CN106074727A - A kind of sclerotin disappears pain Chinese medicine composition and preparation method thereof - Google Patents
A kind of sclerotin disappears pain Chinese medicine composition and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The present invention relates to provide a kind of sclerotin to disappear pain Chinese medicine composition and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.The sclerotin of the present invention pain Chinese medicine composition that disappears includes the component of following weight portion, Radix Puerariae 320～450 parts, Radix Saposhnikoviae 150～230 parts, Ramulus Cinnamomi 150～250 parts, the Radix Angelicae Dahuricae 140～220 parts, Rhizoma Atractylodis 140～220 parts, Flos Carthami 160～240 parts, Rhizoma Et Radix Notopterygii 150～250 parts, Rhizoma Corydalis 150～250 parts, Caulis Spatholobi 140～220 parts, beta cyclodextrin 20～300 parts.Chinese medicine composition expelling wind and removing dampness that the present invention prepares, disperse blood stasis and dredge collateral, pain relieving, it is possible to be applied to the neck shoulder arm pain caused by rheumatism stasis blocking card, numbness, the movable disadvantageous cervical spondylosis of cervical region, and effectively treat cervical spondylotic radiculopathy.
Description
Technical field
The present invention relates to a kind of technical field of traditional Chinese medicine preparation, be specifically related to a kind of sclerotin and disappear pain Chinese medicine composition and preparation thereof
Method.
Background technology
Cervical spondylosis, also known as cervical spine syndrome, is osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, cervical vertebra
The general name of Spondylosis disease；It it is a kind of disease changing into basis with degeneration pathology；Also be due primarily to cervical vertebra strain for a long time,
Hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and causes cervical vertebra spinal cord, nerve root or vertebral artery pressurized, a series of merits of appearance
The clinical syndrome of energy obstacle.The clinical manifestation of cervical spondylosis is vertebra joint unstability, loosens；Nucleus pulposus or abjection；Bony spur is formed；Tough
The plump spinal canal stenosis etc. with secondary of band, stimulates or has oppressed neighbouring nerve root, spinal cord, vertebral artery and cervical region sympathetic nerve etc.
Tissue, causes series of symptoms and sign.
The treatment of cervical spondylosis generally use medicine, move, draw, massage, physical therapy, hot compress and therapeutic method of surgery etc., mesh
Front Drug therapy mainly uses analgesic, tranquilizer and vitamin (such as B1、B12) etc., the alleviation of symptom is had by these medicines
Certain effect.Cervical spondylotic radiculopathy sickness rate in cervical spondylosis is the highest, has a strong impact on the quality of life of patient.Existing medicine
Thing mostly is the class medicine that relieves the pain, common with chemical medicine, and predominantly relieve the pain effect, it is easy to recurrent exerbation, the Chinese medicine system that clinical practice is more
Agent contains resinae medicine, stimulates gastric mucosa relatively big after taking, and side effect is bigger.
Summary of the invention
It is an object of the invention to provide a kind of sclerotin to disappear pain Chinese medicine composition, this Chinese medicine composition have expelling wind and removing dampness,
Disperse blood stasis and dredge collateral, the effect of pain relieving, it is possible to be adapted to the neck shoulder arm pain caused by rheumatism stasis blocking card, numbness, cervical region activity disadvantageous
Cervical spondylosis, and effectively treat cervical spondylotic radiculopathy.
The invention provides a kind of sclerotin to disappear pain Chinese medicine composition, including the component of following weight portion, Radix Puerariae 320～450
Part, Radix Saposhnikoviae 150～230 parts, Ramulus Cinnamomi 150～250 parts, the Radix Angelicae Dahuricae 140～220 parts, Rhizoma Atractylodis 140～220 parts, Flos Carthami 160～240
Part, Rhizoma Et Radix Notopterygii 150～250 parts, Rhizoma Corydalis 150～250 parts, Caulis Spatholobi 140～220 parts, beta-schardinger dextrin-20～300 parts.
It is further preferred that include the component of following weight portion, Radix Puerariae 360～420 parts, Radix Saposhnikoviae 180～220 parts, Ramulus Cinnamomi 180
～220 parts, the Radix Angelicae Dahuricae 160～210 parts, Rhizoma Atractylodis 160～210 parts, Flos Carthami 180～220 parts, Rhizoma Et Radix Notopterygii 180～230 parts, Rhizoma Corydalis 180
～220 parts, Caulis Spatholobi 160～210 parts, beta-schardinger dextrin-40～240 parts.
