CN107412318A - A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound - Google Patents
A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound Download PDFInfo
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- CN107412318A CN107412318A CN201710408814.2A CN201710408814A CN107412318A CN 107412318 A CN107412318 A CN 107412318A CN 201710408814 A CN201710408814 A CN 201710408814A CN 107412318 A CN107412318 A CN 107412318A
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- CN
- China
- Prior art keywords
- enoxolone
- glycyrrhizic acid
- supernatant
- flavonoids compound
- divalent metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims abstract description 22
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960003720 enoxolone Drugs 0.000 claims abstract description 22
- -1 liquorice flavonoids compound Chemical class 0.000 claims abstract description 19
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 claims abstract description 18
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims abstract description 15
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 15
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000001685 glycyrrhizic acid Substances 0.000 claims abstract description 15
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 15
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 15
- 239000006228 supernatant Substances 0.000 claims abstract description 15
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 14
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 14
- 229930003935 flavonoid Natural products 0.000 claims abstract description 14
- 235000017173 flavonoids Nutrition 0.000 claims abstract description 14
- 235000011477 liquorice Nutrition 0.000 claims abstract description 14
- 239000002244 precipitate Substances 0.000 claims abstract description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 9
- 239000000047 product Substances 0.000 claims abstract description 8
- 239000003513 alkali Substances 0.000 claims abstract description 6
- 239000000725 suspension Substances 0.000 claims abstract description 5
- 238000001556 precipitation Methods 0.000 claims abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 24
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 8
- 239000000292 calcium oxide Substances 0.000 claims description 6
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 5
- 230000033228 biological regulation Effects 0.000 claims description 4
- 239000000395 magnesium oxide Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 239000000920 calcium hydroxide Substances 0.000 claims description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 3
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 3
- 239000000347 magnesium hydroxide Substances 0.000 claims description 3
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 238000012797 qualification Methods 0.000 abstract description 4
- 239000013049 sediment Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 description 6
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 229910052681 coesite Inorganic materials 0.000 description 3
- 229910052906 cristobalite Inorganic materials 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229910052682 stishovite Inorganic materials 0.000 description 3
- 229910052905 tridymite Inorganic materials 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000011435 rock Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 229930194248 Licoflavone Natural products 0.000 description 1
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 206010041277 Sodium retention Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052593 corundum Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 229910001845 yogo sapphire Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of efficiency to reduce the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, comprises the following steps:4 5% salt containing divalent metal ion is added in alkali suspension, is stirred 60 minutes, during precipitometer, sediment discards, and collects supernatant, adds appropriate hydrochloric acid, it is 5 to adjust pH value, precipitation, is centrifuged, and supernatant discards, taking precipitate is washed to pH value as 7, centrifuge, abandoning supernatant, taking precipitate it is dry finished product.Present invention reduces content of the glycyrrhetic acid content without reducing active ingredient, product qualification rate is substantially increased, qualification rate is by original 30% to 95%.
Description
Technical field
The present invention relates to liquorice flavonoids compound technical field, more particularly to a kind of efficiency to reduce licoflavone class chemical combination
The method of glycyrrhizic acid and enoxolone in thing.
Background technology
Liquorice flavonoids compound has the effect such as antitumor, anti-inflammatory, anti-oxidant, anti-arrhythmia, liver protection.From radix glycyrrhizae or
When liquorice flavonoids compound is extracted in glycyrrhiza extract, part glycyrrhizic acid and enoxolone, glycyrrhizic acid and radix glycyrrhizae are often extracted
Hypo acid may cause the side effects such as water-sodium retention after being taken in by human body, therefore glycyrrhizic acid (enoxolone) is usually listed in radix glycyrrhizae
Limitation in flavone compound medicine checks part.
Diatomite is a kind of siliceous rock, is a kind of biogenic siliceous sedimentary rock, it is mainly by the something lost of ancient times diatom
The bones of the body are formed.Its chemical composition contains a small amount of Fe2O3, CaO, MgO, Al2O3 and organic impurities based on SiO2.Diatomite
It is in generally light yellow or light grey, matter is soft, porous and light, decolorising agent and super-cell, catalyst on pharmacy food technology
Carrier etc..Experiment shows that SiO2 plays stabilization to active component, and increases with K2O or Na2O contents and strengthen.Catalyst
Activity is also relevant with the decentralization and pore structure of carrier.After diatomite acid treatment, oxide impurity content reduces, SiO2 contents
Increase, specific surface area and pore volume also increase, so the carrier effect of terra silicea purificata is better than natural diatomaceous earth.So multi-party experiment
We employ diatomite as precipitating reagent, shorten the sedimentation time during alkali soluble, improve separating effect.Recycle diatomite
Glycyrrhizic acid and enoxolone are reduced containing calcium salt, is killed two birds with one stone.
Existing method treatment effect is undesirable, because liquorice flavonoids compound active ingredient molecule and enoxolone phase
Closely, property is close, reduces glycyrrhetic acid content simultaneously and reduces the content of active ingredient, it is qualified to influence product.
The content of the invention
It is an object of the invention to provide a kind of efficiency to reduce glycyrrhizic acid and enoxolone in liquorice flavonoids compound
Method, to solve above-mentioned technical problem.
The present invention uses following technical scheme to achieve the above object：
A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, comprises the following steps:
The 4-5% salt containing divalent metal ion is added in alkali suspension, is stirred 60 minutes, during precipitometer, sediment discards, and receives
Collect supernatant, add appropriate hydrochloric acid, regulation pH value is 5, precipitates, centrifuges, supernatant discards, and taking precipitate is washed to pH value and is
7, centrifuge, abandoning supernatant, taking precipitate it is dry finished product.
