CN106616595A - Health-care food preparation having strong oxidation resistance and oxygen deficient resistance and application - Google Patents

Abstract

The invention belongs to a strong anti-oxidation and anti-hypoxia health food preparation and its application; it comprises the preparation of the following raw materials according to parts by weight: 0.1-10 parts of total ginsenosides, 20-1500 parts of salvia miltiorrhiza, 20-1500 parts of grape seeds, Haematococcus 10-800 parts, taurine 10-200 parts, γ-aminobutyric acid 10-80 parts; it is easy to absorb, safe and efficient and can be taken for a long time.

Description

A health food preparation with strong anti-oxidation and anti-hypoxia and its application

technical field

The invention belongs to the technical field of health food, and in particular relates to a health food preparation with strong anti-oxidation and anti-hypoxia and its application.

Background technique

Oxygen is an essential substance for the metabolism of body tissue cells. Normal tissue cell oxygen supply mainly involves five links: atmospheric oxygen partial pressure, lung ventilation, lung ventilation, gas transport and tissue ventilation. An obstacle in any of these links will lead to hypoxia in tissue cells. The fast-paced society puts the burden on the brain and the oxygen consumption is constantly increasing. Altitude, aviation, diving, high-intensity training, disease, and sub-health will all cause hypoxia in the body.

In addition, the metabolism of human cells will continuously produce free radicals, mainly peroxides. As the body ages, the ability to scavenge free radicals (peroxides) decreases. Free radicals are unpaired molecules, atoms, ions, and outer layers of groups. Electrons, with strong energy, can snatch and capture an electron of normal biomolecules to pair with themselves, destroy biological cell membranes, lysosomes, mitochondria, DNA, RNA and protein structures, etc., interfere with the normal functions of biological cells, and make the lipids of cells Carbohydrates, sugar peroxidation, protein denaturation, enzyme body inactivation, immune impairment, gene changes, causing cancer, fibrosis, atherosclerosis, arthritis, dementia, premature aging and many other diseases, are all chronic diseases and premature aging common roots.

In society, firstly, ischemia and hypoxia will occur in the late stage of many diseases, not only anti-hypoxic treatment is needed, but also hypoxic oxidative stress injury needs to be prevented; Hypoxia will occur in healthy people, and treatment requires not only anti-hypoxia, but also prevention and treatment of hypoxic oxidative stress damage; third, the elderly not only need to delay aging through anti-oxidation, but also need anti-hypoxia to maintain the health of tissue cells , enhance the vitality of body tissue cells.

Current status: Most of the health care preparations on the market are products with a single function, and there are few or no natural health care preparations with anti-oxidation and anti-hypoxia functions in the same product. psychological burden. Therefore, the research and development of strong anti-oxidation and anti-hypoxia preparations can meet the needs of the above three groups of people and has a great market demand. It is of great significance for improving the body's anti-hypoxia and anti-oxidation capabilities and maintaining human health.

Contents of the invention

The purpose of the present invention is to overcome the defects in the prior art, and provide a health food preparation and application that is easy to absorb, safe and efficient, and can be taken for a long time with strong anti-oxidation and anti-hypoxia.

The object of the present invention is achieved in this way: the following raw materials are prepared according to parts by weight: 0.1 to 10 parts of total ginsenosides, 20 to 1500 parts of salvia miltiorrhiza, 20 to 1500 parts of grape seeds, 10 to 800 parts of Haematococcus, bovine 10-200 parts of sulfonic acid, 10-80 parts of γ-aminobutyric acid.

A health food preparation with strong anti-oxidation and anti-hypoxia, consisting of 5 parts of total ginseng saponins, 1000 parts of salvia miltiorrhiza, 860 parts of grape seeds, 26 parts of haematococcus, 80 parts of taurine, and 72 parts of gamma aminobutyric acid.

A health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 1.8 parts of total ginsenosides, 1200 parts of salvia miltiorrhiza, 60 parts of grape seeds, 780 parts of haematococcus, and 160 parts of taurine , 20 parts of gamma aminobutyric acid.

A health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 0.2 parts of total ginsenosides, 600 parts of salvia miltiorrhiza, 1280 parts of grape seeds, 505 parts of haematococcus, and 50 parts of taurine , 46 parts of gamma aminobutyric acid.

The present invention also provides the application of the above-mentioned health food preparation in the preparation of a strong anti-oxidation and anti-hypoxia health food.

