CN107375366A - Ointment for treating solar dermatitis and preparation method thereof - Google Patents
Ointment for treating solar dermatitis and preparation method thereof Download PDFInfo
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- CN107375366A CN107375366A CN201710822595.2A CN201710822595A CN107375366A CN 107375366 A CN107375366 A CN 107375366A CN 201710822595 A CN201710822595 A CN 201710822595A CN 107375366 A CN107375366 A CN 107375366A
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- 239000002674 ointment Substances 0.000 title claims abstract description 29
- 206010041303 Solar dermatitis Diseases 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000003756 stirring Methods 0.000 claims abstract description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 41
- 241001533159 Brucea javanica Species 0.000 claims abstract description 19
- 235000010889 Rhus javanica Nutrition 0.000 claims abstract description 19
- 229940105847 calamine Drugs 0.000 claims abstract description 19
- 229910052864 hemimorphite Inorganic materials 0.000 claims abstract description 19
- 239000004575 stone Substances 0.000 claims abstract description 19
- 235000014692 zinc oxide Nutrition 0.000 claims abstract description 19
- 239000011787 zinc oxide Substances 0.000 claims abstract description 19
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 claims abstract description 19
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims abstract description 14
- 229960003022 amoxicillin Drugs 0.000 claims abstract description 14
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 210000004700 fetal blood Anatomy 0.000 claims abstract description 3
- 239000011505 plaster Substances 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 17
- 238000004321 preservation Methods 0.000 claims description 13
- 229910000831 Steel Inorganic materials 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- 239000010959 steel Substances 0.000 claims description 12
- 210000002969 egg yolk Anatomy 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 230000019612 pigmentation Effects 0.000 abstract description 10
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 description 46
- 230000000052 comparative effect Effects 0.000 description 19
- 229940079593 drug Drugs 0.000 description 5
- 230000000857 drug effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 3
- 239000002075 main ingredient Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 1
- 229960001140 cyproheptadine Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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- Botany (AREA)
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Abstract
The present invention relates to pharmaceutical field, specifically discloses a kind of ointment for being used to treat solar dermatitis, and its preparation method is：Java brucea is crushed, mixed in the lump with Amoxicillin and calamine stone, mass fraction is added and is stirred for 80% 90% ethanol, egg oil is then added, stirs, obtain thick plaster, encapsulate, Cord blood.Ointment preparation method of the present invention is simple, and the effect for treating solar dermatitis is good, and moreover, the pigmentation after drug withdrawal at sufferer is few so that the normal colour of skin can be recovered at sufferer in the short period of time, it is deep to be liked by patient.
Description
Technical field
The present invention relates to pharmaceutical field, and in particular to a kind of to be used to treat medicine of solar dermatitis and preparation method thereof.
Background technology
The fash occurred after solar radiation, referred to as solar dermatitis, it that is to say the solar dermatitis alleged by doctor trained in Western medicine and photosensitive skin
It is scorching.There is red swelling of the skin in exposure portion in a few hours typically after being exposed to the sun, can also play blister or bleb, be that one kind is drawn by light
Allergic reaction dermatoses rising, betiding exposure portion.Cutaneous lesion has burn feeling, gargalesthesia or shouting pain.The lighter 1-2 days
Fash can gradually disappear, and have furfur or leave different degrees of pigmentation；Severe one can such as be sent out with similar cold symptoms
Burning, weak, general malaise etc., it can recover within about one week or so.For patients with mild, it can use outside the anti-inflammatory medicine of dilution and wipe, sternly
Severe one can beyond wipe on the basis of, oral 2mg antithistamines cyproheptadine 3 times a day.But above method treatment solar dermatitis is present
Course for the treatment of length, the deficiency of weak curative effect.
The traditional Chinese medical science thinks that solar dermatitis is more due under sunlight exposure, the evil intrusion body surface of positive heat toxin, accumulateing strongly fragrant skin, skin wound of burning
Flesh and cause, it is scorchingly hot folder summer-heat and damp or with interior wet knot of fighting, contamination skin caused by.Therefore, based on Chinese medicine principle, if preparing Chinese and Western knot
The medicine of conjunction will effectively improve the therapeutic effect of solar dermatitis.
The content of the invention
The primary and foremost purpose of the present invention is to provide a kind of be formulated simply, using the eutherapeutic ointment for being used to treat solar dermatitis.
To achieve the above object, the technical solution adopted by the present invention is：A kind of ointment for being used to treat solar dermatitis：It includes
The raw material of following parts by weight：Amoxicillin 5-15 parts, egg oil 20-30 parts, Java brucea 2-8 parts, calamine stone 2-8 parts, matter
Measure the ethanol 3-10 that fraction is 85%-90%.
