CN106236697A - Flavoured syrups of discomfort mouthfeel and preparation method thereof when improving oral drug preparation - Google Patents
Flavoured syrups of discomfort mouthfeel and preparation method thereof when improving oral drug preparation Download PDFInfo
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- CN106236697A CN106236697A CN201610641889.0A CN201610641889A CN106236697A CN 106236697 A CN106236697 A CN 106236697A CN 201610641889 A CN201610641889 A CN 201610641889A CN 106236697 A CN106236697 A CN 106236697A
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- China
- Prior art keywords
- discomfort
- mouthfeel
- oral drug
- flavoured syrups
- preparation
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- 230000000149 penetrating effect Effects 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- IZPNTDOWOBGHEG-UHFFFAOYSA-M sodium benzene formate Chemical compound [Na+].[O-]C=O.C1=CC=CC=C1 IZPNTDOWOBGHEG-UHFFFAOYSA-M 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
- 229940124586 β-lactam antibiotics Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of flavoured syrups of discomfort mouthfeel and preparation method thereof when improving oral drug preparation without ingredient, by weight calculating, described syrup includes: sucrose 20.0%～85.0%(w/v), sweeting agent 0.10%～55.0%(w/v), aromatic 0.1%～5.0%(w/v), preservative 0.01%～0.50%(w/v), appropriate pH value regulator and water.This syrup gas fragrance, taste is dense, it is possible to improve rapidly the bad smell of various medicines, correct the oral cavity sense of discomfort of the patient that takes medicine, the difficulty person that effectively helps to take medicine takes medicine, and is particularly well-suited to infant, child and gerontal patient, the compliance of raising patient medication and the therapeutic effect of medicine.
Description
Technical field
The present invention relates to a kind of without ingredient when improving oral drug preparation discomfort mouthfeel flavoured syrups and
Its preparation method, belongs to food, medicine processing technique field.
Background technology
The conventional water such as oral solid pharmaceutical dosage tablet, capsule, pill are swallowed, and granule, dry suspension, powder etc. are logical
Commonly use warm boiled water or leach with warm water, taking after stirring evenly；The liquid such as oral solution, herb mixture, suspensoid, syrup
Dosage form, the most oral.For infant, child, the failure of taking medicine being difficult to accept to cause because of drug smell is being faced
On bed of common occurrence.Infant produces resistance for the disagreeable taste of medicine, and drug administration process is constantly cry and screamed, refused to take medicine, is even
After making under clothes, the phenomenon such as secondary Nausea and vomiting, all causes the poor effect of clinical treatment.Especially liquid preparation (includes with front
Need to be with mixing in water for oral taking or the solid preparation leached), the peculiar tastes such as it is bitter, sour, pungent or other abnormal flavour are to affect infant, child
The key factor of patient's drug compliance.Even the medicine of the solid form such as capsule, tablet, for the patient of dysphagia
Such as child, old man etc., taking with water or boiled water is also relative difficult.
Generally, medicine uses suitable method to improve its abnormal smells from the patient when making preparation, as added sweeting agent, aromatic, rubber cement
Agent etc., or medicine is made the methods such as clathrate, microencapsulation, Cotton seeds, but these methods or taste masking effect are poor, or technique
Complicated, relatively costly, or affect medicine release in time etc., effect is the most not ideal enough.It is special that a lot of clinical commonly used drugs have
Abnormal smells from the patient, conventional preparation formulation and technique are difficult to cover completely.The most wide variety of macrolide antibiotics Ah
Miramycin, clarithromycin, beta-lactam antibiotic amoxicillin, cefaclor, CEFUROXIME AXETIL, antihistaminic hydrochloric acid west is replaced
Profit piperazine, loratadine, antiviral agents oseltamivir phosphate, ribavirin and other class medicine MK, ambroxol hydrochloride, cloth
A lot of medicine such as ibuprofen all problems that there is compliance difference because it allows the bitterness that people is difficult to accept.Even if being made into sheet
The solid dosage forms such as agent, capsule successfully masks its bitterness, if when taking in the oral cavity the time of staying longer, unintentionally chew or
Other reasons causes active component to contact with taste bud, also may feel that bitterness.Additionally, Chinese medicine preparation such as four seasons Anti-virus Mixture,
The blue antiinflammatory oral liquid in Pu ground, medicine, the penetrating odor exclusive because of it or the uncomfortable mouthfeel such as the granule of crude drug/medical herbs also make
Child, the patient such as old is difficult to accept.
