, 0.3~0.7 part of the compound of glauber-salt and liquorice, 30~40 parts of water.Lucidum spore powder pharmaceutical formulation provided by the invention and preparation method thereof, it can effectively alleviate the symptoms such as cough, abundant expectoration, preparation method is simple, and cost is low, compared to other preventing phlegm from forming and stopping coughing class medicines, Reishi sporule powder preparation few side effects provided by the invention.
Description
Technical field
The present invention relates to pharmaceutical techniques field, and in particular to a kind of Reishi sporule powder preparation and preparation method thereof.
Background technology
Cough with lung heat's abundant expectoration is due to that wind-heat evil poison violates lung, or chillization heat, and lung burnt by heat toxin, lose dropped in a surname it is respectful clearly,
Phlegm heat is internal to cause intrapulmonary hot and suffocating, a kind of disease based on cough occurs, often occurs after lung heat flu, without cold symptoms.
Cough with lung heat is often more common in the crowd of hypoimmunity, is mainly shown as repeated coughing.It is clinical mainly oral using lung heat cough and asthma
The Chinese patent drugs for treatment such as liquid, the pharyngeal and wriggling of bronchus cilium can be obviously promoted and strengthen expectoration effect, while decoction can be covered in
On the pharyngeal mucosa of inflammation, alleviate inflammatory stimulus, antitussive effect is notable and lasting.One of cough with lung heat's cardinal symptom is cough repeatedly
Cough, be often accompanied by fever with aversion to cold, pectoralgia of coughing, phlegm is few and viscous, breathes unfavorable, dry mouth and throat, and thin lingual fur is yellow.Part is also with chest side of body
Secret anguish, shortness of breath and fatigue, spontaneous sweating, low-heat or hectic fever, lustreless complexion, body such as are become thin at the symptom.The symptom is in smoking people simultaneously
It is also more typical in group.
The content of the invention
The present invention is in order to solve the above technical problems, provide a kind of Reishi sporule powder preparation and preparation method thereof.
The technical problems to be solved by the invention are realized using following technical scheme：
A kind of Reishi sporule powder preparation, is made up of the raw material of following weight parts：
6~8 parts of lucidum spore powder, 0.5~0.7 part of catechin, 0.4~1.0 part of honey, ginkgo biloba p.e 0.8~1.2
Part, 0.3~0.5 part of rock sugar, 0.2~0.4 part of Tea Polyphenols, 0.1~0.3 part of euphausia superba powder, 0.2~0.4 part of B B-complex,
0.3~0.7 part of pearl powder, 0.3~0.7 part of the compound of glauber-salt and liquorice, 30~40 parts of water.
Preferably, the Reishi sporule powder preparation is made up of the raw material of following weight parts：
7 parts of lucidum spore powder, 0.6 part of catechin, 0.7 part of honey, 1.0 parts of ginkgo biloba p.e, 0.4 part of rock sugar, tea is more
0.3 part of phenol, 0.2 part of euphausia superba powder, 0.3 part of B B-complex, 0.5 part of pearl powder, 0.5 part of the compound of glauber-salt and liquorice, 35 parts of water.
A kind of lucidum spore powder formulation preparation method, comprises the following steps：
(1) Reishi sporule raw material is weighed, sieving removes impurity, the Reishi sporule after must sieving；
(2) stood after the Reishi sporule after sieving being added into purified water stirring, remove the flat shell in upper strata, lower floor's silt with it is miscellaneous
Matter, middle level spore suspension is taken, centrifugal drying moisture removal, obtains wet Reishi sporule；
(3) wet Reishi sporule is put into thermostatic drying chamber and dried, obtain dried Reishi sporule；
(4) broken wall treatment is carried out to dried Reishi sporule, obtains the lucidum spore powder of broken wall；
(5) by the lucidum spore powder after broken wall, it is put into ultra micro vibratory sieve and sieves, obtain finely ultrapure wall-broken ganoderma spore
Powder；
(6) fine ultrapure ganoderma spove powder is put into steam sterilization case, opens steam sterilization case and purified water is set
It is standby, sterilizing-drying processing is carried out to lucidum spore powder, obtains dried fine sterilizing glossy ganoderma spore powder with crushed sporoderm；
(7) by ginkgo leaf extractor, Extraction solvent is added, pressurizes and keeps pressure for a period of time, then pressure release is gone forward side by side
Row filtering, filtrate are placed in refrigerating chamber and refrigerated first, and the filtrate after refrigeration terminates first is centrifuged first, are collected
Supernatant, secondary refrigeration, secondary centrifuging separation are then carried out, supernatant is collected and ginkgo biloba p.e is made；
(8) lucidum spore powder, catechin, honey, ginkgo biloba p.e, rock sugar, Tea Polyphenols, South Pole phosphorus are weighed by formula ratio
Shrimp med, B B-complex, pearl powder, the compound of glauber-salt and liquorice and water, dissolve and stir to being completely dissolved, be cooled to room temperature and the ganoderma lucidum is made
Spore powder preparation.
