CN106659902A - Human medical and veterinary applications of light for therapeutic compounds - Google Patents

Abstract

Medical and veterinary applications for the application of light to therapeutic compounds include a solution holder, the solution holder being adapted to contain a therapeutic solution for application to a user's tissue; a fiber optic cable; a light source, the light source being coupled to the fiber optic cable and providing light of a predetermined wavelength to the fiber optic cable; and a light terminal, the light terminal being on the fiber optic cable and exposing the light to the therapeutic solution. The formulation includes an oxidizing agent; a therapeutic solution having an initial therapeutic effect; and light of a predetermined frequency, the light of the predetermined frequency synergistically reacting with the oxidizing agent to improve the initial therapeutic effect of the solution.

Description

Human medical and veterinary applications of light for therapeutic compounds

Cross References to Related Applications

This application claims the benefit of the filing date of U.S. Patent Application No. 62/026,498 (P679-104), filed July 18, 2014 - the entire contents of which are hereby incorporated by reference into this application; also Claims the benefit of U.S. Patent Application No. 14/497,269 (P679-104A) filed September 24, 2014 - which is hereby incorporated by reference in its entirety; Interest in U.S. Patent Application No. 14/536,633 (P679-104B) filed on December 9 - the entire contents of which are hereby incorporated by reference into this application; this application requires filing on December 26, 2014 US Patent Application No. 14/583,580 (P679-104C) - which is hereby incorporated by reference in its entirety; Application No. 14, filed February 24, 2015 /630,513 U.S. Patent Application (P679-104E) - The entire contents of which U.S. Patent Application is hereby incorporated by reference into this application; Benefit of Patent Application (P679-104F) - This U.S. Patent Application is hereby incorporated by reference in its entirety; and this application claims U.S. Patent Application No. 14/697,579 filed April 27, 2015 ( P679-104D) - The entire contents of this US patent application are hereby incorporated by reference into this application.

Background technique

The present invention relates generally to therapies involving the improvement of the effect of chemical agents by light, and more particularly to human medical and veterinary applications of light to antibacterial and antineoplastic chemical agents including antibacterial and antineoplastic solutions.

Germs that cause injury and disease exist in the living tissues of humans and animals. Masses or tumors - such as carcinomas also cause tissue damage in humans and animals.

Certain wavelengths of light have been shown to ameliorate or "boost" certain drugs or targeted chemicals - such as antibacterial and antineoplastic agents - by synergistically destroying or inhibiting the growth of germs or tumors Effect.

It is hoped that some antibacterial or antineoplastic agents or both will increase light exposure, so that a synergistic effect can be formed to destroy or inhibit the growth of germs or tumors.

Contents of the invention

In one aspect of the present invention, a device includes a solution holder, a fiber optic cable, a light source, and a light terminal, wherein the solution holder is adapted to contain a treatment solution for tissue of a user; the light source and the fiber optic cable A fiber optic cable is connected and provides light of a predetermined wavelength to the fiber optic cable; the light termination is located on the fiber optic cable and exposes the light to a therapeutic solution.

In another aspect of the present invention, the formula product (also referred to as preparation, formulation) includes: a solution containing an oxidizing agent; a therapeutic solution having an initial therapeutic effect; combined reaction, thereby improving the initial therapeutic effect of the solution.

Description of drawings

Figure 1 depicts an embodiment of a dental device according to the invention;

Figure 2 depicts an embodiment of a container according to the invention;

Figure 3 depicts an embodiment of a bowl according to the invention;

Figure 4 depicts an embodiment of a full body suit according to the invention;

Figures 5A-5E depict an embodiment of a garment according to the present invention;

Figure 6 depicts an embodiment of a helmet according to the invention;

Figure 7 depicts an embodiment of a catheter according to the invention;

Figure 8 depicts an embodiment of a horse rug according to the invention; and

9A-9C depict an embodiment of an animal hood according to the present invention.

detailed description

The preferred embodiment and other embodiments which can be used in the industry and which include the best mode now known for carrying out the invention are described in detail herein with reference to the accompanying drawings. Further embodiments, features and advantages will become apparent from the ensuing description or can be learned without undue experimentation. Unless otherwise indicated, the drawings are not necessarily drawn to scale. The following description of the embodiments - even if worded "the invention" or what the embodiments are - should not be read for purposes of limitation, but describe the manner and process of making and using the invention. The scope of coverage of the present invention is set forth in the claims. The order of steps listed in the claims does not necessarily indicate that the steps must be performed in this order. The word "and/or" between two elements means only the first element, only the second element or both elements together.

Embodiments of the invention generally provide devices and therapeutic solutions for the application of light to therapeutic compounds for the purpose of human disease treatment and animal disease treatment.

Embodiments of the present invention generally provide a medicine having an improved effect by irradiating light of a predetermined frequency onto the medicine.

