CN106616910A - Fructo-oligosaccharide compound prebiotics, as well as preparation method and application thereof - Google Patents
Fructo-oligosaccharide compound prebiotics, as well as preparation method and application thereof Download PDFInfo
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- 235000013406 prebiotics Nutrition 0.000 title claims abstract description 31
- 229940107187 fructooligosaccharide Drugs 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims description 11
- -1 Fructo-oligosaccharide compound Chemical class 0.000 title abstract 7
- 235000007542 Cichorium intybus Nutrition 0.000 claims abstract description 34
- 229930006000 Sucrose Natural products 0.000 claims abstract description 31
- 239000005720 sucrose Substances 0.000 claims abstract description 31
- 241000723343 Cichorium Species 0.000 claims abstract description 15
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- 238000002156 mixing Methods 0.000 claims description 32
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 29
- 244000298479 Cichorium intybus Species 0.000 claims description 19
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical class OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims description 13
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses fructo-oligosaccharide compound prebiotics. The fructo-oligosaccharide compound prebiotics comprises the following ingredients: sucrose fructo-oligosaccharides and chicory fructo-oligosaccharides in a weight ratio of 1: (2-5). According to the invention, the sucrose fructo-oligosaccharides enriched in kestose GF2 and the chicory fructo-oligosaccharides enriched in hexasaccharides and heptasaccharides are compounded so as to produce compound fructo-oligosaccharides with excellent overall effects. The prepared fructo-oligosaccharides have the following advantages: (1), the product is rich in GF2 content, so that the product is capable of comprehensively and rapidly proliferating 7 kinds of prebiotics; (2), the product is rational in GF2 content, so that the product is capable of reducing the side effects, including flatulence and laxation, caused by excessively rapid fermentation speed; (3), the product has greatly improved solubility and palatability, so that the consumer experience is improved; and (4), the product is rich in hexasaccharide and heptasaccharide contents, so that the prebiotics can be produced in the middle and rear segments of the colon. Test results have proven that the fructo-oligosaccharide compound prebiotics have relatively good effects.
Description
Technical field
The invention belongs to prebiotics technical field, more particularly to a kind of FOS complex prebiotics and preparation method thereof and
Using.
Background technology
Prebiotics is a kind of can in specific manner to be changed in enteron aisle to the group of host health profitable strain by selective fermentation
Into the dispensing with activity, can keep lossless and large intestine is entered by alimentary canal.Can be had from the prebiotics of external environment condition intake
Bacterium institute's metabolism of selective transporter is simultaneously grown using the carbohydrate.Research finds that prebiotics can affect enteron aisle group
Bacterium, changes bowel habit, interacts with mineral matter is absorbed, and occurs with cell propagation in enteron aisle and periphery cancer resistance tissue
Interact, adjust immunologic function, endocrine activity and fat metabolism etc., it is highly beneficial to human body.
FOS is typical prebiotics, with propagation intestinal beneficial bacterium, balanced human's Tiny ecosystem, relaxes bowel, carries
The effects such as high immunity of organisms, it is widely used in health food and food service industry：As dispensed food for baby, dairy products, beverage,
The fields such as bakery.
