CN106389552A - Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage - Google Patents
Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage Download PDFInfo
- Publication number
- CN106389552A CN106389552A CN201510967829.3A CN201510967829A CN106389552A CN 106389552 A CN106389552 A CN 106389552A CN 201510967829 A CN201510967829 A CN 201510967829A CN 106389552 A CN106389552 A CN 106389552A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicinal
- traditional chinese
- medicinal ointment
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 13
- 206010014612 Encephalitis viral Diseases 0.000 title claims abstract description 11
- 201000002498 viral encephalitis Diseases 0.000 title claims abstract description 11
- 230000006931 brain damage Effects 0.000 title abstract 2
- 231100000874 brain damage Toxicity 0.000 title abstract 2
- 208000029028 brain injury Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 20
- 241000270273 Ptyas dhumnades Species 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 11
- 241000209495 Acorus Species 0.000 claims description 7
- 241001339782 Scapharca broughtonii Species 0.000 claims description 7
- 244000221860 Podophyllum emodi Species 0.000 claims description 6
- 235000010169 Podophyllum emodi Nutrition 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 6
- 229910000805 Pig iron Inorganic materials 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000003480 eluent Substances 0.000 claims description 4
- 238000010828 elution Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 244000131316 Panax pseudoginseng Species 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
- 239000006286 aqueous extract Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 235000008434 ginseng Nutrition 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- AZHSSKPUVBVXLK-UHFFFAOYSA-N ethane-1,1-diol Chemical compound CC(O)O AZHSSKPUVBVXLK-UHFFFAOYSA-N 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 238000005728 strengthening Methods 0.000 abstract description 2
- 241000242759 Actiniaria Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 241000222355 Trametes versicolor Species 0.000 abstract 1
- 210000005013 brain tissue Anatomy 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 11
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000003773 Meningism Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000000653 nervous system Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 2
- 229960004150 aciclovir Drugs 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000002636 symptomatic treatment Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- KSDSYIXRWHRPMN-UHFFFAOYSA-N 4'-O-beta-D-Galactopyranoside-6''-p-Coumaroylprunin-4',5,7-Trihydroxyflavanone Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC(O)=C3C(=O)C2)C=C1 KSDSYIXRWHRPMN-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 240000007772 Anthriscus sylvestris Species 0.000 description 1
- 235000005749 Anthriscus sylvestris Nutrition 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 206010008531 Chills Diseases 0.000 description 1
- 241000270292 Colubridae Species 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 208000003164 Diplopia Diseases 0.000 description 1
- 206010014909 Enterovirus infection Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 241000237903 Hirudo Species 0.000 description 1
- 238000007187 Keck reaction Methods 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- DEMKZLAVQYISIA-ONJCETCRSA-N Liquiritin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)c1ccc([C@@H]2Oc3c(C(=O)C2)ccc(O)c3)cc1 DEMKZLAVQYISIA-ONJCETCRSA-N 0.000 description 1
- DEMKZLAVQYISIA-UHFFFAOYSA-N Liquirtin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-UHFFFAOYSA-N 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010058483 Nuchal rigidity Diseases 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 206010040026 Sensory disturbance Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000005859 cell recognition Effects 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- HKQYGTCOTHHOMP-UHFFFAOYSA-N formononetin Chemical compound C1=CC(OC)=CC=C1C1=COC2=CC(O)=CC=C2C1=O HKQYGTCOTHHOMP-UHFFFAOYSA-N 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 208000023513 hiccough Diseases 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000000091 immunopotentiator Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- DEMKZLAVQYISIA-ZRWXNEIDSA-N liquiritin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([C@H]2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-ZRWXNEIDSA-N 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 208000018316 severe headache Diseases 0.000 description 1
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage. The traditional Chinese medicinal ointment is characterized by being prepared from the following traditional Chinese medicinal raw materials in parts by weight: 6-9 parts of coriolus versicolor, 4-6 parts of ferrosic oxide, 6-8 parts of concha arcae, 6-8 parts of zaocys dhumnade, 4-6 parts of rhizoma cimicifugae, 6-8 parts of fructus podophylli, 4-6 parts of rhizoma anemones altaicae and 4-6 parts of liquorice root. The traditional Chinese medicinal ointment has the beneficial effects that the traditional Chinese medicinal ointment is capable of strengthening body resistance and eliminating pathogenic factors, opening orifices, dispelling wind, removing stasis and dredging collaterals, and the traditional Chinese medicinal ointment conforms to the treatment principle of repairing damaged brain tissue; and the traditional Chinese medicine provided by the invention is rapid to take a curative effect, high in cure rate and free from toxic and side effects.