Most preferably, including the component of following weight portion, Radix Puerariae 400 parts, Radix Saposhnikoviae 200 parts, Ramulus Cinnamomi 200 parts, the Radix Angelicae Dahuricae 200
Part, Rhizoma Atractylodis 200 parts, 200 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 200 parts, Rhizoma Corydalis 200 parts, Caulis Spatholobi 200 parts, beta-schardinger dextrin-60 parts.
Present invention also offers the preparation method of Chinese medicine composition described in technique scheme, comprise the following steps:
Distill 4～8h after Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii being mixed with water, respectively obtain volatile oil, medicinal residues and the first filter
Liquid；
By described volatile oil beta-schardinger dextrin-inclusion, obtain the beta-cyclo dextrin included compound of volatile oil；
Described medicinal residues are mixed decoction with Flos Carthami, Caulis Spatholobi and water, obtains the second filtrate；
Being concentrated into relative density after described first filtrate being merged with the second filtrate is 1.05～1.10, obtains first clear
Cream；
By Rhizoma Corydalis, Radix Puerariae and the Radix Angelicae Dahuricae and volumetric concentration be 65～80% ethanol mix, reflux, extract, the second that will obtain
It is 1.10～1.15 that alcohol mixed liquor is concentrated into relative density, obtains the second clear paste；
Being concentrated into relative density after described first clear paste and the second clear paste being mixed is 1.30～1.35, obtains thick paste, will
Described thick paste dry, pulverize into fine powder；
Described fine powder is mixed with the beta-cyclo dextrin included compound of volatile oil, obtain sclerotin disappear pain Chinese medicine composition.
Preferably, the preparation method of the beta-cyclo dextrin included compound of described volatile oil specifically includes:
It is 1:(6～10 by described volatile oil, beta-schardinger dextrin-and water according to mass ratio): (75～90) mix, 55
～inclusion 1～2h under 65 DEG C of stirring conditions；
The product cold preservation 18～32h that described inclusion is obtained；
By the product drying after described cold preservation and pulverizing, obtain the beta-cyclo dextrin included compound of volatile oil.
Preferably, described dry temperature is 35～40 DEG C.
Preferably, the particle diameter after described pulverizing is 80～100 mesh.
Preferably, in described concentration process, temperature is set as 45～55 DEG C.
The present invention provide Chinese medicinal components thing include Radix Puerariae, Radix Saposhnikoviae, Ramulus Cinnamomi, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Flos Carthami, Rhizoma Et Radix Notopterygii, Rhizoma Corydalis and
Caulis Spatholobi, this sclerotin disappear pain Chinese medicine composition can expelling wind and removing dampness, disperse blood stasis and dredge collateral, it is possible to be advantageously applied to caused by rheumatism stasis blocking
Shoulder arm tired weight, pain, numbness, cervical region activity is unfavorable, nose heave etc., and can effectively treat cervical spondylotic radiculopathy.
Detailed description of the invention
The invention provides a kind of sclerotin to disappear pain Chinese medicine composition, including the component of following weight portion, Radix Puerariae 320～450
Part, Radix Saposhnikoviae 150～230 parts, Ramulus Cinnamomi 150～250 parts, the Radix Angelicae Dahuricae 140～220 parts, Rhizoma Atractylodis 140～220 parts, Flos Carthami 160～240
Part, Rhizoma Et Radix Notopterygii 150～250 parts, Rhizoma Corydalis 150～250 parts, Caulis Spatholobi 140～220 parts, beta-schardinger dextrin-20～300 parts.
The sclerotin that the present invention the provides raw material in pain Chinese medicine composition that disappears includes the Radix Puerariae of 320～450 parts, preferably 350
～420 parts, more preferably 400 parts.In the present invention, described Radix Puerariae expelling pathogenic factors from muscles, rash, yang invigorating, dredge the meridian passage.The present invention is to described
The source of Radix Puerariae does not has special restriction, uses the commercial goods of Radix Puerariae well known to those skilled in the art.
The sclerotin that the present invention the provides raw material in pain Chinese medicine composition that disappears includes the Radix Saposhnikoviae of 150～230 parts, preferably 180
～220 parts, more preferably 400 parts.In the present invention, described Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, the effect of relieving convulsion.The present invention couple
The source of described Radix Saposhnikoviae does not has special restriction, uses the commercial goods of Radix Saposhnikoviae well known to those skilled in the art.
The sclerotin that the present invention the provides raw material in pain Chinese medicine composition that disappears includes the Ramulus Cinnamomi of 150～250 parts, preferably 180
～220 parts, more preferably 200 parts.In the present invention, described Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI.The present invention couple
The source of described Ramulus Cinnamomi does not has special restriction, uses the commercial goods of Ramulus Cinnamomi well known to those skilled in the art.
