CN106726765A - A kind of antiallergic moisturizing toner and preparation method thereof - Google Patents
A kind of antiallergic moisturizing toner and preparation method thereof Download PDFInfo
- Publication number
- CN106726765A CN106726765A CN201611211846.5A CN201611211846A CN106726765A CN 106726765 A CN106726765 A CN 106726765A CN 201611211846 A CN201611211846 A CN 201611211846A CN 106726765 A CN106726765 A CN 106726765A
- Authority
- CN
- China
- Prior art keywords
- antiallergic
- moisturizing toner
- toner
- skin
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 53
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 17
- 239000011734 sodium Substances 0.000 claims abstract description 17
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 17
- 150000001261 hydroxy acids Chemical class 0.000 claims abstract description 16
- 150000004040 pyrrolidinones Chemical class 0.000 claims abstract description 16
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 15
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 15
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims abstract description 15
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims abstract description 14
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims abstract description 14
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 14
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 14
- 229940036350 bisabolol Drugs 0.000 claims abstract description 14
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 14
- 229960004999 lycopene Drugs 0.000 claims abstract description 14
- 235000012661 lycopene Nutrition 0.000 claims abstract description 14
- 239000001751 lycopene Substances 0.000 claims abstract description 14
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 14
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 14
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims abstract description 14
- 229960003237 betaine Drugs 0.000 claims abstract description 13
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960000541 cetyl alcohol Drugs 0.000 claims abstract description 13
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 13
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004006 olive oil Substances 0.000 claims abstract description 13
- 235000008390 olive oil Nutrition 0.000 claims abstract description 13
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims abstract description 12
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000003002 pH adjusting agent Substances 0.000 claims abstract description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 18
- 229940083542 sodium Drugs 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 15
- 239000004310 lactic acid Substances 0.000 claims description 9
- 235000014655 lactic acid Nutrition 0.000 claims description 9
- ZGBFGAHZKZQSLG-UMCOJZBLSA-N [30-oxo-30-[[(e,2s,3r,6r)-1,3,6-trihydroxyoctadec-4-en-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCC[C@@H](O)\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC ZGBFGAHZKZQSLG-UMCOJZBLSA-N 0.000 claims description 5
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 4
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 4
- 229940106189 ceramide Drugs 0.000 claims description 4
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 4
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 6
- 239000002537 cosmetic Substances 0.000 abstract description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- 238000012360 testing method Methods 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 5
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000002804 anti-anaphylactic effect Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 230000036559 skin health Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- -1 acyl Amine Chemical class 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to cosmetic field, and in particular to a kind of antiallergic moisturizing toner and preparation method thereof.The invention provides a kind of antiallergic moisturizing toner, including following components and its percentage by weight：Sodium hyaluronate 5 10%, pyrrolidones hydroxy acid sodium 1 5%, cetanol 2 4%, butanediol 2 6%, Cer NS 6%, glycine betaine 4 8%, olive oil 1 2%, dipotassium glycyrrhizinate 0.5 1%, lycopene 0.5 1%, bisabolol 0.5 1%, methylisothiazolinone 0.1 0.5%, pH adjusting agent 0.1 0.5% and water 55 81.3%.The gentle non-stimulated, skin of antiallergic moisturizing toner that the present invention is provided is easy to absorb, and moistening effect is good, can for a long time keep the moisture of face skin, and antiallergic anti-inflammatory is applicable crowd wide.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of antiallergic moisturizing toner and preparation method thereof.
Background technology
With the improvement of people ' s living standards, the market demand of cosmetics will persistently rise, and numerous women are to shield
Skin cosmetics are extremely paid close attention to, and this is just for developing rapidly for beauty services industry has laid solid foundation.Cosmetics have become women
Necessity, the basic maintenance of skin is generally divided into cleaning, activity, moisturizing three major types, and moisturizing is then as human body needs intake daily
Vegetables meat supplements the nutrients equally, and moisturizing of the toner to skin is indispensable.Our skin usually compare it is greasy and
It is yellow dark, dry mostly because moisturizing is not enough.When the moisture that skin surface is cuticula reaches 15~25%, when aqueous sufficient, skin
Skin not only can soft smooth there is no microgroove, in feel also can full of elasticity.If our skin surface is sticky greasy, the inside is still
So lack moisture content wizened, drying regime does not change a bit.And because fat secretion is more, moisture content amount the reason for oily skin
Few, water oil amount loses equilibrium, so the maintenance of moisturizing, moisturizing to skin is extremely important.
