CN106742610A - A kind of plastic ampoule injection double-layer sterile packaging structure and preparation method thereof - Google Patents
A kind of plastic ampoule injection double-layer sterile packaging structure and preparation method thereof Download PDFInfo
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- CN106742610A CN106742610A CN201710160722.7A CN201710160722A CN106742610A CN 106742610 A CN106742610 A CN 106742610A CN 201710160722 A CN201710160722 A CN 201710160722A CN 106742610 A CN106742610 A CN 106742610A
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- Prior art keywords
- plastic ampoule
- ampoule bottle
- barrier protection
- protection bag
- double
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- 229920003023 plastic Polymers 0.000 title claims abstract description 107
- 239000004033 plastic Substances 0.000 title claims abstract description 107
- 239000003708 ampul Substances 0.000 title claims abstract description 106
- 238000004806 packaging method and process Methods 0.000 title claims abstract description 31
- 238000002347 injection Methods 0.000 title claims abstract description 25
- 239000007924 injection Substances 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 230000004888 barrier function Effects 0.000 claims abstract description 64
- 238000007789 sealing Methods 0.000 claims abstract description 32
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 8
- 230000001954 sterilising effect Effects 0.000 claims description 26
- 238000012856 packing Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 5
- 238000010999 medical injection Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 239000011521 glass Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 238000009455 aseptic packaging Methods 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000028399 Critical Illness Diseases 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D31/00—Bags or like containers made of paper and having structural provision for thickness of contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/12—Sterilising contents prior to, or during, packaging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D33/00—Details of, or accessories for, sacks or bags
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D33/00—Details of, or accessories for, sacks or bags
- B65D33/16—End- or aperture-closing arrangements or devices
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a kind of plastic ampoule injection double-layer sterile packaging structure and preparation method thereof, it is solved in the prior art for plastic ampoule bottle insulating, sealing and less stable, the groove of bottleneck cannot thorough disinfection problem, with substantially increasing insulating, sealing and the stability of plastic ampoule bottle, and keep the aseptic beneficial effect of bottleneck groove.Its technical scheme is：Double-layer sterile packaging structure, including barrier protection bag, are plastic material; it is internally provided with least one annular seal space; a plastic ampoule bottle is accommodated in each annular seal space, the shape of annular seal space is engaged with the shape of plastic ampoule bottle, sealing cavity wall is brought into close contact setting with plastic ampoule bottle outer wall；The bottleneck of the plastic ampoule bottle sets groove thinning area, the aseptic process between plastic ampoule bottle and barrier protection bag.
Description
Technical field
The present invention relates to plastic ampoule bottle packaging structure field, and in particular to a kind of plastic ampoule injection double-layer sterile packaging
Structure and preparation method thereof.
Technical background
Ampoule bottle is a kind of sealed vial for holding low dose of liquid, volume in 1-25ml, can be used to depositing vaccine,
Serum etc., is nowadays also largely used to storage oral liquid etc..Glass is to be used to manufacturing the material of ampoule bottle earliest, its insulating is good,
Stable chemical performance, translucency are good, high temperature resistant, easily various good characteristics such as sterilization, but glass ampoule bottles are easy in transport
It is broken, there is fracture phenomena when filling, and also glass density is larger, and product is heavier, increased cost of transportation；Different batches are produced
The quality of product be difficult to it is completely the same, packaging external appearance design be restricted, it is difficult to printing etc..It is topmost, glass open when
Incision position can produce the substantial amounts of particulate insoluble in liquid, and human body is entered in company with parenteral solution, and the health to human body produces harm.Again
It is exactly that during the unlatching and use of glass ampule, sharp glass easily hurts medical personnel.Plastics are pacified as making
The new material of small jar bottle, the particulate matter that the plastic ampoule bottle of preparation is produced when opening will be far less than glass ampule
Bottle.But plastics packed insulating, sealing and stability are low relative to glass, and in the market application plastic ampoule bottle
It is very deep recessed compressing one of its bottleneck position by big mold clamping force usually when its bottleneck position is in blow molding
Groove, cannot thoroughly be sterilized it by cotton swab before, in groove transport, storage, the particulate hidden during use and
Bacterium etc. cannot be eliminated, and there is larger potential safety hazard.
In sum, in the prior art for plastic ampoule bottle insulating, sealing and less stable, bottleneck it is recessed
Groove cannot thorough disinfection problem, still lack effective solution.
