CN106581303A - Mouth wash for preventing recurrent canker sore - Google Patents
Mouth wash for preventing recurrent canker sore Download PDFInfo
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- CN106581303A CN106581303A CN201611087387.4A CN201611087387A CN106581303A CN 106581303 A CN106581303 A CN 106581303A CN 201611087387 A CN201611087387 A CN 201611087387A CN 106581303 A CN106581303 A CN 106581303A
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- Prior art keywords
- extract
- canker sore
- mouth wash
- mouthwash
- preventing
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- 208000020670 canker sore Diseases 0.000 title claims abstract description 26
- 239000002324 mouth wash Substances 0.000 title claims abstract description 25
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 25
- 230000000306 recurrent effect Effects 0.000 title abstract description 5
- 239000000284 extract Substances 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000010239 Grewia biloba Nutrition 0.000 claims abstract description 14
- 241000332404 Grewia biloba Species 0.000 claims abstract description 14
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 11
- 239000003765 sweetening agent Substances 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 8
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 8
- 239000000341 volatile oil Substances 0.000 claims abstract description 8
- 239000011746 zinc citrate Substances 0.000 claims abstract description 8
- 229940068475 zinc citrate Drugs 0.000 claims abstract description 8
- 235000006076 zinc citrate Nutrition 0.000 claims abstract description 8
- 239000005844 Thymol Substances 0.000 claims abstract description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 7
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 7
- 229960000790 thymol Drugs 0.000 claims abstract description 7
- 238000004140 cleaning Methods 0.000 claims abstract description 4
- 244000025254 Cannabis sativa Species 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 8
- 240000002547 Rosa roxburghii Species 0.000 claims description 7
- 235000000640 Rosa roxburghii Nutrition 0.000 claims description 7
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- 239000007900 aqueous suspension Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- 235000014347 soups Nutrition 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000003020 moisturizing effect Effects 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 abstract description 9
- 244000269722 Thea sinensis Species 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 210000003296 saliva Anatomy 0.000 abstract description 2
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 235000004789 Rosa xanthina Nutrition 0.000 abstract 1
- 241000109329 Rosa xanthina Species 0.000 abstract 1
- 244000277286 Silene armeria Species 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000000474 nursing effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 description 8
- 208000025865 Ulcer Diseases 0.000 description 7
- 231100000397 ulcer Toxicity 0.000 description 7
- 244000241235 Citrullus lanatus Species 0.000 description 3
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010028034 Mouth ulceration Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Alternative & Traditional Medicine (AREA)
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- Oral & Maxillofacial Surgery (AREA)
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- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of oral cavity nursing, and particularly relates to mouth wash for preventing recurrent canker sore. The mouth wash is prepared from thymol, silene armeria essential oil, green fructus forsythia extracts, zinc citrate, grewia biloba extracts, hirtula roses extraction liquid, tea polyphenol, sweetening agents, humectants and distilled water. Compared with the prior art, the mouth wash has the following advantages that the mouth wash can be used for cleaning the oral cavity and treating the canker sore in an auxiliary way; partial active ingredients in the mouth wash can replace ingredients in oral saliva; the continuous bacteriostatic effect can be achieved in the oral cavity; meanwhile, the fast heeling of the wound is facilitated; the functionality is high; the inhabitation effect is achieved on the recurrent canker sore; and the mouth wash is suitable to be popularized and used.
Description
Technical field
The invention belongs to oral care techniques field, and in particular to a kind of mouthwash for preventing repeatability canker sore.
Background technology
Canker sore, is also called " aphtha ", is the superficial ulcer occurred on oral mucosa, and big I is from the grain of rice to Huang
Beans size, circular or oval, ulcer surface for it is recessed, around it is congested, pain can be caused because of irritable food, it is general one or two
Week can be repeated with self-healing, canker sore into periodicity, medically claim " recurrent oral ulceration ", and can fall ill number for 1 year
It is secondary, it is also possible to fall ill several times within one month, or even new and old pathology is alternately present, canker sore inducement is probably local trauma, spirit
Anxiety, food, medicine, hormonal readiness change and vitamin or microelement deficiencies, systemic disease, heredity, immune and micro- life
Thing may play an important role in the generation, development of canker sore, and the medicine generally existing of existing treatment canker sore cures slow,
More the problem easily recurred after.
The content of the invention
The purpose of the present invention is for existing problem, there is provided a kind of mouthwash for preventing repeatability canker sore.
The present invention is achieved by the following technical solutions：A kind of mouthwash for preventing repeatability canker sore, it is by hundred
In fragrant phenol, high basket essential oil, green grass or young crops stick up extract, zinc citrate, bilobed grewia extract, Rosa roxburghii extract, Tea Polyphenols, sweetener,
NMF, distilled water composition；
Wherein, green grass or young crops stick up extract preparation method be take fresh green grass or young crops stick up pericarp cleaning, crushed after being dried be particle diameter be 60-80nm
Green grass or young crops sticks up powder, is heated to 65 DEG C with 80% ethanol and flows back 5 times, 3 hours/time, and concentration and recovery solvent is obtained to without alcohol after decompression
Total extract, by total extract aqueous suspension after, with ethyl acetate extraction, obtain final product.