Description
Technical field
The present invention relates to one kind treats viral encephalitis with encephaloclastic Chinese medicinal ointment.
Background technology
It is known that viral encephalitis is virus through enteron aisle (as enterovirus) or respiratory tract (as adenovirus and Rash diease)
Enter lymphatic system breeding, then through the outer some internal organs of blood flow (arboviruse is directly entered blood flow) infection cranium, now patient can have
The constitutional symptoms such as heating.Morbidity is anxious, rapid onset.Clinical nervous system damage symptom is more rare, once in a while find stravismus, diplopia,
Sensory disturbance, incoordination, tendon reflex is asymmetric and pathologic reflex is positive.Severe one may occur in which the disease of the nervous system damages such as lethargic sleep
, comparatively fast tonic neck in shape and typical meningeal irritation sign such as Kernig levies the positive.Severe one may occur in which that the nervous systems such as lethargic sleep are damaged
The symptom of evil.The traditional Chinese medical science thinks based on genus " heat, phlegm, wind, frightened ".Conventional ACV (acyclovir) and symptomatic treatment treatment.
Antiviral therapy and symptomatic treatment at present.Cure the symptoms, not the disease, bring body and mind not enough to patient.
Content of the invention
Treatment by Chinese herbs beneficial effect of the present invention is：Strengthening vital QI to eliminate pathogenic factors, have one's ideas straightened out, wind-dispelling, stagnation resolvation, dredging collateral, repair impaired brain group
It is woven to the rules for the treatment of, the preparation of this medicine is simple, low cost, curative effect are fast, and cure rate is high, has no toxic side effect, clinic is often according to different card types
Diagnosis and treatment based on an overall analysis of the illness and the patient's condition.
For achieving the above object, a kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that the bulk drug number of Chinese medicine
As follows：6～9 parts of rainbow conk, the pig iron fall 4～6 parts, 6～8 parts of blood clam, 6～8 parts of zaocys dhumnade, 4～6 parts of rattletop, leaflet
6～8 parts of lotus, 4～6 parts of acorus graminens soland, 4～6 parts of Radix Glycyrrhizae.
Prepared by technique：Zaocys dhumnade is ground into fine powder with blood clam after corrugation sub-pieces scalding standby.First by ginseng water extraction 1 hour,
Filtrate is standby.Residue and rattletop, Himalayan mayapple fruit, acorus graminens soland, Radix Glycyrrhizae are put in Multifunctional Chinese medicine extractor, with 10 times, concentration
For 65% alcohol extract 2 hours, extract 3 times, filter, merge extract and reclaim ethanol to the greatest extent；On extract, D101 type is big
Macroporous adsorbent resin post, first with distillation water elution, wash-out distilled water is 12 times of column volume, and eluent discards, then with 65%
Ethanol carries out gradient elution, and wash-out ethanol is 8 times of column volume, and eluent reclaims ethanol to the greatest extent, obtains leachate, denseer
Contract, be dried, obtain final product.Again by residue：Decocting three times, by 3: 2: 1 hours, filters after decocting, takes filtrate standby.Will be above-mentioned standby
Medication powder, alcohol extract, Aqueous extracts merge, and stir evenly, plus paste made by dextrin, obtains final product.
In the present invention, rainbow conk belongs to immunomodulator containing coriolan, strengthens immunity of organisms, is good immunopotentiator, tool
There are enhancing immune cell function and recognition capability, improve the amount of IgM.The pig iron falls to having relieving convulsion.For demented, easily frightened kind anger,
Insomnia.Blood clam taste is salty, mild-natured.Return lung, stomach, Liver Channel.Dissolving phlegm stagnation resolvation, softening and resolving hard mass, relieving haperacidity pain relieving.For stupid phlegm glue
Knot, sticky difficulty is coughed up, goiter and tumor, scrofula, lump in the abdomen lump in the abdomen, pantothenic acid of having a stomachache.Himalayan mayapple fruit bitter, micro-pungent, warm in nature.Return liver and kidney channel.