Chinese patent CN103721264A discloses a kind of for helping the gel swallowing oral solid pharmaceutical formulation, and it contains
Have in acid and promote disintegrate and have lubrication and the gel rubber material of parcel performance, correctives and water.Oral solid pharmaceutical formulation can be wrapped up, every
From the uncomfortable taste of medicine and increase smooth mouthfeel, dysphagia person is helped to take medicine.But the method and described Gel Compositions
Thing is only applicable to help swallows oral solid formulation, improves the medicine such as tablet, capsule and directly swallows the foreign body sensation of rear throat with water
And sense of discomfort, correct oral cavity taste when being not particularly suited for taking liquid preparation and the dosage form such as granule, dry suspension, be also unsuitable for
Medicine is dissolved with it.
Chinese patent CN102526752A discloses a kind of solid pharmaceutical preparation improving bitterness, comprises pharmaceutically active
Point, aromatic and pharmaceutically acceptable adjuvant, wherein active constituents of medicine refers to macrolide antibiotics and medicinal
Salt, particle diameter is at 40-120 mesh.Pharmaceutical preparation prepared by this invention improves the sensory issues of Macrolide bitter drug, helps
In the compliance improving clinical application.But the solid pharmaceutical preparation that the method provides contains certain kinds active component, the most only
It is applicable to macrolide antibiotics, is not intended to correct the peculiar taste of all oral drug preparations.
Chinese patent CN101820893A discloses a kind of medicinal granulated gel drink for taking lower crude drug and/or medical herbs
Material, comprises the bitterness masking ingredient of Vegetable oil lipoprotein and/or animal oil, and bitterness covers auxiliary element sugar alcohol, assembles suppression gelling
Chemical conversion point, flavoring ingredients and water.This beverage can adjust the medicine such as crude drug of bitter taste, tart flavour or the sweet taste with uniqueness
Or the taste of medical herbs, so that medicine is easy-to-swallow.But the granular jelly beverage for medication formulation ingredients that this invention provides and technique
Complicated (containing oils and fats, water, gel rubber material etc.), the granulated gel poor stability of formation.
Summary of the invention
Present invention seek to address that the problems referred to above that prior art exists, and when providing one for improving oral drug preparation
Flavoured syrups of uncomfortable mouthfeel and preparation method thereof, this syrup fragrant odour, taste is dense, it is possible to improve rapidly various medicines
The bad smell of thing, corrects the oral cavity sense of discomfort of patient of taking medicine, and the difficulty person that effectively helps to take medicine takes medicine, and is particularly well-suited to baby young
Youngster, child and gerontal patient, improve the compliance of patient medication, and this syrup good stability, can be with most of clinical common medicines
Thing compatibility uses, and does not affect the normal dissolution of medicine, discharges and absorb, it is possible to increase clinical medication effect.
The present invention solves its technical problem and the technical scheme is that
A kind of flavoured syrups of discomfort mouthfeel when improving oral drug preparation, by weight, including: sucrose 20.0%～
85.0%(w/v), sweeting agent 0.10%～55.0%(w/v), aromatic 0.1%～5.0%(w/v) and, preservative 0.01%～0.50%
(w/v), appropriate pH value regulator and water.
The preparation method of above-mentioned flavoured syrups, comprises the following steps:
(1) take suitable quantity of water, heated and boiled, with sucrose, be stirred to dissolve；
(2) sweeting agent, preservative, aromatic are added in appropriate purified water, stirring while adding so that it is to be completely dissolved, filter；
(3) (1) will be heated to 100 DEG C by solution, and filter, be cooled to 65 85 DEG C；
(4) in (2) adding (3), stir, let cool to room temperature；
(5) regulation medicinal liquid (4) pH value, pH value range is 3.0 7.0；The boiling water let cool in right amount to room temperature is added to entirely on filter
Amount, stirs evenly, to obtain final product.
Further, the preferred version of the present invention is:
Described sweeting agent include aspartame, fructose, glucose, lactose, alitame, maltose alcohol, xylitol, sorbitol,
One or more compositions in mannitol, hydrogenated maltose syrup, high fructose syrup, steviosin, Mel.