The content of the invention
It is double-deck it is an object of the invention to provide a kind of plastic ampoule bottle injection for the above-mentioned problems in the prior art
Aseptic packaging structure, including barrier protection bag and plastic ampoule bottle, barrier protection bag is plastic material, and it is internally provided with least
A plastic ampoule bottle is accommodated in one annular seal space, each annular seal space, the shape of annular seal space matches with the shape of plastic ampoule bottle
Close, sealing cavity wall is brought into close contact setting with plastic ampoule bottle outer wall；The bottleneck of the plastic ampoule bottle sets groove and subtracts
Thin area, aseptic process between plastic ampoule bottle and barrier protection bag.
Barrier protection bag is plastic material, with certain sealing, barrier and stability, is put when by plastic ampoule bottle
When being placed in the annular seal space of barrier protection bag, and sealing cavity wall is brought into close contact setting with plastic ampoule bottle outer wall, equivalent to
The bottle wall of plastic ampoule bottle is bilayer, improves sealing, barrier and the stability of plastic ampoule bottle.Meanwhile, plastic ampoule
Bottle is sealed in barrier protection bag, and the groove thinning area of its bottleneck is protected, it is to avoid received in storage and transportation
Power breakage is revealed.
Additionally, the annular seal space in barrier protection bag is sealing setting, the pollutant such as extraneous bacterium, solid particle will not
Contacted with plastic ampoule bottle by barrier protection bag, for plastic ampoule bottle provides one barrier.During production, by plastic ampoule bottle
Outer wall, the sealing cavity wall of barrier protection bag and position between the two thoroughly sterilize, and also ensure that plastic ampoule bottle bottleneck
Groove thinning area is aseptic.Under the barrier action of barrier protection bag, even if during transport, storage and use, plastic ampoule
The bottleneck groove thinning area of bottle need to only remove barrier protection bag all without the enrichment for having particulate and bacterium before use, without
Groove thinning area is sterilized, you can directly use.And then solve bottleneck groove thinning area of the prior art cannot be thorough
The problem of sterilization.
Further, 3-10 annular seal space is provided with each barrier protection bag, a plastics is placed in each annular seal space
Ampoule bottle.
Each barrier protection bag and plastic ampoule bottle therein are produced, stored and transported as an entirety, when every
During annular seal space negligible amounts in individual barrier protection bag, the cost of production is improve, and total is more scattered, is unfavorable for
Storage and transport, when barrier protection bag in annular seal space quantity it is more when, take apart barrier protection bag, plastic ampoule bottle therein without
Method first use is finished, and remaining plastic ampoule bottle loses barrier protection, easily contaminated.
Further, 6-9 annular seal space is provided with each barrier protection bag, a plastics is placed in each annular seal space
Ampoule bottle.
Further, the periphery sealing of the barrier protection bag is set.
The annular seal space sealing of barrier protection bag is set, and forms first sealing barrier, and the periphery sealing of barrier protection bag sets
Put, form second sealing barrier, further prevent the pollution of the solid particle and bacterium in the external world to plastic ampoule bottle.
Further, vacuumized in the annular seal space of the barrier protection bag.
When being vacuumized in annular seal space, it is brought into close contact between sealing cavity wall and plastic ampoule bottle, is more beneficial for improving modeling
Expect insulating, sealing and the stability of ampoule bottle.
In order to prepare above-mentioned plastic ampoule injection double-layer sterile packaging structure, the invention provides above-mentioned plastic ampoule
The preparation method of injection double-layer sterile packaging structure, comprises the following steps：
1) liquid drug in plastic ampoule bottle, forms small-volume injection；
2) in A grades of toilet, sterilizing, dried plastic ampoule bottle are encapsulated into the sealed chamber of barrier protection bag
In, sealing is set, and barrier protection bag is sealed, and obtains double-layer packing structure, is obtained final product.
After plastic ampoule bottle sterilizing, drying, the bacterium on its surface is more thoroughly removed, A grades of toilet
Middle packaging barrier protection bag, sealed chamber is sealed and is set, and then seals barrier protection bag, and plastic ampoule bottle can be avoided to exist
It is secondarily contaminated during packaging external packing.
Further, step 2) in, being sterilized using water-bath type sterilizing cabinet, sterilising temp is 121 DEG C, and sterilization time is
15min, temperature≤50 DEG C of offeing for sale.
