CN106692578A - Pharmaceutical composition for preventing and treating oral ulcer and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for preventing and treating oral ulcer and preparation method of pharmaceutical composition Download PDFInfo
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 208000002399 aphthous stomatitis Diseases 0.000 title abstract description 5
- 208000007117 Oral Ulcer Diseases 0.000 title abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 49
- DFYRUELUNQRZTB-UHFFFAOYSA-N apocynin Chemical compound COC1=CC(C(C)=O)=CC=C1O DFYRUELUNQRZTB-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229940079593 drug Drugs 0.000 claims abstract description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 133
- 208000025865 Ulcer Diseases 0.000 claims description 42
- 231100000397 ulcer Toxicity 0.000 claims description 41
- 238000010521 absorption reaction Methods 0.000 claims description 28
- 238000000605 extraction Methods 0.000 claims description 28
- 239000011148 porous material Substances 0.000 claims description 28
- 239000011347 resin Substances 0.000 claims description 28
- 229920005989 resin Polymers 0.000 claims description 28
- 239000002904 solvent Substances 0.000 claims description 28
- 239000012467 final product Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- 241001290564 Fimbristylis Species 0.000 claims description 23
- 241000983344 Trachelospermum jasminoides Species 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 22
- 235000013399 edible fruits Nutrition 0.000 claims description 21
- 241000167562 Pittosporum tobira Species 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000012141 concentrate Substances 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 238000010828 elution Methods 0.000 claims description 7
- 239000006187 pill Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 238000007796 conventional method Methods 0.000 claims description 3
- 241000722948 Apocynum cannabinum Species 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 3
- 241001411371 Trachelospermum axillare Species 0.000 abstract description 2
- 244000150239 Fimbristylis dichotoma Species 0.000 abstract 1
- 241001092090 Pittosporum Species 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 9
- 208000020670 canker sore Diseases 0.000 description 6
- KFMPVUGBZZOSGH-UHFFFAOYSA-N Cyperaquinone Chemical compound O1C(C(=C)C)=CC(C2=O)=C1C(=O)C1=C2C(C)=CO1 KFMPVUGBZZOSGH-UHFFFAOYSA-N 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- 244000037909 Scirpus dichotomus Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000003306 harvesting Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 229930190987 pterosin Natural products 0.000 description 3
- 230000000306 recurrent effect Effects 0.000 description 3
- 230000000472 traumatic effect Effects 0.000 description 3
- VUVRVUQZOVPLPS-UHFFFAOYSA-N 5-methyl-2-prop-1-en-2-yl-2,3,5,6-tetrahydrofuro[3,2-f][1]benzofuran-4,8-dione Chemical compound CC1COC(C2=O)=C1C(=O)C1=C2OC(C(C)=C)C1 VUVRVUQZOVPLPS-UHFFFAOYSA-N 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 241000345998 Calamus manan Species 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical compound C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- DKTHZTCRZGYKCV-UHFFFAOYSA-N 4-hydroxy-6-(2-hydroxyethyl)-2-(hydroxymethyl)-2,5,7-trimethyl-3h-inden-1-one Chemical compound CC1=C(CCO)C(C)=C2C(=O)C(C)(CO)CC2=C1O DKTHZTCRZGYKCV-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000083416 Androsace umbellata Species 0.000 description 1
- 241000208327 Apocynaceae Species 0.000 description 1
- 241000722949 Apocynum Species 0.000 description 1
- 241000879217 Apocynum androsaemifolium Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 240000003211 Corylus maxima Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241001453651 Cyclosorus Species 0.000 description 1
- 241000006479 Cyme Species 0.000 description 1
- 241000234646 Cyperaceae Species 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 241001120815 Dennstaedtia scabra Species 0.000 description 1
- 241000196119 Dicksonia Species 0.000 description 1
- NBEKXDAUYUYRQM-UHFFFAOYSA-N Dihydrocyperaquinone Natural products O1C(C(=C)C)CC(C2=O)=C1C(=O)C1=C2C(C)=CO1 NBEKXDAUYUYRQM-UHFFFAOYSA-N 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020112 Hirsutism Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241001453658 Onychium japonicum Species 0.000 description 1
- 206010050172 Oral mucosa atrophy Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241001092092 Pittosporaceae Species 0.000 description 1
- 241001533116 Pittosporum glabratum Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- GPHSJPVUEZFIDE-CWSKPEISSA-N Ptaquiloside Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]12[C@H](C(=O)[C@H](C)C1)[C@@](O)(C)C1(C(C)=C2)CC1 GPHSJPVUEZFIDE-CWSKPEISSA-N 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000583552 Scleranthus annuus Species 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 206010044546 Traumatic ulcer Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 230000001989 choleretic effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229930186746 dennstoside Natural products 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- -1 hydroxyl cyperaquinone Chemical compound 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 208000001921 latent autoimmune diabetes in adults Diseases 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000005976 liver dysfunction Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- DKTHZTCRZGYKCV-HNNXBMFYSA-N onitisin Natural products CC1=C(CCO)C(C)=C2C(=O)[C@](C)(CO)CC2=C1O DKTHZTCRZGYKCV-HNNXBMFYSA-N 0.000 description 1