At present, the FOS applied in industry has two kinds of sources：The FOS that produced as raw material with sucrose and with chrysanthemum
Lettuce is the FOS of raw material production.Wherein 3～5, its structural formula is expressed as GFn (G to the FOS degree of polymerization of Sucrose Sources
For glucosyl group, F is fructosyl, n=2～4).Sucrose FOS each components are respectively：The degree of polymerization is 3 ketose GF2, polymerization
Spend Nystose GF3, the GF4 GF4 that the degree of polymerization is 5 for 4, molecular weight between 504～828, wherein FOS
Ketose GF2 components are relatively low due to the degree of polymerization, can be utilized by the beneficial bacterium of the big enteral of human body rapidly, the big enteral of fast breeding
Beneficial bacterium, but the enteron aisle side effect that the Rapid Fermentation such as small molecule GF2 of low polymerization degree easily causes, such as flatulence, hypocatharsis, to baby
Child, the application of infant foods are a larger obstacles.Witloof source the FOS degree of polymerization 2～8, what it was included
Structural formula has two kinds, and one kind is expressed as GFn, and (G is glucosyl group, and F is fructosyl, n=2～7), and another kind is expressed as Fn, and (F is
Fructosyl, n=2～8).The component that witloof FOS is included has：Fruit fruit disaccharides F2, fruit fruit trisaccharide F3, ketose GF2, fruit fruit four
Sugared F4, Nystose GF3, fruit fruit pentasaccharides F5, GF4 GF4, fruit six sugar F6 of fruit, sugarcane six sugar GF5 of fruit, fruit seven sugar F7 of fruit, sugarcane
Really seven sugar GF6, fruit eight sugar F8 of fruit, sugarcane really eight sugar GF7.Witloof FOS molecular weight is between 342～1314.In mouthfeel, witloof
FOS carries its distinctive local flavor, the smell of the local flavor similarly melon seedling, and acceptance is relatively low in ordinary consumer.Due to witloof
The average degree of polymerization of FOS is higher, and product dissolubility is poor, and the dispersiveness, dissolubility in water is bad, is also easy to conglomeration, consumption
Person is difficult to obtain good experience sense.Additionally, GF2 is less in fructo oligosaccharide in chicory, and GF2 is that have in FOS each component
The monomer of most excellent efficacy, can breed bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium longum, bifidobacterium breve, acidophilus
The probios such as lactobacillus, Lactobacillus plantarum, Lactobacillus salivarius.
In sum, single sucrose FOS or fructo oligosaccharide in chicory itself all comes with some shortcomings, and needs development
A kind of FOS prebiotics of comprehensive excellent results is meeting demand.
The content of the invention
In order to solve the above problems, it is an object of the invention to provide a kind of FOS complex prebiotics and preparation method thereof
And application.
The purpose of the present invention is achieved through the following technical solutions：
A kind of FOS complex prebiotics, it is characterised in that comprising sucrose FOS and fructo oligosaccharide in chicory, wherein
The weight proportion of the sucrose FOS and fructo oligosaccharide in chicory is 1:2～5.
Preferably, described sucrose FOS and the weight proportion of fructo oligosaccharide in chicory is 1:3.
Preferably, in described sucrose FOS ketose GF2 contents account for the 70% of sterling sucrose FOS with
On, the content sum of Nystose GF3 and GF4 GF4 accounts for less than the 30% of sterling sucrose FOS.
Preferably, seven sugar F7 of fruit fruit, sugarcane seven sugar GF6 of fruit, fruit six sugar F6 of fruit and sugarcane fruit six in described fructo oligosaccharide in chicory
The content sum of sugared GF5 accounts for more than the 20% of sterling fructo oligosaccharide in chicory, fruit fruit disaccharides F2, fruit fruit trisaccharide F3, ketose
GF2, fruit fruit tetrose F4, Nystose GF3, the content sum of fruit fruit pentasaccharides F5 and GF4 GF4 account for the oligomeric fruit of sterling witloof
Less than the 80% of sugar.
A kind of method for preparing FOS complex prebiotics, sucrose FOS, fructo oligosaccharide in chicory are existed in proportion
Mixing, dissolving, filtration, sterilizing, concentration under room temperature condition is prepared.
A kind of FOS complex prebiotics application, should be in food or health products.
A kind of FOS complex prebiotics preparation, is made up of above-mentioned FOS complex prebiotics as active component
It is adapted to oral preparation.
Preferably, described FOS complex prebiotics preparation is pulpous state or powdery.