Ointment disclosed by the invention has advantages below：1st, raw material is easy to get, is formulated simply；2nd, it is low to prepare cost；3rd, use
Effect is good.
It is that the parts by weight of each raw material are as further preferred scheme：Amoxicillin 6-8 parts, egg oil 26-30
Part, Java brucea 2-4 parts, calamine stone 2-4 parts, the ethanol 4-7 that mass fraction is 85%-90%.
Another object of the present invention is to provide a kind of ointment preparation method for being used to treat solar dermatitis as described above, its
Step is as follows：Java brucea is crushed, mixed in the lump with Amoxicillin and calamine stone, it is 85%-90%'s to add mass fraction
Ethanol stirs, and then adds egg oil, stirs, encapsulates, Cord blood.
It is using beneficial effect caused by above-mentioned technical proposal：Ointment preparation method of the present invention is simple, processing
Easy control of process conditions, and the affected part of patient can fully recover quickly during use, moreover, skin can also recover normal quickly
The colour of skin.Specifically, being coated now at the beginning of solar dermatitis, effect is especially notable, weight patient coat be within 2-3 days it is visible be clearly better, 4-5
It can thoroughly be fully recovered, and calm pigment is substantially desalinated after 10-15 days, and using effect is good, firmly get liking for people.It is of the present invention
Ointment raw material is easy to get, and preparation cost is low, and it can both be produced in batches processing sell by pharmacy corporation, and user can also oneself purchase
Buy material to be in preparation, be very easy to realize, therefore can also the popularization and application in life.
Main ingredient composition in ointment of the present invention is Amoxicillin and egg oil, and other several raw materials belong to auxiliary material group
Point, although also playing the role of that treatment solar dermatitis can be played when disclosing some component individualisms in the present invention in the prior art,
But there is slow curative effect and deposit after recovery at sufferer the problem of pigmentation in it.And drug effect, the pharmacology of each component are multiple
It is miscellaneous, not in the related change of ratio between therapeutic effect and each component.Applicant is had been surprisingly found that by largely testing, and is passed through
Formula provided by the invention carries out compatibility, and it is good that it not only treats the effect of solar dermatitis, and after being discontinued, the pigmentation at sufferer
It is few so that the skin at sufferer can recover the normal colour of skin in the short period of time, achieve unexpected technique effect.
Specific scheme is that the preparation method of the egg oil is：Raw egg is cooked, peeled off, is placed in small fire in frying pan
Smash to pieces and stir 15-25mim, cool down, dregs of fat mixture is filtered, obtain egg oil.The preparation of egg oil generally needs to follow elder generation
Small fire is fuel-displaced, and rear moderate heat improves the principle of oil yield, and initial stage, fire easily caused egg to burn very much greatly, do not simply fail to it is fuel-displaced, and
Even if fuel-displaced, it also has smell of scorching, influences the using effect of medicine.
Preferably, when stirring egg, first smashed to pieces under the conditions of 45-50 DEG C of pot temperature and stir 10-15min, then in 70-75
DEG C pot temperature under the conditions of smash to pieces and stir 5-8min, can so greatly improve the oil yield of egg and the preparation quality of egg oil.
Specifically, the ointment being prepared is placed in preservation under -4~0 DEG C of cryogenic conditions, experiment proves that, in the temperature
Being preserved in the range of degree can ensure in ointment 1 year using effective.In addition, it is necessary to supplementary notes, Amoxicillin autopath
Disable ointment of the present invention.
Further, the dregs of fat mixture after cooling is to use aperture as 0.5-1mm steel wire net filtration, obtains egg oil,
Egg residue therein can so be effectively filtered out.
Compared with prior art, the present invention is using egg oil, Java brucea, calamine stone and the Western medicine group equivalent to Chinese medicine
Point Amoxicillin is prepared, while adds the ethanol that a small amount of mass fraction is 80%-90%, although formula material species
It is few, but drug effect is notable, affected part calmness pigment takes off soon.
Embodiment
To further illustrate technical scheme, 1-6 and comparative example 1-5 makees further by the following examples
It is bright.
Embodiment 1：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 3g to crush, is mixed in the lump with 7g Amoxicillins, 3g calamine stones, is added 5g mass fractions and is
85%-90% ethanol stirs, and then adds 28g eggs oil, stirs, encapsulate, is subsequently placed in -4~0 DEG C low
Preservation under the conditions of temperature, using being valid for one year.
Embodiment 2：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 2g to crush, is mixed in the lump with 7g Amoxicillins, 2g calamine stones, is added 6g mass fractions and is
85%-90% ethanol stirs, and then adds 29g eggs oil, stirs, encapsulate, is subsequently placed in -4~0 DEG C low
Preservation under the conditions of temperature, using being valid for one year.