- 229940037201 oris Drugs 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- GPHSJPVUEZFIDE-YVPLJZHISA-N ptaquiloside Chemical compound O([C@@]12C[C@H](C([C@@H]1[C@](C)(O)C1(CC1)C(C)=C2)=O)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GPHSJPVUEZFIDE-YVPLJZHISA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition for preventing and treating oral ulcer and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared by taking fimbristylis dichotoma, pittosporum xylocarpum seed, apocynine, scabrous boulder fern and trachelospermum axillare as crude drugs according to the proportions, can be prepared into various dosage forms according to a conventional preparation process and has a remarkable effect of preventing and treating the oral ulcer.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of anti-treating dental ulcer pharmaceutical composition and its preparation side
Method.
Background technology
Canker sore is also known as RAU (Recurrent Oral Ulcer, ROU), recurrent aphthous ulcer, mouth
Scorching (Recurrent Aphtlous Ulcer, RAU), is a kind of more typical disease of cari oris mucosa, and its reason is complicated and not complete
Illustrate entirely, mostly bacterium or virus infection causes.The canker sore incidence of disease is high and easily recurs, and have an intense pain sense during morbidity,
Influence is taken food and is spoken, and huge painful and inconvenience is brought to patient, and when particularly meeting sour, salty, peppery food, the pain increased.
Though it is the small disease in oral cavity, it is painful to can't bear, or even feel restless, it is uncomfortable, it is depressed.It is with local treatment clinically
It is main, supplemented by whole body therapeutic.
Traumatic canker sore clinical onset rate is higher, and different age group can occur, but between twenty and fifty patient,
As long as removing bad mechanical stimulus factor, can comparatively fast take a turn for the better and fully recover.Then ulcer healing is slower for gerontal patient, is primarily due to
Oral environment is complicated, including missing tooth it is many, abutment condition is bad, oral mucosa atrophy is thinning, oral hygiene is poor etc., and factor is made
It is prolonged refractory into scabies secondary infection, formation ulcer.Clinic with the dissolving of oral cavity partial mucous epithelium, ulceration, come off, and form non-spy
Different in nature ulcer is main pathology.Chinese medical discrimination belongs to liver dysfunction, liver-fire flaming.Based on ulcer local treatment, while taking into account
Whole body, with heat clearing and blood circulation promoting, the effect of qi-restoratives myogenic, for the treatment of traumatic canker sore, can shorten treatment time, reduce and suffer from
The pain of person.
Rib fruit pittosporum tobira：This product is Pittosporaceae Chart database plant rib fruit pittosporum tobira Pittosporum
The seed of trigonocarpum L é vl [P.glabratum sensu Rehd.].8-9 month harvesting ripe fruits, except removal core,
Seed is taken out to dry.【Nature and flavor】Bitter, micro-puckery, is slightly cold.【Indication】Astringing to arrest diarrhea, clearing heat and relieving fidgetness.Cure mainly diarrhoea, dysentery, pharynx
Bitterly, dysphoria and insomnia.【Former phytomorph】, without hair, tender shoots has pubescence for evergreen shrubs, spray, and old branch grey has hole skin.Leafage gives birth to
Yu Zhiding, biennial, keratin, obovate or square circle fall lanceolar, long 7-14 centimetres, wide 2.5-4 centimetres, tip suddenly short point, base
The narrow wedge shape in portion, above it is green, shinny, do after breen, below it is light brown, without hair；Lateral vein about 6 pairs, with net vein in upper and lower surface
Not substantially, edge is open and flat, and petiole is about 1 centimetre.Umbel 3-5 basidixed, spends majority；Bennet is long 1-2.5 centimetres, fine
Carefully, without hair；Sepal is avette, long 2 millimeters, ciliation；Petal is long 1.2 centimetres, separates, or part combination；Stamen is long 8 millimeters, female
Stamen is isometric with stamen, and ovary has pubescence, parietal placenta 3, ovule 9-15.Capsule Chang Dansheng, it is oval, dry rear triangle or
Circle, long 2.7 centimetres, hairiness, ovary handle is short, long only 2 millimeters, harbors that style is long 3 millimeters, and carpopodium is about 1 centimetre, there is soft
Hair, 3 split, and chankings is thin, keratin, rough surface, and every has seed 3-5；Seed is red, is about 5-6 centimetres, and seedstalk is long by 2
Millimeter, flattens, scattered on the placenta of lengthwise.Record in dictionary of medicinal plant.
