CN107199127A - Medicine centrifuges extraction element in a kind of transparent capsule - Google Patents
Medicine centrifuges extraction element in a kind of transparent capsule Download PDFInfo
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- CN107199127A CN107199127A CN201710473174.3A CN201710473174A CN107199127A CN 107199127 A CN107199127 A CN 107199127A CN 201710473174 A CN201710473174 A CN 201710473174A CN 107199127 A CN107199127 A CN 107199127A
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- 239000003814 drug Substances 0.000 title claims abstract description 98
- 229940079593 drug Drugs 0.000 title claims abstract description 69
- 239000002775 capsule Substances 0.000 title claims abstract description 58
- 238000000605 extraction Methods 0.000 title claims description 18
- 238000012377 drug delivery Methods 0.000 claims abstract description 18
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 239000002699 waste material Substances 0.000 abstract description 4
- 229960000074 biopharmaceutical Drugs 0.000 abstract description 2
- 238000004925 denaturation Methods 0.000 abstract description 2
- 230000036425 denaturation Effects 0.000 abstract description 2
- 230000001590 oxidative effect Effects 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 239000000843 powder Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 241000700159 Rattus Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 238000003255 drug test Methods 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000013067 intermediate product Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/08—Rotary bowls
- B04B7/12—Inserts, e.g. armouring plates
- B04B7/16—Sieves or filters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B11/00—Feeding, charging, or discharging bowls
- B04B11/04—Periodical feeding or discharging; Control arrangements therefor
- B04B11/05—Base discharge
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
本发明属于生物制药技术领域，公开了一种透明胶囊内药物离心提取装置，离心固定管内上部通过螺栓固定有胶囊盛装盒；胶囊盛装盒下端铺设有药物过滤网；药物过滤网中心开有孔；孔上镶嵌有药品输送管螺母；所述药品输送管通过螺母内丝与位于药物过滤网下端的药物收集管外丝紧密连接；药物收集管开口端通过螺栓固定在过滤网下端，药物收集管另一端放于离心固定管内下部。本发明适用透明胶囊药物的随时方便利用，实现随用随取，可实现无菌取用，按刻度量取用，避免胶囊内药物漏出过多而造成浪费和不精确；具有无需学生、研究人员或者工人一一剪破，握持，降低药物过久暴露空气氧化变性，降低劳动强度，省时省力的优点。
The invention belongs to the technical field of biopharmaceuticals, and discloses a centrifugal extracting device for medicine in a transparent capsule. A capsule containing box is fixed on the upper part of the centrifugal fixing tube by bolts; a medicine filter is laid on the lower end of the capsule containing box; a hole is opened in the center of the medicine filter; The drug delivery tube nut is inlaid on the hole; the drug delivery tube is tightly connected with the drug collection tube outer thread located at the lower end of the drug filter through the nut inner thread; One end is placed in the lower part of the centrifuge fixed tube. The present invention is suitable for the convenient utilization of transparent capsule medicine at any time, realizes taking aseptically aseptically, and taking according to the scale, so as to avoid waste and inaccuracy caused by excessive leakage of medicine in the capsule; Or the workers cut and hold them one by one, which can reduce the oxidative denaturation of the medicine when it is exposed to the air for a long time, reduce the labor intensity, and save time and effort.
Description
技术领域technical field
本发明属于生物制药技术领域，尤其涉及一种透明胶囊内药物离心提取装置。The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a centrifugal extraction device for drugs in transparent capsules.
背景技术Background technique
目前，由于不同药物的粉体直径存在差别，因此采用过滤筛进行分离。通过过滤，使得粉体直径较小的药物通过过滤筛，而粉体直径较大的药物滞留在过滤筛上，从而实现了两种药物粉料的分离。At present, due to the difference in powder diameter of different drugs, filter screens are used for separation. Through filtration, the drug with a smaller powder diameter passes through the filter sieve, while the drug with a larger powder diameter stays on the filter sieve, thereby realizing the separation of the two drug powders.
但是，现有的过滤设备采用振动过滤的方法进行过滤，其振动强度较小，无法使容易结团结块的中间产物粉碎，因而使过滤性能大大降低，滞留在过滤筛上的粉料依然是两种药物粉料的混合物。如欲实现完全过滤，则需要长时间的振动使结团结块的中间产物粉碎，其耗时将大大增加。同时，现有的过滤设备结构复杂，相互关联的运动部件过多，导致其故障率高。However, the existing filtering equipment adopts the method of vibrating filtering for filtering, and its vibration intensity is small, and it is impossible to crush the intermediate products that are easy to agglomerate, thereby greatly reducing the filtering performance, and the powder remaining on the filter screen is still two A mixture of drug powders. If complete filtration is to be achieved, long-term vibration is required to pulverize the agglomerated intermediate product, which will greatly increase the time-consuming. At the same time, the existing filter equipment has a complex structure and too many interrelated moving parts, resulting in a high failure rate.