Reishi sporule adds after purified water stirs 10~30 minutes and stands 20~30 minutes in the step (2).
Wet Reishi sporule moisture after drying process is 5~7% in the step (3).
Dried Reishi sporule carries out broken wall treatment in the step (4), sporoderm-broken rate is reached 95%~100%.
Lucidum spore powder in the step (5) after broken wall crosses 300~450 mesh sieves in ultra micro vibratory sieve.
Between the air pressure of steam sterilization case is transferred into -50Pa~-70Pa when steam sterilizing is dried in the step (6), steam
Stripping temperature is between 80 DEG C~120 DEG C.
The steam sterilizing drying process time is 60min~120min in the step (6).
Extraction solvent addition is 2~3 times of ginkgo leaf weight in the step (7).
In the step (7), moulding pressure is 180~200Mpa, and pressure hold time is 20~30min.
In the step (7), refrigerated storage temperature is 0~3 DEG C first, and cold preservation time is 1~2h；Secondary refrigerated storage temperature is 5-10
DEG C, cold preservation time is 2~3h.
In the step (7), the rotating speed that centrifuges first is 1800~2000r/min, disengaging time is 10~
20min；The rotating speed of secondary centrifuging separation is 2000~2200r/min, and disengaging time is 20~30min.
Beneficial effects of the present invention are：
(1) containing abundant terpene lactone compound in ginkgo biloba p.e, with the laurate in lucidum spore powder, Pork and beans
Cool acid, palmitic acid combine, and formed with the material beneficial to preventing phlegm from forming and stopping coughing, can significantly improve throat's lubrication state, reduce amount of expectoration, together
When play a part of lubricate enteron aisle；
(2) compositions such as catechin, honey, Tea Polyphenols, euphausia superba powder are added in being formulated so that preparation good mouthfeel, perfume (or spice)
Taste is strong, nutritious, has the effect of preventing phlegm from forming and stopping coughing, clearing heat and detoxicating and stomach moistening lung；Multiple formulations component is added, nutrition is rich
Richness, compatibility science, complements each other, preventing phlegm from forming and stopping coughing positive effect；
(3) ginkgo biloba p.e passes through high pressure extraction in preparation method provided by the invention, secondary refrigeration and secondary separation,
Extraction efficiency is high, and the extract prepared can greatly preserve the active ingredient in ginkgo leaf, improves activity；
(4) lucidum spore powder pharmaceutical formulation provided by the invention and preparation method thereof, the diseases such as cough, abundant expectoration can effectively be alleviated
Shape, preparation method is simple, and cost is low, and compared to other preventing phlegm from forming and stopping coughing class medicines, Reishi sporule powder preparation provided by the invention is secondary to be made
With less.
Embodiment
In order that the technical means, the inventive features, the objects and the advantages of the present invention are easy to understand, tie below
Embodiment is closed, the present invention is expanded on further.
Embodiment 1
A kind of Reishi sporule powder preparation, is made up of the raw material of following weight parts：
6 parts of lucidum spore powder, 0.5 part of catechin, 0.4 part of honey, 0.8 part of ginkgo biloba p.e, 0.3 part of rock sugar, tea is more
0.2 part of phenol, 0.1 part of euphausia superba powder, 0.2 part of B B-complex, 0.3 part of pearl powder, 0.3 part of the compound of glauber-salt and liquorice, 30 parts of water.