Described aromatic includes one or more the combination in fruit essence, miscellaneous fruital essence, chocolate essence
Thing.
Described fruit essence include aqua methnae, Pericarpium Citri junoris fourth, strawberry essence, fragrant citrus essence, flavoring pineapple essence, blueberry flavor,
One or more compositions in apple essence, red Punica granatum L. essence.
One or more the combination in benzoic acid and salt, oxybenzene ester and sorbic acid of the described preservative
Thing.
Described pH value regulator is selected from lactic acid, fumaric acid, DL-malic acid, DL-tartaric acid, L-AA, succinum
One or more compositions in acid, acetic acid, sodium acetate, sodium carbonate, sodium bicarbonate, citric acid, citrate.
By weight, also include: coloring agent 0.0001% 0.001%(w/v).
Described coloring agent includes cocoa pigment, radish red, beet red, safran, more Exocarpium Citri Rubrum, grape skin color
In one or more compositions.
Described flavoured syrups selects powder, granule, pill, tablet, capsule, dry suspension, suspensoid, is administered orally
At least one dosage form in solution, mixture.
Using the present invention of technique scheme, compared with prior art, it provides the benefit that:
The flavoured syrups that the present invention provides is without ingredient, it is adaptable to auxiliary takes liquid oral or solid pharmaceutical preparation.
First, syrup viscosity increases, and medicine can be stoped to spread to taste bud, may interfere with again the sense of taste of taste bud, the most commonly coagulate simultaneously
Colloid taste is dense, it is possible to the sense organ of strong sweet stimulus user.Secondly, syrup composition stable in physicochemical property, can
Use with most of clinical commonly used drug compatibilities, and the composition of food such as milk, fruit juice is complicated, not only stable to soda acid, photo-thermal etc.
Property poor, and easily there is incompatibility with some drugs, drug absorption can be affected with clothes and play a role.And, the present invention provides
Syrup regulation pH value be acidity, it is possible to paralysis taste bud and reach flavored action.
Detailed description of the invention
Below in conjunction with embodiment in detail the present invention is described in detail.By following example, can more specifically understand the present invention, but this
Bright it is not limited to following example.
Embodiment 1:
A kind of flavoured syrups of discomfort mouthfeel when improving oral drug preparation, by sucrose 850g, peach flavor 2.0ml, benzene
Sodium formate 2.0g, lactic acid 2.0ml, water are appropriate, make 1000ml.
Preparation method: take 450ml water, heated and boiled, add sucrose, be stirred to dissolve, continue to be heated to 100 DEG C, filter,
It is cooled to 65 85 DEG C；Sodium benzoate is added in appropriate purified water, is stirred to dissolve, instill peach flavor, stir,
Filter, this liquid is added in above-mentioned 65 85 DEG C of sucrose solutions, continues to be stirred until homogeneous, let cool to room temperature, add lactic acid and adjust
Joint pH value, to 4.0 5.0, adds the boiling water let cool in right amount to room temperature on filter to full dose, stirs evenly, to obtain final product.
Embodiment 2:
A kind of flavoured syrups of discomfort mouthfeel when improving oral drug preparation is fragrant by sucrose 650g, aspartame 10g, fragrant citrus
Essence 2.0ml, sodium benzoate 2.0g, citric acid 0.5g, water are appropriate, make 1000ml.
Preparation method: take suitable quantity of water, heated and boiled, add sucrose, be stirred to dissolve, continue to be heated to 100 DEG C, filter,
It is cooled to 65 85 DEG C；Aspartame and sodium benzoate are added in appropriate purified water, are stirred to dissolve, instill fragrant citrus essence,
Stir, filter, this liquid is added in the sucrose solution of above-mentioned 65 85 DEG C, continue to be stirred until homogeneous, let cool to room temperature,
Add citric acid regulation medicinal liquid pH value to 4.0 5.0, on filter, add the boiling water let cool in right amount to room temperature to full dose, stir evenly,
Obtain.
Embodiment 3:
A kind of flavoured syrups of discomfort mouthfeel when improving oral drug preparation, by sucrose 450g, xylitol 200g, apple essence
2g, ethyl hydroxybenzoate 0.5g, malic acid 0.4g, water are appropriate, make 1000ml.