The sclerotin that the present invention the provides raw material in pain Chinese medicine composition that disappears includes the Radix Angelicae Dahuricae of 140～220 parts, preferably 160
～210 parts, more preferably 200 parts.In the present invention, described Radix Angelicae Dahuricae relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping.The present invention is to the described Radix Angelicae Dahuricae
Source does not has special restriction, uses the commercial goods of the Radix Angelicae Dahuricae well known to those skilled in the art.
The sclerotin that the present invention the provides raw material in pain Chinese medicine composition that disappears includes the Rhizoma Atractylodis of 140～220 parts, preferably 160
～210 parts, more preferably 200 parts.In the present invention, described Rhizoma Atractylodis expelling wind and cold.The source of described Rhizoma Atractylodis is not had by the present invention
Special restriction, uses the commercial goods of Rhizoma Atractylodis well known to those skilled in the art.
The sclerotin that the present invention the provides raw material in pain Chinese medicine composition that disappears includes the Flos Carthami of 160～240 parts, preferably 180
～220 parts, more preferably 200 parts.In the present invention, described Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The present invention is to described Flos Carthami
Source does not has special restriction, uses the commercial goods of Flos Carthami well known to those skilled in the art.
The sclerotin that the present invention the provides raw material in pain Chinese medicine composition that disappears includes the Rhizoma Et Radix Notopterygii of 150～250 parts, preferably 180
～230 parts, more preferably 200 parts.In the present invention, described Rhizoma Et Radix Notopterygii relieving exterior syndrome and dispelling cold, expelling wind and removing dampness, pain relieving.The present invention is to described
The source of Rhizoma Et Radix Notopterygii does not has special restriction, uses the commercial goods of Rhizoma Et Radix Notopterygii well known to those skilled in the art.
The raw material that the sclerotin that the present invention provides disappears in pain Chinese medicine composition includes the Rhizoma Corydalis of 150～250 parts, is preferably
180～220 parts, more preferably 200 parts.In the present invention, described Rhizoma Corydalis enrich blood, invigorate blood circulation, circulation of qi promoting, pain relieving.The present invention is to institute
The source stating Rhizoma Corydalis does not has special restriction, uses the commercial goods of Rhizoma Corydalis well known to those skilled in the art.
The raw material that the sclerotin that the present invention provides disappears in pain Chinese medicine composition includes the Caulis Spatholobi of 140～220 parts, is preferably
160～210 parts, more preferably 200 parts.In the present invention, described Caulis Spatholobi enrich blood, invigorate blood circulation, circulation of qi promoting, pain relieving.The present invention is to institute
The source stating Caulis Spatholobi does not has special restriction, uses the commercial goods of Caulis Spatholobi well known to those skilled in the art.
The raw material that the sclerotin that the present invention provides disappears in pain Chinese medicine composition includes the beta-schardinger dextrin-of 20～300 parts, is preferably
40～240 parts, more preferably 60 parts.In the present invention, described beta-schardinger dextrin-is used for inclusion volatile oil, makes volatile oil component steady
Fixed, it is ensured that the stability of volatile oil during drug quality and long term storage.The source of described beta-schardinger dextrin-is not had by the present invention
Special restriction, uses the commercial goods of beta-schardinger dextrin-well known to those skilled in the art.
In the present invention, the described sclerotin pain Chinese medicine composition that disappears preferably includes the component of following weight:
Radix Puerariae 400 parts, Radix Saposhnikoviae 200 parts, Ramulus Cinnamomi 200 parts, the Radix Angelicae Dahuricae 200 parts, Rhizoma Atractylodis 200 parts, 200 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 200
Part, Rhizoma Corydalis 200 parts, Caulis Spatholobi 200 parts, beta-schardinger dextrin-60 parts；More preferably in terms of unit of weight g.