Beneficial effects of the present invention：
FOS can breed internal beneficial bacterium, but the compound sugar of each component breeds the species difference of beneficial bacterium.Sugarcane
The fertile beneficial bacterium species of sugared FOS has：It is bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium longum, bifidobacterium breve, thermophilic
Totally 7 kinds of Lactobacillus lactis, Lactobacillus plantarum, Lactobacillus salivarius, wherein GF2 can all breed above-mentioned 7 kinds of beneficial bacteriums, and GF3 can only
Breeding above-mentioned first three beneficial bacterium (bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium longum), GF4 can only breed first two
Beneficial bacterium (bifidobacterium adolescentis, bifidobacterium infantis), it is seen then that GF2 is classic component in sucrose FOS.The oligomeric fruit of witloof
2～8, wide in range polymerization scope can bring more longlasting breeding to sugared chain length range.Wherein, 6 sugar, 7 sugar, 8 sugar due to
There is the higher degree of polymerization, beneficial bacterium cannot be utilized directly to it in enteron aisle, there is slower fermenting speed in human body intestinal canal, can
Reach up to transverse colon and colon descendens position is just utilized by beneficial bacterium, the Rapid Fermentations such as small molecule GF2 not only can be avoided and drawn
The enteron aisle side effect for rising, such as flatulence, hypocatharsis, can also make the beneficial bacterium of latter end in colon can also obtain nutrient source and increase in a large number
Grow, the SCFA produced by beneficial bacterial metabolic can supplement the energy needed for this section of colon epithelial cell propagation.But, witloof
GF2 is less in FOS.The sucrose FOS and the fructo oligosaccharide in chicory rich in 6 sugar, 7 sugar that will be enriched in GF2 is combined, and can produce
The compound FOS with comprehensive excellent results is born, the product has advantages below：(1) product G F2 rich content, can
Comprehensively, 7 kinds of beneficial bacteriums are bred rapidly；(2) product G F2 content rationally, can mitigate the too fast flatulence brought of fermenting speed, hypocatharsis etc.
Side effect；(3) product dissolubility, palatability are significantly lifted, and consumer experience sense is improved；(4) sugar of product 6,7 sugared contents
It is abundant, beneficial bacterium can be bred in colon posterior segment.
Description of the drawings
Fig. 1 is the chromatogram of sucrose FOS pasty products (solid content DS75%).
Fig. 2 is the chromatogram of witloof FOS powder products (moisture 5%).
Fig. 3 is the chromatogram of compound GFO FOSs (DS75%) prepared by embodiment 1.
Specific embodiment
The present invention is further described with reference to specific embodiment.
Embodiment 1
Witloof FOS is dissolved into into the solution of DS25% with 40 DEG C of warm water, then heating evaporation moisture is to DS75%.Take sucrose
FOS pasty products (solid content DS75%), by sucrose FOS syrup and witloof FOS syrup weight 1 is compared：3 ratio mixing is equal
Even, dissolving, filtration, sterilizing, concentration prepare compound GFO FOSs (DS75%).
Embodiment 2
Witloof FOS is dissolved into into the solution of DS25% with 40 DEG C of warm water, then heating evaporation moisture is to DS75%.Take sucrose
FOS pasty products (solid content DS75%), by sucrose FOS syrup and witloof FOS syrup weight 1 is compared：2 ratio mixing is equal
Even, dissolving, filtration, sterilizing, concentration and spray drying prepare compound GFO FOSs (moisture≤5%).
Embodiment 3
Witloof FOS is dissolved into into the solution of DS25% with 40 DEG C of warm water, then heating evaporation moisture is to DS75%.Take sucrose
FOS pasty products (solid content DS75%), by sucrose FOS syrup and witloof FOS syrup weight 1 is compared：4 ratio mixing is equal
Even, dissolving, filtration, sterilizing, concentration prepare compound GFO FOSs (DS75%).
Embodiment 4
Witloof FOS is dissolved into into the solution of DS25% with 40 DEG C of warm water, then heating evaporation moisture is to DS75%.Take sucrose
FOS pasty products (solid content DS75%), by sucrose FOS syrup and witloof FOS syrup weight 1 is compared：5 ratio mixing is equal
Even, dissolving, filtration, sterilizing, concentration and spray drying prepare compound GFO FOSs (moisture≤5%).
Experimental example 1
Compound GFO FOSs (DS75%) prepared by Example 1, with equipped with quaternary gradient pump and pulsed amperometric inspection
The ICS-500 ion chromatographs for surveying device detect the content of each component, and its result is listed in Table 1, and chromatogram is as shown in Figure 3.
The detection data of table 1 and compounding result
Experimental example 2
Effect of the present invention is proved below by way of clinical laboratory data.