Used as further improvement of these options, the percentage by weight of its raw material is：Thymol 0.04-0.08%, height
Basket essential oil 0.04-0.07%, green grass or young crops stick up extract 0.2-0.3%, zinc citrate 0.02-0.04%, bilobed grewia extract 0.4-
0.6%th, Rosa roxburghii extract 1-2%, Tea Polyphenols 1-2%, sweetener 0.2-0.4%, NMF 6-8%, balance of distilled water.
Used as further improvement of these options, the NMF is the mixture of sorbierite and propylene glycol, is mixed
Weight ratio is 3:1；Sweetener is that honey element, sorb soup is mixed, any one in saccharin sodium.
Used as further improvement of these options, the extracting method of the bilobed grewia extract is：Bilobed grewia is dried
Root skin drying to water content is less than 6%, is crushed, and extracts evaporated under reduced pressure with 80% alcohol reflux and obtains total medicinal extract, by total medicinal extract
In being suspended from water, extracted with n-butanol, evaporated under reduced pressure solvent obtains finished product.
Used as further improvement of these options, its preparation method is to mix the raw material by corresponding weight proportion,
8-10 hours are refrigerated under conditions of 2-4 DEG C, it is filling after sterilizing.
Mouthwash is used after the meal in the present invention, and each mouthwash retains in the oral cavity after 20s, discharge of gargling.
The present invention has compared to existing technology advantages below：Water energy of gargling in the present invention cleans oral cavity, auxiliary treatment oral cavity
Component permutation in ulcer, the part active ingredient in mouthwash and saliva of buccal cavity, play the role of in the oral cavity it is persistently antibacterial, while
Contribute to wound healing, feature is strong, has inhibitory action to repeatability canker sore, is suitable to promote the use of.
Specific embodiment
Embodiment 1
A kind of mouthwash for preventing repeatability canker sore, the percentage by weight of its raw material is：Thymol 0.04%, high basket
Essential oil 0.07%, green grass or young crops sticks up extract 0.2%, zinc citrate 0.04%, bilobed grewia extract 0.6%, Rosa roxburghii extract 1%, Tea Polyphenols
2%th, sweetener 0.2%, NMF 8%, balance of distilled water；
Wherein, green grass or young crops stick up extract preparation method be take fresh green grass or young crops stick up pericarp cleaning, crushed after being dried be particle diameter be 60-80nm
Green grass or young crops sticks up powder, is heated to 65 DEG C with 80% ethanol and flows back 5 times, 3 hours/time, and concentration and recovery solvent is obtained to without alcohol after decompression
Total extract, by total extract aqueous suspension after, with ethyl acetate extraction, obtain final product；
The NMF is the mixture of sorbierite and propylene glycol, and mixed weight ratio is 3:1；Sweetener is honey element, sorb
Soup is mixed, any one in saccharin sodium；The extracting method of the bilobed grewia extract is：By bilobed grewia dry root skin drying to water
Content is less than 6%, is crushed, and extracts evaporated under reduced pressure with 80% alcohol reflux and obtains total medicinal extract, total medicinal extract is suspended from water, with just
Butanol is extracted, and evaporated under reduced pressure solvent obtains finished product.
Wherein, its preparation method is to mix the raw material by corresponding weight proportion, and 8-10 is refrigerated under conditions of 2-4 DEG C
Hour, it is filling after sterilizing.
Embodiment 2
A kind of mouthwash for preventing repeatability canker sore, the percentage by weight of its raw material is：Thymol 0.08%, high basket
Essential oil 0.04%, green grass or young crops sticks up extract 0.2%, zinc citrate 0.04%, bilobed grewia extract 0.4%, Rosa roxburghii extract 2%, Tea Polyphenols
1%th, sweetener 0.4%, NMF 6%, balance of distilled water；
Remaining content is in the same manner as in Example 1.
Embodiment 3
A kind of mouthwash for preventing repeatability canker sore, the percentage by weight of its raw material is：Thymol 0.06%, high basket
It is many that essential oil 0.06%, green grass or young crops sticks up extract 0.25%, zinc citrate 0.03%, bilobed grewia extract 0.5%, Rosa roxburghii extract 1.5%, tea
Phenol 1.5%, sweetener 0.3%, NMF 7%, balance of distilled water；
Remaining content is in the same manner as in Example 1.
Tested in 60 repeatability oral cavity canker sore patients, be randomly divided into two groups, one of which is using this enforcement
Mouthwash and water melon frost is coordinated to treat in example 3, two groups adopt mass concentration and substitute mouthwash for 0.9% physiological saline, and coordinate
Water melon frost treat, three groups only with water melon frost treatment, observe and compare patient's contrafluxion after three groups of treatments, oedema, pain and
The situation of ulcer healing；
(in December, 2000 China's stomatology can oral mucosal disease with reference to canker sore the standard of curative effect evaluation for efficacy assessment standard
The 3rd plenary session of Professional Committee the 1st passes through) formulate criterion of therapeutical effect.