Embodiment 3：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 4g to crush, is mixed in the lump with 7g Amoxicillins, 4g calamine stones, is added 5g mass fractions and is
85%-90% ethanol stirs, and then adds 30g eggs oil, stirs, encapsulate, is subsequently placed in -4~0 DEG C low
Preservation under the conditions of temperature, using being valid for one year.
Embodiment 4：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
15min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 5min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 4g to crush, is mixed in the lump with 7g Amoxicillins, 4g calamine stones, is added 5g mass fractions and is
85%-90% ethanol stirs, and then adds 29g eggs oil, stirs, encapsulate, is subsequently placed in -4~0 DEG C low
Preservation under the conditions of temperature, using being valid for one year.
Embodiment 5：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 6g to crush, is mixed in the lump with 10g Amoxicillins, 6g calamine stones, is added 8g mass fractions and is
85%-90% ethanol stirs, and then adds 24g eggs oil, stirs, encapsulate, is subsequently placed in -4~0 DEG C low
Preservation under the conditions of temperature, using being valid for one year.
Embodiment 6：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 8g to crush, is mixed in the lump with 15g Amoxicillins, 8g calamine stones, is added 10g mass fractions and is
85%-90% ethanol stirs, and then adds 30g eggs oil, stirs, encapsulate, is subsequently placed in -4~0 DEG C low
Preservation under the conditions of temperature, using being valid for one year.
Comparative example 1：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 4g to crush, is mixed in the lump with 4g calamine stones, adds the second that 5g mass fractions are 85%-90%
Alcohol stirs, and then adds 28g eggs oil, stirs, encapsulates, be subsequently placed in preservation under -4~0 DEG C of cryogenic conditions.
Comparative example 2：
The ethanol that 5g mass fractions are 85%-90% is added into 7g Amoxicillins to stir, and is encapsulated, so
Preservation under -4~0 DEG C of cryogenic conditions is placed in afterwards.
Comparative example 3：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) 7g Amoxicillins and 4g calamine stones are mixed, it is equal adds the ethanol stirring that 5g mass fractions are 85%-90%
It is even, 29g eggs oil is then added, is stirred, encapsulates, preservation under -4~0 DEG C of cryogenic conditions is subsequently placed in, using effective
1 year phase.
Comparative example 4：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 3g to crush, is mixed in the lump with 20g Amoxicillins, 3g calamine stones, is added 5g mass fractions and is
85%-90% ethanol stirs, and then adds 35g eggs oil, stirs, encapsulate, is subsequently placed in -4~0 DEG C low
Preservation under the conditions of temperature.
Comparative example 5：
1) 10 raw eggs are taken, is cooked, is peeled off, take yolk to be placed in frying pan, are smashed to pieces under the conditions of being first 45-50 DEG C in pot temperature
8min is stirred, is then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stirs 6min, is cooled down, with aperture is 0.5- by dregs of fat mixture
1mm steel wire net filtration, obtain egg oil；
2) Java brucea for taking 10g to crush, is mixed in the lump with 7g Amoxicillins, 10g calamine stones, adds 12g mass fractions
Stirred for 85%-90% ethanol, then add 28g eggs oil, stir, encapsulate, be subsequently placed in -4~0 DEG C
Preservation under cryogenic conditions, using being valid for one year.
Medicine prepared by above example and comparative example can be used safely in the outer of skin and smear, certainly for Amoxicillin mistake
Quick patient, in addition to comparative example 1, other obtained medicines disable.
Medicine contrast test：
Tested respectively using medicine made from above example 1-6 and comparative example 1-5, every group of experiment chose for 10 day
Shine sore severe patient.Compared with embodiments of the invention, comparative example 1 is not add western medicine component Amoxicillin；Comparative example 2 is only
With ethanol and western medicine component Amoxicillin；Comparative example 3 does not add auxiliary material component Java brucea；Comparative example 4 is main ingredient composition egg
The amount ranges that the dosage of oil and Amoxicillin is protected beyond the present invention；Comparative example 5 is auxiliary material component Java brucea, calamine stone
The amount ranges protected with the dosage of ethanol beyond the present invention.Medicine frequency of this experiment is each in the morning, afternoon and evening daily outer to smear one
It is secondary.Drug effect is divided into four judged results：1st, cure, i.e., the symptom such as solar dermatitis clinical manifestation redness, blister disappears；2nd, it is effective, i.e.,
Cardinal symptom and sore face substantially mitigate；3rd, effectively, i.e., cardinal symptom and sore face mitigate；4th, invalid, i.e., cardinal symptom is entirely without change
Change, now to avoid delaying patient's treatment, medicine used can be abandoned and continue to try out.In addition, observation be discontinued 30 days after affected part
Pigmentation level, divide Three Estate：A levels, pigmentation are very deep, it will be apparent that；B levels, pigmentation is deeper, more apparent；C
Level, pigmentation is shallow, unobvious；D levels, substantially colorless element are calm.Experiment and result are as shown in the table.