Volunteer 1：28 years old women, without medical history, eating habit：1 day 1 cup of black tea, light, physique is trembled with fear partially, without allergies；Even
The continuous product for taking the embodiment of the present invention 13 days, disposably takes 20mL, and mode of taking respectively directly takes/directly takes/
In admixing breakfast porridge；When Time of Administration is empty stomach/breakfast in empty stomach/morning in the morning；Take reactionless in the phase, body-sensing is better than taking it
Before, this product can be received and continue to take.
Volunteer 2：36 years old normal females, eating habit：Cantonese, eats once in a while peppery, physique partial heat, without allergies；Continuous clothes
With the product 5 days of the embodiment of the present invention 1, take after mixing it with water 10mL of the present invention per warm washing water；After the meal/morning is empty during Time of Administration is respectively
Abdomen/morning on an empty stomach/in after the meal/it is early after the meal；Take response situation daily in the phase has an exhaust for exhaust defecation/idol, defecation once/
Nothing/dispute has dry sensation/dispute to have dry sensation；Body-sensing is better than before taking, sensation this product taste is pretty good, sugariness is moderate.
Volunteer 3：30 years old women, there is constipation and acute gastroenteritis medical history, and physique is damp and hot, without allergies；Continuously take this
The product of inventive embodiments 16 days, directly takes daily 10mL；Time of Administration be respectively it is early after the meal/it is early after the meal/sleep before/sleep before/
In before the meal/it is early after the meal；Response situation daily in the phase is taken for abdominal distension/abdominal distension/nothing/nothing/nothing/nothing；Body-sensing and class before taking
Seemingly, it is subjected to the mouthfeel of this product.
Volunteer 4：28 years old women, there is halitosis and constipation medical history, and physique is trembled with fear partially, without allergies；Continuously take of the invention real
Apply the product of example 15 days, daily 10/20/20/10/10mL of the present invention, the mode of taking be respectively hot water take after mixing it with water/hot water punching
Clothes/other/hot water takes after mixing it with water/other；Time of Administration is after empty stomach/before lunch/morning empty stomach/lunch in empty stomach/morning in the morning；Take
Daily response situation is borborygmus exhaust/nothing/exhaust defecation/nothing/exhaust defecation in phase；Body-sensing feels this better than before taking
Products taste quality is dense, prefers.
Volunteer 5：38 years old women, have constipation medical history, eating habit：Eat much, physique partial heat, without allergies；Continuous clothes
With the product 5 days of the embodiment of the present invention 1,20/10/10/10/10mL of the present invention is disposably taken respectively daily, take mode point
Wei directly not take/hot water takes after mixing it with water/hot water takes after mixing it with water/directly takes/directly take；Time of Administration is respectively after the full abdomen of lunch/the noon
After the full abdomen of after the meal/lunch/lunch after/dinner after；Take response situation daily in the phase and be slight exhaust；Body-sensing is better than taking
Before, feel that sugariness is adapted to, can receive.
Volunteer 6：27 years old women, there is diarrhoea and intestinal irritable syndrome medical history, eating habit：It is light, physique partially tremble with fear with
Phlegm wet, there is allergies；Continuously take the product of the embodiment of the present invention 16 days, taken after mixing it with water the present invention with hot water between the tea time in the afternoon daily
10mL；Take response situation daily in the phase be respectively have a dry/borborygmus exhaust, dry, amount of drinking water increase/trick relatively warm up,
Have a dry, the long exhaust/long acne of life, menarche cold and pain in the lower abdomen disease alleviated/menarche cold and pain in the lower abdomen disease alleviated；
Body-sensing can receive the mouthfeel of the present invention better than before taking.
Volunteer 7：37 years old normal females, eating habit：Jing often eats peppery, and physique is trembled with fear partially, without allergies；Continuously take this
The product of bright embodiment 16 days, daily in the afternoon 2 points taken after mixing it with water 10mL of the present invention with hot water；Take response situation daily in the phase point
It is not nothing/nothing/micro- abdominal distension/nothing/nothing/nothing；Body-sensing can receive the mouthfeel of the present invention, the smell ratio of bath better than before taking
It is more comfortable.