The sclerotin that the present invention provides disappears in pain Chinese medicine composition, and Radix Puerariae is monarch drug, for pungent cool product, has an expelling pathogenic factors from muscles, rash,
Yang invigorating, the effect of dredge the meridian passage, for treating the key medicine of stiff nape and back.Ministerial drug is Radix Saposhnikoviae, Ramulus Cinnamomi and the Radix Angelicae Dahuricae, Radix Saposhnikoviae acrid in the mouth, sweet, and property is micro-
Temperature, has expelling pathogenic wind from the body surface, removing dampness to relieve pain, the effect of relieving convulsion；Ramulus Cinnamomi acrid in the mouth, sweet, warm in nature, can diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yangization
Gas；Radix Angelicae Dahuricae acrid in the mouth, warm in nature, take its relieving exterior syndrome and dispelling cold, the effect of wind-expelling pain-stopping；Common compatibility, have dispeling the wind, induce sweat, the effect of pain relieving, can
Strengthen the expelling pathogenic factors from muscles of monarch drug, the merit of rash, neutralize the property of monarch drug simultaneously.Adjuvant drug is Rhizoma Atractylodis, Flos Carthami and Rhizoma Et Radix Notopterygii, Rhizoma Atractylodis acrid in the mouth, hardship, property
Temperature, can expelling wind and cold, Flos Carthami acrid in the mouth, warm in nature, there is promoting blood circulation to restore menstrual flow, the effect of eliminating stasis to stop pain；Rhizoma Et Radix Notopterygii acrid in the mouth, hardship, warm in nature, can induce sweat
Cold expelling, expelling wind and removing dampness, pain relieving；Above three taste property of medicine temperature, are all adjuvant drug and can strengthen prescription and dispel the wind, cold expelling, the effect of dehumidifying.Rhizoma Corydalis
Rope, Caulis Spatholobi two medicine are all and make medicine, have enrich blood, invigorate blood circulation, circulation of qi promoting, effect of pain relieving, the effect of we's pain relieving can be strengthened.Quan Fang
Play altogether and there is expelling wind and removing dampness, disperse blood stasis and dredge collateral, effect of pain relieving, it is adapted to neck shoulder arm pain, numbness, the neck caused by rheumatism stasis blocking card
The movable disadvantageous cervical spondylosis in portion
Present invention also offers the preparation method of Chinese medicine composition described in technique scheme, comprise the following steps:
Distill 4～8h after Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii being mixed with water, respectively obtain volatile oil, medicinal residues and the first filter
Liquid；
By described volatile oil beta-schardinger dextrin-inclusion, obtain the beta-cyclo dextrin included compound of volatile oil；
Described medicinal residues are mixed decoction with Flos Carthami, Caulis Spatholobi and water, obtains the second filtrate；
Being concentrated into relative density after described first filtrate being merged with the second filtrate is 1.05～1.10, obtains first clear
Cream；
By Rhizoma Corydalis, Radix Puerariae and the Radix Angelicae Dahuricae and volumetric concentration be 65～80% ethanol mix, reflux, extract, the second that will obtain
It is 1.10～1.15 that alcohol mixed liquor is concentrated into relative density, obtains the second clear paste；
Being concentrated into relative density after described first clear paste and the second clear paste being mixed is 1.30～1.35, obtains thick paste, will
Described thick paste dry, pulverize into fine powder；
Described fine powder is mixed with the beta-cyclo dextrin included compound of volatile oil, obtain sclerotin disappear pain Chinese medicine composition.
The present invention Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii are mixed with water after distill 4～8h, respectively obtain volatile oil, medicinal residues and
First filtrate.In the present invention, the gross mass of described Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii and the mass ratio of water be preferably 1:8～
12, more preferably 1:10.Described distillation preferably employs steam and distills, and vapo(u)rizing temperature is 85～100 DEG C.
The volatile oil beta-schardinger dextrin-inclusion that technique scheme is obtained by the present invention, obtains the beta-schardinger dextrin-bag of volatile oil
Knot thing.In the present invention, the preparation method of the beta-cyclo dextrin included compound of described volatile oil preferably specifically includes following steps:
It is 1:(6～10 by described volatile oil, beta-schardinger dextrin-and water according to mass ratio): (75～90) mix, 55
～inclusion 1～2h under 65 DEG C of stirring conditions；
The product cold preservation 18～32h that described inclusion is obtained；
By the product drying after described cold preservation and pulverizing, obtain the beta-cyclo dextrin included compound of volatile oil.
In the present invention, the mass ratio of described volatile oil, beta-schardinger dextrin-and water is preferably 1:8:80.The temperature of described inclusion
It is preferably 60 DEG C.
In the present invention, the time of described cold preservation is preferably 20～30h, more preferably 22～28h, most preferably 24h；Institute
The temperature stating cold preservation is 4～20 DEG C, more preferably 10～15 DEG C.
In the present invention, described baking temperature is 35～40 DEG C；
The fine powder particle diameter that described pulverizing obtains is 80～100 mesh.