One embodiment of the invention may provide a device for maintaining a solution in contact with tissue, such as skin, teeth, or the skin of an animal, while the tissue and solution are simultaneously exposed to certain wavelengths of light. Such a device may have components that enhance the effect of the antimicrobial solution by using light of a certain wavelength. Antibacterial, antineoplastic or other therapeutic solutions may or may not be activated by light at any given time. When illuminated by light, the therapeutic solution is "supercharged" by the light. This synergistic effect eliminates or reduces more germs than using the solution alone.

Embodiments of therapeutic solutions may maintain oxidative, antibacterial, or antineoplastic agents in contact with tissue, such as human or animal skin, while the tissue and solution are simultaneously exposed to certain wavelengths of light. Various embodiments may have ingredients that enhance the effects of antibacterial, antiviral, and antitumor solutions through the use of certain wavelengths of light. When light is applied to the solution, the solution is "pressurized" by the light. This synergistic effect eliminates or reduces more germs or lumps than using the solution alone. This can be achieved in a variety of ways including: light directly from a light source, or in combination with a dental tray or other dish or container, mask, bandage, horse rug or animal hood, or for application A device for treatment with antibacterial or antineoplastic chemical agents.

Germs that cause injury or disease are present in living tissue. By adding exposure to light of certain wavelengths to a device that holds certain therapeutic agents close to tissue, a synergistic effect can be created to destroy or inhibit germs or tumor growth. For example, in the oral cavity, such a device may be a disc designed to cover the teeth and gums. Such a disc will emit light of certain wavelengths which when combined with certain antibacterial and/or antineoplastic solutions in said disc will result in synergistic antibacterial and/or Antitumor effect. The light can be generated, for example, by light emitting diodes (LEDs) or lasers. The external light source may be connected to the fiber optic cable in a solution containing device having a fiber optic connection cable, which may further include a fiber optic connection splice or plug.

Various embodiments of the invention may form additional ways to treat disease. An antibacterial or antineoplastic solution pressurized by light of certain wavelengths can cause the solution to eliminate or reduce germs and/or tumor tissue at a higher percentage than using the solution alone. Various embodiments may create a synergistic effect between certain wavelengths of light and antibacterial and/or antitumor solutions that, when applied to tissue, eliminate or reduce disease-causing microorganisms and/or or tumor tissue.

Various embodiments of the invention may include solution containing devices or means that emit light of certain wavelengths into the solution. When this light and solution combination is applied to tissue, there is a synergistic effect of reducing or eliminating disease-causing microorganisms and/or tumor tissue. The base part is 1. The solution holding device is 2. The light source is 3. Have an antibacterial solution or an antineoplastic solution or both.

Various embodiments may employ blue light or some other predetermined wavelength of light that is supercharged by exposure for a few seconds to a few minutes. Various embodiments may also include H2O2 solutions - eg gels - with a suitable eg antibacterial, antiviral or antineoplastic agent or compound at a concentration of 0.3 mM or any concentration.

In one embodiment, for safety, a "burn chart" may indicate that water exposure at 130 degrees Fahrenheit for 30 seconds is safe, but results in burns after that. Exposure to water at 120 degrees Fahrenheit for up to 5 minutes is probably safe. Hydrogen peroxide (H2O2) can kill 96% of germs within 20 seconds when exposed to light with a wavelength of 400-500 nanometers. This solution works best at 57 degrees Celsius (134 degrees Fahrenheit).

Various alternative embodiments may include heating elements that may heat the therapeutic solution to warm and further enable pressurization. In various embodiments, a device may contain heating or cooling components, or both. In one embodiment, the antiseptic solution may be preheated to a desired or optimal temperature prior to its exposure to synergistic light, or used where the pH may or may not be altered. For example, hydrogen peroxide may preferably be exposed to light of 400-500 nanometers at 57 degrees Celsius (134 degrees Fahrenheit) for less than 20 seconds. Other chemicals may have different preferred temperatures and pH values.

Embodiments of the human medical and veterinary device may include an integrated or internal heating element disposed adjacent to the light emitting cable in the device. Embodiments of an integrated heating element may be located in only part of the device - for example at the bottom of a container, garment or cover. The heating element may draw power from the same source as the light source, such as a battery or wall power. Energy can be supplied to the heating element in the device via a fiber optic connection cable or via an energy connection cable extending alongside the connection cable.

Alternative embodiments of the heating element may be spaced apart from the portion of the device containing the therapeutic solution. A separate heating element may be used to heat the therapeutic solution to an optimal temperature before the solution is added to the device - for example by means of a heating plate or oven, or may be used to apply the antibacterial and/or antineoplastic solution in place - for example by Soldering iron or wire for heating.