Volunteer 8：29 years old women, there is constipation and acute gastroenteritis medical history, physique partial heat, without allergies；Continuously take this
The product of inventive embodiments 12 days, daily 2 times, is taken after mixing it with water 10/10/20/20mL of the present invention with hot water respectively every time, Time of Administration point
Not Wei after the full abdomen of breakfast/the full abdomen of breakfast after/in empty stomach/morning in the morning on an empty stomach, take response situation daily in the phase be without/a little on
Fire/nothing/nothing；Body-sensing is similar with before taking, and feels that the taste of this product is general.
Volunteer 9：34 years old normal females, digest all right, eating habit：Eat peppery once in a while, without allergies；Continuously take
The product of the embodiment of the present invention 13 days, takes after mixing it with water of the present invention 20mL2 time per daily 200mL hot water；Time of Administration is morning on an empty stomach
Before sleeping with evening；Take reactionless in the phase；Body-sensing can receive the mouthfeel of the present invention better than before taking, and not drink out other tastes
Road.
Volunteer 10：25 years old women, have constipation, eating habit：Like eating peppery snacks, functions of intestines and stomach is not so good, physique
Tremble with fear partially, without allergies；Take the product of the embodiment of the present invention 15 days, take 10/10/10/10/20mL respectively daily；The side of taking
Formula is respectively directly taken/is added in breakfast/is added in breakfast/adds in oatmeal/add in breakfast, during Time of Administration is respectively
Before the meal/breakfast when/when drinking oatmeal/when drinking oatmeal/when drinking oatmeal, take response situation daily in the phase to there is awareness of defecation/have awareness of defecation
Diarrhoea/nothing/nothing/flatulence；Body-sensing is similar with before taking, and feels the mouthfeel of the present invention very well, and raw green grass or young crops taste is somewhat dense, but can connect
Receive.
Volunteer 11：35 years old normal females, eating habit：Light, physique is trembled with fear partially, without allergies；Continuously take the present invention
The product of embodiment 13 days, is taken after mixing it with water 10mL of the present invention daily with hot water；Time of Administration be respectively in after before the meal/supper/it is early before the meal；
Burp is few, borborygmus for exhaust to take response situation daily in the phase, body heat/defecation easily/exhaust is frequent, body heat；Body-sensing
Better than before taking, mouthfeel is pretty good.
Volunteer 12：26 years old women, there is the medical history of constipation, diarrhoea, chronic enterogastritis, and physique is trembled with fear partially, without allergies, continuously
Take the product of the embodiment of the present invention 15 days, take 20/10/10/10/10mL respectively daily；The mode of taking is respectively hot water punching
Take/directly take/directly take/hot water takes after mixing it with water/hot water takes after mixing it with water, Time of Administration be respectively breakfast and in after the meal/in before the meal/Chinese meal
Afterwards/in before the meal/in after the meal, take response situation daily in the phase be respectively vented, exhaust in afternoon it is many/exhaust is more, excretion it is smooth/
Borborygmus aerogenesis is more/borborygmus aerogenesis/borborygmus aerogenesis；Body-sensing can receive the mouthfeel of the present invention better than before taking.
Volunteer 13：25 years old normal females, physique partial heat, without allergies, first continuously takes the product of the embodiment of the present invention 1
2 days, then continuously take 4 days, taken after mixing it with water 10mL with hot water daily；Time of Administration is respectively early after after the meal/after the meal early/lunch break/lunch break
After afterwards/lunch break/lunch break after, take response situation daily in the phase and be respectively toxin expelling, follow-up frequently exhaust/toxin expelling, follow-up frequent
Exhaust/toxin expelling, follow-up frequently exhaust/toxin expelling, follow-up frequently exhaust/follow-up frequently exhaust/follow-up frequently exhaust；Body-sensing with take
It is similar to before, the mouthfeel of the present invention can be received, feel easy entrance, does not have too strong taste.
Volunteer 14：32 years old women, there is constipation medical history, and physique partial heat, without allergies, continuously takes the embodiment of the present invention 1
Product 5 days, taken after mixing it with water 10mL with hot water daily；Time of Administration is early after the meal (9：00-10:00) reaction daily in the phase, is taken
Situation is exhaust；Body-sensing likes the mouthfeel of the present invention better than before taking.