Chinese patent application CN105662913A discloses a kind of toner of efficient moisture-retention, including following parts by weight
Composition：Lactic acid 0.05-0.3 parts, 5-17 parts of pyrrolidones hydroxy acid sodium, glycine betaine 2-10 parts, sorbierite 2.5-11 parts, alanine
0.5-4.5 parts, proline 0.5-5 parts, serine 0.5-4 parts, threonine 0.5-4.5 parts, arginine 0.5-5 parts, urea 3-12
Part, 0.5-5 parts of epithelical cell growth factor EGF, 0.05-0.5 parts and deionized water 925-945 parts of ceramide sodium.The invention
Can quickly be fully absorbed by the skin of human body and the effect with efficient moisture-retention, but its antiallergic antiseptic effect has much room for improvement.
Chinese patent application CN104546573A discloses a kind of new toner and preparation method thereof, and dispensing is：It is pure
Water, EDTA-Na2, allantoin, glycerine, propane diols, peppermint, amino acid humectant, rose, methylisothiazolinone.This is new
Type skin toner being capable of deep layer cleaning, effect of moisturizing, but its moisturizing effect has much room for improvement.
The content of the invention
In order to solve problems of the prior art, it is an object of the invention to provide a kind of antiallergic moisturizing toner and
Its preparation method.The gentle non-stimulated, skin of antiallergic moisturizing toner that the present invention is provided is easy to absorb, and moistening effect is good, can grow
Phase keeps the moisture of face skin, and antiallergic anti-inflammatory is applicable crowd wide.
The invention provides a kind of antiallergic moisturizing toner, including following components and its percentage by weight：
Sodium hyaluronate 5-10%, pyrrolidones hydroxy acid sodium 1-5%, cetanol 2-4%, butanediol 2-6%, Cer NS-
6%th, glycine betaine 4-8%, olive oil 1-2%, dipotassium glycyrrhizinate 0.5-1%, lycopene 0.5-1%, bisabolol 0.5-
1%th, methylisothiazolinone 0.1-0.5%, pH adjusting agent 0.1-0.5% and water 55-81.3%.
The reasonable science of compatibility of the present invention, each component interacts, and collaboration plays moisturizing water lock.
Further, described antiallergic moisturizing toner is made up of following components and its percentage by weight：
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine
6%th, olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, pH adjusting agent 0.3% and water 68.15%.
Further, the pH adjusting agent is by lactic acid and citric acid by weight 2:3 compositions.
Meanwhile, present invention provides a kind of preparation method of antiallergic moisturizing toner, comprise the following steps：
S1 heats water to 60-70 DEG C, and stirring adds cetanol, butanediol, glycine betaine and olive oil, stirs, and obtains
Solution A；
Step S1 resulting solutions A is cooled to 40-50 DEG C by S2, and stirring adds sodium hyaluronate, pyrrolidones hydroxy acid sodium, neural acyl
Amine, dipotassium glycyrrhizinate, lycopene and bisabolol, stir, and obtain solution B；
Step S2 resulting solutions B is cooled to 25 DEG C by S3, adds pH adjusting agent, regulation pH value to be eventually adding to 5.0-6.0
Methylisothiazolinone, stirring, obtains final product.
Further, the pH value in the step S3 is 5.5.
Sodium hyaluronate (C in antiallergic moisturizing toner prepared by the present invention28H44N2O23, CAS NO：9004-61-9) have and protect
It is wet, go wrinkle, absorbefacient effect；Pyrrolidones hydroxy acid sodium (C5H6NNaO3, CAS NO：28874-51-3) there is moisturizing, water suction
Effect；Ceramide (C34H66NO3R, CAS NO：100403-19-8) have and promote cell metabolism, the work of regulation moisture of skin
With；Dipotassium glycyrrhizinate (C42H60K2O16, CAS NO：68797-35-3) there is anti-inflammatory, antiallergy, skin whitening effect；Lycopene
(C40H56, CAS NO：502-65-8) there is anti-oxidant, the effect of regulation cell growth metabolism；Bisabolol (C15H26O, CAS
NO：515-69-5) there is anti-inflammatory, antianaphylactic effect.The reasonable science of compatibility of the present invention, each component interacts, and has cooperateed with increasing
Strong immunity, absorbs moisture, promotes the absorption of skin, antiallergy anti-inflammatory, so as to reach moisturizing, antianaphylactic effect.
