CN106633926A - Self-repairing prosthetic material for ultrasonic puncture, and preparation method and application thereof - Google Patents

Abstract

The invention discloses a prosthesis material for self-repairing ultrasonic puncture and its preparation method and application. The active components of the prosthesis material are mainly biopolymer, water and copper sulfate. The prosthesis material for self-repairing ultrasonic puncture of the present invention is similar to the mechanical properties of human tissue, and can be self-repairing after multiple ultrasonic punctures through ultrasound, and can be recycled; the validity period of the prosthesis material for self-repairing ultrasonic puncture of the present invention is long and can be stored for 3 to 6 months; the method of the present invention uses engineering means to solve medical problems, and further promotes the development of interdisciplinary engineering and medicine; the prosthesis material of the present invention realizes puncture practice under the guidance of ultrasound, The solid material is easy to prepare and low in cost, and can be used for teaching guidance and practice operations.

Description

A self-repairing prosthesis material for ultrasonic puncture, its preparation method and application

technical field

The invention belongs to the field of biomedicine, and relates to a prosthetic tissue capable of replacing biological soft tissue, in particular to a prosthetic material for self-repairing ultrasonic puncture and its preparation method and application.

Background technique

Cancer, also called malignant tumor, is a disease caused by the dysfunction of related mechanisms of cell growth and proliferation. In addition to abnormal proliferation, cancer cells will also locally invade the surrounding normal tissues and even spread to other tissues of the human body through the circulatory system or lymphatic system. Great danger. The main method of diagnosing cancer is cytopathological examination, which first requires obtaining a tissue sample of the target organ. Due to the advantages of low cost, less trauma, fewer complications, and faster healing, the current preferred method for extracting tissue samples clinically is needle biopsy.

Needle biopsy is actually a process of using a biopsy needle to penetrate biological soft tissue and extract a sample. The study of the needle biopsy process obviously needs to start from two aspects: biological soft tissue and biopsy needle. However, the mechanical properties of different biological soft tissues vary greatly, and factors such as gender, age, and physical fitness will also affect their mechanical properties. This difference will not only increase the complexity of the mechanical properties of biological soft tissues, but will inevitably interfere with the puncture Analysis of needle tip behavior. On the other hand, since most biological soft tissues are opaque, it greatly increases the difficulty of observing the puncture process. In fact, most biological soft tissue puncture tests often need to be observed with the help of ultrasonic imaging (B-ultrasound), scanning and other technologies, which not only makes the test Complicated, but also increased the cost of testing.

In response to the above problems, an effective method is to use ultrasound-transparent, transparent, and mechanically stable prosthetic materials instead of biological soft tissues as the puncture target. Using prosthetic tissue instead of biological soft tissue as the puncture target can effectively reduce the impact of biological tissue differences on the analysis of the biopsy process, which is conducive to simplifying the obstacle interference of the biopsy needle during the biopsy process and clarifying the force of the biopsy needle during the puncture process In addition, the accuracy and efficiency of biopsy can be improved by optimizing the structure of the biopsy needle, optimizing the needle insertion parameters, and compensating for puncture errors.

At present, the commonly used puncture prosthesis materials include imitation muscle ballistic test materials, plastisol, PVC (polyvinyl chloride), agar, etc. However, the mechanical properties of some materials are different from those of real tissues, and they are not reliable as puncture prostheses. , and the needle track left after one or more punctures will seriously degrade the quality of B-ultrasound imaging.

Contents of the invention

The technical problem to be solved: In order to overcome the defects of the existing technology, obtain a prosthetic material with similar mechanical properties to human tissue, which is transparent to ultrasound, can be self-repaired after multiple ultrasonic punctures, can be recycled, and has a long validity period. The invention provides a prosthesis material for self-repairing ultrasonic puncture, its preparation method and application.

Technical solutions:

A method for preparing a prosthesis material for self-repairing ultrasonic puncture, comprising the following steps:

(1) Under the condition of 40-50°C, mix the biopolymer and water at a volume ratio of 1:5-1:20, and fully stir until a uniform aqueous solution is formed;

(2) Add 5%wt-10%wt copper sulfate to the aqueous solution of step (1), and continue to stir until completely dissolved and mixed evenly with the biopolymer aqueous solution;

(3) Pour the mixed solution of step (2) into a container for cooling and molding to form a solid gel;

(4) After the gel in step (3) is used for ultrasonic puncture, it is heated until it dissolves, and then it is cooled and molded to realize recycling.

Preferably, the biopolymer is gelatin.

Preferably, the biopolymer is mixed with water in a volume ratio of 1:10.

Preferably, the mass fraction of copper sulfate is 10%wt.

The self-repairing ultrasonic puncture prosthesis material prepared by any one of the methods described above.

Application of the self-repairing ultrasonic puncture prosthesis material in B-mode ultrasonic guided puncture biopsy.

