CN106616995A - Brain-strengthening oral liquid and production method thereof - Google Patents
Brain-strengthening oral liquid and production method thereof Download PDFInfo
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- CN106616995A CN106616995A CN201611224641.0A CN201611224641A CN106616995A CN 106616995 A CN106616995 A CN 106616995A CN 201611224641 A CN201611224641 A CN 201611224641A CN 106616995 A CN106616995 A CN 106616995A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses brain-strengthening oral liquid and a production method thereof. The brain-strengthening oral liquid is prepared by pretreating green goat brain and walnut kernels, mixing the green goat brain and the walnut kernels according to a certain proportion, carrying out colloid milling, homogenation, adipolysis and proteolysis, adding lecithin and saccharose inoculated compound bacteria for mixed fermentation, carrying out filtering, adding sesamin, VE and the like, and carrying out canning to obtain a finished product. The product is good in brain-strengthening effect, rich in nutrition and unique in flavor.
Description
Technical field
The present invention relates to a kind of brain boosting oral liquid and its production method, belong to food technology field.
Background technology
The cerebral diseases such as the existing old man more than 200,000,000 of China, Parkinson, senile dementia, cerebellar atrophy and cerebral hemorrhage cerebral infarction are in
Trend occurred frequently.Cerebrolysin easily directly acts on the nucleic acid metabolism and protein synthesis of nerve cell through blood-brain barrier, and affects
Its respiratory chain, with the activity for activating, improving intracerebral neurotransmitter and enzyme, increases utilization of the brain tissue to glucose, improves brain
Cell hypoxia state, has protective effect to the brain cell of anoxic, can tonifying Qi establish the yang function, nourshing kidney brain tonic, intelligence promoting and tranquilization, decline for nerve
Weak, after the tired dizziness of body, apoplexy, hemiplegia, hypertensive cerebral hemorrhage that cerebral arteriovenous malformation causes cephalophyma, cerebral thrombus, lose
Dormancy dreaminess, failure of memory etc. belong to conscience deficiency, the empty patient of gas sun two.It is domestic but the Cerebrolysin of external import is expensive
Also in the experimental stage, also without large-scale production.
Grey Goats (scientific name：Goral Naemorhedusgoral) belong to a kind of alpine animal that Artiodactyla goral belongs to.Jing often puts
Body is on the steep cliff of isolated peak.It is good at jumping and climbs, can run between cliffs and precipices and remote mountains deep and secluded valley, can also jumps and jump off
Deep deep mountain stream more than 10m and it is safe.Blazon in the Shandong of China, northeast, North China, northwest, south China and southwestern all provinces and regions.Grey Goats are numerous
Grow ability strong, ripe ewe is produced per year 2 times, 5 or so every time, can provide more brain source；It is lived, and ripple is active, and body weight is petite, product
It is of fine quality good, it is the desirable feedstock for producing Cerebrolysin.Sheep brain is sweet；It is warm in nature, about 76.3 grams of the moisture content per 100 grams, protein 11.3
Gram, 10.7 grams of fat, 0.1 gram of carbohydrate, 61 milligrams of calcium, 356 milligrams of phosphorus, 1.24 milligrams of zinc, 0.17 milligram of thiamine, core
0.27 milligram of flavine, 3.5 milligrams of niacin.Primary efficacy：Qi-restoratives brain tonic, moisturizing.
Walnut kernel has good brain strengthening function.In per 100 grams of walnuts, fatty 50～64 grams, the fat in walnut
71% is linoleic acid, and 12% is leukotrienes, and protein is 15～20 grams, and protein is also high-quality protein, fat and egg in walnut
It is in vain the best nutriment of brain.Carbohydrate be 10 grams, and containing calcium, phosphorus, iron, carrotene, riboflavin (vitamin B2),
The nutriments such as vitamin B6, vitamin E, juglandis folia quinone, phosphatide, tannin.Contained phosphatide has brain supplementing action, is that nerve cell is new
The base substance of old metabolism, therefore walnut kernel is referred to as natural docosapentaenoic acid.Simultaneously alpha-linolenic acid contained in walnut kernel can be in human body
Change into DHA, EPA etc..
The present invention is compounded using Grey Goats brain and walnut kernel, overcomes green hill sheep brain to lack, it is difficult to which industrialized production etc. is asked
Topic.