After obtaining medicinal residues, medicinal residues described in technique scheme are mixed decoction with Flos Carthami, Caulis Spatholobi and water by the present invention, obtain
Second filtrate.Described medicinal residues and Flos Carthami, the gross mass of Caulis Spatholobi are 1:8～12 with the mass ratio of water；Described decoction process carries out 3
～5 times, each 1～2h.
After obtaining the first filtrate and the second filtrate, the present invention is concentrated into phase after described first filtrate and the second filtrate being merged
It is 1.05～1.10 to density, obtains the first clear paste.The temperature of described concentration is 45～55 DEG C.
The present invention by Rhizoma Corydalis, Radix Puerariae and the Radix Angelicae Dahuricae and volumetric concentration be 65～80% ethanol mix, reflux, extract, will
To alcohol mixeding liquid to be concentrated into relative density be 1.10～1.15, obtain the second clear paste.In the present invention, described Rhizoma Corydalis,
The gross mass of Radix Puerariae and the Radix Angelicae Dahuricae and volumetric concentration be 65～80% the volume ratio of ethanol be preferably 1:4～8, more preferably 1:6.
The volumetric concentration of described ethanol is more preferably 70～75%.The temperature of described concentration is 45～55 DEG C.
After obtaining the first clear paste and the second clear paste, the present invention is concentrated into phase after described first clear paste and the second clear paste being mixed
It is 1.30～1.35 to density, obtains thick paste, described thick paste be dry, pulverize into fine powder.The temperature of described concentration is 45～55
℃.In the present invention, described dry temperature is preferably 35～40 DEG C, more preferably 38 DEG C；Described be dried to thick paste water content≤
8%.In the present invention, the granularity of described fine powder is 80～100 mesh.
In the present invention, in described concentration process, temperature is set as 45～55 DEG C, more preferably 50 DEG C.
After obtaining the beta-cyclo dextrin included compound of fine powder and volatile oil, the present invention is by the beta-schardinger dextrin-of described fine powder Yu volatile oil
Inclusion complex mix, obtain sclerotin disappear pain Chinese medicine composition.
Do below in conjunction with specific embodiment a kind of sclerotin of the present invention disappeared pain Chinese medicine composition and preparation method thereof
Further details of introduction, technical scheme includes but not limited to following example.
Embodiment 1
Weigh Radix Puerariae 420g, Radix Saposhnikoviae 210g, Ramulus Cinnamomi 160g, Radix Angelicae Dahuricae 170g, Rhizoma Atractylodis 190g, Flos Carthami 220g, Rhizoma Et Radix Notopterygii 180g, prolong
Rhizoma Corydalis 220g, Caulis Spatholobi 180g, beta-schardinger dextrin-55g.
After Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii are mixed with 7500mL water at 100 DEG C distill 6h, respectively obtain volatile oil,
Medicinal residues and the first filtrate；
It is that 1:8:85 mixes by the volatile oil obtained and beta-schardinger dextrin-and water according to mass ratio, at 60 DEG C of stirring conditions
Lower inclusion 1.5h；The product cold preservation 30h that will obtain subsequently, dry, pulverize 100 mesh under the conditions of 35 DEG C by the product after cold preservation
Sieve, obtains the beta-cyclo dextrin included compound of volatile oil；
Being mixed with Flos Carthami, Caulis Spatholobi by the medicinal residues obtained, add the soak by water 3 times of 8 times of quality, merging filtrate obtains the second filter
Liquid；
After first filtrate being merged with the second filtrate, being concentrated into relative density in 50 DEG C is 1.05, obtains the first clear paste；
It is that Rhizoma Corydalis, Radix Puerariae and the Radix Angelicae Dahuricae are mixed by 1:6 with the ethanol that volumetric concentration is 75% according to mass volume ratio, backflow
Extracting, in 50 DEG C, the alcohol mixeding liquid obtained is concentrated into relative density is 1.15, obtains the second clear paste；
After described first clear paste and the second clear paste being mixed, being concentrated into relative density in 55 DEG C is 1.30, obtains thick paste, will
Described thick paste dry, pulverize into fine powder；
Described fine powder is mixed with the beta-cyclo dextrin included compound of volatile oil, obtain sclerotin disappear pain Chinese medicine composition.
Embodiment 2
Weigh Radix Puerariae 380g, Radix Saposhnikoviae 190g, Ramulus Cinnamomi 220g, Radix Angelicae Dahuricae 180g, Rhizoma Atractylodis 160g, Flos Carthami 220g, Rhizoma Et Radix Notopterygii 190g, prolong
Rhizoma Corydalis 230g, Caulis Spatholobi 150g, beta-schardinger dextrin-102g.
After Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii are mixed with 8000mL water at 90 DEG C distill 7h, respectively obtain volatile oil,
Medicinal residues and the first filtrate；
It is that 1:10:75 mixes by the volatile oil obtained and beta-schardinger dextrin-and water according to mass ratio, stirs bars at 56 DEG C
Inclusion 1.8h under part；The product cold preservation 20h that will obtain subsequently, dry, pulverize 100 by the product after cold preservation under the conditions of 38 DEG C
Mesh sieve, obtains the beta-cyclo dextrin included compound of volatile oil；
Being mixed with Flos Carthami, Caulis Spatholobi by the medicinal residues obtained, add the soak by water 4 times of 10 times of quality, merging filtrate obtains second
Filtrate；
After first filtrate being merged with the second filtrate, being concentrated into relative density in 55 DEG C is 1.10, obtains the first clear paste；
It is that Rhizoma Corydalis, Radix Puerariae and the Radix Angelicae Dahuricae are mixed by 1:4 with the ethanol that volumetric concentration is 75% according to mass volume ratio, backflow
Extracting, in 50 DEG C, the alcohol mixeding liquid obtained is concentrated into relative density is 1.12, obtains the second clear paste；
After described first clear paste and the second clear paste being mixed, being concentrated into relative density in 50 DEG C is 1.32, obtains thick paste, will
Described thick paste dry, pulverize into fine powder；
Described fine powder is mixed with the beta-cyclo dextrin included compound of volatile oil, obtain sclerotin disappear pain Chinese medicine composition.
Embodiment 3
Weigh Radix Puerariae 320g, Radix Saposhnikoviae 190g, Ramulus Cinnamomi 230g, Radix Angelicae Dahuricae 210g, Rhizoma Atractylodis 160g, Flos Carthami 200g, Rhizoma Et Radix Notopterygii 190g, prolong
Rhizoma Corydalis 240g, Caulis Spatholobi 180g, beta-schardinger dextrin-160g.
Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii are mixed with 8000mL water rear 100 DEG C of distillation 4h, respectively obtains volatile oil, medicinal residues
With the first filtrate；
It is that 1:7:80 mixes by the volatile oil obtained and beta-schardinger dextrin-and water according to mass ratio, at 64 DEG C of stirring conditions
Lower inclusion 1.2h；The product cold preservation 26h that will obtain subsequently, dry, pulverize 80 mesh under the conditions of 40 DEG C by the product after cold preservation
Sieve, obtains the beta-cyclo dextrin included compound of volatile oil；
Being mixed with Flos Carthami, Caulis Spatholobi by the medicinal residues obtained, add the soak by water 3 times of 12 times of quality, merging filtrate obtains second
Filtrate；
After first filtrate being merged with the second filtrate, being concentrated into relative density in 45 DEG C is 1.08, obtains the first clear paste；
It is that Rhizoma Corydalis, Radix Puerariae and the Radix Angelicae Dahuricae are mixed by 1:8 with the ethanol that volumetric concentration is 75% according to mass volume ratio, backflow
Extracting, in 45 DEG C, the alcohol mixeding liquid obtained is concentrated into relative density is 1.10, obtains the second clear paste；
After described first clear paste and the second clear paste being mixed, being concentrated into relative density in 55 DEG C is 1.35, obtains thick paste, will
Described thick paste dry, pulverize into fine powder；
Described fine powder is mixed with the beta-cyclo dextrin included compound of volatile oil, obtain sclerotin disappear pain Chinese medicine composition.
Embodiment 4
The pain that disappeared by the sclerotin that above-described embodiment 1 prepares Chinese medicine composition is used for treating the neck shoulder arm pain that cervical spondylosis causes
Clinical observation bitterly
Inclusive criteria: meet the diagnostic criteria of doctor trained in Western medicine cervical spondylotic radiculopathy.The disease meeting traditional Chinese medical science rheumatism stasis blocking card is sentenced
Disconnected standard.Similar drug and other related methods for the treatment of (such as traction massage etc.) is not accepted in 2 weeks before medication.Subject age is
30 to 65 years old.