Volunteer 15：34 years old women, there is canker sore medical history, like eating peppery and seafood, and physique partial heat, without allergies, connects
The continuous product for taking the embodiment of the present invention 15 days, is taken after mixing it with water 10mL daily with hot water；Time of Administration is respectively morning empty stomach/breakfast
Before/it is early after the meal/empty stomach in empty stomach/morning in the morning, take response situation daily in the phase and be respectively exhaust defecation/exhaust, sensuously
Fire/be vented, feel to get angry/be vented, feel to get angry/be vented, feel to get angry；It is very flat after feeling to take before body-sensing is not as taking
It is light.
Volunteer 16：28 years old women, there is halitosis medical history, and diet is lighter, without allergies, takes the embodiment of the present invention 1
Product 6 days, afterwards 5 days it is continuous, a few days ago plus lemon honey takes 10mL of the present invention, taken after mixing it with water 10mL with hot water within 4 days afterwards；Time of Administration point
In not being after the meal/in after after the meal/dinner/in after the meal/after drinking/it is early after the meal, take response situation daily in the phase and be respectively without/row
Just and after defecation after anus discomfort/defecation and defecation anus it is uncomfortable and with anus discomfort after exhaust/defecation and defecation and with
Anus is uncomfortable and with anus discomfort after exhaust/defecation and defecation and with exhaust after exhaust/defecation and defecation；Body-sensing is better than clothes
With before, be easier receive the present invention mouthfeel, add lemon honey beverage after mouthfeel more preferably.
Volunteer 17：26 years old normal females, physique is trembled with fear partially, without allergies, continuously takes the product 2 of the embodiment of the present invention 1
My god, taken after mixing it with water 10mL with hot water every time；Time of Administration for it is early after the meal after 9:00, take response situation daily in the phase and respectively arrange
Gas/get angry a little/；Body-sensing is pretty good to the mouthfeel common sensation of the present invention better than before taking, and taste is not liked a bit.
Volunteer 18：30 years old normal females, have tea everyday, without allergies, continuously take the product 6 of the embodiment of the present invention 1
My god, 10mL is taken daily, the mode of taking is respectively the green tea/ginger of the green tea/breakfast noodle soup/breakfast noodle soup/ginger bubble of ginger bubble
The green tea of the green tea of bubble/ginger bubble；Time of Administration is respectively after breakfast about 1h/breakfast when/breakfast about 1h after/breakfast about 1h
After afterwards/breakfast about 1h/breakfast about 1h after, take response situation daily in the phase slightly get angry for defecation, throat discomfort；Body-sensing is not so good as
Before taking, the mouthfeel of the present invention can be received.
Volunteer 19：28 years old male sex, have gastrointestinal disease and chronic enterogastritis medical history, eating habit：Have tea, eat peppery, without mistake
Quick history, continuously takes the product of the embodiment of the present invention 13 days, is taken after mixing it with water 20mL with hot water daily, and morning and afternoon is respectively once；Time of Administration
In respectively after after the meal/dinner/it is early after the meal/in after the meal/it is early after the meal/in after the meal, take response situation daily in the phase and be respectively
Nothing/borborygmus exhaust/borborygmus exhaust, hypocatharsis/borborygmus exhaust, hypocatharsis/borborygmus exhaust, hypocatharsis/borborygmus exhaust, hypocatharsis；Body-sensing is better than
Before taking, the inulin taste for feeling the present invention has just started to rush a little, may cause the discomfort of some people.
Volunteer 20：30 years old male sex, underweight, eating habit：Have tea once in a while, physique is trembled with fear partially, without allergies, continuous clothes
With the product 4 days of the embodiment of the present invention 1, taken after mixing it with water 20/10/10/20mL with hot water daily, morning and afternoon is respectively once；Time of Administration point
Not Wei it is early after the meal/in empty stomach/afternoon in the afternoon on an empty stomach/it is early after the meal/it is early after the meal/afternoon on an empty stomach, take response situation daily in the phase and divide
Wei not borborygmus/nothing/borborygmus/borborygmus；Body-sensing feels the product taste of the present invention well better than before taking, it is light some.