The content of the invention
For the problems referred to above, the invention provides a kind of brain boosting oral liquid and its production method.The present invention is first by green hill
Sheep brain and walnut kernel are pre-processed, and Jing colloid mills, homogenate, fat splitting, protein hydrolysis, mixing after mixing by a certain percentage is sent out
Ferment, ultrafiltration etc. are filling for finished product, and the product not only has good brain-healthy effect, goes back comprehensive nutrition, unique flavor.
The technical scheme is that：A kind of brain boosting oral liquid production method, is characterized in that, comprise the following steps：
1) pre-process
By the green hill sheep brain after impurity elimination and the walnut kernel in mass ratio 2～4 gone after thin skin:6～8 mixing；Then Jing colloids
Wear into after colloidal again using refiner homogenate；
2) fat splitting
Then mixture adds lipase Novozym435 enzymolysis at pH 7.0-8.0,40～50 DEG C of temperature, must hydrolyze
Liquid；
3) protein hydrolysis
Hydrolyzate adds tryptose to digest at pH 8.0-9.0,40～50 DEG C of temperature；
4) mixed fermentation
Then it is under 2.0-4.0, to add the sucrose of its quality 1.5～2.5% and 1.5～2.5% lecithin, nothing in pH
Bacterium accesses lactic acid bacteria, Bifidobacterium Bifidum and saccharomycetic compound bacteria and carries out mixed fermentation；
5) filter, allocate
Zymotic fluid ultrafiltration after plate-frame filtering；Ultrafiltrate adds 0.01～0.5% sesamin and 0.1～0.5% VE,
It is filling after stirring.
Preferably, the step 2) and step 3) be first heated to being cooled to 40～50 DEG C again after micro-boiling at digest.
Preferably, the step 3) fat splitting be：It is 7.0～8.0 to adjust pH with NaOH solution, is cooled down after heating micro-boiling
To 40～50 DEG C, add lipase Novozym435 to digest 2～5 hours by 1.5～2.5% mass ratio, obtain hydrolyzate.
Preferably, the step 4) protein be hydrolyzed to：It is 8.0～9.0 to adjust pH with NaOH solution, cold after heating micro-boiling
But to 40～50 DEG C, trypsin digestion is added 3～8 hours by 1.5～2.5% mass ratio.
Preferably, the step 4) mixed fermentation be：With citric acid adjust pH be 2.5～3.0, add its quality 1.5～
2.5% sucrose and 1.5～2.5% lecithin, the ml l of aseptic inoculation lactic acid bacteria 15～25, the ml l of Bifidobacterium 10～20
With the ml l of saccharomycete 10～20,35～40 DEG C of mixed fermentation 10～15 hours.Sesame oil froth breaking is adopted in above-mentioned fermentation.
The step 5) (common to preserve more than 3 months) is preserved if necessary to long-term, need it is possible to additionally incorporate tertiary butyl to benzene
Diphenol (TBHQ), its shelf-life can reach more than 18 months.The step adopts 80 mesh plate-frame filterings.
Total N >=5mg/ml of the brain boosting oral liquid of present invention production, small peptide >=30mg/ml, free amino acid >=30mg/
Ml, meets the requirement of the Ministry of Public Health of republic of People's Republic of China (PRC) WS-198 (X-171) -97 (1).
The invention has the beneficial effects as follows：
(1) present invention is rich in several amino acids, phosphatide, Ni Ke with green hill sheep brain and walnut kernel as primary raw material in product
Acid, DHA, containing multivitamin (especially Cobastab, C and E) and mineral matter, and rich in various brain cell proliferations, growth,
Growth factor and regulatory factor needed for development and metabolism, these improve cerebral anoxia, god for the basic function for maintaining brain
Jing is weak and insomnia forgetfulness situation has good curative effect.
(2) this product contains the probios such as lactic acid bacteria, Bifidobacterium and saccharomycete, improves stomach ecological environment, while Jing
Cross enzymolysis, fermentation and filter, the macromolecular substances such as protein, fat and polysaccharide are converted into small peptide, amino acid, DHA and monose etc.,
The nutriment of these small molecules is transported to brain easily in intestinal absorption, and to brain cell enough nutriments are provided, and increases
Strong brain vigor, improves cranial nerve function.
(3) present invention adds sesamin and VE etc., with alcohol Flavor through natural enzymolysis；Simultaneously can be anti-oxidant, extend
The shelf-life of product.
(4) present invention takes animal-plant material to combine, that is, solve the problems, such as sheep brain insufficient raw material, and nutrient content phase is made again
Mutually supplement, for brain comprehensive nutriment provided, product quality more preferably, health-care effect it is more preferable.