The present invention can be made into different dosage forms according to different market demands and preparation techniques, such as capsule preparations, granules, oral liquids, tableted candies and the like. The capsule preparation is 200-500 mg per tablet, the compressed candy is 300-6000 mg per tablet, and the granule is 3-50 g per pack.

The pharmacological basis of the present invention's selected composition:

(1) Anti-hypoxia ingredients: total ginseng saponins and salvia miltiorrhiza, which can synergistically resist heart and brain hypoxia, have a significant protective effect on acute heart and brain hypoxia, and can treat angina pectoris, palpitations, fatigue, dizziness, and brain swelling.

(2) Antioxidant ingredients: Haematococcus and grape seeds, which can inhibit oxidative stress and prevent damage to body cells caused by oxidative stress;

(3) Heart-nourishing and heart-strengthening ingredients: total ginseng saponins and taurine, which can nourish the myocardium, enhance heart function, accelerate blood circulation, improve the body's oxygen supply capacity, and treat palpitations and fatigue;

(4) Soothe the nerves and protect the brain: γ-aminobutyric acid, which can relieve tension, reduce brain oxygen consumption, increase blood supply and oxygen supply to the brain, and treat dizziness, dizziness, and memory impairment;

(5) The 6 ingredients work synergistically, are strong in anti-hypoxia and anti-oxidation, and can significantly improve the anti-oxidation and anti-hypoxia abilities of patients and normal people.

6 kinds of compositions of the present invention are played according to the role played by the emperor, minister and assistant:

1. Total ginseng saponins: Total ginseng saponins are the king drug, which is ginseng extract. Can nourish both qi and blood, invigorate the spleen and lungs, soothe the nerves and improve intelligence. [Pharmacological effects] ① Ginseng can regulate the excitation and inhibition process of the central nervous system, calm the nerves, and restore nervous and disordered nerve activities. ② Regulating blood lipids, regulating blood sugar, anti-oxidation, protecting the brain and heart muscle, increasing the secretion of adrenal cortex hormones. ③Inhibit platelet aggregation, stimulate hematopoietic function, stabilize cell membrane, increase protein synthesis, enhance memory, etc.

2. Salvia miltiorrhiza: Salvia miltiorrhiza is a ministerial drug, its taste is bitter and slightly pungent, and its nature is slightly cold; Guixin and liver channels. [Functions and Indications] Promoting blood circulation and removing blood stasis, promoting menstrual flow and relieving pain, clearing away heart-fire and relieving restlessness. [Pharmacological action] ①The circulatory system can expand coronary arteries, improve cardiac ischemia, infarction and cardiac function, protect myocardial cells, improve microcirculation; anticoagulation, promote fibrinolysis, inhibit platelet aggregation, and inhibit thrombosis; lower blood lipids; improve The body's ability to tolerate hypoxia. ② There is a milder estrogenic activity that works through the ovary. ③ Inhibit the central nervous system, enhance immunity, lower blood sugar and other effects.

3. Haematococcus: Haematococcus is a ministerial drug, which is listed as a new food resource by [Wei Shi Xin Shi Zi (2007) No. 0011]. [Pharmacological effects] ①Haematococcus contains astaxanthin, which is the strongest antioxidant in nature. It has super antioxidant activity, which is 550 times that of vitamin E. It can block lipid peroxidation and increase HDL And the function of lowering LDL, preventing ischemic heart and brain damage caused by arteriosclerosis. ②It can pass through the blood-brain barrier to protect the brain and eyes. ③Enhance immunity, improve metabolism, relieve fatigue, etc.

4. Adjuvant grape seed: Grape seed is an adjuvant, which is rich in anthocyanins and resveratrol. 【Pharmacological Actions】①Strengthen the heart, dilate blood vessels, regulate blood lipids, lower blood viscosity, resist ischemic heart disease, and contain phytoestrogens to soften blood vessels. ② The antioxidant activity is 50 times that of vitamin E and 20 times that of vitamin C, which can delay aging and enhance immunity. ③ Inhibit platelet aggregation, promote fibrinolysis, resist thrombosis, protect vascular endothelial cells, inhibit smooth machine cell proliferation, cross the blood-brain barrier to protect neurons, improve sleep, etc.