Promoting blood circulation for regulating menstruation, dispelling wind and eliminating dampness.For blood stasis is through closing, traumatic injury, arthralgia due to wind-dampness.Zaocys dhumnade belongs to the bodily form for Colubridae zaocys dhumnade
Larger snake.Medicinal material is the hirudo leech of Colubridae animal zaocys dhumnade.Zaocys dhumnade is cut open the belly or first peels off snakeskin to let the hair grow tail, remove in
Dirty, it is coiled into the shape of a disc, drying forms, and gathers and processes in summer, Qiu Liangji more.Zaocys dhumnade is mild-natured, sweet, has wind-dispelling, dredging collateral, stops
Effect of convulsion, can treat rheumatoid arthritis stubborn, numbness contracture, the middle air port eye illness such as tiltedly.Acorus graminens soland taste is pungent, warm in nature.The thoughts of returning home,
Stomach.Function with cure mainly：Reducing phlegm by resuscitation, activating spleen and easing mental stress.For pyreticosis coma, epilepsy, Hiccough and deaf, abdominal distension uncomfortable in chest, food
It is intended to depressed；Control outward ulcer sore tinea.Radix Glycyrrhizae, is the composition having medical value extracting from Radix Glycyrrhizae.Licorice generally comprises：
Glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, formoononetin, Quercetin etc..For yellow extremely
Brownish-yellow powder.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription.All medicines are joined above
5 this disease for the treatment of, bring out the best in each other.
The present invention follows the prescriptions principle of the traditional Chinese medical science, and the present invention is according to clinical verification：Cure rate be more than 85%, efficient
More than 90%, have no toxic side effect.
Specific embodiment
With reference to implementing case, the invention will be further described：
Embodiment 1：One kind treats viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that weighing material medicine by following weight：6～9 parts of rainbow conk,
The pig iron fall 4～6 parts, 6～8 parts of blood clam, 6～8 parts of zaocys dhumnade, 4～6 parts of rattletop, 6～8 parts of Himalayan mayapple fruit, 4～6 parts of acorus graminens soland, sweet
4～6 parts of grass.Preparation is ibid.
Embodiment 2；One kind treats viral encephalitis with encephaloclastic Chinese medicine composition it is characterised in that weighing material medicine by following proportionings：9 parts of rainbow conk,
The pig iron fall 6 parts, 8 parts of blood clam, 8 parts of zaocys dhumnade, 4 parts of rattletop, 8 parts of Himalayan mayapple fruit, 4 parts of acorus graminens soland, 6 parts of Radix Glycyrrhizae.Preparation is with enforcement
Example 1.
Clinical efficacy is summarized：
First, we for many years in clinical practice extensively, treat 68 patients, and curative effect frequency is good.
2nd, diagnostic criteria：Have flu history, onset is acute or subacute, have severe headache, heating, vomiting, neck rigidity,
Typical meningeal irritation sign such as Kernig levies the positive, and have general malaise, pharyngalgia, photophobia, dizziness, listless, feel different
Often, myalgia, stomachache and shiver with cold etc..Some patientss may occur in which the symptoms such as angina, eye-blurred.Enterovirus infection may occur in which
Fash, is mostly occurred with heating simultaneously, continues 4～10 days.COxsackie A5,9,16 virus and ECHO4,6,9,16,
30 virus infection, cerebrospinal pressure increases.
3rd, administrated method：It is decocted in water for oral dose, daily 1 dose of adult, 1/2～1/3 dose of children, all 2 times a day for 1/3 dose of child,
Early, late sub-service.1/4 dose of baby, divides and feeds for 3～5 times.
4th, efficacy evaluation：
Cure：Clinical symptoms are wholly absent.
Take a turn for the better：Clinical symptoms are improved.
Do not heal：Clinical symptoms are no improved or are increased.
5th, therapeutic effect：This disease for the treatment of by Chinese herbs of the present invention, through statistics cure rate more than 85%, efficient more than 90%.
6th, model case
1st, Lee XX, female, 38 years old, in October, 2011 went to a doctor, patient main suit：Heating, Nausea and vomiting, larynx before 2 days
Bitterly, through giving antiviral agent, antibiotic therapy, effect on driving birds is not good in local hospital.Laboratory examination：Adenovirus can be found.Suffer from
Person requires to take 10 doses of Chinese medicine of the present invention, and clinical symptoms are wholly absent, and laboratory examination recovers normal, and half a year follow-up is not recurred again.