Further, step 2), A grades of pure air is blown to the plastic ampoule bottle after sterilizing, dry it.
By the way of A grades of pure air is blown plastic ampoule bottle is dried, it is to avoid plastics are pacified in drying process
Small jar bottle causes secondary pollution.
Further, above-mentioned preparation method also includes the step of being vacuumized to barrier protection bag.
Further, the vacuum for vacuumizing is 0.02-0.04MPa.
When using such vacuum, exterior barrier protective bag to the insulating of internal layer plastic ampoule bottle, sealing and
Stability plays best castering action.
In order to prepare above-mentioned plastic ampoule injection double-layer sterile packaging structure, the invention provides another above-mentioned modeling
Expect the preparation method of ampoule injection double-layer sterile packaging structure, comprise the following steps：
1) liquid drug in plastic ampoule bottle, forms small-volume injection；
2) plastic ampoule bottle is encapsulated into the sealed chamber of barrier protection bag, sealing is set；
3) barrier protection bag is sealed, obtains double-layer packing structure；
4) double-layer packing structure is sterilized, is obtained final product after drying.
Due to having water vapour in sterilization process, will be sterilized after barrier protection bag sealing, it is to avoid water vapour and modeling
, in follow-up drying process, only need to be dried for barrier protection bag, it is to avoid plastic ampoule bottle outer wall by material ampoule bottle contact
The bacteria breed that moisture remnants are caused.
Further, above-mentioned preparation method also includes the step of being vacuumized to barrier protection bag.
Further, the vacuum for vacuumizing is 0.02-0.04MPa.
In order to preferably solve the problems, such as plastic ampoule bottle in the prior art, present invention also offers above-mentioned plastics peace
Application of the small jar injection double-layer sterile packaging structure in medical injection.
Beneficial effects of the present invention are：
Double-layer packing structure of the invention compared with prior art, with safety in utilization and its convenience higher.
While ensuring that liquid in product inner packing plastic ampoule is aseptic, also ensure that it is also aseptic between inner packing and outer packaging bag,
Thus ensure that inner packing plastic ampoule injection product is latter until the use of medical space from sterilizing or aseptic packaging, be in
Under aseptic condition, pollution is not affected by.When used for the strict medical space of sanitary grade requirement (such as Surgical Operating Room, critically ill patient
ICU etc.), environment will not be polluted, Carried bacteria does not enter medical space.Therefore, product enter clinical ingredients with
During the environment for the sterility requirements such as using higher, outer packaging bag only need to be sloughed, without being sterilized one by one through medical personnel again.
The barrier protection bag of outer layer plays barrier action, improves insulating, sealing and the stability of plastic ampoule bottle.
Brief description of the drawings
The Figure of description for constituting the part of the application is used for providing further understanding of the present application, and the application's shows
Meaning property embodiment and its illustrated for explaining the application, does not constitute the improper restriction to the application.
Fig. 1 is structural representation of the invention.
Wherein, 1, barrier protection bag, 2, sealing structure, 3, groove, 4, plastic ampoule bottle.
Specific embodiment
It is noted that described further below is all exemplary, it is intended to provide further instruction to the application.Unless another
Indicate, all technologies used herein and scientific terminology are with usual with the application person of an ordinary skill in the technical field
The identical meanings of understanding.
It should be noted that term used herein above is merely to describe specific embodiment, and be not intended to restricted root
According to the illustrative embodiments of the application.As used herein, unless the context clearly indicates otherwise, otherwise singulative
Be also intended to include plural form, additionally, it should be understood that, when in this manual use term "comprising" and/or " bag
Include " when, it indicates existing characteristics, step, operation, device, component and/or combinations thereof.
Term explains part：
Groove thinning area, is provided in the thinning groove 3 of the neck part of plastic ampoule bottle, is easy to plastic ampoule neck part
Turn on, convenient operation.As shown in figure 1, the groove 3 is deep and narrow, common cotton swab is difficult to touch the bottom dead of groove, so
It is difficult to sterilizing.
Barrier protection bag, is coated on the outside of plastic ampoule bottle, can play a part of isolation air, bacterium, so will
It is named as barrier protection bag.