Preferably, the salt containing divalent metal ion is calcium oxide, calcium hydroxide, magnesia, magnesium hydroxide, silica
Any or its composition.
Preferably, the salt containing divalent metal ion is diatomite.
The beneficial effects of the invention are as follows：Content present invention reduces glycyrrhetic acid content without reduction active ingredient, greatly
Product qualification rate is improved greatly, qualification rate is by original 30% to 95%.
Embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
Only part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belong to the model that the present invention protects
Enclose.
A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, comprises the following steps:
The 4-5% salt containing divalent metal ion is added in alkali suspension, is stirred 60 minutes, during precipitometer, sediment discards, and receives
Collect supernatant, add appropriate hydrochloric acid, regulation pH value is 5, precipitates, centrifuges, supernatant discards, and taking precipitate is washed to pH value and is
7, centrifuge, abandoning supernatant, taking precipitate it is dry finished product.
Salt containing divalent metal ion be calcium oxide, calcium hydroxide, magnesia, magnesium hydroxide, silica it is any or
Its composition or diatomite.
By taking diatomite as an example：Add different diatomite amounts in the alcohol extract of 500ml workshops, addition design be respectively 10g,
15g, 20g, 25g, 30g, stir 60 minutes, subsequent step imitates plant manufacturing process and liquorice flavonoids compound is made, and determines
Its enoxolone amount, glycyrrhetic acid content are respectively 1.21%, 0.92%, 0.89%, 1.12%, 1.05%, enoxolone point
37.2%, 40.6%, 41.5%, 39.1% is not reduced.
By taking calcium oxide as an example：5% calcium oxide is added in alkali suspension, is stirred 60 minutes, during precipitometer, sediment is abandoned
Go, collect supernatant, add appropriate hydrochloric acid, regulation pH value is 5, precipitates, centrifuges, supernatant is discarded, and taking precipitate is washed to
PH value is 7, centrifuge, abandoning supernatant, taking precipitate it is dry finished product, measure can reduce by more than 40% enoxolone.
Prove that diatomite can effectively reduce the content of glycyrrhizic acid and enoxolone by above-mentioned experiment.Contain divalent metal
The salt of ion can be used for the removal of glycyrrhizic acid and enoxolone, extracting and developing in liquorice flavonoids compound.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (3)
1. a kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound, it is characterised in that including such as
Lower step:The 4-5% salt containing divalent metal ion is added in alkali suspension, is stirred 60 minutes, during precipitometer, precipitation
Thing discards, and collects supernatant, adds appropriate hydrochloric acid, and regulation pH value is 5, precipitates, centrifuges, supernatant discards, taking precipitate water
PH value is washed till as 7, is centrifuged, abandoning supernatant, taking precipitate it is dry finished product.
2. a kind of efficiency according to claim 1 reduces the side of glycyrrhizic acid and enoxolone in liquorice flavonoids compound
Method, it is characterised in that the salt containing divalent metal ion is calcium oxide, calcium hydroxide, magnesia, magnesium hydroxide, silica times
A kind of or its composition.
3. a kind of efficiency according to claim 1 reduces the side of glycyrrhizic acid and enoxolone in liquorice flavonoids compound
Method, it is characterised in that the salt containing divalent metal ion is diatomite.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710408814.2A CN107412318A (en) | 2017-06-02 | 2017-06-02 | A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710408814.2A CN107412318A (en) | 2017-06-02 | 2017-06-02 | A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107412318A true CN107412318A (en) | 2017-12-01 |
Family
ID=60429429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710408814.2A Pending CN107412318A (en) | 2017-06-02 | 2017-06-02 | A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107412318A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803789A (en) * | 2006-01-20 | 2006-07-19 | 华中科技大学 | Method for extracting glycyrrhizicacid, licorice flavone and licorice polysaccharide |
| CN102276678A (en) * | 2011-06-02 | 2011-12-14 | 甘肃亚兰药业有限公司 | Method for preparing glycyrrhetinic acid |
| CN104147096A (en) * | 2014-08-15 | 2014-11-19 | 宝鸡金森制药有限公司 | Preparation method for licorice fluid extract |
| CN104725458A (en) * | 2015-02-15 | 2015-06-24 | 李玉山 | Preparation method of sodium glycyrrhizinate and hydrates thereof |
| CN106376820A (en) * | 2016-08-30 | 2017-02-08 | 新疆全安药业股份有限公司 | Solid drink for dispelling stomach cold and protecting gastric mucosa and preparation method thereof |
-
2017
- 2017-06-02 CN CN201710408814.2A patent/CN107412318A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803789A (en) * | 2006-01-20 | 2006-07-19 | 华中科技大学 | Method for extracting glycyrrhizicacid, licorice flavone and licorice polysaccharide |
| CN102276678A (en) * | 2011-06-02 | 2011-12-14 | 甘肃亚兰药业有限公司 | Method for preparing glycyrrhetinic acid |
| CN104147096A (en) * | 2014-08-15 | 2014-11-19 | 宝鸡金森制药有限公司 | Preparation method for licorice fluid extract |
| CN104725458A (en) * | 2015-02-15 | 2015-06-24 | 李玉山 | Preparation method of sodium glycyrrhizinate and hydrates thereof |
| CN106376820A (en) * | 2016-08-30 | 2017-02-08 | 新疆全安药业股份有限公司 | Solid drink for dispelling stomach cold and protecting gastric mucosa and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郝利平等: "《食品添加剂》", 31 July 2016, 中国农业大学出版社 * |
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| PB01 | Publication | ||
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Application publication date: 20171201 |