Dichotomous fimbristylis herb：It is Cyperaceae genus fimbristylis plant two qi dichotomous fimbristylis herb Fimbristylis dichotoma (L) Vahl
[Scirpus dichotomus L.;S.annuus All.;Fimbristylis annua(All.)Roem.et Schult]
Herb.Summer, autumn harvesting, clean, and dry.【Nature and flavor】It is lightly seasoned；It is cold in nature.【Return through】Kidney；Bladder warp.【Indication】Heat-clearing profit
Urine；Removing toxic substances.Main difficult urination；Damp and hot edema；Gonorrhoea；Infant fetal toxin.【Chemical analysis】Containing dihydrocyperaquinone
(dihydrooyperaqnone), tetrahydrocyperaquinone.(tetrahydrocyperaquinone), cyperaquinone
(cyperapuinone), hydroxyl cyperaquinone (hydroxycyperapuinone), removes first cyperaquinone
(demethylcyperapuinone).【Former phytomorph】Not tally dichotomous fimbristylis herb, draft.Stalk is grown thickly, 20-50cm high.Complete stool without
Hair has thin pubescence.Leaf is linear, is shorter than stalk, and 1-2.5mm wide, tip is suddenly sharp or blunt；Sheath base portion keratin.Lobate bract under inflorescence
3-4, normal 1-2 pieces, is longer than inflorescence.Cyme is appeared again or simply；Small ear is avette or round shape long is avette, 5-12mm long, 2- wide
3mm, there is most flowers；Scale is avette or Long Circle, 2-2.5mm long, and sepia is glossy, there is 3-5 arteries and veins, and tip has short point；Stamen
2-3；Style is flat, and echinid is arranged at top；Column cap 2.Pyrene obovate wide, biconvex shape, 1-1.2mm long, white to filbert,
Surface is grown crosswise circular reticulate pattern, and longitudinal rib 7-9 bars, significant protuberance has brown short handle.Flower, the fruiting period 7-10 months.Record in the big diction of Chinese medicine
Allusion quotation.
Bowl fern：It is bowl Pteridiaceae bowl Cyclosorus plant bowl fern Dennstaedtia scabra (Wall.) Moore [Dicksonia
Scabra Wall.] herb.【Nature and flavor】It is pungent；It is cool.【Return through】Bladder warp.【Indication】Wind-dispelling；Relieving superficies by cooling.Main flu head
Bitterly；Arthralgia pain due to rheumatism.【Chemical analysis】Aerial part contains pterosin（pterosin）A, F, K, V, onychium japonicum Kunze are pungent（onitisin）That is 4-
Hydroxyl pterosin（4-hydroxypterosin）A, Europe fern Yi Lu glucosides（ptaquiloside）, bowl fern glucoside（dennstoside）A.
【Proterties】Root-like stock cylinder, thick long, surface rufous, the close nodular hair by brown, it descends the fibrous root for giving birth to numerous grey blacks.
Petiole 20-35cm long, slightly rufous, gloss；Blade 20-35cm long, 15-20cm wide, three to quadripinnate drastic crack；Triangular shape
Lanceolar or square are circular, and papery, brown-green, the nodular that leaf two sides, pinna rachis and vein have brown becomes mildewed；End time sliver is short, blunt
Point, full edge has scun 1 per sliver, and tip enlarges into water pocket, not up to limb；Sporangiorus is born in scun tip, sorus teabowl with a cover
Shape, slightly celadon, hair.Matter is crisp, and gas is micro-, lightly seasoned.Record in dictionary of medicinal plant.