2nd, open X, man, 33 years old, goes to a doctor in August, 2013, patient main suit has a headache, nausea, kecks 1 week, through existing
After local hospital anodyne, after improvement again repeatedly, effect on driving birds is not good.Have a medical check-up：Meningeal irritation sign, laboratory examination：Find intestines
Road virus.The patient head of a family requires to take 10 doses of Chinese medicine of the present invention, 1/2 amount of adult, clinical symptoms are wholly absent, laboratory inspection
Look into recovery normal, follow-up after this year is not recurred again.
3rd, king XX, female, 10 years old, go to a doctor in May, 2014, before the head of a family tells 5 days in generation, heating, nausea, meninx pierces
Swash and levy the positive, not good with children coryza medicine therapeutic effect, increase companioned with headache, laboratory examination today：Find enterovirus.Suffer from
Mother person patient requests take 8 doses of Chinese medicine of the present invention, and with 1/2 amount of adult, clinical symptoms are wholly absent, laboratory examination recovery
Normally, after March, follow-up is not recurred again.
Claims (2)
1. a kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that bulk drug part of Chinese medicine
Number is as follows：A kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment it is characterised in that the bulk drug number of Chinese medicine is as follows：
6～9 parts of rainbow conk, the pig iron fall 4～6 parts, 6～8 parts of blood clam, 6～8 parts of zaocys dhumnade, 4～6 parts of rattletop, Himalayan mayapple fruit 6～
8 parts, 4～6 parts of acorus graminens soland, 4～6 parts of Radix Glycyrrhizae.
2. according to claim 1 a kind of treat viral encephalitis with encephaloclastic Chinese medicinal ointment technique prepare,
It is characterized in that first with blood clam, zaocys dhumnade being ground into fine powder after corrugation sub-pieces scalding standby.First by ginseng water extraction 1
Hour, filtrate is standby.Residue and rattletop, Himalayan mayapple fruit, acorus graminens soland, Radix Glycyrrhizae are put into Multifunctional Chinese medicine and extract
In tank, with 10 times, concentration be 65% alcohol extract 2 hours, extract 3 times, filter, merge extract
Reclaim ethanol to the greatest extent；D101 type large pore resin absorption column on extract, first with distillation water elution, wash-out steams
Distilled water is 12 times of column volume, and eluent discards, then carries out gradient elution, wash-out second with 65% ethanol
Alcohol is 8 times of column volume, and eluent reclaims ethanol to the greatest extent, obtains leachate, then concentrates, is dried, and obtains final product.
Again by residue：Decocting three times, by 3: 2: 1 hours, filters after decocting, takes filtrate standby.By above-mentioned standby medicinal powder,
Alcohol extract, Aqueous extracts merge, and stir evenly, plus paste made by dextrin, obtains final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510967829.3A CN106389552A (en) | 2015-12-14 | 2015-12-14 | Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510967829.3A CN106389552A (en) | 2015-12-14 | 2015-12-14 | Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389552A true CN106389552A (en) | 2017-02-15 |
Family
ID=58008323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510967829.3A Pending CN106389552A (en) | 2015-12-14 | 2015-12-14 | Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106389552A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107137593A (en) * | 2017-06-29 | 2017-09-08 | 贵州松桃信仁苗药有限公司 | It is a kind of to promote Chinese medicinal ointment of wound healing after operation and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260201A (en) * | 1999-09-10 | 2000-07-19 | 张发平 | Chinese preparatory medicine and its preparation method |
| CN102861189A (en) * | 2012-09-16 | 2013-01-09 | 丛艳彬 | Traditional Chinese medicine composition for treating viral encephalitis |
| CN103920042A (en) * | 2014-04-23 | 2014-07-16 | 王林 | Drug for treating heat invasion nutritive blood type virus meningitis, as well as preparation method thereof |
| CN104095961A (en) * | 2014-07-15 | 2014-10-15 | 烟台海研制药有限公司 | Traditional Chinese medicine combination for treating viral encephalitis of mink |
| CN104178399A (en) * | 2014-08-11 | 2014-12-03 | 济南环太机电技术有限公司 | Health medical liquor for cephalomeningitis sequela |
| CN104721748A (en) * | 2015-03-26 | 2015-06-24 | 侯荣耀 | Chinese patent medicine for treating viral encephalitis and preparation method of Chinese patent medicine |