Specific embodiment
1. pre-process
(1) green hill sheep brain pretreatment：Take green hill sheep brain, with scalpel, scissors and tweezers etc. choose blood vessel, nerve and muscle every
The impurity such as film, are washed with sterile purified water, and sheep brain is cut into small pieces；
(2) walnut kernel pretreatment：Walnut kernel is soaked into 3-5 hours in water, is then peeled, washed with sterile purified water；
2. crush
According to sheep brain and walnut kernel mass ratio 3:7 ratio mixing, then Jing colloid mills crush, be crushed to particle mean size≤
50 μm of colloidal slurry；It is then pumped into refiner homogenate, 600 revs/min of rotating speed, 10 minutes time；
3. fat splitting
In pumping into retort, it is 7.4 to adjust pH with the NaOH solution of 10mol/L, 45 DEG C is cooled to after heating micro-boiling, by 2%
Mass ratio add lipase Novozym435 to digest 3.5 hours, obtain hydrolyzate；
4. protein hydrolysis
Hydrolyzate pumps into retort, and it is 8.0-9.0 to adjust pH with 10mol/LNaOH, and after heating micro-boiling 45 DEG C are cooled to, and presses
2% mass ratio adds trypsin digestion 5-6 hours；
5. mixed fermentation
Hydrolyzate pumps into fermentation tank, and it is 2.5-3.0 to adjust pH with 10mol/L citric acids, adds its sucrose of quality 2% and 2%
Lecithin, the ml l of aseptic inoculation lactic acid bacteria 20, the ml l of Bifidobacterium 15 and the ml l of saccharomycete 15,37 DEG C of mixing are sent out
Ferment 12 hours, plus 1 ‰ sesame oil froth breakings；
Lactic acid bacteria, Bifidobacterium and saccharomycetic content are required to as >=1 hundred million cfu/ml based on viable count.
6. filter, allocate
80 mesh plate-frame filterings, filtrate pumps into HPS-1 ultrafiltrations；Ultrafiltrate pumps into agitator tank, and addition 0.02% is special
Butylhydroquinone (TBHQ), 0.1% sesamin and 0.1% VE, stir.
7. filling
Bottle placer is then pumped into, canned in million grades of clean rooms, (the Jing sterile purified waters such as brown bottle, lid wash, go out
Bacterium, drying), every bottle of 5-10ml.Inspection, qualified products packaging and storage.
Instructions of taking：It is daily 2-3 time, each 5-10ml, it is adaptable to the old age of cerebral anoxia, neurasthenia, insomnia forgetfulness etc.
People takes.Adhere to taking 3 months, effect is obvious.
The cfu/ml of brain tonic bacteria agent total amount containing profitable probliotics 0.75 hundred million of the present embodiment production；Total N5.23mg/ml is little
Peptide 36.9mg/ml, free amino acid 37.1mg/ml, wherein lysine 2.61mg/100ml, tryptophan 0.51mg/100ml, benzene
Alanine 2.09mg/100ml, methionine 1.28mg/100ml, threonine 1.83mg/100ml, isoleucine 1.96mg/
100ml, leucine 3.51mg/100ml, valine 2.35mg/100ml, meet the Ministry of Public Health of republic of People's Republic of China (PRC) WS-
198 (X-171) -97 (1) is required.
Toxicological test：Orally administration oral liquid 40ml/kg of Jing mouse, security is good, has no adverse reaction；Skin is pierced
Sharp intensity evaluation standard, ＜ 0.5 is nonirritant for integration；Eye irritant test of rabbit is equally divided into 5 points, shows that the oral liquid is light
Degree pungent.
This product is rich in the growth factor and regulatory factor needed for various brain cell proliferations, growth, development and metabolism, Jing
Experiment on white mice, to cerebral anoxia effect is significant.
This product contains the probios such as lactic acid bacteria, Bifidobacterium and saccharomycete, improves stomach ecological environment, while through enzyme
The macromolecular substances such as solution, fermentation and filtration, protein, fat and polysaccharide are converted into small peptide, amino acid, DHA and monose, Jing little Bai
Mouse is tested, notable to gastrointestinal disturbances assimilation effect.
This product adds TBHQ, sesamin and VE etc., with alcohol Flavor through natural enzymolysis；Simultaneously can be anti-oxidant, prolong
The shelf-life of long products.
Embodiment 2
By sheep brain and walnut kernel mass ratio 2:8 ratio mixing, remaining is with embodiment 1.