Compared with prior art, the gentle non-stimulated, skin of antiallergic moisturizing toner that the present invention is provided is easy to absorb, moisturizing
Effect is good, can for a long time keep the moisture of face skin, and antiallergic anti-inflammatory is applicable crowd wide.
Specific embodiment
Below by specific embodiment, the present invention is described in more detail, and these embodiments are only used for the purpose of illustration,
It is not intended to limit protection scope of the present invention.
A kind of antiallergic moisturizing toner of embodiment 1
The antiallergic moisturizing toner is made up of following components and its percentage by weight：
Sodium hyaluronate 5%, pyrrolidones hydroxy acid sodium 1%, cetanol 2%, butanediol 2%, Cer NS %, glycine betaine
4%th, olive oil 1%, dipotassium glycyrrhizinate 0.5%, lycopene 0.5%, bisabolol 0.5%, methylisothiazolinone
0.1%th, lactic acid 0.04%, citric acid 0.06% and water 55%.
Preparation method：
S1 heats water to 65 DEG C, and stirring adds cetanol, butanediol, glycine betaine and olive oil, stirs, and obtains solution
A；
Step S1 resulting solutions A is cooled to 45 DEG C by S2, stirring add sodium hyaluronate, pyrrolidones hydroxy acid sodium, ceramide,
Dipotassium glycyrrhizinate, lycopene and bisabolol, stir, and obtain solution B；
Step S2 resulting solutions B is cooled to 25 DEG C by S3, adds lactic acid and citric acid, and regulation pH value is eventually adding to 5.5
Methylisothiazolinone, stirring, obtains final product.
A kind of antiallergic moisturizing toner of embodiment 2
The antiallergic moisturizing toner is made up of following components and its percentage by weight：
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine
6%th, olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, lactic acid 0.12%, citric acid 0.18% and water 68.15%.
Preparation method is similar to Example 1.
A kind of antiallergic moisturizing toner of embodiment 3
The antiallergic moisturizing toner is made up of following components and its percentage by weight：
Sodium hyaluronate 10%, pyrrolidones hydroxy acid sodium 5%, cetanol 4%, butanediol 6%, Cer AP %, glycine betaine
8%th, olive oil 2%, dipotassium glycyrrhizinate 1%, lycopene 1%, bisabolol 1%, methylisothiazolinone 0.5%, lactic acid
0.2%th, citric acid 0.3% and water 81.3%.
Preparation method is similar to Example 1.
A kind of antiallergic moisturizing toner of comparative example 1
The antiallergic moisturizing toner is made up of following components and its percentage by weight：
Pyrrolidones hydroxy acid sodium 10.5%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine 6%, olive oil
1.5%th, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone 0.3%, lactic acid
0.12%th, citric acid 0.18% and water 68.15%.
Preparation method is similar to Example 1.
Difference with embodiment 2 is to be not added with sodium hyaluronate, increased the consumption of pyrrolidones hydroxy acid sodium.
A kind of antiallergic moisturizing toner of comparative example 2
The antiallergic moisturizing toner is made up of following components and its percentage by weight：
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, sorbierite 3%, butanediol 4%, ceramide 4%, glycine betaine
6%th, olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, lactic acid 0.12%, citric acid 0.18% and water 68.15%.
Preparation method is similar to Example 1.
Difference with embodiment 2 is that cetanol is replaced with into sorbierite.
Test example one, safety evaluatio
1. test material：Antiallergic moisturizing toner prepared by embodiment 1-3.
2. subjects：60 people, women, 25-50 Sui, skin health, without skin disease allergies.
3. test method：
1) subject is randomly divided into 3 groups, every group of 20 people are denoted as embodiment 1-3 groups；
2) from qualified spot examination device, with closed patch experiment method, by tested material (antiallergic prepared by embodiment 1-3
Moisturizing toner) in spot examination device, external application special adhesive tape is covered on subject back to about 0.2-0.3mL drops, is removed after 24h tested
Thing, respectively remove after 0.5,6,12,24,48h observation dermoreaction, according to《Cosmetics health specification》Middle dermoreaction classification mark
Standard records its result.