Preparation method: take suitable quantity of water, heated and boiled, add sucrose, be stirred to dissolve, continue to be heated to 100 DEG C, filter,
It is cooled to 65 85 DEG C；Xylitol and ethyl hydroxybenzoate are added in appropriate purified water, is stirred to dissolve, instill fragrant citrus essence, stir
Mix uniformly, filter, this liquid is added in above-mentioned 65 85 DEG C of sucrose solutions, continues to be stirred until homogeneous, let cool to room temperature, add
Appropriate Fructus Mali pumilae acid for adjusting pH value, to 4.0 5.0, adds the boiling water let cool in right amount to room temperature on filter to full dose, stirs evenly, i.e.
?.
Embodiment 4:
A kind of flavoured syrups of discomfort mouthfeel when improving oral drug preparation, by sucrose 450g, fructose 420g, strawberry essence
2.0ml, ethyl hydroxybenzoate 0.5g, citric acid 0.5g, water are appropriate, make 1000ml.
Preparation method: take suitable quantity of water, heated and boiled, add sucrose, be stirred to dissolve, continue to be heated to 100 DEG C, filter,
It is cooled to 65 85 DEG C；Fructose and ethyl hydroxybenzoate are added in appropriate purified water, is stirred to dissolve, instill fragrant citrus essence, stirring
Uniformly, filter, this liquid is added in above-mentioned 65 85 DEG C of sucrose solutions, continues to be stirred until homogeneous, let cool to room temperature, add Chinese holly
Rafter acid for adjusting pH value, to 4.0 5.0, adds the boiling water let cool in right amount to room temperature on filter to full dose, stirs evenly, to obtain final product.
Embodiment 5:
A kind of flavoured syrups of discomfort mouthfeel when improving oral drug preparation, by sucrose 200g, steviosin 10g, Mel 200g,
Fragrant citrus essence 2.0g, sodium benzoate 2g, citric acid 0.5g, water are appropriate, make 1000ml.
Preparation method: take suitable quantity of water, heated and boiled, adds sucrose and is stirred to dissolve, continue to be heated to 100 DEG C, filter, cold
But to 65 85 DEG C；Steviosin adds 60-7O DEG C of warm water soaking dissolve, adds citric acid, sodium benzoate, be stirred to dissolve,
Add Mel, stir, instill fragrant citrus essence, filter, this liquid is added in above-mentioned 65 85 DEG C of sucrose solutions, continue
Stirring, lets cool to room temperature, adds the boiling water let cool in right amount to room temperature to full dose, stir evenly, to obtain final product on filter.
The foregoing is only the embodiment that the present invention is the most feasible, not thereby limit to the interest field of the present invention,
The equivalence change that all utilization description of the invention and content are made, within being both contained in the interest field of the present invention.
Claims (10)
1. the flavoured syrups of discomfort mouthfeel when improving oral drug preparation, it is characterised in that by weight, including:
Sucrose 20.0%～85.0%(w/v), sweeting agent 0.10%～55.0%(w/v), aromatic 0.1%～5.0%(w/v) and, preservative
0.01%～0.50%(w/v), appropriate pH value regulator and water.
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 1, it is characterised in that institute
The sweeting agent stated include aspartame, fructose, glucose, lactose, alitame, maltose alcohol, xylitol, sorbitol, mannitol,
One or more compositions in hydrogenated maltose syrup, high fructose syrup, steviosin, Mel.
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 1, it is characterised in that institute
The aromatic stated includes one or more the compositions in fruit essence, miscellaneous fruital essence, chocolate essence.
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 3, it is characterised in that institute
The fruit essence stated includes aqua methnae, Pericarpium Citri junoris fourth, strawberry essence, fragrant citrus essence, flavoring pineapple essence, blueberry flavor, apple essence, red
One or more compositions in Punica granatum L. essence.
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 1, it is characterised in that institute
The preservative stated one or more compositions in benzoic acid and salt, oxybenzene ester and sorbic acid.
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 1, it is characterised in that institute
The pH value regulator stated is selected from lactic acid, fumaric acid, DL-malic acid, DL-tartaric acid, L-AA, succinic acid, acetic acid, acetic acid
One or more compositions in sodium, sodium carbonate, sodium bicarbonate, citric acid, citrate.
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 1, it is characterised in that press
Mass ratio range, also includes: coloring agent 0.0001% 0.001%(w/v).
