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CN107432836A - Wrinkle resistance, whitening Essence - Google Patents

Wrinkle resistance, whitening Essence Download PDF

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Publication number
CN107432836A
CN107432836A CN201710795628.9A CN201710795628A CN107432836A CN 107432836 A CN107432836 A CN 107432836A CN 201710795628 A CN201710795628 A CN 201710795628A CN 107432836 A CN107432836 A CN 107432836A
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Prior art keywords
parts
skin
wrinkle resistance
whitening
essence
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Pending
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CN201710795628.9A
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Chinese (zh)
Inventor
张燕丹
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Individual
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Priority to CN201710795628.9A priority Critical patent/CN107432836A/en
Publication of CN107432836A publication Critical patent/CN107432836A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • A61K8/355Quinones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of wrinkle resistance, whitening Essence, include the raw material of following components by weight percent:60 80 parts of water, 24 parts of caprylic/capric triglyceride, 1,238 parts of pentanediol, 26 parts of glycerine, 35 parts of ethanol, 24 parts of xanthans, 3 10 parts of lecithin, 13 parts of pear oligose alcohol, 13 parts of ubiquinone.Wrinkle resistance, whitening Essence of the present invention has significant antioxidation, can effectively prevent that skin light decay is old, can promote the generation of the U.S. sarcous element such as collagen and hyaluronic acid, make skin it is tender it is full, full of elastic force and gloss, reduce wrinkle.