Volunteer 21：42 years old normal males, eating habit：Vegetarian diet, without allergies, continuously takes the embodiment of the present invention 1
Product 6 days, takes daily 10mL；Take mode respectively directly take/hot water takes after mixing it with water/directly takes/hot water takes after mixing it with water/hot water punching
Clothes/hot water is taken after mixing it with water, Time of Administration be respectively in before the meal/morning on an empty stomach/it is early after the meal/it is early before the meal/morning on an empty stomach/it is early after the meal, take
Daily response situation is respectively relatively warm normal defecation/stomach after 3h, other nothings, drains normal/nothing/nothing/nothing/nothing in phase；Body
Sense is similar with before taking, and mouthfeel is normally subjected to.
Volunteer 22：41 years old normal males, eating habit：Have tea, without allergies, discontinuously take the embodiment of the present invention 1
Product 3 days, taken after mixing it with water 10/20/10mL with hot water respectively daily；It is empty that Time of Administration is respectively the empty stomach/morning in empty stomach/morning in the afternoon
Abdomen, takes response situation daily in the phase and is respectively not substantially/not substantially/slight exhaust；Body-sensing likes this better than before taking
The smell of invention, smell is not obvious after bath.
Volunteer 23：40 years old male sex, have diarrhoea, underweight medical history, eating habit：Can suffer from diarrhoea during hot gas, physique partial heat,
There are allergies, continuously take the product of the embodiment of the present invention 16 days, taken after mixing it with water 10mL with hot water daily；Time of Administration is respectively meal
Before/before meals/before meals/after meal/before meals/after meal, take response situation daily in the phase be respectively it is normal/normal/normal/normal/
Defecation 3 times after normally/supper；Body-sensing is similar with before taking, and can receive the mouthfeel of the present invention.
Volunteer 24：48 years old normal males, eating habit：It is light, do not eat tea and peppery, physique partial heat, without allergies, continuously
Take the product of the embodiment of the present invention 16 days, 10mL is directly taken daily；Time of Administration be respectively in after the meal/in after the meal/dinner
When/in after after the meal/dinner/dinner when, it is nothing to take response situation daily in the phase；Before body-sensing is better than taking, can be direct
Entrance, feels that strange taste mitigates, and sugariness is acceptable (unlike FOS-P95L sugarinesses are so weighed).
Volunteer 25：36 years old male sex, there is high fat of blood, chronic enterogastritis medical history, and physique is trembled with fear partially, without allergies, discontinuous clothes
With the product 3 days of the embodiment of the present invention 1, taken after mixing it with water 10/20/20mL with hot water daily；Time of Administration is morning empty stomach, is taken in the phase
Daily response situation is respectively nothing/abdominal distension/abdominal distension, and body-sensing is better than before taking, and sensation mouthfeel is a shade better.
Volunteer 26：29 years old male sex, have obesity medical history, eating habit：Have tea everyday, be on the drink, liking to eat peppery, physique
Partial heat, without allergies, continuously takes the product of the embodiment of the present invention 16 days, is taken after mixing it with water 10mL with hot water daily；Time of Administration is early
Morning, on an empty stomach taking response situation daily in the phase and being respectively had awareness of defecation/have awareness of defecation/have awareness of defecation, pin warm/have awareness of defecation, discharge capacity to subtract
Lack/there is awareness of defecation, whole body warm/have awareness of defecation, whole body to warm；Body-sensing is similar with before taking, and mouthfeel is a little too sweet.
Conclusion：The 26 examinations person of clothes (18 female 8 are male) are taken after the product of the present invention, wherein the body-sensing for having 17 people is better than taking
Before, accounting is 65%, and majority are satisfied to the mouthfeel of the present invention.These all show that the present invention has preferably effect.
Claims (8)
1. a kind of FOS complex prebiotics, it is characterised in that comprising sucrose FOS and fructo oligosaccharide in chicory, wherein institute
The weight proportion for stating sucrose FOS and fructo oligosaccharide in chicory is 1:2～5.
2. FOS complex prebiotics according to claim 1, it is characterised in that described sucrose FOS and chrysanthemum
The weight proportion of lettuce FOS is 1:3.