Pale reddish brown trachelospermum jasminoide：This product is the pale reddish brown trachelospermum jasminoide Trachelospermum axillare of Apocynaceae trachelospermum jasminoide platymiscium
Hook.f. stem rattan and stem skin.Summer, autumn harvesting, are cleaned, and segment is dried.【Nature and flavor】It is pungent；Slight bitter；It is warm in nature；It is poisonous.【Return through】
Lung；Liver Channel.【Indication】Expel pathogenic wind from the body surface；Active pain relieving.Main cold headache；Cough；Arthralgia pain due to rheumatism；Traumatic injury.【Proterties】
Stem rattan cylinder, outer surface taupe, hole skin transverse projections, and have the band of micro-protuberance；Matter is hard, and skin zone has sparse when fractureing
White collodion silk, it is nonelastic.Gas is micro-, mildly bitter flavor.Stem skin drum or channel-shaped, outer surface taupe, inner surface yellow-white or yellowish-brown
Color, has thin longitudinal crack.There is sparse white collodion silk when fractureing.Record in dictionary of medicinal plant.
Acetovanillone（Acetovanillone）：CAS 498-02-2, molecular formula C9H10O3, molecular weight 166.18.【Medicine
Reason is acted on】Choleretic effect is shown as to rabbit.There are contraction rat uterus and suppress the frog heart and act on.【Purposes】It is stable, cholagogic, effect
In uterus.【Ingredient origin】Ginseng section plant Huang side Picrorrhiza kurrooa Royle ex Benth, Apocynaceae is planted
Thing, apocynum cannabinum Apocynum cannabinum L. rhizomes, Androsace umbellata leaf tea flower Apocynum
Androsaemifolium Linn. rhizomes.
1 bulk drug chemical constitution：
Acetovanillone（Acetovanillone）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effectively anti-treating dental ulcer
And preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the anti-treating dental ulcer be：
The sub- 360-364 weight portions acetovanillone 12-14 weight portions bowl fern 350- of dichotomous fimbristylis herb 356-358 weight portion rib fruit pittosporum tobiras
The pale reddish brown trachelospermum jasminoide 330-336 weight portions of 352 weight portions.
The pharmaceutical composition of anti-treating dental ulcer is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion rib fruit pittosporum tobira of the dichotomous fimbristylis herb 357 son 362 weight portion acetovanillone 13 weight portion bowl pale reddish brown network of weight portion of fern 351
The weight portion of stone 333.
A kind of pharmaceutical composition of anti-treating dental ulcer, it is characterised in that pharmaceutical composition can be using the routine of galenic pharmacy
Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition of anti-treating dental ulcer, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Preventing and treating stomatocace medicine.
A kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The dichotomous fimbristylis herb 356-358 weight portion 360-364 weight portions bluish dogbanes of rib fruit pittosporum tobira
The peaceful 12-14 weight portions bowl pale reddish brown trachelospermum jasminoide 330-336 weight portions of fern 350-352 weight portions；
Preparation method：
（1）Dichotomous fimbristylis herb, rib fruit pittosporum tobira, acetovanillone, bowl fern, pale reddish brown trachelospermum jasminoide are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 48.5% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 7 hours, often
Secondary solvent load is 22 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid is first washed with water, then use weight percent concentration by HPD-100A large pore resin absorption columns
34% ethanol solution elutes HPD-100A large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 34%, reclaims second
Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 13 times is carried every time
The time is taken for 0.4 hour, each solvent load is 25 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 76% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 76%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer, it is characterised in that make as follows
It is standby：
The composition and weight portion of bulk drug be：The weight portion rib fruit pittosporum tobira of the dichotomous fimbristylis herb 357 son weight of 362 weight portion acetovanillone 13
The pale reddish brown weight portion of trachelospermum jasminoide 333 of weight portion of part bowl fern 351；
Preparation method：
（1）Dichotomous fimbristylis herb, rib fruit pittosporum tobira, acetovanillone, bowl fern, pale reddish brown trachelospermum jasminoide are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 48.5% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 7 hours, often
Secondary solvent load is 22 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid is first washed with water, then use weight percent concentration by HPD-100A large pore resin absorption columns
34% ethanol solution elutes HPD-100A large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 34%, reclaims second
Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 13 times is carried every time
The time is taken for 0.4 hour, each solvent load is 25 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 76% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 76%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer, it is characterised in that pharmaceutical composition can be using system
The conventional method of agent prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer, it is characterised in that pharmaceutical composition and chemical drugs or
Chinese medicine composition preventing and treating stomatocace medicine.
The anti-treating dental ulcer of pharmaceutical composition is evident in efficacy.