Embodiments of the device may include light emitting fiber optic cables that may expose the therapeutic solution to light of a certain wavelength - for example light of a purposefully selected wavelength or frequency from an LED or laser. The cover can contain an antiseptic solution. One embodiment may include multiple light terminations or other light emitting devices on the light emitting fiber optic cable. Each light terminal is tapped into a fiber optic cable to output some light at the end of the terminal to emit light into the therapeutic solution. The device can be adjustable so that terminals can be added or moved or the number and position of optical terminals can be measured to suit a single user. The light terminations may be positioned within the sheath or on the surface of the sheath such that each light termination will be positioned within a predetermined location within the holder, such as in the vicinity of tissue to be treated. The fiber optic cable may be opaque with light emitting devices spaced along its length, or may be at least partially translucent so as to emit light along its length. Users can be humans or animals.

In one embodiment, the fiber optic cable may be connected to the light source by a fiber optic connection cable. The connection cable can enter the holder or boot and be optically connected to the fiber optic cable through the fiber optic connection joint so that the light source can be connected and disconnected after use. One embodiment of the splice may include a fiber optic connection cable mounted to a fiber optic cable. Another embodiment of the interface may include a socket that mates with a plug on the connection cable so that the light source can be connected and disconnected after use.

One embodiment may include a device having a light source and an antibacterial and/or antineoplastic solution. Various embodiments may include covers for various human and animal bodies or body parts.

One embodiment of the invention may include a holder or mantle for applying a therapeutic solution to a human, horse or other animal. The holder can be connected to a light source. Various embodiments may include a large number of fiber optic terminals. The holder may have a heating element.

Various embodiments of the holder may include: dental trays containing antibacterial, antineoplastic, or other therapeutic solutions for the user's teeth; medical solution holders adapted to hold antibacterial or antineoplastic solutions for the tissues of the human user ; bucket or container; bowl; full body suit; arm sleeve; mitt; stocking; toe cover; helmet; catheter; medical or therapeutic solution suitable for containing an antibacterial or antineoplastic solution applied to the tissue of an animal blankets; blankets for horses or other animals; or covers for limbs or body parts of animals.

Embodiments may include a fiber optic cable that is wrapped around an interior surface of the device. The fiber optic cable may have optical fiber terminations spaced along the fiber optic cable within the device. One embodiment may include a heating element within the device. The heating element may comprise a heating wire extending adjacent the fiber optic cable within the device. The fiber optic cable can be connected to the light source by a connecting cable. A connection joint or plug may connect an external light source or release said external light source from the device. The heating element may receive power from the light source via the same light source connection cable or via a single energy connection cable. The switch may allow the light source to be connected, heating energy, or both to be turned on or off.

To use one embodiment, a therapist may apply a therapeutic solution to the interior of the device, which is then worn on a person or animal to receive therapy. The therapist can turn on the heater or the power or both.

Various embodiments of therapeutic solutions may include antibacterial, antiviral, antineoplastic compounds for contact with human or animal skin. Such solutions may be in the form of liquids, gels, mixtures, creams or other suitable forms. The solution may or may not be heated by the device. Various embodiments may or may not include compounds that adjust the pH of the solution.

Various embodiments may include light sources that emit light at certain wavelengths (perhaps 400-500nM). Such light sources may be manual. The light source may be in contact with the therapeutic solution or may be maintained or placed within an effective distance. The combination of antibacterial and/or antineoplastic solutions and light of a certain wavelength can form a synergistic effect, resulting in a response that is greater than the sum of the responses of the components individually (synergistic effect). Embodiments of this combination of certain wavelengths of light with antibacterial and/or antineoplastic solutions can be used to treat acne, actinic keratoses, or any other skin or systemic symptoms or conditions.

Once applied, antibacterial, antiviral, antineoplastic or other therapeutic chemicals can be exposed to light at wavelengths that create a synergistic effect, improving the efficacy of the therapeutic chemical. This synergistic effect resulted in a greater reduction of germ-associated bacteria or cancer-associated masses than application of therapeutic solution alone or light alone.

In one embodiment, the chemical agent can be used without storage. The chemical agent can be inserted directly into the body cavity and exposed to light through a fiber optic wand with a plurality of light emitting fibers. Various embodiments of the carrier or reservoir may be a solution itself or a gel. This gel can be inserted into a body cavity through a catheter and exposed to synergistic light through the same catheter or a different catheter. Delivery devices may include, but are not limited to, reservoirs, bandages, gels, solutions, head coverings, animal hoods, wraps, socks, stockings, hats, helmets, potions, suits, tents, probes, or catheters.

Hydrogen peroxide (H2O2) can be an oxidizing or reducing agent. When H2O2 is used as an oxidizing agent, oxygen is reduced to H2O. When H2O2 is used as a reducing agent, oxygen is oxidized to O2 and generation of bubbles can be seen. Various embodiments of the present invention may use H2O2 and formulations of H2O2 as oxidizing agents or reducing agents to provide antibacterial, antitumor, and/or antiviral effects. The formulation or drug will include an "oxidizing agent" if it includes H2O2.