Embodiment 3
By sheep brain and walnut kernel mass ratio 4:6 ratio mixing, remaining is with embodiment 1.
Embodiment 4
Without 0.02% tert-butylhydroquinone (TBHQ), 0.2% sesamin of addition and 0.3% VE remaining with implementing
Example 1, products obtained therefrom requires to be taken in 3 months.
Embodiment 5
Without 0.02% tert-butylhydroquinone (TBHQ), 0.3% sesamin of addition and 0.25% VE remaining with real
Example 1 is applied, products obtained therefrom requires to be taken in 3 months.
Embodiment 6
Add 1.8% sucrose and 2.2% lecithin, remaining is with embodiment 1.
Embodiment 7
Add 2.3% sucrose and 1.8% lecithin, remaining is with embodiment 1.
Total N >=5mg/ml of the brain boosting oral liquid of embodiment 2-7 production, small peptide >=30mg/ml, free amino acid >=
30mg/ml, meets the requirement of the Ministry of Public Health of republic of People's Republic of China (PRC) WS-198 (X-171) -97 (1).
Claims (9)
1. a kind of brain boosting oral liquid production method, is characterized in that, comprise the following steps：
1) pre-process
By the green hill sheep brain after impurity elimination and the walnut kernel in mass ratio 2～4 gone after thin skin:6～8 mixing；Then Jing colloids are worn into
Again using refiner homogenate after colloidal；
2) fat splitting
Then mixture adds lipase Novozym435 enzymolysis at pH 7.0-8.0,40～50 DEG C of temperature, obtains hydrolyzate；
3) protein hydrolysis
Hydrolyzate adds tryptose to digest at pH 8.0-9.0,40～50 DEG C of temperature；
4) mixed fermentation
Then it is under 2.0-4.0, to add the sucrose of its quality 1.5～2.5% and 1.5～2.5% lecithin in pH, it is aseptic to connect
Entering lactic acid bacteria, Bifidobacterium Bifidum and saccharomycetic compound bacteria carries out mixed fermentation；
5) filter, allocate
Zymotic fluid ultrafiltration after plate-frame filtering；Ultrafiltrate adds 0.01～0.5% sesamin and 0.1～0.5% VE, stirring
It is filling after uniform.
2. a kind of brain boosting oral liquid production method as claimed in claim 1, is characterized in that, the step 2) and step 3) first add
Heat is digested at being cooled to 40～50 DEG C again to micro-boiling.
3. a kind of brain boosting oral liquid production method as claimed in claim 2, is characterized in that, the step 3) fat splitting
For：It is 7.0～8.0 to adjust pH with NaOH solution, and after heating micro-boiling 40～50 DEG C are cooled to, and is added by 1.5～2.5% mass ratio
Lipase Novozym435 is digested 2～5 hours, obtains hydrolyzate.
4. a kind of brain boosting oral liquid production method as claimed in claim 2, is characterized in that, the step 4) protein hydrolysis
For：It is 8.0～9.0 to adjust pH with NaOH solution, and after heating micro-boiling 40～50 DEG C are cooled to, and is added by 1.5～2.5% mass ratio
Trypsin digestion 3～8 hours.
5. a kind of brain boosting oral liquid production method as claimed in claim 1, is characterized in that, the step 4) mixed fermentation
For：It is 2.5～3.0 to adjust pH with citric acid, adds its sucrose of quality 1.5～2.5% and 1.5～2.5% lecithin, aseptic inoculation
The ml l of lactic acid bacteria 15～20, the ml l of Bifidobacterium 10～20 and the ml l of saccharomycete 10～20,35～40 DEG C of mixing are sent out
Ferment 10～15 hours.
6. a kind of brain boosting oral liquid production method as claimed in claim 1, is characterized in that, the step 4) mixed fermentation in
Using sesame oil froth breaking.
7. a kind of brain boosting oral liquid production method as claimed in claim 1, is characterized in that, the step 5) if necessary to long-term
Preserve, need to it is possible to additionally incorporate tert-butylhydroquinone.
8. a kind of brain boosting oral liquid production method as claimed in claim 1, is characterized in that, the step 5) using 80 keevil frames
Filter.
9. the brain boosting oral liquid of the method production in claim 1-8 described in any one, is characterized in that, its total N >=5mg/ml,
Small peptide >=30mg/ml, free amino acid >=30mg/ml.
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| CN111329071A (en) * | 2020-03-13 | 2020-06-26 | 江西康宝医药生物科技有限公司 | Preparation process of brain polypeptide |
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