Specific embodiment
Embodiment 1：Pharmaceutical composition of anti-treating dental ulcer and preparation method thereof
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating dental ulcer be：Dichotomous fimbristylis herb 357g rib fruits pittosporum tobira
The pale reddish brown trachelospermum jasminoide 333g of 13g bowls of fern 351g of 362g acetovanillones；
Preparation method：
（1）Dichotomous fimbristylis herb, rib fruit pittosporum tobira, acetovanillone, bowl fern, pale reddish brown trachelospermum jasminoide are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 48.5% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 7 hours, often
Secondary solvent load is 22 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid is first washed with water, then use weight percent concentration by HPD-100A large pore resin absorption columns
34% ethanol solution elutes HPD-100A large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 34%, reclaims second
Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 13 times is carried every time
The time is taken for 0.4 hour, each solvent load is 25 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 76% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 76%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition of anti-treating dental ulcer and preparation method thereof
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating dental ulcer be：Dichotomous fimbristylis herb 356g rib fruits pittosporum tobira
The pale reddish brown trachelospermum jasminoide 330g of 12g bowls of fern 352g of 364g acetovanillones；
Preparation method：
（1）Dichotomous fimbristylis herb, rib fruit pittosporum tobira, acetovanillone, bowl fern, pale reddish brown trachelospermum jasminoide are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 48.5% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 7 hours, often
Secondary solvent load is 22 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid is first washed with water, then use weight percent concentration by HPD-100A large pore resin absorption columns
34% ethanol solution elutes HPD-100A large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 34%, reclaims second
Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 13 times is carried every time
The time is taken for 0.4 hour, each solvent load is 25 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 76% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 76%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition of anti-treating dental ulcer and preparation method thereof
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating dental ulcer be：Dichotomous fimbristylis herb 358g rib fruits pittosporum tobira
The pale reddish brown trachelospermum jasminoide 336g of 14g bowls of fern 350g of 360g acetovanillones；
Preparation method：
（1）Dichotomous fimbristylis herb, rib fruit pittosporum tobira, acetovanillone, bowl fern, pale reddish brown trachelospermum jasminoide are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 48.5% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 7 hours, often
Secondary solvent load is 22 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid is first washed with water, then use weight percent concentration by HPD-100A large pore resin absorption columns
34% ethanol solution elutes HPD-100A large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 34%, reclaims second
Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 13 times is carried every time
The time is taken for 0.4 hour, each solvent load is 25 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 76% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 76%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 94g of Example 1, adds starch 156g, mixes, and granulation is dried, plus microcrystalline cellulose 33g, stearic acid
Magnesium 2g, mixes, and is pressed into 400, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 86g of Example 2, adds starch 150g, mixes, and granulation is dried, whole grain, adds appropriate magnesium stearate,
Mix, encapsulated 400, obtain final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 350g water-baths and boil molten, add the pharmaceutical composition 17g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is -3 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.3cm away from liquid level, and drop speed is optimum condition with every point 49 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：The pharmaceutical composition of anti-treating dental ulcer
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating dental ulcer be：
The weight portion of the dichotomous fimbristylis herb 383 bowl pale reddish brown weight portion of trachelospermum jasminoide 340 of the weight portion of fern 365.
Embodiment 8：The pharmaceutical composition of anti-treating dental ulcer
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating dental ulcer be：
The weight portion of the acetovanillone 12 bowl pale reddish brown weight portion of trachelospermum jasminoide 250 of the weight portion of fern 136.
Embodiment 9：The pharmaceutical composition of anti-treating dental ulcer
The composition and weight portion of the bulk drug of the pharmaceutical composition of anti-treating dental ulcer be：
The weight portion of the acetovanillone 14 bowl pale reddish brown weight portion of trachelospermum jasminoide 345 of the weight portion of fern 350.
Experimental example 1：The experimental study of anti-treating dental ulcer
1 clinical data
Observation and treatment 24, are this city department of stomatology, Hospital outpatient service and are diagnosed as the traumatic canker sore trouble that removable denture causes altogether
Person, wherein man 12, female 12；Age 60-80 Sui, average age 67.8 years old.All patients meet following condition:It is traumatic
Ulcer occurs to be no more than 48 hours；Any immune formulation is not used within nearly 3 months；Without liver, kidney, hemopoietic system and LADA disease
Medical history；Medicine-less allergy history.It is randomly divided into treatment group and each 12 of control group.Two groups of clinical datas compare that there was no significant difference
(P>0.05), with comparativity.