Embodiment 1
As shown in figure 1, plastic ampoule bottle injection double-layer sterile packaging structure, including barrier protection bag 1 and plastic ampoule bottle
4, barrier protection bag 1 is plastic material, and it is internally provided with least one annular seal space, and a plastics peace is accommodated in each annular seal space
Small jar bottle 4, the shape of annular seal space is engaged with the shape of plastic ampoule bottle 4, makes sealing cavity wall tight with the outer wall of plastic ampoule bottle 4
Laminating is set；The bottleneck of the plastic ampoule bottle 4 sets the thinning area of groove 3, between plastic ampoule bottle 4 and barrier protection bag 1
Aseptic process.
8 annular seal spaces are provided with each barrier protection bag 1, a plastic ampoule bottle 4, sealing are sealed in each annular seal space
Chamber sealing is set, and the periphery of barrier protection bag 1 is sealed by sealing structure 2.
Production line is using U.S.'s Weiler Engineering, Inc. productions640 types of series set
It is standby, its feature：
1. the equipment integrates blowing, filling and sealing.
2. the mould of ampoule shaping keeps malleation and its cleaning by A grades of pure air.
3. used by being blow molded is A grades of clean compressed air.
4. cutting knife separates the parison in mould with parison head, and cutting knife has two kinds：One kind is hot knife, and one kind is Kleen
KutTM cutting knifes.
5. transmitted by balladeur train.
6. collection and the record of data are carried out by special software program.
7. bulking system is made up of solenoid, outer tube and filling tube.
8. fixture is provided with vacuum passage and cold passage.
9. intelligence machine interface is provided with.
10. particle matter removing is carried out by the vacuum system of compound air inlet pipe.
Product pipeline has special wet sterilization equipment.
Relevant parameter is as shown in table 1：
Table 1
The ASM series A SM.DE-2.5 types that Ampul sterilizer is produced using Xinhua Medical Apparatus Co., Ltd. Shandong,
Sterilizing is using water-bath type sterilizing cabinet sterilizing.Into setup parameter interface, sterilising temp and time are set, make system default " certainly
It is dynamic ".Open cabinet door and sterilising prods are loaded into vehicle of sterilization, in feeding sterilizing cabinet.Cabinet door, startup optimization are closed, is entirely sterilized and is reached automatic
Complete.Sterilizing terminates, and practices backdoorism, and goes out car.
Ampul sterilizer major parameter is as shown in table 2：
Table 2
It is required that leak detection negative pressure of vacuum answers minimum to reach -70Kpa, in case vacuum leak hunting does not reach requirement.The leak detection time is 20
Minute.A grades of cleanliness class parameter is as shown in table 3：
Table 3
As a kind of specific embodiment, the preparation method of the plastic ampoule bottle injection double-layer sterile packaging structure, bag
Include following steps：
1) plastic grain is made plastic ampoule bottle, is sealed after liquid drug；
2) plastic ampoule bottle by embedding after good is inserted Ampul sterilizer and is sterilized, and sterilising conditions are 121 DEG C, 15 points
Clock, F0Value >=12, the temperature control that offers for sale is at≤50 DEG C；
3) to the A grades of pure air of inner packing plastic ampoule blowing after sterilizing, dry it；
4) in toilet, dried inner packing plastic ampoule bottle feeding packing machine is carried out into external packing barrier protection bag
Packaging, obtain double-layer sterile packaging plastic ampoule injection；
5) case, be put in storage.
As another specific embodiment, the preparation method of the plastic ampoule bottle injection double-layer sterile packaging structure,
Comprise the following steps：
1) plastic grain is made plastic ampoule bottle, is sealed after liquid drug；
2) inner packing plastic ampoule bottle feeding packing machine is carried out the packaging of external packing barrier protection bag, double-layer sterile is obtained
The plastic ampoule injection of packaging；
3) the plastic ampoule injection that double-layer sterile is packed is sterilized, sterilising conditions are 121 DEG C, 15 minutes, F0Value >=
12, the temperature control that offers for sale is at≤50 DEG C；, obtained final product after drying.
The preferred embodiment of the application is the foregoing is only, the application is not limited to, for the skill of this area
For art personnel, the application can have various modifications and variations.It is all within spirit herein and principle, made any repair
Change, equivalent, improvement etc., should be included within the protection domain of the application.