By recovery from illness, effective, effective, invalid three-level evaluation：
Recovery from illness：Canker sore terminates recurrence more than half a year；
It is effective：Intermittent time extends and ulcer number is reduced；
Effectively：Intermittent time extends or ulcer number is reduced；
It is invalid：Intermittent time or ulcer number are without change.
Its treatment, recurrent interval time and recurrence number are compared, the track record time is 1 year：
The treatment of table 1
| Treatment situation | One group | Two groups | Three groups |
| Recovery from illness（People） | 15 | 8 | 4 |
| It is effective（People） | 2 | 5 | 7 |
| Effectively（People） | 1 | 3 | 2 |
| It is invalid（People） | 2 | 4 | 7 |
Table 2 recurs number and interval time
| Treatment situation | One group | Two groups | Three groups |
| Recurrence number（People） | 3 | 12 | 16 |
| Mean Time Between Replacement（My god） | 142 | 85 | 37 |
Can be seen that mouthwash in the present invention by data in Tables 1 and 2 has auxiliary therapeutic action to repeatability canker sore,
Obvious inhibition can be played, oral cavity fresh and cool can be kept, be suitable to promote the use of.
Claims (5)
1. a kind of mouthwash for preventing repeatability canker sore, it is characterised in that it is stuck up by Thymol, high basket essential oil, green grass or young crops
Extract, zinc citrate, bilobed grewia extract, Rosa roxburghii extract, Tea Polyphenols, sweetener, NMF, distilled water composition；
Wherein, green grass or young crops stick up extract preparation method be take fresh green grass or young crops stick up pericarp cleaning, crushed after being dried be particle diameter be 60-80nm
Green grass or young crops sticks up powder, is heated to 65 DEG C with 80% ethanol and flows back 5 times, 3 hours/time, and concentration and recovery solvent is obtained to without alcohol after decompression
Total extract, by total extract aqueous suspension after, with ethyl acetate extraction, obtain final product.
2. a kind of as claimed in claim 1 mouthwash for preventing repeatability canker sore, it is characterised in that the weight hundred of its raw material
Point ratio is：Thymol 0.04-0.08%, high basket essential oil 0.04-0.07%, green grass or young crops stick up extract 0.2-0.3%, zinc citrate
0.02-0.04%, bilobed grewia extract 0.4-0.6%, Rosa roxburghii extract 1-2%, Tea Polyphenols 1-2%, sweetener 0.2-0.4%, moisturizing
Agent 6-8%, balance of distilled water.
3. such as a kind of mouthwash for preventing repeatability canker sore described in claim 1 or 2, it is characterised in that the moisturizing
Agent is the mixture of sorbierite and propylene glycol, and mixed weight ratio is 3:1；Sweetener is that honey element, sorb soup is mixed, in saccharin sodium
Any one.
4. as claimed in claim 3 a kind of mouthwash for preventing repeatability canker sore, it is characterised in that the bilobed grewia is extracted
The extracting method of thing is：It is less than 6% by bilobed grewia dry root skin drying to water content, crushes, is extracted with 80% alcohol reflux
Evaporated under reduced pressure obtains total medicinal extract, and total medicinal extract is suspended from water, is extracted with n-butanol, and evaporated under reduced pressure solvent obtains finished product.
5. as claimed in claim 3 a kind of mouthwash for preventing repeatability canker sore, it is characterised in that its preparation method be by
The raw material is mixed by corresponding weight proportion, and 8-10 hours are refrigerated under conditions of 2-4 DEG C, filling after sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611087387.4A CN106581303A (en) | 2016-12-01 | 2016-12-01 | Mouth wash for preventing recurrent canker sore |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611087387.4A CN106581303A (en) | 2016-12-01 | 2016-12-01 | Mouth wash for preventing recurrent canker sore |
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| Publication Number | Publication Date |
|---|---|
| CN106581303A true CN106581303A (en) | 2017-04-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611087387.4A Withdrawn CN106581303A (en) | 2016-12-01 | 2016-12-01 | Mouth wash for preventing recurrent canker sore |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107242993A (en) * | 2017-06-23 | 2017-10-13 | 王会海 | A kind of spearmint ferment mouthwash and preparation method thereof |
| CN108403585A (en) * | 2018-04-18 | 2018-08-17 | 佛山科学技术学院 | A kind of mouthwash for treating canker sore |
| CN108721176A (en) * | 2018-08-31 | 2018-11-02 | 黄冈师范学院 | A kind of mouthwash and preparation method thereof |
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| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
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| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107242993A (en) * | 2017-06-23 | 2017-10-13 | 王会海 | A kind of spearmint ferment mouthwash and preparation method thereof |
| CN107242993B (en) * | 2017-06-23 | 2020-07-31 | 王会海 | Spearmint enzyme mouthwash and preparation method thereof |
| CN108403585A (en) * | 2018-04-18 | 2018-08-17 | 佛山科学技术学院 | A kind of mouthwash for treating canker sore |
| CN108721176A (en) * | 2018-08-31 | 2018-11-02 | 黄冈师范学院 | A kind of mouthwash and preparation method thereof |
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