科研中细胞培养，大鼠药物灌胃实验,药物物质基础分析及第三方药物检测等，胶囊内产品收集比较麻烦，而且胶囊内药物在倒出时，有遗漏。In scientific research, such as cell culture, drug gavage experiments in rats, drug material basis analysis and third-party drug testing, etc., the collection of products in capsules is cumbersome, and there are omissions when pouring out the drugs in capsules.
综上所述，现有技术存在的问题是：实验用的胶囊内药物在倒出时，不能全部漏出，造成成浪费和实验不精确；对遗漏的药品需学生、研究人员或者工人一一剪破，握持，非常费力。To sum up, the problems existing in the prior art are: when pouring out the medicines in the capsules used in the experiment, all the medicines in the capsules cannot be leaked out, resulting in waste and inaccurate experiments; the missing medicines need to be cut by students, researchers or workers one by one. Breaking, holding, very laborious.
发明内容Contents of the invention
针对现有技术存在的问题，本发明提供了一种透明胶囊内药物离心提取装置。Aiming at the problems in the prior art, the invention provides a centrifugal extraction device for medicine in a transparent capsule.
本发明是这样实现的，一种透明胶囊内药物离心提取装置，所述透明胶囊内药物离心提取装置的离心固定管内上部通过螺栓固定有胶囊盛装盒；所述胶囊盛装盒下端铺设有药物过滤网；所述药物过滤网中心开有孔；所述孔上镶嵌有药品输送管；所述药品输送管通过螺母内丝与位于药物过滤网下端的药物收集管外丝紧密连接；药物收集管开口端通过螺栓固定在过滤网下端，药物收集管另一端放于离心固定管内下部。The present invention is achieved in this way, a centrifugal extracting device for medicine in a transparent capsule, the upper part of the centrifugal fixing tube of the centrifugally extracting device for medicine in a transparent capsule is fixed with a capsule holding box by bolts; the lower end of the capsule holding box is laid with a medicine filter There is a hole in the center of the drug filter; the hole is inlaid with a drug delivery tube; the drug delivery tube is tightly connected with the outer wire of the drug collection tube at the lower end of the drug filter through the nut inner wire; It is fixed on the lower end of the filter screen by bolts, and the other end of the drug collection tube is placed in the lower part of the centrifuge fixed tube.
进一步，所述药物收集管开口端通过螺栓固定在过滤网下端，药物收集管另一端放于离心固定管内下部。。Further, the open end of the drug collection tube is fixed to the lower end of the filter screen by bolts, and the other end of the drug collection tube is placed in the lower part of the centrifuge fixed tube. .
进一步，所述胶囊盛装盒上端开有胶囊放置口且通过螺纹旋拧有螺旋口盖。Further, the upper end of the capsule containing box is provided with a capsule placement opening and a screw cap is screwed on.
进一步，所述透明胶囊内药物离心提取装置由可蒸汽灭菌塑料和不锈钢材料制成，两种材料均可以实现无菌处理，所获得药物可以无菌过滤。Further, the centrifugal extraction device for the drug in the transparent capsule is made of steam sterilizable plastic and stainless steel, both materials can realize aseptic treatment, and the obtained drug can be aseptically filtered.
进一步，所述药物过滤网为双层过滤结构，上层为不同孔径的过滤片，中间可以安装0.22um和0.45um的微孔纤维素酯膜，下层为安装螺母的过滤片固定结构。Further, the drug filter has a double-layer filter structure, the upper layer is a filter sheet with different pore sizes, the middle layer can be installed with 0.22um and 0.45um microporous cellulose ester membranes, and the lower layer is a filter sheet fixed structure with nuts.
进一步，所述的透明胶囊内药物离心提取装置，其特征在于，所述药品输送管根据药物量的数量，可以采用不同孔径螺母的过滤片固定结构及配套的不同长度的药品输送管。Furthermore, the device for centrifugally extracting drugs in transparent capsules is characterized in that, according to the amount of drugs, the drug delivery tube can adopt filter plate fixing structures of nuts with different apertures and matching drug delivery tubes of different lengths.