Exclusion standard: do not meet above-mentioned doctor trained in Western medicine and tcm diagnosis standard, non-cervical spondylotic radiculopathy, the age less than 30 years old or
More than 65 years old.Due to the disease based on upper extremity pain caused by non-cervical vertebra degeneration, such as Thoracic outlet syndrome, tennis
Elbow, complication of wrist, scapulohumeral periarthritis etc..Other rheumatisms overlapping, such as systemic lupus erythematosus (sle), dry syndrome, serious kneecap
Property arthritis etc..It is associated with the severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic.Under
Row lab index is abnormal: liver function (ALT) exceedes the normal range value upper limit more than 1.5 times；Renal function (Cr) exceedes normal value
The value range upper limit；Blood leukocytes sum<3.0 × 109, or>12.0 × 109, there is the arrhythmia of clinical meaning.Gestation or the food in one's mouth
Breast phase women.Allergic constitution or to known medicine constituent allergy sufferers.Suspect or truly have ethanol, drug dependence history, or
Judgement according to researcher, have and reduce into group research probability or other pathological changes of making research complicate.Participate in other drug
The patient of test.Above patient is eliminating object.
The course for the treatment of: take surrounding continuously, boiled water is taken after mixing it with water, each 5g, three times on the one.
Observation index: the change situation before and after neck shoulder arm pain symptom treatment.
Curative effect determinate standard: with reference to " the bench coach principle of new Chinese medicine treatment cervical spondylosis ".
Clinic control: neck shoulder arm pain symptom reduces 95%；
Effective: neck shoulder arm pain symptom reduces 70%, < 95%；
Effective: neck shoulder arm pain symptom reduces 30%, < 70%；
Invalid: neck shoulder arm pain symptom reduces < 30%；
Instructions of taking: three times on the one, each 5g.Take after mixing it with water.
Taking surrounding, statistical analysis continuously, therapeutic outcome is shown in Table 1.
Table 1. sclerotin disappear pain traditional Chinese medicine composition for treating neck shoulder arm pain symptom observation of curative effect
Show according to table 1 result, this compositions make sclerotin disappear pain traditional Chinese medicine composition for treating cervical spondylosis cause neck shoulder arm
Pain symptom the most effectively reaches 85.09%.
Embodiment 5
The pain that disappeared by the sclerotin that above-described embodiment 2 prepares Chinese medicine composition is used for treating the neck stiffness that cervical spondylosis causes
Symptom clinical observation
Inclusive criteria: with embodiment 4；
Exclusion standard: with embodiment 4；
The course for the treatment of: take surrounding continuously, boiled water is taken after mixing it with water, each 5g, three times on the one.
Observation index: the change situation before and after the neck stiffness symptom treatment that cervical spondylosis causes.
Curative effect determinate standard: with reference to " the bench coach principle of new Chinese medicine treatment cervical spondylosis ".
Clinic control: neck stiffness symptom reduces 95%；
Effective: neck stiffness symptom reduces 70%, < 95%；
Effective: neck stiffness symptom reduces 30%, < 70%；
Invalid: neck stiffness shape reduces < 30%；
Instructions of taking: three times on the one, each 5g.Take after mixing it with water.
Taking surrounding, statistical analysis continuously, therapeutic outcome is shown in Table 2.
Table 2. sclerotin disappear pain traditional Chinese medicine composition for treating neck stiffness symptom observation of curative effect
Showing according to table 2 result, it is stiff that this compositions makes the sclerotin pain neck that causes of traditional Chinese medicine composition for treating cervical spondylosis that disappears
Hard symptom the most effectively reaches 83.33%.
Embodiment 6
The pain that disappeared by the sclerotin that above-described embodiment 3 prepares Chinese medicine composition is used for treating the upper limb numbness that cervical spondylosis causes
Symptom clinical observation
Inclusive criteria: with embodiment 4；
Exclusion standard: with embodiment 4；
The course for the treatment of: take surrounding continuously, boiled water is taken after mixing it with water, each 5g, three times on the one.
Observation index: the change situation before and after the upper limb numbness symptom treatment that cervical spondylosis causes.
Curative effect determinate standard: with reference to " the bench coach principle of new Chinese medicine treatment cervical spondylosis ".
Clinic control: upper limb numbness symptom reduces 95%；
Effective: upper limb numbness symptom reduces 70%, < 95%；
Effective: upper limb numbness symptom reduces 30%, < 70%；
Invalid: upper limb numbness symptom reduces < 30%；
Instructions of taking: three times on the one, each 5g.Take after mixing it with water.
Taking surrounding, statistical analysis continuously, therapeutic outcome is shown in Table 3.