4 result of the tests：
Result shows, after the antiallergic moisturizing toner that each group subject is prepared using embodiment 1-3,0.5,6,12,24,
48h observes dermoreaction, and skin has no adverse reaction, and illustrates that the antiallergic moisturizing toner of present invention preparation is safe and non-stimulating.
Test example two, moistening effect evaluation
1. test material：Antiallergic moisturizing toner prepared by embodiment 1-3 and comparative example 1-2.
2. subjects：100 people, women, 22-45 Sui, skin health, without skin disease allergies.
3. test method：
1) subject is randomly divided into 5 groups, every group of 20 people are denoted as embodiment 1-3 groups and comparative example 1-2 groups；
2) after subject's clear water washes one's face, forehead, left face, right face are tested respectively with Fes Kai Er SK-I skin moistures detectors
With the moisture of chin skin, and arithmetic mean of instantaneous value is taken；Subject uses above-mentioned antiallergic moisturizing toner, and uniform application is in face
Portion, gently pats, and with the skin moisture content of test forehead, left face, right face and chin same location after 15min, and takes arithmetic
Average value, tests one time again after 12h, takes arithmetic mean of instantaneous value.
4. result of the test：Skin moisture content test result is shown in Table 1.
The skin moisture content test result of table 1
As shown in Table 1, the antiallergic moisturizing toner moisturizing of present invention preparation, water lock effect are preferable.And prepared by comparative example 1-2
The moisturizing of antiallergic moisturizing toner, water lock effect it is poorer than the effect of antiallergic moisturizing toner prepared by embodiment 1-3, illustrate this
The reasonable science of invention compatibility, each component is interacted, and the effect of moisturizing, water lock is played in collaboration, reaches the effect of long-term moisturizing, skin
Skin water profit is vibrant.
Claims (5)
1. a kind of antiallergic moisturizing toner, it is characterised in that including following components and its percentage by weight：
It is sodium hyaluronate 5-10%, pyrrolidones hydroxy acid sodium 1-5%, cetanol 2-4%, butanediol 2-6%, Cer NS -6%, sweet
Dish alkali 4-8%, olive oil 1-2%, dipotassium glycyrrhizinate 0.5-1%, lycopene 0.5-1%, bisabolol 0.5-1%, methyl
OIT 0.1-0.5%, pH adjusting agent 0.1-0.5% and water 55-81.3%.
2. antiallergic moisturizing toner as claimed in claim 1, it is characterised in that by following components and its percentage by weight group
Into：
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine 6%,
Olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, pH adjusting agent 0.3% and water 68.15%.
3. antiallergic moisturizing toner as claimed in claim 1 or 2, it is characterised in that the pH adjusting agent is by lactic acid and lemon
Acid is by weight 2:3 compositions.
4. the preparation method of the antiallergic moisturizing toner as described in claim 1-3 is any, it is characterised in that including following step
Suddenly：
S1 heats water to 60-70 DEG C, and stirring adds cetanol, butanediol, glycine betaine and olive oil, stirs, and obtains solution
A；
Step S1 resulting solutions A is cooled to 40-50 DEG C by S2, stirring add sodium hyaluronate, pyrrolidones hydroxy acid sodium, ceramide,
Dipotassium glycyrrhizinate, lycopene and bisabolol, stir, and obtain solution B；
Step S2 resulting solutions B is cooled to 25 DEG C by S3, adds pH adjusting agent, regulation pH value to be eventually adding methyl to 5.0-6.0
OIT, stirring, obtains final product.