5. Taurine as an adjuvant drug: Taurine is an adjuvant drug, which is an amino acid in the human body, and has a wide range of physiological and pharmacological activities: ① It is a central inhibitory transmitter, which can nourish the brain, regulate body temperature, relieve fever, calm, calm Pain, anticonvulsant, inhibiting cataract, etc.; ②It can nourish the myocardium, enhance myocardial contractility, and resist arrhythmia; ③Promote the digestion and absorption of lipids, lower blood cholesterol, protect the liver and gallbladder, detoxify, enhance immunity, anti-inflammation, Anti-rheumatic effect.

6. Drug γ-aminobutyric acid (GABA): GABA is the drug. ①It is a natural non-protein amino acid, an important inhibitory neurotransmitter in the human body, which can open the chloride ion channel and cause cell membrane hyperactivity. Polarization, sedative hypnotic, anticonvulsant, hypotensive effect. ② It has the effects of strengthening brain and intelligence, beautifying and moisturizing skin, inhibiting obesity, and delaying brain aging.

The scope of application of the strong anti-oxidation and anti-hypoxia natural preparation of the present invention: one is acute and chronic body hypoxia and oxidative stress damage caused by diseases; Oxidative oxidative stress damage; the third is the middle-aged and elderly people who are healthy and anti-aging.

The invention has the advantages of being pure natural, easy to absorb, high efficacy, non-toxic and harmless, and can be taken for a long time.

detailed description

The invention is a health food preparation with strong anti-oxidation and anti-hypoxia, which comprises the following raw materials formulated in parts by weight: 0.1-10 parts of total ginsenosides, 20-1500 parts of salvia miltiorrhiza, 20-1500 parts of grape seeds, red ball 10-800 parts of algae, 10-200 parts of taurine, and 10-80 parts of gamma aminobutyric acid.

A health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 5 parts of total ginseng saponins, 1000 parts of salvia miltiorrhiza, 860 parts of grape seeds, 26 parts of haematococcus, and 80 parts of taurine , 72 parts of gamma aminobutyric acid.

A health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 1.8 parts of total ginsenosides, 1200 parts of salvia miltiorrhiza, 60 parts of grape seeds, 780 parts of haematococcus, and 160 parts of taurine , 20 parts of gamma aminobutyric acid.

A health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 0.2 parts of total ginsenosides, 600 parts of salvia miltiorrhiza, 1280 parts of grape seeds, 505 parts of haematococcus, and 50 parts of taurine , 46 parts of gamma aminobutyric acid.

The present invention also provides the application of the above-mentioned health food preparation in the preparation of a strong anti-oxidation and anti-hypoxia health food.

In order to explain the present invention in more detail, the present invention will be further elaborated in combination with examples. Specific examples are as follows:

Embodiment one

A natural health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 0.2 parts of total ginsenosides, 200 parts of salvia miltiorrhiza, 200 parts of grape seeds, 100 parts of haematococcus, and 10 parts of taurine , 10 parts of gamma aminobutyric acid.

Embodiment two

A natural health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 5 parts of total ginsenosides, 1420 parts of salvia miltiorrhiza, 1200 parts of grape seeds, 800 parts of haematococcus, and 100 parts of taurine , 50 parts of gamma aminobutyric acid.

Embodiment three

A natural health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 2.5 parts of total ginsenosides, 100 parts of salvia miltiorrhiza, 100 parts of grape seeds, 500 parts of haematococcus, and 100 parts of taurine , 55 parts of gamma aminobutyric acid.

Embodiment Four

A strong anti-oxidation and anti-hypoxia natural health food preparation, comprising the following raw materials formulated in parts by weight: 0.5 parts of total ginsenosides, 1200 parts of salvia miltiorrhiza, 1000 parts of grape seeds, 600 parts of haematococcus, and 100 parts of taurine , 30 parts of gamma aminobutyric acid.

Embodiment five

A natural health food preparation with strong anti-oxidation and anti-hypoxia, comprising the following raw materials formulated in parts by weight: 8 parts of total ginsenosides, 50 parts of salvia miltiorrhiza, 21 parts of grape seeds, 1360 parts of haematococcus, and 140 parts of taurine , 20 parts of gamma aminobutyric acid.

Embodiment six

A natural health food preparation with strong anti-oxidation and anti-hypoxia, including the following raw materials formulated in parts by weight: 3 parts of total ginseng saponins, 50 parts of salvia miltiorrhiza, 400 parts of grape seeds, 625 parts of haematococcus, and 36 parts of taurine , 10.6 parts of gamma aminobutyric acid.