| CN104906390A (en) * | 2015-06-17 | 2015-09-16 | 周镔 | Medicine for treating occupational chronic lead poisoning caused by spleen-stomach disharmony and preparation method |
| CN105051005A (en) * | 2012-10-12 | 2015-11-11 | 武田药品工业株式会社 | Cyclopropylamine compounds and uses thereof |
-
2015
- 2015-12-14 CN CN201510967829.3A patent/CN106389552A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260201A (en) * | 1999-09-10 | 2000-07-19 | 张发平 | Chinese preparatory medicine and its preparation method |
| CN102861189A (en) * | 2012-09-16 | 2013-01-09 | 丛艳彬 | Traditional Chinese medicine composition for treating viral encephalitis |
| CN105051005A (en) * | 2012-10-12 | 2015-11-11 | 武田药品工业株式会社 | Cyclopropylamine compounds and uses thereof |
| CN103920042A (en) * | 2014-04-23 | 2014-07-16 | 王林 | Drug for treating heat invasion nutritive blood type virus meningitis, as well as preparation method thereof |
| CN104095961A (en) * | 2014-07-15 | 2014-10-15 | 烟台海研制药有限公司 | Traditional Chinese medicine combination for treating viral encephalitis of mink |
| CN104178399A (en) * | 2014-08-11 | 2014-12-03 | 济南环太机电技术有限公司 | Health medical liquor for cephalomeningitis sequela |
| CN104721748A (en) * | 2015-03-26 | 2015-06-24 | 侯荣耀 | Chinese patent medicine for treating viral encephalitis and preparation method of Chinese patent medicine |
| CN104906390A (en) * | 2015-06-17 | 2015-09-16 | 周镔 | Medicine for treating occupational chronic lead poisoning caused by spleen-stomach disharmony and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 李怀生: "脑炎后遗症治验", 《世界中医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107137593A (en) * | 2017-06-29 | 2017-09-08 | 贵州松桃信仁苗药有限公司 | It is a kind of to promote Chinese medicinal ointment of wound healing after operation and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101537089A (en) | Pharmaceutical composition for curing allergic rhinitis and preparation method thereof | |
| CN104173950B (en) | A kind of herbal composite for treating prostate cancer | |
| CN106389552A (en) | Traditional Chinese medicinal ointment for treating viral encephalitis accompanied with brain damage | |
| CN104383486A (en) | Medicament for treating bronchitis of children | |
| CN100348235C (en) | Traditional Chinese medicine preparation for treating infantile diarrhea and preparation method thereof | |
| CN101843829B (en) | Chinese medicament for treating pulmonary heart diseases | |
| CN106138785A (en) | One treats neurasthenic Chinese medicine composition and preparation method thereof | |
| CN103961579A (en) | Traditional Chinese medicament for treating chronic bronchitis and preparation method thereof | |
| CN110946950A (en) | A Chinese medicinal composition for treating senile vascular dementia, and its preparation method | |
| CN103316235B (en) | Traditional Chinese medicine used for treating asthma, and preparation method thereof | |
| CN101884704B (en) | Traditional Chinese medicine for treating asthma | |
| CN102641441B (en) | Traditional Chinese medicine for treating phlegmatic disease | |
| CN103223075B (en) | Traditional Chinese medicinal capsule for treating diphtheria | |
| CN101897847B (en) | Traditional Chinese medicine for curing asthma | |
| CN101829213B (en) | Medicine composition for treating asthma and preparation method thereof | |
| CN108310243A (en) | Chinese medicine and preparation method thereof for specially controlling heredity icterohepatitis | |
| CN104873879A (en) | Medicinal preparation for treating insomnia | |
| CN105168860A (en) | A traditional Chinese medicine composition for treating asthma in children and its preparation method | |
| CN105770815A (en) | Folium artemisiae argyi-containing traditional Chinese medicine composition for treating postpartum collapse and preparation method thereof | |
| CN105816631A (en) | Traditional Chinese medicine composition for treating reactive depression caused by heart deficiency and weak spirit | |
| CN105232816A (en) | Traditional Chinese medicine for treating vocal cord paralysis | |
| CN118924819A (en) | A Chinese medicine formula for treating liver, kidney and other diseases | |
| CN101850079B (en) | Chinese medicament for treating asthma | |
| CN111419896A (en) | Medicated bath composition, medicated bath bag containing same and application | |
| CN103948836A (en) | Traditional Chinese medicine composition for treating child anorexia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170215 |
|
| WD01 | Invention patent application deemed withdrawn after publication |