Claims (10)
1. a kind of plastic ampoule bottle injection double-layer sterile packaging structure, it is characterised in that：Including barrier protection bag and plastic ampoule
Bottle, barrier protection bag is plastic material, and it is internally provided with least one annular seal space, and a plastics peace is accommodated in each annular seal space
Small jar bottle, the shape of annular seal space is engaged with the shape of plastic ampoule bottle, sealing cavity wall is closely pasted with plastic ampoule bottle outer wall
Close and set；The bottleneck of the plastic ampoule bottle sets groove thinning area, aseptic between plastic ampoule bottle and barrier protection bag
Treatment.
2. double-layer sterile packaging structure according to claim 1, it is characterised in that：3- is provided with each barrier protection bag
10 annular seal spaces, place a plastic ampoule bottle in each annular seal space.
3. double-layer sterile packaging structure according to claim 2, it is characterised in that：6- is provided with each barrier protection bag
A plastic ampoule bottle is placed in 9 annular seal spaces, each annular seal space.
4. double-layer sterile packaging structure according to claim 1, it is characterised in that：The periphery sealing of the barrier protection bag
Set.
5. double-layer sterile packaging structure according to claim 4, it is characterised in that：In the annular seal space of the barrier protection bag
Vacuumize.
6. the preparation method of any plastic ampoule injection double-layer sterile packaging structures of claim 1-5, it is characterised in that：Bag
Include following steps：
1) liquid drug in plastic ampoule bottle, forms small-volume injection；
2) in A grades of toilet, will sterilize, dried plastic ampoule bottle be encapsulated into barrier protection bag sealed chamber in, it is close
Envelope is set, and barrier protection bag is sealed, and obtains double-layer packing structure, is obtained final product.
7. preparation method according to claim 6, it is characterised in that：Step 2) in, sterilized using water-bath type sterilizing cabinet, go out
Bacterium temperature is 121 DEG C, and sterilization time is 15min, temperature≤50 DEG C of offeing for sale.
8. preparation method according to claim 6, it is characterised in that：Step 2), blow A grades to the plastic ampoule bottle after sterilizing
Pure air, dries it.
9. the preparation method of any plastic ampoule injection double-layer sterile packaging structures of claim 1-5, it is characterised in that：Bag
Include following steps：
1) liquid drug in plastic ampoule bottle, forms small-volume injection；
2) plastic ampoule bottle is encapsulated into the sealed chamber of barrier protection bag, sealing is set；
3) barrier protection bag is sealed, obtains double-layer packing structure；
4) double-layer packing structure is sterilized, is obtained final product after drying.
10. application of any plastic ampoule injection double-layer sterile packaging structures of claim 1-5 in medical injection.
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| CN201710160722.7A CN106742610B (en) | 2017-03-17 | 2017-03-17 | Double-deck aseptic packaging structure of plastics ampoule injection |
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| CN201710160722.7A CN106742610B (en) | 2017-03-17 | 2017-03-17 | Double-deck aseptic packaging structure of plastics ampoule injection |
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|---|---|---|---|---|
| CN2149358Y (en) * | 1992-12-22 | 1993-12-15 | 蔡亿华 | Tray for holding ampules |
| CN101792028A (en) * | 2010-02-26 | 2010-08-04 | 四川沱牌药业有限责任公司 | Application of double-layer aseptic technique in outer package of large capacity injection |
| CN201626644U (en) * | 2010-03-02 | 2010-11-10 | 浙江天瑞药业有限公司 | Plastic ampoule |
| CN201971300U (en) * | 2011-04-14 | 2011-09-14 | 成都普什制药有限公司 | External package for plastic ampoule |
| CN201971293U (en) * | 2011-05-31 | 2011-09-14 | 成都普什制药有限公司 | Outer flexible package for plastic ampoule bottle |
| CN202295770U (en) * | 2011-10-14 | 2012-07-04 | 辰欣药业股份有限公司 | Packing material of plastic ampoule injection |
| CN202657467U (en) * | 2012-04-12 | 2013-01-09 | 山东圣鲁制药有限公司 | Placement device special for plastic ampoule |
| CN103637976A (en) * | 2013-11-14 | 2014-03-19 | 汕头保税区洛斯特制药有限公司 | Aseptic preparation production process |
| WO2016191535A2 (en) * | 2015-05-27 | 2016-12-01 | Becton, Dickinson And Company | Packaging method to enable re-sterilization of medical device |
| CN205441258U (en) * | 2016-03-25 | 2016-08-10 | 中国人民解放军第四军医大学 | Anesthesia medicine bottle case |
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| CN106742610B (en) | 2020-03-17 |
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