Embodiments of the drug include a variety of components including certain wavelengths of light as well as chemicals that alone or in combination with other means inhibit, retard and/or deter microorganisms and/or bacteria and/or tumor growth. Said drug may be similar to antibacterial and/or antiviral and/or antineoplastic chemical agents in terms of their chemical and functional profile in living organisms. The drug may have light as one of its components. It reliably produces similar antibacterial and/or antiviral and/or antitumor effects in humans or other animals at clinically prescribed doses. It is designated to control light of a certain wavelength from at least one or more of the following chemicals: H2O2, lauric acid, lauryl acid, topical antibiotics, local anesthetics, niacin, niacinamide, e.g. clindamycin Phosphate antibacterial agent, methyl 7-chloro-6,7,8-trihydroxy-6-(1-methyl-trans-4-propyl-L-2-carboxamide azolane)- 1-Thio-L-threo-α-D-lacto-octylpyranoside 2-(dihydrogen phosphate)(Methyl7–chloro-6,7,8–trideoxy-6-(1-methyl-trans- 4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside2-(dihydrogen phosphate)), salicylic acid, sulfur, such as 6-[3-(1-adamantane )-4-Methoxy-phenyl]naphthalene-2-carboxylic acid retinoids, alpha hydroxy acids, tretinoin, borax, caprylic acid, capric acid, myristic acid and additional chemicals useful in the process potion.

The pharmaceutical dosage form of the present invention may comprise certain wavelengths of light and a mixture of one or more of the following chemicals: H2O2, lauric acid, lauryl acid, topical antibiotics, local anesthetics, niacin, niacinamide, for example chlorine Antibacterial agent of lincomycin phosphate, methyl 7-chloro-6,7,8-trihydroxy-6-(1-methyl-trans-4-propyl-L-2-carboxamide azapentane Cyclo)-1-thio-L-threo-α-D-lacto-octylpyranoside 2-(dihydrogenphosphate), salicylic acid, sulfur, such as 6-[3-(1-adamantane) - Retinoids of 4-methoxy-phenyl]naphthalene-2-carboxylic acid, alpha hydroxy acids, tretinoin, borax, caprylic acid, capric acid, myristic acid, and pharmaceutically acceptable carriers in all Additional chemicals useful in the methods described above.

Embodiments of targeting chemicals may include compounds with one or more of antibacterial, biocidal, or bactericidal agents. Various embodiments of antimicrobial agents may include chlorhexidine compounds. Embodiments of targeting chemicals may include non-steroidal anti-inflammatory compounds, such as derivatives of indene. Various embodiments of targeting chemicals may include iodine compounds. Various embodiments of targeting chemicals may include tumor necrosis factor, or components of the TNF family of cytokines. Various embodiments of targeting chemistries may include metals - eg silver (Ag) or transition metals such as Cu or Fe. Various embodiments of targeting chemical agents may include enzymes. Multiple embodiments of enzymes may include one or more of protease, pectinase or elastase. Various embodiments of targeted chemical agents may include antineoplastic agents. Various embodiments of targeted chemical agents may include antibiotics - such as ciprofloxacin. Various embodiments of targeted chemical agents may include antispasmodics - such as methylene bichloride.

In one embodiment, the first reaction may involve the combination of light of a certain wavelength, eg, 400-500 nanometers, with an oxidizing agent such as hydrogen peroxide. Light plus oxidizing agents can be completely self-healing. The second reaction may involve the combination of light of a certain wavelength with the oxidizing agent and further with the targeting chemical agent in a synergistic reaction. Embodiments of the drug may include light-modified oxidizing agents and light-modified targeting chemicals in order to provide a drug with a light-modified therapeutic effect. The drug may be a solution that remains in contact with the user when light is applied from a light source, or a solution that may be modified with light prior to application. The light may comprise two frequencies of light that are applied to the drug or solution simultaneously, or can be applied in such a way that a first frequency of light is applied followed by a second frequency of light in succession.

Selected targeting chemicals may be used in combination with surfactants, humectants, chelating agents, or benefit components. The various embodiments of the medical drug can be administered in the form of tablets, pills, capsules, gels, liquids, sprays, mixtures, creams or pastes. Various embodiments can be used at varying temperatures to adjust their efficacy.

Dental Appliance FIG. 1 depicts an embodiment of a dental appliance 10 . The light-emitting fiber optic cable 12 may expose the antimicrobial solution 14 to a certain wavelength of light, such as a purposefully selected wavelength or frequency of light from an LED or laser. Disc 16 may contain antiseptic solution 14 . Multiple light terminations 18 or other light emitting devices on light emitting fiber optic cable 12 may be included in one embodiment. Each light terminal 18 joins the fiber optic cable 12 to output light at the top of the terminal to emit light into the antimicrobial solution 14 . The device can be adjustable so that terminals 18 can be added or moved or the number and position of optical terminals 18 can be measured to suit individual users. The light terminals 18 may be positioned within the disc 16 such that each light terminal 18 will be positioned between adjacent teeth or adjacent to a user's teeth. The fiber optic cable may be opaque with light emitting devices spaced along its length, or may be at least partially translucent so as to emit light along its length. In one embodiment, fiber optic cable 12 may be connected to light source 20 by a fiber optic connection cable 22 . A connection cable 22 may enter disc 16 and be optically connected to fiber optic cable 12 by fiber optic connection joint 24 so that light source 20 may be connected and disconnected after use. One embodiment of the splice 24 may include an aperture in the wall of the disc 16 in which the fiber optic connection cable 22 is mounted to the fiber optic cable 12 . Another embodiment of the interface 24 may include a socket on the disk 16 that mates with a plug on the connection cable 22 so that the light source 20 can be connected and disconnected after use.