Experimental example

1. Anti-hypoxic pharmacodynamics experiment of rat cardiomyocytes and brain cells

Note: (1) *Compared with the model group, p<0.05.

(2) Experimental Group 1: It is a patent titled "A Strong Antioxidant Composition for Preventing Atherosclerosis and Its Application", the application number is "201610584155.3", and the application date is July 14, 2016 .

(3) Experimental group 2: "An anti-atherosclerosis cardio-cerebral ischemia composition and its application" is ready to apply for an invention patent.

From the experimental results of cardiomyocyte anti-hypoxic pharmacodynamics, it can be seen that the anti-hypoxic drug effect of the present invention group>experimental group 2>captopril group>experimental group 1>Shexiang Baoxin Pill group.

From the experimental results of anti-hypoxic pharmacodynamics of brain cells, it can be seen that the anti-hypoxic drug effect of the group of the present invention>experiment 2 group, captopril group>experiment 1 group>Shexiang Baoxin pill group

2. Antioxidant Pharmacodynamics Experiment of Human Embryo Umbilical Vein Endothelial Cells

group no SOD(U/ml) MDA (pmol/ml) normal control group 8 21.63±5.72* 141.53±11.67* Hydrogen peroxide (H ₂ O ₂ ) injury group 8 4.14±0.76 292.25±22.16 Tongxinluo capsule group 8 10.31±3.53* 215.38±24.51* Shexiang Baoxin Pill Group 8 9.79±2.22* 223.47±21.81* Danshen dripping pill group 8 7.93±3.05* 203.51±14.51* Captopril group 8 15.37±3.41* 179.71±12.46* Experiment 1 group 8 14.73±1.95* 188.25±15.63* Experiment 2 groups 8 15.12±0.91* 181.73±13.44* Invention group 8 16.64±1.43* 172.23±14.62*

Note: (1) Hydrogen peroxide (H ₂ O ₂ ) is peroxidized water, a strong oxidant, which is toxic and damaging to cells.

(2) *Compared with the model group, p<0.05.

(3) Experimental Group 1: It is a patent titled "A Strong Antioxidant Composition for Preventing Atherosclerosis and Its Application", the application number is "201610584155.3", and the application date is July 14, 2016 .

(4) Experimental group 2: "An anti-atherosclerosis cardio-cerebral ischemia composition and its application" is preparing to apply for an invention patent.

From the results of endothelial cell anti-oxidation pharmacodynamics experiment, it can be seen that the group of the present invention has the strongest anti-oxidation effect, can significantly increase SOD, and the effect of increasing SOD>captopril group>anti-AS heart and brain ischemia group>Wuwei Antioxidant group > Tongxinluo Capsule group > Shexiang Baoxin Pill group > Danshen Dripping Pill group; and significantly reduced MDA, the effect of reducing MDA > Captopril group > Anti-AS heart and brain ischemia group > Wuwei antioxidation group > Danshen dripping pill group > Tongxinluo capsule group > Shexiang Baoxin pill group.

3. Normal people are hypoxic at high altitude, and the symptoms can be significantly improved after taking the present invention.

4. Before and during the exam, sleep can be improved after taking the present invention, and brain thinking can be kept clear.

5. Acute heart and brain hypoxia due to atherosclerosis can quickly improve hypoxic symptoms and stabilize the condition after taking the present invention.

6. Middle-aged and elderly people can obviously improve their health and mental state after taking the present invention, improve immunity and vitality, significantly reduce colds, and greatly shorten the duration of colds.

The present invention is a health food preparation composed of pure natural substances with strong anti-oxidation and anti-hypoxia, and all its components are health food raw materials stipulated by the state.

The extracts contained in the six components of the present invention can be replaced by the original medicinal materials containing the same amount of functional components; the original medicinal materials contained in the six components of the present invention can be replaced by the extracts containing the same amount of functional components.

The dosage form of the present invention can be processed into different dosage forms according to market demands and manufacturing techniques, and corresponding auxiliary materials meeting national regulations can be added according to the requirements of the dosage forms.

Case 1: Li, male, 57 years old, had hypertensive coronary heart disease for 7 years, and diabetes for 3 years. He suffered from sudden angina pectoris in June 2016. He was relieved by taking the capsule preparation prepared by the present invention. Atherosclerotic heart and brain ischemia preparations, insisted on taking so far without hospitalization, still go to work.