5. the preparation method of antiallergic moisturizing toner as claimed in claim 4, it is characterised in that the pH value in the step S3
It is 5.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611211846.5A CN106726765A (en) | 2016-12-25 | 2016-12-25 | A kind of antiallergic moisturizing toner and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611211846.5A CN106726765A (en) | 2016-12-25 | 2016-12-25 | A kind of antiallergic moisturizing toner and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106726765A true CN106726765A (en) | 2017-05-31 |
Family
ID=58919438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611211846.5A Withdrawn CN106726765A (en) | 2016-12-25 | 2016-12-25 | A kind of antiallergic moisturizing toner and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106726765A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613656A (en) * | 2019-11-13 | 2019-12-27 | 渭南师范学院 | Brightening toner |
| CN115607473A (en) * | 2022-10-24 | 2023-01-17 | 周嘉奇 | Anti-allergy soothing toner and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735458A (en) * | 2013-12-25 | 2014-04-23 | 珠海市时代经典化妆品有限公司 | Novel anti-allergy repairing composition for skin |
| CN104546594A (en) * | 2014-12-11 | 2015-04-29 | 罗生芳 | Moisturizing toner and preparation method thereof |
| CN105213252A (en) * | 2015-09-25 | 2016-01-06 | 斐丝肌(上海)商贸有限公司 | A kind ofly lock essence of water moisture-keeping efficacy and preparation method thereof |
-
2016
- 2016-12-25 CN CN201611211846.5A patent/CN106726765A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735458A (en) * | 2013-12-25 | 2014-04-23 | 珠海市时代经典化妆品有限公司 | Novel anti-allergy repairing composition for skin |
| CN104546594A (en) * | 2014-12-11 | 2015-04-29 | 罗生芳 | Moisturizing toner and preparation method thereof |
| CN105213252A (en) * | 2015-09-25 | 2016-01-06 | 斐丝肌(上海)商贸有限公司 | A kind ofly lock essence of water moisture-keeping efficacy and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 上海钾盐工程技术研究中心: "《中国钾盐工业概览》", 31 July 2009, 上海交通大学出版社 * |
| 吕百龄: "《实用工业助剂全书》", 31 August 2001, 化学工业出版社 * |
| 江松敏: "《营养健康与疾病预防》", 31 March 2015, 军事医学科学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613656A (en) * | 2019-11-13 | 2019-12-27 | 渭南师范学院 | Brightening toner |
| CN115607473A (en) * | 2022-10-24 | 2023-01-17 | 周嘉奇 | Anti-allergy soothing toner and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109966186B (en) | Soothing and moisturizing repairing composition containing mineral hot spring | |
| CN103767973B (en) | There is external skin-care composition and preparation method thereof and the application of three-dimensional moisturizing, three-dimensional moisture-keeping efficacy | |
| CN104146925A (en) | Facial mask with functions of improving skin barrier and delaying senescence and preparation method thereof | |
| CN111329802B (en) | Skin moisturizing emulsion and preparation method thereof | |
| CN105168112A (en) | Anti-wrinkle toner and preparation method thereof | |
| CN105342882A (en) | A kind of multifunctional composite moisturizing stock solution and its application method | |
| CN110974758A (en) | Moisture mask and preparation method thereof | |
| CN104800096A (en) | Efficient moisturizing composition applied to cosmetics | |
| CN114224779A (en) | Eye repair composition and application thereof | |
| CN114246817A (en) | Wrinkle-removing composition and preparation method and application thereof | |
| CN111557886B (en) | Plant-nourishing efficient moisturizing cream and preparation method thereof | |
| CN103417466B (en) | Natural moisture-preserving and skin-protecting composition and application thereof in cosmetics | |
| CN110755331B (en) | Antibacterial infant washing and caring preparation and application thereof | |
| CN103330671A (en) | Penetrative tissue-promoting toner composition containing pansy flower extract, guava extract and hydrolyzed pearl | |
| CN113425661A (en) | Plant composition with cleaning and repairing effects and application thereof | |
| WO2006083072A1 (en) | Composition of skin external application containing rose extract and epigallocatechin gallate(egcg) | |
| KR20190024637A (en) | Cosmetic composition of high viscosity cream type and mask pack using the same | |
| CN106726765A (en) | A kind of antiallergic moisturizing toner and preparation method thereof | |
| CN103006477A (en) | Camellia oil emollient cream | |
| CN111840157B (en) | Camellia flower compound composition | |
| CN114246820A (en) | Composition of night cream | |
| CN108836904A (en) | A kind of skin care compositions of wrinkle reduction and the preparation method and application thereof | |
| CN112370395A (en) | Amino acid facial cleanser and preparation method thereof | |
| CN116139060B (en) | Composition with anti-inflammatory and anti-aging effects and preparation method and application thereof | |
| CN112438905A (en) | Moisturizing and skin-brightening composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170531 |
|
| WW01 | Invention patent application withdrawn after publication |