Container As depicted in FIG. 2 , an embodiment of a medical device 30 may include a container 32 having a wall 34 , a bottom 36 , and a carrying handle 38 . Various embodiments may include fiber optic cable 40 wrapped around the inner surface of wall 34 . A fiber optic terminal 42 may be located on the fiber optic cable 40 inside the container. Heating element 44 may be positioned around the bottom of container 32 . The fiber optic cable 40 may be connected to the light source 46 by a fiber optic connection cable 48 .

Bowl As depicted in FIG. 3 , an embodiment of a medical device 50 may include a bowl 52 having a fiber optic cable 54 wrapped around an inner surface 56 of the bowl 52 . Fiber optic cable 54 may have fiber optic terminations 58 . Various embodiments may have a base 60 which may contain a heating element 62 . Fiber optic cable 54 may be connected to light source 64 by a fiber optic connection cable 66 . The light source 64 may include an on/off switch 68 or a timer control 69 .

Full Body Suit As depicted in FIG. 4 , an embodiment of a medical device 70 may include a full body suit 72 having an integrated torso portion 74, sleeves 76, pants 78, foot portion 80, and hood 82 and a removable Gloves 84 or mittens 86 . The sleeve 76 may have a cuff 88 to wrap around the user's wrist. The hood 82 may have an elastic portion 90 to wrap around the user's face. Various embodiments may include, for example, an input tube 92 on one shoulder of the torso section 74 and an exhaust tube 94 on an opposing shoulder of the torso section 74 . Various embodiments may include fiber optic cables 96 spaced along the inner fabric of the suit 72 . A fiber optic terminal 98 may be positioned on the fiber optic cable 96 within the housing 72 . The heating element may be embedded within the fabric of the suit 72 . The fiber optic cable 96 or the heating element or both may be connected to the light source by a fiber optic connection cable.

Garment Figures 5A, 5B, 5C, 5D, and 5E depict an embodiment of a medical device that includes a garment to carry a light-modified antiseptic solution to a user wearing the garment. FIG. 5A depicts an embodiment of an arm sleeve 122 . FIG. 5B depicts an embodiment of a glove 124 . FIG. 5C depicts an embodiment of a toe cover 126 . FIG. 5D depicts an embodiment of a stocking with toe covering portion 128 or without toe covering portion 130 . FIG. 5E depicts an embodiment of a foot stocking 132 with a girdle 134 .

Helmet As depicted in FIG. 6 , an embodiment of a medical device 140 may include a helmet 142 having a fiber optic cable 144 wrapped around an inner surface 146 of the helmet 142 . Fiber optic cable 144 may have fiber optic terminations 148 . Various embodiments may include a heating element 150, which may include wires located in the helmet liner. Fiber optic cable 144 may be connected to light source 152 by fiber optic connection cable 154 .

Conduit As depicted in FIG. 7 , an embodiment of a medical device 160 may include a conduit 162 having a conduit conduit 164 , a distributor screen 166 , and a fiber optic cable 168 having one or more optical fiber terminations 170 . Heating element 172 may be external to catheter tubing 164 and may provide heated antiseptic solution 174 through input tubing 176 . Light source 178 may be connected to fiber optic cable 168 having fiber optic connection splice 182 by a fiber optic connection cable 180 .

Horse Throw Blanket As depicted in FIG. 8 , an embodiment of a complete horse sash 200 may include a cover portion 202 , a neck portion 204 , and an upper leg portion 206 . The throw blanket 200 may include a strap 208 to close the covering portion. The blanket 200 may be coated with an antibacterial solution or gel inside it. Various embodiments may include a fiber optic cable 210 that is wrapped around an interior surface of the cover portion 202 . Various embodiments may include a heating element 212 , which may include heating wires inside the cover portion 202 . Various embodiments may include a connection joint 214 that connects the fiber optic cable 210 to a light source 216 . Fiber optic terminals 218 may be positioned on fiber optic cables 210 within blanket 200 . The light source 216 may have an on/off switch 200 or a timer control.