Description

Wrinkle resistance, whitening Essence
Technical field
The present invention relates to a kind of Essence, more particularly to a kind of wrinkle resistance, whitening Essence.
Background technology
The aging of human body is the inexorable law of life growth, wherein the most obvious with the change of skin, general women is 25 After year, skin is in falling tendency, and after 30 years old, aging makes first appearance.Skin senescence refers to that skin surface is coarse and wrinkles Line.
Specifically, the form of skin senescence is mainly that naturally-aged (i.e. endogenous aging) and light aging are (i.e. exogenous Aging), naturally-aged is mainly caused by body inherent cause, is limited to systemic sites, hence it is evident that is characterized as wrinkle and relaxation, and occurs Phenomena such as pigmentation.Light aging is mainly the skin senescence caused by ultraviolet damage accumulation, is that naturally-aged and ultraviolet shine Coefficient result is penetrated, is limited to skin exposure portion, is mainly characterized by pachylosis tarnish, steady overstriking is walked and deepens, pigment Calmness is deepened, and skin microcirculation is deteriorated, elastosis, and epidermis shows as removing power, collagen and elastin laminin synthesis Ability and immunity degradation, phenomena such as dermis thickness is thinning, easy generation allergy inflammation.
Cosmetics are a kind of well known chemical industrial products, and it belongs to field of fine chemical, be primarily referred to as with smear, The methods of sprinkling, any position of human body surface, such as hair, face, neck, oxter, nail, lips and teeth are uniformly distributed in, with Reach cleaning, maintenance, beauty, modification, change outward appearance etc. for the purpose of, make one chemical industrial product for the purpose of maintaining a good state or Fine chemical product.
Essence, it is the superfine product in cosmetics, composition is exquisite, effect is powerful, significant effect, remains what it possessed Noble and mysterious, its effect has anti-aging, crease-resistant, moisturizing, whitening, despeckle etc..Essence divides aqua, two kinds of finish, institute Extraction is high nutrient and concentrated.
The content of the invention
To achieve the above object, the technical problems to be solved by the invention are to provide a kind of wrinkle resistance, whitening Essence.
Specifically, adopt the following technical scheme that:
A kind of wrinkle resistance, whitening Essence, including following raw material:Water, caprylic/capric triglyceride, 1,2- pentanediol, glycerine, Ethanol, xanthans, lecithin.
A kind of wrinkle resistance, whitening Essence, include the raw material of following components by weight percent:Water 60-80 parts, caprylic/capric triglyceride 2-4 parts, 1,2- pentanediol 3-8 parts, glycerine 2-6 parts, ethanol 3-5 parts, xanthans 2-4 parts, lecithin 3-10 parts.
A kind of wrinkle resistance, whitening Essence, include the raw material of following components by weight percent:Water 60-80 parts, caprylic/capric triglyceride 2-4 parts, 1,2- pentanediol 3-8 parts, glycerine 2-6 parts, ethanol 3-5 parts, xanthans 2-4 parts, lecithin 3-10 parts, pear oligose alcohol 1- 3 parts.
A kind of wrinkle resistance, whitening Essence, include the raw material of following components by weight percent:Water 60-80 parts, caprylic/capric triglyceride 2-4 parts, 1,2- pentanediol 3-8 parts, glycerine 2-6 parts, ethanol 3-5 parts, xanthans 2-4 parts, lecithin 3-10 parts, pear oligose alcohol 1- 3 parts, ubiquinone 1-3 parts.
Caprylic/capric triglyceride, No. CAS:65381-09-1, it is clear extremely faint yellow, it is that height clearly spends tasteless grease, belongs to The derivative of palm oil or coconut oil.It is easy to be absorbed by the skin, good effect is played to the uniform and smooth of cosmetics, makes skin Skin lubrication is glossy, can be as the base-material of moisturizing factor, frequently as stabilizer, antifreezing agent and homogeneous agent in cosmetics.
1,2- pentanediol, colourless transparent liquid, it is dissolved in the organic solvents such as alcohol, ether and ethyl acetate.As excellent performance Small molecule NMF, can be applied in cosmetics;There is antisepsis simultaneously, the product of preservative free can be prepared, reduce anti- Allergy can improve the water-resistance of sunscreen product formula caused by rotten agent;The active component of indissoluble is also can dissolve, as cosmetics Solvent.
Glycerine, nickname glycerine is colourless, odorless, sweet, and outward appearance is in clear and bright viscous liquid state.Often make small molecule in cosmetics Moisturizing ingredient, the almost all of skin care item with moisture-keeping functions all contain glycerine, during for skin, skin can be made to keep soft Soft, water profit state.It is more significant with the moistening effect of glycerine in the NMF of polyalcohol, moisture can be stayed in cuticula, And have the function of preventing cosmetics dry and cracked, thus it is widely used in various cosmetics.
Ethanol, commonly used in cosmetics to be used as solvent, can moment pore refining formation refrigerant sense.
Xanthans:Also known as Xanthan gum, goat glue or xanthan gum, No. CAS:11138-66-2, light yellow or light brown powder, Xanthans is bigger in various temperature and stability range under pH value, is suitable as the matrix of smart oil-like emulsions, is commonly used in cosmetics Gelatinous matrix, frequently as stabilizer, thickener, emulsifying agent, suspending agent.
Lecithin, No. CAS:8002-43-5, be the indispensable material of each cell of human body, be normally present in yolk and In soya bean.Appropriate intake lecithin, can ensure skin regeneration vigor.Lecithin is a kind of natural surfactant, is had Good hydrophily and lipophile, emulsifying agent is commonly used in cosmetics, while also there is the effect such as moisturizing, anti-oxidant, commonly used In the cosmetics such as eye cream, emulsion, creams, lipstick.
Pear oligose alcohol:Alias sorbierite, No. CAS:50-70-4.Pear oligose alcohol can be used to make up as the substitute of glycerine In product, moisture retention relaxes compared with glycerine, is also used in combination with other NMFs, in the hope of the moistening effect of collaboration, as cosmetic material It is usually used in cream kind, shampoo powder, various toners, lipstick.
Ubiquinone, No. CAS:303-98-0, Co-Q10 is commonly referred to as again, belong to oil soluble material, be widely present in organism Fat-soluble quinones.Having studied confirms that ubiquinone is the anti-oxidant composition in human body, is used as in cosmetics anti-oxidant Agent, it is main to protect the cell membrane and fat deposit of organism, and have certain skin-care effect.The outer used time can defend ultraviolet to hinder Evil, prevent attack of the free radical to healthy cell.
Wrinkle resistance, whitening Essence of the present invention can also add 0.5-2.5 parts by weight whitening agents.
That is, a kind of wrinkle resistance, whitening Essence, is made up of the raw material of following components by weight percent:Water 60-80 parts, caprylic/capric are sweet Oily three ester 2-4 parts, 1,2- pentanediol 3-8 parts, glycerine 2-6 parts, ethanol 3-5 parts, xanthans 2-4 parts, lecithin 3-10 parts, sorb Candy alcohol 1-3 parts, ubiquinone 1-3 parts, whitening agent 0.5-2.5 parts.
Preferably, the whitening agent is four hexyl decyl alcohol acid ascorbyl esters and/or 3-O- ethylascorbyl ethers, optimal , the whitening agent is four hexyl decyl alcohol acid ascorbyl esters and 3-O- ethylascorbyls ether is 1 in mass ratio:0.5-1:2.5 Composition.
Wrinkle resistance, whitening Essence of the present invention can be prepared using this area conventional method.
The application method of the present invention:Face cleaning, after toner, take and be gently massaged into absorption at required position on the face in right amount.One It is using twice.Essence can also be instilled in the breast of cutin maintenance basis, it is better.The suitable crowd of the present invention:It is various Skin, especially extreme dryness and the skin of aging.