Table 3. sclerotin disappear pain traditional Chinese medicine composition for treating upper limb numbness symptom observation of curative effect
Show according to table 3 result, this compositions make sclerotin disappear pain traditional Chinese medicine composition for treating cervical spondylosis cause upper limb fiber crops
Wood symptom the most effectively reaches 74.56%.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (8)
1. a sclerotin disappears pain Chinese medicine composition, it is characterised in that include the component of following weight portion, Radix Puerariae 320～450 parts,
Radix Saposhnikoviae 150～230 parts, Ramulus Cinnamomi 150～250 parts, the Radix Angelicae Dahuricae 140～220 parts, Rhizoma Atractylodis 140～220 parts, Flos Carthami 160～240 parts, Qiang
150～250 parts alive, Rhizoma Corydalis 150～250 parts, Caulis Spatholobi 140～220 parts, beta-schardinger dextrin-20～300 parts.
Chinese medicine composition the most according to claim 1, it is characterised in that include the component of following weight portion, Radix Puerariae 360～
420 parts, Radix Saposhnikoviae 180～220 parts, Ramulus Cinnamomi 180～220 parts, the Radix Angelicae Dahuricae 160～210 parts, Rhizoma Atractylodis 160～210 parts, Flos Carthami 180～
220 parts, Rhizoma Et Radix Notopterygii 180～230 parts, Rhizoma Corydalis 180～220 parts, Caulis Spatholobi 160～210 parts, beta-schardinger dextrin-40～240 parts.
Chinese medicine composition the most according to claim 1, it is characterised in that include the component of following weight portion, Radix Puerariae 400
Part, Radix Saposhnikoviae 200 parts, Ramulus Cinnamomi 200 parts, the Radix Angelicae Dahuricae 200 parts, Rhizoma Atractylodis 200 parts, 200 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 200 parts, Rhizoma Corydalis 200 parts, chicken
Caulis seu Radix Schisandrae Henryi 200 parts, beta-schardinger dextrin-60 parts.
4. the preparation method of Chinese medicine composition described in claims 1 to 3 any one, comprises the following steps:
Distill 4～8h after Rhizoma Atractylodis, Radix Saposhnikoviae, Ramulus Cinnamomi and Rhizoma Et Radix Notopterygii being mixed with water, respectively obtain volatile oil, medicinal residues and the first filtrate；
By described volatile oil beta-schardinger dextrin-inclusion, obtain the beta-cyclo dextrin included compound of volatile oil；
Described medicinal residues are mixed decoction with Flos Carthami, Caulis Spatholobi and water, obtains the second filtrate；
Being concentrated into relative density after described first filtrate being merged with the second filtrate is 1.05～1.10, obtains the first clear paste；
By Rhizoma Corydalis, Radix Puerariae and the Radix Angelicae Dahuricae and volumetric concentration be 65～80% ethanol mix, reflux, extract, the ethanol obtained is mixed
Closing liquid and being concentrated into relative density is 1.10～1.15, obtains the second clear paste；
Being concentrated into relative density after described first clear paste and the second clear paste being mixed is 1.30～1.35, obtains thick paste, by described
Thick paste dry, pulverize into fine powder；
Described fine powder is mixed with the beta-cyclo dextrin included compound of volatile oil, obtain sclerotin disappear pain Chinese medicine composition.
Preparation method the most according to claim 4, it is characterised in that the preparation of the beta-cyclo dextrin included compound of described volatile oil
Method specifically includes:
It is 1:(6～10 by described volatile oil, beta-schardinger dextrin-and water according to mass ratio): (75～90) mix, 55～65
Inclusion 1～2h under DEG C stirring condition；
The product cold preservation 18～32h that described inclusion is obtained；
By the product drying after described cold preservation and pulverizing, obtain the beta-cyclo dextrin included compound of volatile oil.
Preparation method the most according to claim 5, it is characterised in that described dry temperature is 35～40 DEG C.
Preparation method the most according to claim 5, it is characterised in that the particle diameter after described pulverizing is 80～100 mesh.
Preparation method the most according to claim 4, it is characterised in that in described concentration process, temperature is set as 45～55
℃。
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| CN1686202A (en) * | 2005-04-14 | 2005-10-26 | 北京昭翰医药科技研究所 | Bone pain dispersing granular composition and its preparation method |
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2016
- 2016-06-29 CN CN201610494550.2A patent/CN106074727A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686202A (en) * | 2005-04-14 | 2005-10-26 | 北京昭翰医药科技研究所 | Bone pain dispersing granular composition and its preparation method |
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| CN107569462A (en) * | 2017-08-16 | 2018-01-12 | 陕西东科制药有限责任公司 | A kind of preparation method of Qinchuan Tongbi tablet |
| CN107569462B (en) * | 2017-08-16 | 2021-02-05 | 陕西东科制药有限责任公司 | Preparation method of Qinchuan Tongbi tablet |
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Application publication date: 20161109 |