进一步，所述透明胶囊内药物离心提取装置药物收集管为带刻度且带盖的试管。Further, the medicine collection tube of the centrifugal extraction device for medicine in the transparent capsule is a test tube with a scale and a cover.
进一步，所述药物收集管和离心固定管的管底的形状相同，一般固定管的管底截面为三角形和圆形。Further, the shape of the tube bottom of the drug collection tube and the centrifuge fixed tube is the same, and generally the section of the bottom of the fixed tube is triangular or circular.
本发明的优点及积极效果为：所述药品输送管为适合于不同药物数量收集可以更换不同长度。所述药物收集管可以不同直径和不同材质(塑料和不锈钢材料)。所述如果各个部件都是可蒸汽灭菌塑料和不锈钢材料，可以高压灭菌，获得的液体直接为无菌的。The advantages and positive effects of the present invention are: the drug delivery tube can be replaced with different lengths for different drug quantity collection. The medicine collecting tube can have different diameters and different materials (plastic and stainless steel materials). Said that if each part is made of steam sterilizable plastic and stainless steel, it can be sterilized by autoclaving, and the obtained liquid is directly sterile.
本发明适用透明胶囊药物的随时方便利用，实现随用随取，按刻度量取用，避免胶囊内药物漏出过多而造成浪费和不精确。本发明无需学生、研究人员或者工人一一剪破胶囊，握持，降低了劳动强度，省时省力。The invention is suitable for the convenient utilization of transparent capsule medicines at any time, realizes the taking-out according to scales, and avoids waste and inaccuracy caused by excessive leakage of medicines in the capsules. The invention does not require students, researchers or workers to cut and hold the capsules one by one, which reduces labor intensity and saves time and effort.
本发明可以保证胶囊内药物的特性、纯度以及保障没有透明胶囊壳的掺杂，同时，可以保证药物的精细过滤，以便于科研中细胞培养，大鼠药物灌胃实验，药物物质基础分析及第三方药物检测等，可以高效，快速地将合格胶囊内产品收集走。The present invention can ensure the characteristics and purity of the medicine in the capsule and ensure that there is no doping of the transparent capsule shell. At the same time, it can ensure the fine filtration of the medicine, so as to facilitate cell culture in scientific research, drug gavage experiments in rats, drug material basis analysis and the first Three-party drug testing, etc., can efficiently and quickly collect products in qualified capsules.
附图说明Description of drawings
图1是本发明实施例提供的透明胶囊内药物离心提取装置示意图。Fig. 1 is a schematic diagram of a centrifugal extraction device for medicine in a transparent capsule provided by an embodiment of the present invention.
图中：1、离心固定管；2、胶囊盛装盒；3、药物过滤网；4、药品输送管螺母；5、药品输送管；6、药物收集管。In the figure: 1. Centrifugal fixing tube; 2. Capsule containing box; 3. Drug filter; 4. Nut of drug delivery tube; 5. Drug delivery tube; 6. Drug collection tube.
具体实施方式detailed description
为能进一步了解本发明的发明内容、特点及功效，兹例举以下实施例，并配合附图详细说明如下。In order to further understand the content, features and effects of the present invention, the following examples are given, and detailed descriptions are given below with reference to the accompanying drawings.
下面结合附图对本发明的结构作详细的描述。The structure of the present invention will be described in detail below in conjunction with the accompanying drawings.
如图1所示，本发明实施例提供的透明胶囊内药物离心提取装置，离心固定管1内上部通过螺栓固定有胶囊盛装盒2；所述胶囊盛装盒2下端铺设有药物过滤网3；所述药物过滤网3中心开有孔4；所述药品输送管螺母4上镶嵌有药品输送管5；所述药品输送管5通过螺母拧接在位于药物过滤网3下层安装螺母的过滤片固定结构上，所述药品输送管5通过螺母内丝与位于药物过滤网下端的药物收集管6外丝紧密连接；药物收集管6开口端通过螺栓固定在过滤网下端，药物收集管另一端放于离心固定管1内下部。As shown in Figure 1, in the centrifugal extraction device for medicine in a transparent capsule provided by the embodiment of the present invention, the upper part of the centrifugal fixing tube 1 is fixed with a capsule containing box 2 by bolts; the lower end of the capsule containing box 2 is laid with a drug filter 3; The drug filter 3 has a hole 4 in the center; the drug delivery tube nut 4 is inlaid with a drug delivery tube 5; the drug delivery tube 5 is screwed to the filter plate fixing structure of the nut installed on the lower layer of the drug filter 3 through a nut. Above, the drug delivery tube 5 is tightly connected with the outer wire of the drug collection tube 6 located at the lower end of the drug filter screen through the inner thread of the nut; the open end of the drug collection tube 6 is fixed on the lower end of the filter screen by bolts, and the other end of the drug collection tube is placed in the centrifuge. Fixed pipe 1 inner lower part.