Case 2: Lou Moumou, male, 49 years old, went on a business trip to Tibet in September 2016. Sudden chest tightness, shortness of breath, dizziness, fatigue, and cyanosis of the lips. After taking the capsule preparation prepared by the present invention, the symptoms were relieved. Adhering to taking it every day, no symptoms of hypoxia occurred.

Case 3: Yu Moumou, male, 82 years old, had frequent angina pectoris attacks within a week in August 2016. Several ECG examinations showed obvious ischemic changes in the ST segment, no infarcted Q waves, and coronary angiography near the left circumflex branch. If the segmental stenosis is 80-90%, it is recommended to put a stent for treatment. The patient insists on conservative treatment, voluntarily insists on taking the capsule preparation prepared by the present invention, and changes to the "anti-atherosclerotic cardio-cerebral ischemia preparation" after one month, and has no chest pain so far. Onset, able to carry out daily activities, mental state is good.

Case 4: Guo Mou, female, 17 years old, took the college entrance examination in May 2016, and experienced dizziness, headache, anorexia, and insomnia. The parents were very anxious and began to take the capsule preparation of the present invention. The symptoms improved and disappeared, and they continued to take it until the college entrance examination End. When I got the admission letter from a key university, I was very excited and expressed my heartfelt thanks.

Case 5: Yu Moumou, female, 53 years old, must have a cold every year when the season changes, and lasts for 30 to 40 days. She began to take the capsule preparation of the present invention in September this year, with a maintenance dose (2 to 4 capsules per day), sleep well, and feel strong all over the body , Suffered from mild cold in October, did not take cold medicine, just got better in two or three days, this lady proposes that she will take for a long time of the present invention.

Case 6: Gao Moumou, male, 85 years old, had been in good health in the past. In late August, he gradually developed drowsiness, anorexia, fatigue, immobility, cold extremities, forgetfulness, listlessness and other aging symptoms. Chinese and Western medicines did not work. Good, the family feels very bad. Knowing the present invention after three weeks, began to try out the capsule preparation of the present invention, 3 times a day, 3 capsules each time, the mental state was improved after two days, obviously improved in a week, and now the patient can take care of himself, walks freely, is willing to communicate, family members I am very happy, and when we met, I praised the medicine as effective and very good.

The above-mentioned embodiments are only examples for clear description, and are not intended to limit the implementation. For those skilled in the art, other changes or changes in different forms can be made on the basis of the above description. It is not necessary and impossible to exhaustively list all the implementation modes here, and the obvious changes or changes derived therefrom are still within the scope of protection of the claims of the present invention.

Claims (5)

1. a kind of health food preparation of strong anti-oxidation anti anoxia, it is characterised in that：Match somebody with somebody according to parts by weight including following raw materials according System is formed：0.1～10 part of general ginsenoside, 20～1500 parts of the red sage root, 20～1500 parts of grape pip, 10～800 parts of haematococcus, ox 10～200 parts of sulfonic acid, 10～80 parts of gamma aminobutyric acid.

2. a kind of health food preparation of strong anti-oxidation anti anoxia, it is characterised in that：Match somebody with somebody according to parts by weight including following raw materials according System is formed：5 parts of general ginsenoside, 1000 parts of the red sage root, 860 parts of grape pip, 26 parts of haematococcus, 80 parts of taurine, gamma aminobutyric acid 72 parts.

3. a kind of health food preparation of strong anti-oxidation anti anoxia, it is characterised in that：Match somebody with somebody according to parts by weight including following raw materials according System is formed：1.8 parts of general ginsenoside, 1200 parts of the red sage root, 60 parts of grape pip, 780 parts of haematococcus, 160 parts of taurine, γ amino fourths 20 parts of acid.

4. a kind of health food preparation of strong anti-oxidation anti anoxia, it is characterised in that：Match somebody with somebody according to parts by weight including following raw materials according System is formed：0.2 part of general ginsenoside, 600 parts of the red sage root, 1280 parts of grape pip, 505 parts of haematococcus, 50 parts of taurine, γ amino fourths 46 parts of acid.

5. a kind of health food preparation as claimed in claim 1 or 2 or 3 or 4 is preparing a kind of strong anti-oxidation anti anoxia health care Application in food.