Beneficial effects: (1) The prosthesis material for self-repairing ultrasonic puncture of the present invention is similar to the mechanical properties of human tissue, and can be self-repairing after multiple ultrasonic punctures, and can be recycled; (2) The self-repairing prosthesis material of the present invention The prosthesis material for repairing ultrasonic puncture has a long validity period and can be stored for 3 to 6 months; (3) the method of the present invention uses engineering means to solve medical problems, which further promotes the development of interdisciplinary engineering and medicine; (4) this The prosthesis material in the invention realizes puncture practice under the guidance of ultrasound, the prosthesis material is simple to prepare and low in cost, and can be used for teaching guidance and practice operations.

detailed description

The following examples further illustrate the content of the present invention, but should not be construed as limiting the present invention. Without departing from the spirit and essence of the present invention, the modifications and substitutions made to the methods, steps or conditions of the present invention all belong to the scope of the present invention. Unless otherwise specified, the technical means used in the embodiments are conventional means well known to those skilled in the art.

Example 1

A method for preparing a prosthesis material for self-repairing ultrasonic puncture, comprising the following steps:

(1) At 40°C, mix gelatin and water at a volume ratio of 1:20, and stir well until a uniform aqueous solution is formed;

(2) Add 10%wt copper sulfate to the aqueous solution of step (1), and continue to stir until fully dissolved and mixed with the biopolymer aqueous solution;

(3) Pour the mixed solution of step (2) into a container for cooling and molding to form a solid gel;

(4) After the gel in step (3) is used for ultrasonic puncture, it is heated to 50° C. to dissolve, and then cooled to 20° C. to be molded for recycling.

The prosthesis material for self-repairing ultrasonic puncture prepared by the above method.

The prosthesis material can be applied to Type B supernatural puncture practice, and the storage period is extended to 3 months.

Example 2

A method for preparing a prosthesis material for self-repairing ultrasonic puncture, comprising the following steps:

(1) At 45°C, mix gelatin and water at a volume ratio of 1:10, and stir well until a uniform aqueous solution is formed;

(2) Add 8%wt copper sulfate to the aqueous solution of step (1), and continue to stir until fully dissolved and mixed with the biopolymer aqueous solution;

(3) Pour the mixed solution of step (2) into a container for cooling and molding to form a solid gel;

(4) After the gel in step (3) is used for ultrasonic puncture, it is heated to 50° C. to dissolve, and then cooled to 20° C. to be molded for recycling.

The prosthesis material for self-repairing ultrasonic puncture prepared by the above method.

The prosthesis material can be applied to Type B supernatural puncture practice, and the storage period is extended to 4 months.

Example 3

A method for preparing a prosthesis material for self-repairing ultrasonic puncture, comprising the following steps:

(1) At 45°C, mix gelatin and water at a volume ratio of 1:5, and stir well until a uniform aqueous solution is formed;

(2) Add 5% wt of copper sulfate to the aqueous solution of step (1), and continue to stir until fully dissolved and mixed with the biopolymer aqueous solution;

(3) Pour the mixed solution of step (2) into a container for cooling and molding to form a solid gel;

(4) After the gel in step (3) is used for ultrasonic puncture, it is heated to 50° C. to dissolve, and then cooled to 20° C. to form, so as to realize recycling.

The prosthesis material for self-repairing ultrasonic puncture prepared by the above method.

The prosthesis material can be applied to B-type supernatural puncture practice, and the storage period is extended to 6 months.

Example 4

A method for preparing a prosthesis material for self-repairing ultrasonic puncture, comprising the following steps:

(1) At 50°C, mix gelatin and water at a volume ratio of 1:5, and stir well until a uniform aqueous solution is formed;

(2) Add 5% wt of copper sulfate to the aqueous solution of step (1), and continue to stir until fully dissolved and mixed with the biopolymer aqueous solution;

(3) Pour the mixed solution of step (2) into a container for cooling and molding to form a solid gel;

(4) After the gel in step (3) is used for ultrasonic puncture, it is heated to 50° C. to dissolve, and then cooled to 20° C. to be molded for recycling.

The prosthesis material for self-repairing ultrasonic puncture prepared by the above method.

The prosthesis material can be applied to Type B supernatural puncture practice, and the storage period is extended to 6 months.

Claims (6)

1. A preparation method for self-repairing ultrasonic puncture prosthesis material, is characterized in that, comprises the following steps: (1) Under the condition of 40-50°C, mix the biopolymer and water at a volume ratio of 1:5-1:20, and fully stir until a uniform aqueous solution is formed; (2) Add 5%wt-10%wt copper sulfate to the aqueous solution of step (1), and continue to stir until completely dissolved and mixed evenly with the biopolymer aqueous solution; (3) Pour the mixed solution of step (2) into a container for cooling and molding to form a solid gel; (4) After the gel in step (3) is used for ultrasonic puncture, it is heated until it dissolves, and then it is cooled and molded to realize recycling. 2 . The method for preparing a self-repairing ultrasonic puncture prosthesis material according to claim 1 , wherein the biopolymer is gelatin. 3. A method for preparing a self-repairing ultrasonic puncture prosthesis material according to claim 1, wherein the biopolymer is mixed with water at a volume ratio of 1:10. 4. A method for preparing a self-repairing ultrasonic puncture prosthesis material according to claim 1, wherein the mass fraction of copper sulfate is 10%wt. 5. The prosthesis material for self-repairing ultrasonic puncture prepared by the method according to any one of claims 1 to 4. 6. The application of the prosthetic material for self-repairing ultrasonic puncture according to claim 5 in B-mode ultrasonic guided puncture biopsy.