Animal Cover As depicted in the embodiment of FIGS. 9A , 9B and 9C , an animal cover 230 may include a soft plastic sheet 232 and an attachment mechanism 234 at one end of the sheet 232 . A shroud 230 may be wrapped around the animal's neck and an attachment mechanism 234 on one end of the sheet may be attached to the other end of the sheet 232 to form a loop. Embodiments may include soft fabric trims 46 at the top and bottom sides where the cover 230 contacts and rubs against the animal or other object. The cover 230 may be coated on the inside with an antimicrobial solution or gel. Various embodiments may include a fiber optic cable 238 wrapped around the inner surface of the sheet 232 . Various embodiments may include a heating element 240, which may comprise a heating wire inside the mantle. Various embodiments may include a connection joint 228 that connects the fiber optic cable 238 to the light source 242 . A fiber optic terminal 244 may be positioned on the fiber optic cable 238 inside the boot. The light source 230 may have an on/off switch 246 or a timer control.

Embodiments of the method of treating acne vulgaris ("acne") may include administering a therapeutically effective amount of a peroxide solution and light in a specific wavelength range that may be combined with one or more other antimicrobial agents or other Other antiseptics or other chemical agents may include topical antibiotics, local anesthetics, niacin, niacinamide, antiseptics such as clindamycin phosphate, methyl 7-chloro-6, 7,8-Trihydroxy-6-(1-methyl-trans-4-propyl-L-2-carboxamide azolane)-1-thio-L-threo-α-D-milk- Octopyranoside 2-(dihydrogen phosphate). Various embodiments of antimicrobial agents may include salicylic acid, sulfur, retinoids such as 6-[3-(1-adamantane)-4-methoxy-phenyl]naphthalene-2-carboxylic acid, hydroxy Acetic acid, tretinoin, borax and chemicals useful in the method. Various embodiments of topical and systemic agents can be used as therapeutic chemicals in embodiments of the invention for treating acne, including hydrogen peroxide, carbamide peroxide, sulfur, such as 6-[3-(1-adamantine Retinoids of alk)-4-methoxy-phenyl]naphthalene-2-carboxylic acid, glycolic acid, borax, resorcinol, salicylic acid, benzoyl peroxide, tretinoin (tretinoin ) and topical and systemic antibiotics. Embodiments comprising combinations of various peroxidic compounds with certain chemical agents are effective in treating acne and have a synergistic effect in treating acne that is greater than that expected from treatment by these individual agents alone . This synergistic effect has an even greater synergistic effect upon exposure to certain wavelengths of light. The second chemical may be a therapeutic chemical or an acne treatment chemical because it contains ingredients that help relieve acne and are used in acne treatment or acne-related therapies.

As an example, studies have shown that embodiments with hydrogen peroxide can kill 30% of bacteria exposed to hydrogen peroxide for 20 seconds. Light with a wavelength of 360nM-500nM can kill 3% of bacteria exposed to this light for 20 seconds. The combination of hydrogen peroxide and light at 360nM-500nM can have a synergistic effect of killing 96% of bacteria exposed to this combination for 20 seconds. The formulation product of the solution used in this embodiment of the invention may include hydrogen peroxide and/or carbamide peroxide and/or benzoyl peroxide and selected from sulfur, such as 6-[3-(1-adamantane)- One of the retinoids of 4-methoxy-phenyl]naphthalene-2-carboxylic acid, glycolic acid, borax, resorcinol, salicylic acid, tretinoin (vitamin A acid), and topical and systemic antibiotics one or more species.

In embodiments of the invention, topical solutions of hydrogen peroxide and/or carbamide peroxide and/or benzoyl peroxide, as well as other chemical agents considered effective, can be delivered in various organic vehicles or carriers. Embodiments of the carrier may include a combination of ethanol and propylene glycol, wherein the active ingredient is present in the range of from about 0.001% to about 50% by volume of the carrier. The pH of the solution can be adjusted to minimize tissue sensitivity without compromising the effectiveness of the solution. The temperature of the solution can be adjusted to optimize its effect.

For safety reasons and to optimize the effect of the solution, a "burn chart" can be provided or used. The chart can indicate that 130-degree water exposure for 30 seconds is safe, but beyond that can cause burns. Water exposure at 120 degrees for up to 5 minutes is safe. A solution above normal body temperature will tend to open the pores exposing bacteria to a larger volume of solution. Systemic antimicrobials may be used as part of the delivery of this treatment in order to enhance its effect. The solution may be exposed to light having a wavelength of 360nM-600nM or other wavelengths that prove effective for a period of time ranging from 1 second to 1 minute. Embodiments may include solutions, possibly warm, and light may create a synergistic effect unique to this invention. This light can be used at varying distances from the solution in order to tune its synergistic effect.