A kind of lucidum spore powder formulation preparation method, comprises the following steps：
(1) Reishi sporule raw material is weighed, sieving removes impurity, the Reishi sporule after must sieving；
(2) stood after the Reishi sporule after sieving being added into purified water stirring, remove the flat shell in upper strata, lower floor's silt with it is miscellaneous
Matter, middle level spore suspension is taken, centrifugal drying moisture removal, obtains wet Reishi sporule；
(3) wet Reishi sporule is put into thermostatic drying chamber and dried, obtain dried Reishi sporule；
(4) broken wall treatment is carried out to dried Reishi sporule, obtains the lucidum spore powder of broken wall；
(5) by the lucidum spore powder after broken wall, it is put into ultra micro vibratory sieve and sieves, obtain finely ultrapure wall-broken ganoderma spore
Powder；
(6) fine ultrapure ganoderma spove powder is put into steam sterilization case, opens steam sterilization case and purified water is set
It is standby, sterilizing-drying processing is carried out to lucidum spore powder, obtains dried fine sterilizing glossy ganoderma spore powder with crushed sporoderm；
(7) by ginkgo leaf extractor, Extraction solvent is added, pressurizes and keeps pressure for a period of time, then pressure release is gone forward side by side
Row filtering, filtrate are placed in refrigerating chamber and refrigerated first, and the filtrate after refrigeration terminates first is centrifuged first, are collected
Supernatant, secondary refrigeration, secondary centrifuging separation are then carried out, supernatant is collected and ginkgo biloba p.e is made；
(8) lucidum spore powder, catechin, honey, ginkgo biloba p.e, rock sugar, Tea Polyphenols, South Pole phosphorus are weighed by formula ratio
Shrimp med, B B-complex, pearl powder, the compound of glauber-salt and liquorice and water, dissolve and stir to being completely dissolved, be cooled to room temperature and the ganoderma lucidum is made
Spore powder preparation.
Reishi sporule adds after purified water stirs 10~30 minutes and stands 20~30 minutes in the step (2).
Wet Reishi sporule moisture after drying process is 5~7% in the step (3).
Dried Reishi sporule carries out broken wall treatment in the step (4), sporoderm-broken rate is reached 95%~100%.
Lucidum spore powder in the step (5) after broken wall crosses 300~450 mesh sieves in ultra micro vibratory sieve.
Between the air pressure of steam sterilization case is transferred into -50Pa~-70Pa when steam sterilizing is dried in the step (6), steam
Stripping temperature is between 80 DEG C~120 DEG C.
The steam sterilizing drying process time is 60min~120min in the step (6).
Extraction solvent addition is 2~3 times of ginkgo leaf weight in the step (7).
In the step (7), moulding pressure is 180~200Mpa, and pressure hold time is 20~30min.
In the step (7), refrigerated storage temperature is 0~3 DEG C first, and cold preservation time is 1~2h；Secondary refrigerated storage temperature is 5-10
DEG C, cold preservation time is 2~3h.
In the step (7), the rotating speed that centrifuges first is 1800~2000r/min, disengaging time is 10~
20min；The rotating speed of secondary centrifuging separation is 2000~2200r/min, and disengaging time is 20~30min.
Embodiment 2
A kind of Reishi sporule powder preparation, is made up of the raw material of following weight parts：
7 parts of lucidum spore powder, 0.6 part of catechin, 0.7 part of honey, 1.0 parts of ginkgo biloba p.e, 0.4 part of rock sugar, tea is more
0.3 part of phenol, 0.2 part of euphausia superba powder, 0.3 part of B B-complex, 0.5 part of pearl powder, 0.5 part of the compound of glauber-salt and liquorice, 35 parts of water.
A kind of lucidum spore powder formulation preparation method, comprises the following steps：
(1) Reishi sporule raw material is weighed, sieving removes impurity, the Reishi sporule after must sieving；
(2) stood after the Reishi sporule after sieving being added into purified water stirring, remove the flat shell in upper strata, lower floor's silt with it is miscellaneous
Matter, middle level spore suspension is taken, centrifugal drying moisture removal, obtains wet Reishi sporule；
(3) wet Reishi sporule is put into thermostatic drying chamber and dried, obtain dried Reishi sporule；
(4) broken wall treatment is carried out to dried Reishi sporule, obtains the lucidum spore powder of broken wall；
(5) by the lucidum spore powder after broken wall, it is put into ultra micro vibratory sieve and sieves, obtain finely ultrapure wall-broken ganoderma spore
Powder；
(6) fine ultrapure ganoderma spove powder is put into steam sterilization case, opens steam sterilization case and purified water is set
It is standby, sterilizing-drying processing is carried out to lucidum spore powder, obtains dried fine sterilizing glossy ganoderma spore powder with crushed sporoderm；
(7) by ginkgo leaf extractor, Extraction solvent is added, pressurizes and keeps pressure for a period of time, then pressure release is gone forward side by side
Row filtering, filtrate are placed in refrigerating chamber and refrigerated first, and the filtrate after refrigeration terminates first is centrifuged first, are collected
Supernatant, secondary refrigeration, secondary centrifuging separation are then carried out, supernatant is collected and ginkgo biloba p.e is made；
(8) lucidum spore powder, catechin, honey, ginkgo biloba p.e, rock sugar, Tea Polyphenols, South Pole phosphorus are weighed by formula ratio
Shrimp med, B B-complex, pearl powder, the compound of glauber-salt and liquorice and water, dissolve and stir to being completely dissolved, be cooled to room temperature and the ganoderma lucidum is made
Spore powder preparation.