2 treatment methods
Treatment group:Pharmaceutical composition（The pharmaceutical composition lot number 20101109 of embodiment 1）.It is decocted in water for oral dose, daily 1 dose, divides 3 times
Clothes, are used in conjunction 5 days.
Control group:With Ampicillin, each 0.5g；Metronidazole, each 0.2g.Three times a day, half an hour takes after meal, is used in conjunction 5
My god.
3 treatment results
3.1 criterions of therapeutical effect
It is effective:Ulcer recovery from illness, pain disappear；
Effectively:Ulcer area reduces and/or pain substantially mitigates；
It is invalid:Ulcer without be obviously reduced and/or pain without substantially mitigation.
3. 2 results (being shown in Table 1)
1 two groups of Clinical efficacy comparisons (example) of table
| Group | Number of cases | It is effective | Effectively | It is invalid | Total effective rate (%) |
| Treatment group | 12 | 8 | 3 | 1 | 91.67* |
| Control group | 12 | 2 | 4 | 6 | 50.00 |
Compare with control group, * P<0.05.
Claims (8)
1. a kind of pharmaceutical composition of anti-treating dental ulcer, it is characterised in that be made the bulk drug of the pharmaceutical composition composition and
Weight portion is：
The sub- 360-364 weight portions acetovanillone 12-14 weight portions bowl fern 350- of dichotomous fimbristylis herb 356-358 weight portion rib fruit pittosporum tobiras
The pale reddish brown trachelospermum jasminoide 330-336 weight portions of 352 weight portions.
2. a kind of pharmaceutical composition of anti-treating dental ulcer according to claim 1, it is characterised in that be made the drug regimen
The composition and weight portion of the bulk drug of thing be：
The weight portion rib fruit pittosporum tobira of the dichotomous fimbristylis herb 357 son 362 weight portion acetovanillone 13 weight portion bowl pale reddish brown network of weight portion of fern 351
The weight portion of stone 333.
3. a kind of pharmaceutical composition of anti-treating dental ulcer according to claim 1, it is characterised in that pharmaceutical composition can be with
Piece agent or capsule or dripping pill are prepared using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition of anti-treating dental ulcer according to claim 1, it is characterised in that pharmaceutical composition with change
Learn the preventing and treating stomatocace medicine of medicine or Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The dichotomous fimbristylis herb 356-358 weight portion 360-364 weight portions bluish dogbanes of rib fruit pittosporum tobira
The peaceful 12-14 weight portions bowl pale reddish brown trachelospermum jasminoide 330-336 weight portions of fern 350-352 weight portions；
Preparation method：
（1）Dichotomous fimbristylis herb, rib fruit pittosporum tobira, acetovanillone, bowl fern, pale reddish brown trachelospermum jasminoide are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 48.5% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 7 hours, often
Secondary solvent load is 22 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid is first washed with water, then use weight percent concentration by HPD-100A large pore resin absorption columns
34% ethanol solution elutes HPD-100A large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 34%, reclaims second
Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 13 times is carried every time
The time is taken for 0.4 hour, each solvent load is 25 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 76% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 76%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer according to claim 5, it is characterised in that by such as
It is prepared by lower step：
The composition and weight portion of bulk drug be：The weight portion rib fruit pittosporum tobira of the dichotomous fimbristylis herb 357 son weight of 362 weight portion acetovanillone 13
The pale reddish brown weight portion of trachelospermum jasminoide 333 of weight portion of part bowl fern 351；
Preparation method：
（1）Dichotomous fimbristylis herb, rib fruit pittosporum tobira, acetovanillone, bowl fern, pale reddish brown trachelospermum jasminoide are taken by bulk drug proportioning, is mixed, use weight percent
The ethanol of specific concentration 48.5% takes as solvent in 34 DEG C of temperature extractions, and extraction time is 18 times, and each extraction time is 7 hours, often
Secondary solvent load is 22 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into phase
To density 1.09, filtration, liquid is first washed with water, then use weight percent concentration by HPD-100A large pore resin absorption columns
34% ethanol solution elutes HPD-100A large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 34%, reclaims second
Alcohol, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 13 times is carried every time
The time is taken for 0.4 hour, each solvent load is 25 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.04 is concentrated into, filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again
Amount percent concentration 76% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect the ethanol elution of weight percent concentration 76%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer according to claim 5, it is characterised in that medicine
Composition can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition of anti-treating dental ulcer according to claim 5, it is characterised in that medicine
Composition and chemical drugs or Chinese medicine composition preventing and treating stomatocace medicine.
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