3. FOS complex prebiotics according to any one of claim 1 or 2, it is characterised in that described sucrose
Ketose GF2 contents account for more than the 70% of sterling sucrose FOS, Nystose GF3 and GF4 in FOS
The content sum of GF4 accounts for less than the 30% of sterling sucrose FOS.
4. FOS complex prebiotics according to any one of claim 1 or 2, it is characterised in that described witloof
The content sum of seven sugar F7 of fruit fruit, sugarcane seven sugar GF6 of fruit, fruit six sugar F6 of fruit and sugarcane six sugar GF5 of fruit accounts for sterling witloof in FOS
More than the 20% of FOS, fruit fruit disaccharides F2, fruit fruit trisaccharide F3, ketose GF2, fruit fruit tetrose F4, Nystose GF3,
The content sum of fruit fruit pentasaccharides F5 and GF4 GF4 accounts for less than the 80% of sterling fructo oligosaccharide in chicory.
5. a kind of method of the FOS complex prebiotics prepared any one of claim 1-4, it is characterised in that will
In proportion at ambient temperature mixing, dissolving, filtration, sterilizing, concentration are prepared for sucrose FOS, fructo oligosaccharide in chicory.
6. the application of the FOS complex prebiotics any one of claim 1-4, it is characterised in that be applied to food
Or in health products.
7. a kind of FOS complex prebiotics preparation, it is characterised in that answered by the FOS of any one of claim 1-4
Close prebiotics and make suitable oral preparation as active component.
8. FOS complex prebiotics preparation according to claim 7, it is characterised in that described FOS is combined
Prebiotic preparation is pulpous state or powdery.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114431473A (en) * | 2022-02-23 | 2022-05-06 | 金建国 | High-stability fructo-oligosaccharide product capable of being used for preparing acidic flavor food |
| CN115444142A (en) * | 2022-10-08 | 2022-12-09 | 鸿志(广州)生物科技有限公司 | Preparation method and application of composite prebiotics |
| CN115474695A (en) * | 2021-05-31 | 2022-12-16 | 仙乐健康科技股份有限公司 | Preparation for regulating balance of host intestinal microorganisms |
| CN115651946A (en) * | 2022-10-09 | 2023-01-31 | 鸿志(广州)生物科技有限公司 | Preparation method of L-arabinose |
| CN118452278A (en) * | 2024-04-24 | 2024-08-09 | 江南大学 | Lactobacillus salivarius CCFM1266 capable of increasing nicotinic acid content in fermented milk |
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| WO2006103698A1 (en) * | 2005-03-31 | 2006-10-05 | Council Of Scientific & Industrial Research | 'edible films and coatings based on fructooligosaccharides with probiotic properties' |
| CN101268830A (en) * | 2008-04-07 | 2008-09-24 | 江门量子高科生物工程有限公司 | Complex prebiotics |
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006103698A1 (en) * | 2005-03-31 | 2006-10-05 | Council Of Scientific & Industrial Research | 'edible films and coatings based on fructooligosaccharides with probiotic properties' |
| CN101268830A (en) * | 2008-04-07 | 2008-09-24 | 江门量子高科生物工程有限公司 | Complex prebiotics |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115474695A (en) * | 2021-05-31 | 2022-12-16 | 仙乐健康科技股份有限公司 | Preparation for regulating balance of host intestinal microorganisms |
| CN115474695B (en) * | 2021-05-31 | 2024-01-19 | 仙乐健康科技股份有限公司 | A preparation for regulating intestinal microbial balance of host |
| CN114431473A (en) * | 2022-02-23 | 2022-05-06 | 金建国 | High-stability fructo-oligosaccharide product capable of being used for preparing acidic flavor food |
| CN115444142A (en) * | 2022-10-08 | 2022-12-09 | 鸿志(广州)生物科技有限公司 | Preparation method and application of composite prebiotics |
| CN115651946A (en) * | 2022-10-09 | 2023-01-31 | 鸿志(广州)生物科技有限公司 | Preparation method of L-arabinose |
| CN118452278A (en) * | 2024-04-24 | 2024-08-09 | 江南大学 | Lactobacillus salivarius CCFM1266 capable of increasing nicotinic acid content in fermented milk |
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