Reishi sporule adds after purified water stirs 10~30 minutes and stands 20~30 minutes in the step (2).
Wet Reishi sporule moisture after drying process is 5~7% in the step (3).
Dried Reishi sporule carries out broken wall treatment in the step (4), sporoderm-broken rate is reached 95%~100%.
Lucidum spore powder in the step (5) after broken wall crosses 300~450 mesh sieves in ultra micro vibratory sieve.
Between the air pressure of steam sterilization case is transferred into -50Pa~-70Pa when steam sterilizing is dried in the step (6), steam
Stripping temperature is between 80 DEG C~120 DEG C.
The steam sterilizing drying process time is 60min~120min in the step (6).
Extraction solvent addition is 2~3 times of ginkgo leaf weight in the step (7).
In the step (7), moulding pressure is 180~200Mpa, and pressure hold time is 20~30min.
In the step (7), refrigerated storage temperature is 0~3 DEG C first, and cold preservation time is 1~2h；Secondary refrigerated storage temperature is 5-10
DEG C, cold preservation time is 2~3h.
In the step (7), the rotating speed that centrifuges first is 1800~2000r/min, disengaging time is 10~
20min；The rotating speed of secondary centrifuging separation is 2000~2200r/min, and disengaging time is 20~30min.
Embodiment 3
A kind of Reishi sporule powder preparation, is made up of the raw material of following weight parts：
8 parts of lucidum spore powder, 0.7 part of catechin, 1.0 parts of honey, 1.2 parts of ginkgo biloba p.e, 0.5 part of rock sugar, tea is more
0.4 part of phenol, 0.3 part of euphausia superba powder, 0.4 part of B B-complex, 0.7 part of pearl powder, 0.7 part of the compound of glauber-salt and liquorice, 40 parts of water.
A kind of lucidum spore powder formulation preparation method, comprises the following steps：
(1) Reishi sporule raw material is weighed, sieving removes impurity, the Reishi sporule after must sieving；
(2) stood after the Reishi sporule after sieving being added into purified water stirring, remove the flat shell in upper strata, lower floor's silt with it is miscellaneous
Matter, middle level spore suspension is taken, centrifugal drying moisture removal, obtains wet Reishi sporule；
(3) wet Reishi sporule is put into thermostatic drying chamber and dried, obtain dried Reishi sporule；
(4) broken wall treatment is carried out to dried Reishi sporule, obtains the lucidum spore powder of broken wall；
(5) by the lucidum spore powder after broken wall, it is put into ultra micro vibratory sieve and sieves, obtain finely ultrapure wall-broken ganoderma spore
Powder；
(6) fine ultrapure ganoderma spove powder is put into steam sterilization case, opens steam sterilization case and purified water is set
It is standby, sterilizing-drying processing is carried out to lucidum spore powder, obtains dried fine sterilizing glossy ganoderma spore powder with crushed sporoderm；
(7) by ginkgo leaf extractor, Extraction solvent is added, pressurizes and keeps pressure for a period of time, then pressure release is gone forward side by side
Row filtering, filtrate are placed in refrigerating chamber and refrigerated first, and the filtrate after refrigeration terminates first is centrifuged first, are collected
Supernatant, secondary refrigeration, secondary centrifuging separation are then carried out, supernatant is collected and ginkgo biloba p.e is made；
(8) lucidum spore powder, catechin, honey, ginkgo biloba p.e, rock sugar, Tea Polyphenols, South Pole phosphorus are weighed by formula ratio
Shrimp med, B B-complex, pearl powder, the compound of glauber-salt and liquorice and water, dissolve and stir to being completely dissolved, be cooled to room temperature and the ganoderma lucidum is made
Spore powder preparation.
Reishi sporule adds after purified water stirs 10~30 minutes and stands 20~30 minutes in the step (2).