Wrinkle resistance, whitening Essence of the present invention has significant antioxidation, can effectively prevent that skin light decay is old, can Promote the generation of the U.S. sarcous element such as collagen and hyaluronic acid, make skin it is tender it is full, full of elastic force and gloss, reduce wrinkle Line.
Embodiment
Embodiment 1
A kind of Essence, it is made up of the raw material of following components by weight percent:70 parts of water, 3 parts of caprylic/capric triglyceride, 1,2- 5 parts of pentanediol, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 5 parts of lecithin, 2 parts of pear oligose alcohol, 2 parts of ubiquinone.
The preparation method of Essence, comprises the following steps:
The first step:Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol and ubiquinone are added to the aqueous phase of homogeneous emulsifying machine In pot container, at a temperature of 85 DEG C with 900r/min rotating speed under stir 10min, obtain aqueous phase material after well mixed;
Second step:Caprylic/capric triglyceride, ethanol and lecithin are added in the oil phase pot container of homogeneous emulsifying machine, At a temperature of 85 DEG C with the rotating speed in 900r/min under stir 15min, obtain oil phase material;
3rd step:Oil phase material is added in aqueous phase material, 6min is stirred with 900r/min rotating speed at a temperature of 85 DEG C;
4th step:35 DEG C are cooled to, after standing 24 hours, filtering and discharging, inspection, filling and package, that is, obtains the present invention's Wrinkle resistance, whitening Essence.
Embodiment 2
A kind of Essence, it is made up of the raw material of following components by weight percent:70 parts of water, 3 parts of caprylic/capric triglyceride, 1,2- 5 parts of pentanediol, 4 parts of glycerine, 4 parts of ethanol, 3 parts of xanthans, 5 parts of lecithin, 2 parts of pear oligose alcohol, 2 parts of ubiquinone, 1 part of whitening agent.
The whitening agent is:Four hexyl decyl alcohol acid ascorbyl esters and 3-O- ethylascorbyls ether are 1 in mass ratio:1 group Into.
The preparation method of Essence, comprises the following steps:
The first step:Water, 1,2- pentanediols, glycerine, xanthans, pear oligose alcohol and ubiquinone are added to the aqueous phase of homogeneous emulsifying machine In pot container, at a temperature of 85 DEG C with 900r/min rotating speed under stir 10min, obtain aqueous phase material after well mixed;
Second step:Caprylic/capric triglyceride, ethanol, whitening agent and lecithin are added to the oil phase pot of homogeneous emulsifying machine In container, at a temperature of 85 DEG C with the rotating speed in 900r/min under stir 15min, obtain oil phase material;
3rd step:Oil phase material is added in aqueous phase material, 6min is stirred with 900r/min rotating speed at a temperature of 85 DEG C;
4th step:35 DEG C are cooled to, after standing 24 hours, filtering and discharging, inspection, filling and package, that is, obtains the present invention's Wrinkle resistance, whitening Essence.
Embodiment 3
Embodiment 3 is substantially the same manner as Example 2, and unique difference is:Four hexyl decyl alcohols that the whitening agent is 100% resist Bad hematic acid ester.
Embodiment 4
Embodiment 4 is substantially the same manner as Example 2, and unique difference is:The 3-O- ethyls that the whitening agent is 100% are anti-bad Hematic acid ether.
Test case 1:Whitening performance test
The whitening performance of embodiment 1-4 wrinkle resistance, whitening Essence is tested.Every group of experimental selection 20 20-60 year Healthy women volunteer, for subject without skin medical history, recipient site is normal, and tested first 15 days and tested period do not smear Any medicine or Essence unrelated with experiment.Melanin content in human body skin is measured, to U.S. of crease-resistant cleawhite over-night essences Contour painting effect is evaluated.
1 day before wrinkle resistance, whitening Essence and the crease-resistant U.S. of continuous use are being used using MEXAMETER MX18 skin pigments instrument White Essence determines the melanin content of its skin of face after 14 days.Determination of the environment:Test environment temperature (22 ± 1) DEG C, humidity (50 ± 5) %, averages.Study subject uses a wrinkle resistance, whitening elite liquid product daily, and application method is:Clean face After skin, dry, 2g wrinkle resistance, whitening Essences are applied on facial skin with hand.Study subject is during test without using it His whitening product.Measured value is higher, illustrates that melanin content is higher in skin.
Melanin reduced rate=(use the melanin content-continuous use wrinkle resistance, whitening essence of 1 day before wrinkle resistance, whitening Essence Magnificent liquid melanin content after 14 days) ÷ uses melanin content × 100% of 1 day before wrinkle resistance, whitening Essence.
Melanin reduced rate is higher, illustrates that whitening effect is better.Specific test result is shown in Table 1.After carry out statistics Analysis, each group comparative result show that P < 0.05, difference has statistical significance.
Table 1:Whitening performance test data table
Melanin reduced rate, %
Embodiment 1 4.5
Embodiment 2 8.1
Embodiment 3 6.9
Embodiment 4 6.6
Test case 2:Anti-aging is tested
The anti-aging performance of embodiment 1-4 wrinkle resistance, whitening Essence is tested.
1st, skin elasticity is tested:It 30 is women that test object, which is, and the age is 35 years old, health.Tester is Germany CK companies skin elasticity tester MPA580 Reviscometer RV600 (elastic fibrous tissue's test probe), survey five times and take Average value.
Test condition:(1) indoor environment;(2) without sunburst or light direct projection;(3) 20 ± 2 DEG C of environment temperature, environment Humidity 40-60%.
Test zone:Left cheekbone portion.
Testing procedure:First measure the blank value (R20, R50, R70) of 30min after tested region clean, then provide by Examination person adheres to the product using embodiment sooner or later daily, test zone skin elasticity index R22, R52, R72 value after testing 2 weeks (it is 450mbar that negative pressure is constant in test process).
Index explanation:For skin elasticity index R20, R50, R70, R22, R52, R72 closer to 1, the elasticity of skin is better.Its In, R2=Ua/Uf;R5=Ur/Ue;R7=Ur/Uf.Uf is skin maximum tension amount, after Ue is added on skin for constant negative pressure, The amount of tension of skin during 0.1s, positioning elastic part amount of tension.After Ur is cancels negative pressure, skin can restore to the original state rapidly state, together Sample is divided into elastic portion score value Ur, that is, after cancelling negative pressure 0.1s, the recovery value and visco-elastic portions value of skin, or shaping part Value.Ua be from the recovery value for cancelling negative pressure to skin when follow-on test skin surface adds negative pressure again next time, calculate R2 growth rates, R5 growth rates and R7 growth rates, acquired results are shown in Table 2.
R2 growth rates=(R22-R20) ÷ R20 × 100%
R5 growth rates=(R52-R50) ÷ R50 × 100%
R7 growth rates=(R72-R70) ÷ R70 × 100%
Table 2:Anti-aging performance test data table
R2 growth rates, % R5 growth rates, % R7 growth rates, %
Embodiment 1 69.2 54.5 59.3
Embodiment 2 69.8 54.7 59.6
Embodiment 3 68.6 53.2 58.6
Embodiment 4 68.3 53.0 58.2
As can be seen from Table 2:After the product of embodiment, skin elasticity index has larger lifting, illustrates this hair It is bright that there are preferable anti-aging effects.
Above example is used for illustrative purposes only, rather than limitation of the present invention, the technology people about technical field Member, without departing from the spirit and scope of the present invention, can also make various conversion or modification.