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 7, it is characterised in that institute
The coloring agent stated include the one in cocoa pigment, radish red, beet red, safran, more Exocarpium Citri Rubrum, grape skin color or
Two or more compositionss.
The flavoured syrups of discomfort mouthfeel when improving oral drug preparation the most according to claim 1, it is characterised in that institute
The flavoured syrups stated selects powder, granule, pill, tablet, capsule, dry suspension, suspensoid, oral solution, conjunction
At least one dosage form in agent.
10. a preparation method for the flavoured syrups of discomfort mouthfeel when improving oral drug preparation as claimed in claim 1,
It is characterized in that, comprise the following steps:
(1) take suitable quantity of water, heated and boiled, with sucrose, be stirred to dissolve；
(2) sweeting agent, preservative, aromatic are added in appropriate purified water, stirring while adding so that it is to be completely dissolved, filter；
(3) (1) will be heated to 100 DEG C by solution, and filter, be cooled to 65 85 DEG C；
(4) in (2) adding (3), stir, let cool to room temperature；
(5) regulation medicinal liquid (4) pH value, pH value range is 3.0 7.0；The boiling water let cool in right amount to room temperature is added to entirely on filter
Amount, stirs evenly, to obtain final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270457A (en) * | 2023-03-22 | 2023-06-23 | 浙江贝灵生物医药有限公司 | A kind of mixed type liquid pharmaceutical excipient used for drug preparation and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682691A (en) * | 2005-02-28 | 2005-10-19 | 丰丽妍 | Process for preparing medicinal syrup |
| CN101152181A (en) * | 2006-09-29 | 2008-04-02 | 北京德众万全药物技术开发有限公司 | Liquid composition containing loratadine and ambroxol hydrochloride |
| CN101390860A (en) * | 2007-09-21 | 2009-03-25 | 北京德众万全药物技术开发有限公司 | Desloratadine syrup and preparation method thereof |
| CN101766567A (en) * | 2009-01-04 | 2010-07-07 | 北京润德康医药技术有限公司 | Oral liquid preparation with dextro-oxiracetam as active component |
| CN101766565A (en) * | 2008-12-31 | 2010-07-07 | 北京利乐生制药科技有限公司 | Oral liquid preparation with levo-oxiracetam as active component |
| CN104173277A (en) * | 2013-05-23 | 2014-12-03 | 上海博悦生物科技有限公司 | Dexibuprofen oral liquid preparation and preparation method thereof |
| CN104208011A (en) * | 2014-09-15 | 2014-12-17 | 广东华润顺峰药业有限公司 | Azithromycin syrup and preparation method thereof |
-
2016
- 2016-08-08 CN CN201610641889.0A patent/CN106236697A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682691A (en) * | 2005-02-28 | 2005-10-19 | 丰丽妍 | Process for preparing medicinal syrup |
| CN101152181A (en) * | 2006-09-29 | 2008-04-02 | 北京德众万全药物技术开发有限公司 | Liquid composition containing loratadine and ambroxol hydrochloride |
| CN101390860A (en) * | 2007-09-21 | 2009-03-25 | 北京德众万全药物技术开发有限公司 | Desloratadine syrup and preparation method thereof |
| CN101766565A (en) * | 2008-12-31 | 2010-07-07 | 北京利乐生制药科技有限公司 | Oral liquid preparation with levo-oxiracetam as active component |
| CN101766567A (en) * | 2009-01-04 | 2010-07-07 | 北京润德康医药技术有限公司 | Oral liquid preparation with dextro-oxiracetam as active component |
| CN104173277A (en) * | 2013-05-23 | 2014-12-03 | 上海博悦生物科技有限公司 | Dexibuprofen oral liquid preparation and preparation method thereof |
| CN104208011A (en) * | 2014-09-15 | 2014-12-17 | 广东华润顺峰药业有限公司 | Azithromycin syrup and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张强，等: "《药剂学》", 31 January 2005, 北京大学医学出版社 * |
| 潘卫三: "《工业药剂学》", 31 August 2015, 北京：中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270457A (en) * | 2023-03-22 | 2023-06-23 | 浙江贝灵生物医药有限公司 | A kind of mixed type liquid pharmaceutical excipient used for drug preparation and preparation method thereof |
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Application publication date: 20161221 |