Wet Reishi sporule moisture after drying process is 5~7% in the step (3).
Dried Reishi sporule carries out broken wall treatment in the step (4), sporoderm-broken rate is reached 95%~100%.
Lucidum spore powder in the step (5) after broken wall crosses 300~450 mesh sieves in ultra micro vibratory sieve.
Between the air pressure of steam sterilization case is transferred into -50Pa~-70Pa when steam sterilizing is dried in the step (6), steam
Stripping temperature is between 80 DEG C~120 DEG C.
The steam sterilizing drying process time is 60min~120min in the step (6).
Extraction solvent addition is 2~3 times of ginkgo leaf weight in the step (7).
In the step (7), moulding pressure is 180~200Mpa, and pressure hold time is 20~30min.
In the step (7), refrigerated storage temperature is 0~3 DEG C first, and cold preservation time is 1~2h；Secondary refrigerated storage temperature is 5-10
DEG C, cold preservation time is 2~3h.
In the step (7), the rotating speed that centrifuges first is 1800~2000r/min, disengaging time is 10~
20min；The rotating speed of secondary centrifuging separation is 2000~2200r/min, and disengaging time is 20~30min.
Experimental data
General information：Patient 200, wherein man 100, female 100, the age is minimum 5 years old, and maximum 60 years old, the course of disease is most short
3d, most long 20d, man, female are respectively divided into four groups, and experimental group 1-3 uses Reishi sporule powder preparation made from embodiment 1-3 respectively, real
Test group 4 and use common lung heat cough and asthma oral liquid, experimental group 5 is without using any medicine.
Diagnostic criteria：Reference《Chinese Internal Medicine》Cough.Symptoms include the coughing with a lot of sputum caused by phlegm dampness in lungs, cough are low voice speaking
Turbid, phlegm is sticky or stiff is blocking, and color is white, gastral cavity ruffian uncomfortable in chest, evil of vomitting, deficiency of food.
Treatment method：Twice daily, each 10ml；Children are cut down according to the circumstance.Medication observes curative effect after 5 days.
Criterion of therapeutical effect：
Recovery from illness：The clinical symptom disappearances such as cough, fluoroscopy of chest are that double lung marking are normal；
Effectively, lighter, other clinical symptom disappearances of cough；
Invalid, cough and other clinical symptoms do not mitigate or aggravated, and double lung perspective enhanced lung markings, thickening, obscure.
Treatment results such as following table：
General principle, principal character and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry
For personnel it should be appreciated that the present invention is not limited to the above embodiments, that described in above-described embodiment and specification is only the present invention
Preference, be not intended to limit the present invention, without departing from the spirit and scope of the present invention, the present invention also have it is various
Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by institute
Attached claims and its equivalent thereof.
Claims (10)
1. a kind of Reishi sporule powder preparation, it is characterised in that be made up of the raw material of following weight parts：
6~8 parts of lucidum spore powder, 0.5~0.7 part of catechin, 0.4~1.0 part of honey, 0.8~1.2 part of ginkgo biloba p.e,
0.3~0.5 part of rock sugar, 0.2~0.4 part of Tea Polyphenols, 0.1~0.3 part of euphausia superba powder, 0.2~0.4 part of B B-complex are precious
0.3~0.7 part of pearl powder, 0.3~0.7 part of the compound of glauber-salt and liquorice, 30~40 parts of water.
2. a kind of Reishi sporule powder preparation as claimed in claim 1, it is characterised in that the Reishi sporule powder preparation is by following
The raw material of parts by weight is made：
7 parts of lucidum spore powder, 0.6 part of catechin, 0.7 part of honey, 1.0 parts of ginkgo biloba p.e, 0.4 part of rock sugar, Tea Polyphenols 0.3
Part, 0.2 part of euphausia superba powder, 0.3 part of B B-complex, 0.5 part of pearl powder, 0.5 part of the compound of glauber-salt and liquorice, 35 parts of water.