Claims (5)

1. a kind of wrinkle resistance, whitening Essence, including following raw material:Water, caprylic/capric triglyceride, 1,2- pentanediol, glycerine, second Alcohol, xanthans, lecithin.
2. a kind of wrinkle resistance, whitening Essence, include the raw material of following components by weight percent:Water 60-80 parts, caprylic/capric triglyceride 2- 4 parts, 1,2- pentanediol 3-8 parts, glycerine 2-6 parts, ethanol 3-5 parts, xanthans 2-4 parts, lecithin 3-10 parts.
3. a kind of wrinkle resistance, whitening Essence, include the raw material of following components by weight percent:Water 60-80 parts, caprylic/capric triglyceride 2- 4 parts, 1,2- pentanediol 3-8 parts, glycerine 2-6 parts, ethanol 3-5 parts, xanthans 2-4 parts, lecithin 3-10 parts, pear oligose alcohol 1-3 Part.
4. a kind of wrinkle resistance, whitening Essence, include the raw material of following components by weight percent:Water 60-80 parts, caprylic/capric triglyceride 2- 4 parts, 1,2- pentanediol 3-8 parts, glycerine 2-6 parts, ethanol 3-5 parts, xanthans 2-4 parts, lecithin 3-10 parts, pear oligose alcohol 1-3 Part, ubiquinone 1-3 parts.
A kind of 5. wrinkle resistance, whitening Essence as claimed in claim 4, it is characterised in that:Also include 0.5-2.5 part whitening agents.
CN201710795628.9A 2017-09-06 2017-09-06 Wrinkle resistance, whitening Essence Pending CN107432836A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394639A (en) * 2018-11-12 2019-03-01 广东科玮生物技术股份有限公司 A kind of anti-ageing activating essence and preparation method thereof containing ferment

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEILA_LI: "DMS 辅酶Q10纳米精华", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_D6F8156440.HTML》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394639A (en) * 2018-11-12 2019-03-01 广东科玮生物技术股份有限公司 A kind of anti-ageing activating essence and preparation method thereof containing ferment

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