In additional embodiments, topical solutions of peroxidic compounds may include hydrogen peroxide and/or carbamide peroxide and and/or benzoyl peroxide. In various embodiments, the compound can be contained in a variety of vehicles or carriers - including solutions, lotions, creams, gels, pastes and ointments and one or more of the following components: Niacin or nicotinamide at a concentration of from 0.001% to 30% by volume of the carrier; erythromycin, clindamycin phosphate, methyl 7- Chloro-6,7,8-trihydroxy-6-(1-methyl-trans-4-propyl-L-2-carboxamide azolane)-1-thio-L-threo-α -D-lacto-octylpyranoside 2-(dihydrogen phosphate). Various embodiments may have tetracycline hydrochloride at a concentration of from 0.001 to 30% by volume; from 0.001 to 30% by volume of the carrier; such as 6-[3-(1-adamantane)-4-methyl oxy-phenyl]naphthalene-2-carboxylic acid retinoids; and other components believed to be effective in the treatment of acne vulgaris. In various embodiments, such carriers may be beneficial in incorporating carbamide peroxide and may include ethanol and propylene glycol, surfactants such as lauryl ether and lauryl, and other carriers effective for the present invention. The carrier and active ingredient can be applied to the face or other affected areas of an acne sufferer. The therapy can be applied at varying intervals, such as 1 to 4 times in a 24-hour period, so that open and closed comedones (blackheads and whiteheads) and inflammatory lesions vary from a few days to several times depending on how many times the therapy is applied per day. significantly reduced over the time period of the week.

Embodiments of the present invention may provide an improved method for treating acne vulgaris involving the periodic use of an antiseptic solution comprising an effective amount of a peroxide agent alone or in combination with a topical antibiotic, topical Anesthetics, niacin, niacinamide, antibacterial agents, salicylic acid, sulfur, retinoids such as 6-[3-(1-adamantane)-4-methoxy-phenyl]naphthalene-2-carboxylic acid , glycolic acid, retinoic acid (tretinoin), borax, and combinations of one or more additional chemical agents that are beneficial in the method. This antiseptic solution can be administered to patients with the inflammatory disease, acne vulgaris. The antiseptic solution can be adjusted to the optimum temperature for the treatment. Antiseptic solutions can be applied to acne vulgaris lesions and associated inflamed tissues. Once applied, the antiseptic solution can be exposed to light of certain wavelengths that create a synergistic effect thereby improving the effectiveness of the antiseptic solution. This synergistic effect resulted in a more significant reduction in acne vulgaris-associated bacteria than application of antibacterial solution alone or light alone.

Embodiments of the solution may contain light-activated pigments that fluoresce upon exposure to certain wavelengths of light employed in the therapy. This pigment can indicate to the user that a synergistic effect has occurred.

The following specific examples help illustrate the invention, but the invention is not limited to the examples.

Example 1. In one embodiment, a 3% hydrogen peroxide solution in a gel is prepared. This solution is administered as a topical application twice daily to the infected areas of patients afflicted with acne vulgaris. After application, the solution was exposed to light at a wavelength of 360nM-500nM for 20 seconds, resulting in a better synergistic effect than application of light alone or solution alone. The entire infected area of the patient is exposed to this light applied by the LED device at once. The solution is then rinsed with clean water. After two weeks of treatment, the number of pimples and inflamed areas caused by acne vulgaris will be significantly reduced. This synergistic effect between solution and light is unique to the present invention.

Example 2. In another embodiment, a solution comprising 3% hydrogen peroxide, 3% benzoyl peroxide and salicylic acid are combined in a vehicle in a cream. The pH of this solution is buffered to 6. Apply this cream to the patient's acne vulgaris-affected area once daily. Once the cream has been applied, exposure to a 10 watt hand lamp emitting light of wavelengths from 410nM-500nM, thus creating a synergistic effect between the solution and the light which results in a greater effect than using the light alone or the solution alone Bacteria are reduced even more. The lamp may have a 15mm diameter terminal that emits such light. This specific size enables targeting of smaller areas of the patient. The light exposure time was one minute. This embodiment of the invention can be used to care for areas that have been affected by acne vulgaris. This synergistic relationship between light and solution is unique to the present invention.

Example 3. In yet another embodiment, the solution contains 15% carbamide peroxide, 2.5% clindamycin phosphate methyl 7-chloro-6,7,8-trihydroxy-6-(1-methyl- trans-4-Propyl-L-2-carboxamidoazolane)-1-thio-L-threo-α-D-lacto-octylpyranoside 2-(dihydrogenphosphate). Various embodiments may include tretinoin combined in a carrier in the form of a gel. This carrier solution is heated to 105 degrees Fahrenheit. Once applied to the affected area, this warm solution helps open the patient's pores. Apply this solution three times a day. The infected area is exposed to 410nM-500nM light provided by a lamp which will expose an area 30 cm in diameter. The infected area and solution are exposed to this specific wavelength of light for 30 seconds. The synergistic effect of the light and the solution, which may have been heated to warm, is greater than the effect of the light or the solution alone. This synergistic effect between light and a solution that may have been heated to lukewarm is unique to this invention.