3. a kind of lucidum spore powder formulation preparation method, comprises the following steps：
(1) Reishi sporule raw material is weighed, sieving removes impurity, the Reishi sporule after must sieving；
(2) stood after the Reishi sporule after sieving being added into purified water stirring, remove upper strata flat shell, lower floor's silt and impurity, take
Middle level spore suspension, centrifugal drying moisture removal, obtain wet Reishi sporule；
(3) wet Reishi sporule is put into thermostatic drying chamber and dried, obtain dried Reishi sporule；
(4) broken wall treatment is carried out to dried Reishi sporule, obtains the lucidum spore powder of broken wall；
(5) by the lucidum spore powder after broken wall, it is put into ultra micro vibratory sieve and sieves, obtain finely ultrapure ganoderma spove powder；
(6) fine ultrapure ganoderma spove powder is put into steam sterilization case, opens steam sterilization case and water purification equipment, it is right
Lucidum spore powder carries out sterilizing-drying processing, obtains dried fine sterilizing glossy ganoderma spore powder with crushed sporoderm；
(7) by ginkgo leaf extractor, Extraction solvent is added, pressurizes and keeps pressure for a period of time, then pressure release and carried out
Filter, filtrate are placed in refrigerating chamber and refrigerated first, and the filtrate after refrigeration terminates first is centrifuged first, collect supernatant
Liquid, secondary refrigeration, secondary centrifuging separation are then carried out, supernatant is collected and ginkgo biloba p.e is made；
(8) lucidum spore powder, catechin, honey, ginkgo biloba p.e, rock sugar, Tea Polyphenols, krill are weighed by formula ratio
Powder, B B-complex, pearl powder, the compound of glauber-salt and liquorice and water, dissolve and stir to being completely dissolved, be cooled to room temperature and the ganoderma lucidum spore is made
Sub- powder preparation.
4. a kind of lucidum spore powder formulation preparation method as claimed in claim 3, it is characterised in that broken in the step (5)
Lucidum spore powder after wall crosses 300~450 mesh sieves in ultra micro vibratory sieve.
5. a kind of lucidum spore powder formulation preparation method as claimed in claim 3, it is characterised in that steamed in the step (6)
Between the air pressure of steam sterilization case is transferred into -50Pa~-70Pa during vapour sterilizing-drying, vapor (steam) temperature is between 80 DEG C~120 DEG C.
6. a kind of lucidum spore powder formulation preparation method as claimed in claim 3, it is characterised in that steamed in the step (6)
Vapour sterilizing-drying processing time is 60min~120min.
7. a kind of lucidum spore powder formulation preparation method as claimed in claim 3, it is characterised in that carried in the step (7)
Take 2~3 times that solvent adding amount is ginkgo leaf weight.
8. a kind of lucidum spore powder formulation preparation method as claimed in claim 3, it is characterised in that in the step (7), add
Pressure pressure is 180~200Mpa, and pressure hold time is 20~30min.
9. a kind of lucidum spore powder formulation preparation method as claimed in claim 3, it is characterised in that first in the step (7)
Secondary refrigerated storage temperature is 0~3 DEG C, and cold preservation time is 1~2h；Secondary refrigerated storage temperature is 5-10 DEG C, and cold preservation time is 2~3h.
A kind of 10. lucidum spore powder formulation preparation method as claimed in claim 3, it is characterised in that in the step (7),
The rotating speed centrifuged first is 1800~2000r/min, and disengaging time is 10~20min；Secondary centrifuging separation rotating speed be
2000~2200r/min, disengaging time are 20~30min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111686156A (en) * | 2020-05-20 | 2020-09-22 | 安徽利民生物科技股份有限公司 | Throat-moistening agent containing ganoderma lucidum spore powder and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020131978A1 (en) * | 2001-03-19 | 2002-09-19 | Xin Liu | Method for extracting oleaginous substances from ganoderma lucidum spores |
| CN105641211A (en) * | 2016-02-25 | 2016-06-08 | 福州东星生物技术有限公司 | Cough-relieving capsules containing ganoderma lucidum and preparation method of cough-relieving capsules |
| CN106822722A (en) * | 2015-12-03 | 2017-06-13 | 陈智松 | A kind of medicine for treating cough |
-
2017
- 2017-08-23 CN CN201710730266.5A patent/CN107496600A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020131978A1 (en) * | 2001-03-19 | 2002-09-19 | Xin Liu | Method for extracting oleaginous substances from ganoderma lucidum spores |
| CN106822722A (en) * | 2015-12-03 | 2017-06-13 | 陈智松 | A kind of medicine for treating cough |
| CN105641211A (en) * | 2016-02-25 | 2016-06-08 | 福州东星生物技术有限公司 | Cough-relieving capsules containing ganoderma lucidum and preparation method of cough-relieving capsules |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111686156A (en) * | 2020-05-20 | 2020-09-22 | 安徽利民生物科技股份有限公司 | Throat-moistening agent containing ganoderma lucidum spore powder and preparation method thereof |
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