The Composition analyzed result of table 1
As can be seen from Table 1：1st, embodiment 1-4 is using optimization formula, and it is best to be made the drug effect of ointment, wherein
30 days after being discontinued using embodiment 1-2 ointment, the substantially colorless element of skin is calm, is optimal preparation method；2nd, with embodiment 1-4
Compare, embodiment 5-6 ointment drug effects are slightly secondary, and pigmentation level and embodiment 3-4 are similar, and generally effect is also than existing skill
Art will get well；Although comparative example 1,3-5 are curative effects, healing time length, and in addition to comparative example 3, after other medicines use
Pigmentation is all deep, so hardly resulting in the favor of patient；Comparative example 2 using 1 day to no effect, to delay the state of an illness, thus not followed by
It is continuous to try out the medicine.From the experiment of comparative example and from result it is recognised that using Chinese medicine of the present invention or west merely
Ointment made from medicine is all difficult to the effect of the treatment solar dermatitis obtained, or even some without effect, in addition, for not in this hair
The ointment of comparative example 4,5 in bright disclosed formula protection domain, its using effect are also substantially not so good as embodiments of the invention
Ointment made from 1-6.
By more than test, using ointment made from method disclosed by the invention can meet simultaneously using curative effect with
Pigmented requirement is avoided, meanwhile, the technique effect that the ointment can be generated also is not simple conventional constituents superposition institute
It can realize.
Claims (7)
- A kind of 1. ointment for being used to treat solar dermatitis：It includes the raw material of following parts by weight：Amoxicillin 5-15 parts, egg oil 20-30 parts, Java brucea 2-8 parts, calamine stone 2-8 parts, the ethanol 3-10 that mass fraction is 85%-90%.
- 2. the ointment according to claim 1 for being used to treat solar dermatitis：The parts by weight of each raw material are：Amoxicillin 6-8 Part, egg oil 26-30 parts, Java brucea 2-4 parts, calamine stone 2-4 parts, the ethanol 4-7 that mass fraction is 85%-90%.
- 3. a kind of ointment preparation method for being used to treat solar dermatitis as claimed in claim 1 or 2, its step are as follows：By Java brucea Crush, mixed in the lump with Amoxicillin and calamine stone, add the ethanol that mass fraction is 80%-90% and stir, then Egg oil is added, stirs, obtains thick plaster, is encapsulated, Cord blood.
- 4. the ointment preparation method according to claim 3 for being used to treat solar dermatitis, it is characterised in that：The egg oil Preparation method is：Raw egg is cooked, peeled off, takes yolk to be placed in small fire in frying pan and smash to pieces and stirs 15-25mim, is cooled down, by the dregs of fat Mixture filters, and obtains egg oil.
- 5. the ointment preparation method according to claim 4 for being used to treat solar dermatitis, it is characterised in that：When stirring egg, First smashed to pieces under the conditions of 45-50 DEG C of pot temperature and stir 10-15min, then smashed to pieces under the conditions of 70-75 DEG C of pot temperature and stir 5- 8min。
- 6. the ointment preparation method according to claim 4 for being used to treat solar dermatitis, it is characterised in that：The medicine being prepared Cream is placed in preservation under -4~0 DEG C of cryogenic conditions.
- 7. the ointment preparation method according to claim 4 for being used to treat solar dermatitis, it is characterised in that：The dregs of fat after cooling Mixture is to use aperture as 0.5-1mm steel wire net filtration, obtains egg oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710822595.2A CN107375366A (en) | 2017-09-13 | 2017-09-13 | Ointment for treating solar dermatitis and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050207998A1 (en) * | 2003-07-21 | 2005-09-22 | Yaoping Lu | Caffeine salt complexes and methods for using the same in the prevention or treatment of cancer |
| CN105582243A (en) * | 2016-01-21 | 2016-05-18 | 孙胜波 | Traditional Chinese medicine composition for treating solar dermatitis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050207998A1 (en) * | 2003-07-21 | 2005-09-22 | Yaoping Lu | Caffeine salt complexes and methods for using the same in the prevention or treatment of cancer |
| CN105582243A (en) * | 2016-01-21 | 2016-05-18 | 孙胜波 | Traditional Chinese medicine composition for treating solar dermatitis |
Non-Patent Citations (3)
| Title |
|---|
| 刘忠恕等主编: "《皮肤科疾病诊断与治疗》", 30 April 2000, 天津科技翻译出版公司 * |
| 李不大主编: "《家庭常见病食疗必读》", 30 September 2005, 中国妇女出版社 * |
| 顾丽萍: "中西医结合治疗日光性皮炎体会", 《内蒙古中医药》 * |
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Application publication date: 20171124 |