所述药物收集管6通过不同直径和形状固定在离心固定管1内下部。The drug collecting tube 6 is fixed in the lower part of the centrifuge fixing tube 1 through different diameters and shapes.
所述胶囊盛装盒2上端开有胶囊放置口且通过螺纹旋拧有螺旋口盖。The upper end of the capsule containing box 2 is provided with a capsule placement opening and screwed with a screw cap.
所述透明胶囊内药物离心提取装置由可蒸汽灭菌塑料和不锈钢材料制成。The centrifugal extraction device for medicine in the transparent capsule is made of steam sterilizable plastic and stainless steel.
所述药物过滤网为双层过滤结构，上层为不同孔径的过滤片，中间可以安装0.22um和0.45um的微孔纤维素酯膜，下层为安装螺母的过滤片固定结构。The drug filter has a double-layer filter structure, the upper layer is a filter sheet with different apertures, the middle layer can be installed with 0.22um and 0.45um microporous cellulose ester membranes, and the lower layer is a filter sheet fixed structure with nuts.
所述透明胶囊内药物离心提取装置药物收集管为带刻度且带盖的试管。The drug collection tube of the drug centrifugal extraction device in the transparent capsule is a test tube with a scale and a cover.
所述药物收集管和离心固定管的管底的形状相同，一般固定管的管底截面为三角形和圆形。The shape of the tube bottom of the drug collection tube and the centrifuge fixed tube is the same, and generally the bottom section of the fixed tube is triangular or circular.
本发明所述药品输送管为适合于不同药物数量收集可以更换不同长度。所述药物收集管可以不同直径和不同材质(可蒸汽灭菌塑料和不锈钢材料)。所述如果各个部件可以高压灭菌，获得的液体直接为无菌的。The drug delivery tube of the present invention can be changed to different lengths to be suitable for collecting different drug quantities. The drug collection tube can have different diameters and different materials (steam sterilizable plastic and stainless steel materials). Said if the individual parts can be autoclaved, the liquid obtained is directly sterile.
下面结合工作原理对本发明作进一步描述。The present invention will be further described in conjunction with the working principle below.
采用本发明，将待分离的胶囊内药物导入到药物收集管中,而透明胶囊的壳留置在过滤网之上,通过离心机离心获得所需药物,此装置可以保证胶囊内药物的特性、纯度以及保障没有透明胶囊壳的掺杂，同时，可以保证药物的精细过滤，以便于科研中细胞培养，大鼠药物灌胃实验，药物物质基础分析及第三方药物检测等，可以高效，快速地将合格胶囊内产品收集走。With the present invention, the drug in the capsule to be separated is introduced into the drug collection tube, and the shell of the transparent capsule is placed on the filter screen, and the required drug is obtained by centrifugation. This device can ensure the characteristics and purity of the drug in the capsule And to ensure that there is no doping of transparent capsule shells. At the same time, it can ensure the fine filtration of drugs, so that cell culture in scientific research, drug gavage experiments in rats, basic analysis of drug substances and third-party drug testing can be efficiently and quickly processed. Collect the products in qualified capsules.
本发明适用透明胶囊药物的随时方便利用，实现随用随取，按刻度量取用，避免胶囊内药物漏出过多而造成浪费和不精确。具有无需学生、研究人员或者工人一一剪破，握持，降低药物过久暴露空气氧化变性，降低劳动强度，省时省力的优点。The invention is suitable for the convenient utilization of transparent capsule medicines at any time, realizes the taking-out according to scales, and avoids waste and inaccuracy caused by excessive leakage of medicines in the capsules. It has the advantages that students, researchers or workers do not need to cut and hold them one by one, which reduces the oxidative denaturation of medicines exposed to air for a long time, reduces labor intensity, and saves time and effort.
以上所述仅是对本发明的较佳实施例而已，并非对本发明作任何形式上的限制，凡是依据本发明的技术实质对以上实施例所做的任何简单修改，等同变化与修饰，均属于本发明技术方案的范围内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention in any form. Any simple modifications made to the above embodiments according to the technical essence of the present invention, equivalent changes and modifications, all belong to this invention. within the scope of the technical solution of the invention.
Claims (8)
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Application publication date: 20170926 |