Claims (15)

1. a kind of device, including：

Solution keeper, the solution keeper is suitable to accommodate the treatment solution of the tissue for user；

Fibre-optic cable；

Light source, the light source is connected with the fibre-optic cable and provides the light of predetermined wavelength to the fibre-optic cable；And

Optical line terminal, the optical line terminal is exposed to the treatment solution on the fibre-optic cable and by light.

2. device according to claim 1, wherein：

The solution has initial antibacterial effect；And

There is synergism reaction in the light, with the treatment solution so as to improve the antibacterial effect of the treatment solution.

3. device according to claim 1, wherein：

The solution has initial antibacterial effect；And

There is synergism reaction in the light, with the treatment solution so as to improve the antibacterial effect of the solution.

4. device according to claim 1, wherein the treatment solution is hydrogen peroxide, and the light produces improvement The synergism reaction of the antibacterial effect of the treatment solution.

5. device according to claim 1, wherein the treatment solution is the oxidant with carrier combinations, and the light Line produces the synergism reaction improved for treating the effect of the treatment solution of acne vulgariss.

6. device according to claim 1, wherein the treatment solution is anti-tumor agents, and the light is produced and changed The synergism reaction of the anticancer effect of the kind treatment solution.

7. device according to claim 1, further includes：

Heating element heater, the heating element heater around the solution keeper inner wrap so as to during application by the treatment Medicament is heated to warm.

8. device according to claim 1, further includes：

External light source, the external light source provides the light of predetermined wavelength；

Fibre opticss connection cables, the fibre opticss connection cables connect the light source by the fibre-optic cable；And

Socket on the solution keeper, the socket with the fibre opticss connection cables mate so as to The light source can be connected and disconnected from.

9. device according to claim 1, wherein the solution keeper includes dentistry disk, the dentistry disk is in the disk Sidepiece on cavity in accommodate the treatment solution；

The fibre-optic cable is contained in the disk；

The tissue is the tooth of user；And

The disk is configured to accommodate the treatment solution being irradiated by light for the tooth；

And described device further includes the multiple optical line terminals on the fibre-optic cable, the plurality of optical line terminal is by light Line from the fibre-optic cable be transmitted into it is described treatment solution in, the optical line terminal be positioned and with enough quantity so that Each sidepiece obtained in two opposed sidepieces of neighbouring each tooth has at least one optical line terminal.

10. device according to claim 1, wherein the fibre-optic cable includes luminous inner core and external protection, it is described outer Protective layer covers the only a part of the luminous inner core so that light is directed to the sidepiece of the fibre-optic cable.

11. devices according to claim 1, wherein the solution keeper includes：

For the full body suit of people；

Input channel, the input channel is input into the treatment solution as mixture；

Region in the suit, the region makes the mixture circulate for user；

The mixture is discharged the suit by discharge line, the discharge line；And

Wherein described fibre-optic cable winds around the inner surface of the full body suit.

12. devices according to claim 1, wherein the solution keeper includes the medicated clothing selected from following groups：

The sleeve of arm, the sleeve of the arm covers the arm of mankind's user and the treatment solution is applied to into the mankind The arm of user；

Glove, the glove covers the handss of mankind's user or a part for handss and treats solution application by described To the handss or a part for handss of mankind's user；

Stocking, the stocking covers the lower limb of mankind's user or a part for lower limb and the treatment solution is applied to into the mankind and makes The lower limb of user or a part for lower limb；

Toe binding, the toe binding covers one or more toes of mankind's user and the treatment solution is applied to into people One or more toes of class user；

The helmet, the helmet covers the head of mankind's user and the treatment solution is applied to into the head of mankind's user Portion；And

Blanket, the blanket has the covering part for being shaped as the back, shoulder, sidepiece and the rear portion that cover animal, further Closed around the animal with releasably holding the blanket with the belt with retaining element.

13. devices according to claim 1, the solution keeper includes：

Duct conduits, the duct conduits receive the treatment solution at the first end of the duct conduits；And

Close to the screen cloth of the second duct conduits end opposed with the first end on the conduit, so as to by the treatment Solution is distributed in the user body；

Wherein described optical line terminal is positioned on the fibre-optic cable close to the screen cloth.

A kind of 14. formula products, including：

Including the solution of oxidant；Treatment solution with initial therapy effect；And

There is synergism reaction in the light of preset frequency, the light of the preset frequency, described molten so as to improve with the oxidant The initial therapy effect of liquid.

15. formula products according to claim 14, wherein the treatment solution includes the targeting combined with oxidant There is synergism reaction in the solution learned medicament and combine, improve antibacterial, antiviral or the antitumor of the treatment solution with light Effect；

Wherein described targeting chemical agent is selected from the group including following compositions：

Antibacterial, biocidal or sterilization compound；

Including the antimicrobial compound of chlorhexidine；

Including the non-steroidal anti-inflammatory disease compound of the derivant of indenes；

Iodine compound；

Tumor necrosis factor；

Protease, pectase or elastin laminin enzyme compound；

Ciprofloxacin；

Spasmolytic；With

Dichloromethane.