CN106039601A - Magnetic-compatibility ultrasonic stimulation system - Google Patents
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Abstract
Description
技术领域technical field
本发明涉及医疗设备领域,尤指一种磁兼容超声刺激系统。The invention relates to the field of medical equipment, in particular to a magnetically compatible ultrasonic stimulation system.
背景技术Background technique
随着抑郁症,帕金森病等脑部疾病的患者逐渐增多,脑部疾病的治疗逐渐成为现代医学研究的焦点,现今脑部治疗除了口服药物之外还提出了许多利用外界条件刺激脑颅核团达到治疗效果的方案,其主要采用的刺激方法为光刺激,电刺激,磁刺激和超声刺激。超声刺激由于其安全性,无创性和有效性得到越来越广泛的关注。现今世界上有许多实验室正在进行超声刺激治疗脑部疾病的研究,并开始在动物(猴子)身上进行超声刺激实验来探索和验证超声对灵长类动物的脑部疾病的治疗效果。With the increasing number of patients with brain diseases such as depression and Parkinson's disease, the treatment of brain diseases has gradually become the focus of modern medical research. In addition to oral drugs, many brain treatments have been proposed to stimulate the cranial nucleus with external conditions. The main methods of stimulation are light stimulation, electrical stimulation, magnetic stimulation and ultrasonic stimulation. Ultrasound stimulation has received more and more attention due to its safety, non-invasiveness and effectiveness. Nowadays, many laboratories in the world are conducting research on the treatment of brain diseases by ultrasonic stimulation, and have begun to conduct ultrasonic stimulation experiments on animals (monkeys) to explore and verify the therapeutic effect of ultrasound on primate brain diseases.
超声作为一种机械波,是由物体(声源)振动产生,并通过压缩和膨胀媒质导致其传播,医学超声通常是指频率在20kHz到10MHz区间内的声波。超声除了具有波的一般属性,还有一个重要特点,其在水、肌肉等人体组织内的衰减很小,可以抵达较深的人体组织。医学超声波与人体组织相互作用,主要应用了声波与物质相互作用的基本物理特性,具有波动效应、力学效应和热效应等三大声学效应,这些效应在生物医学中有着重要的应用或重大潜力。传统的超声基于波动效应和热效应,已经发展成为具有成像诊断和热消融治疗两大基本功能。波动效应可用于B超、彩超、造影等在临床具有十分广泛应用的超声成像诊断技术;热效应可用于肿瘤的热消融和神经核团毁损治疗,比如高强度聚焦超声(HIFU)。超声神经刺激与调控的优势是其非侵入性质。超声在分子、细胞、动物和人脑水平的神经调控最新科学证据有力证明了超声可以穿过人的颅骨无创、有效调节突触可塑性、神经元调控和深部脑区神经核团。Ultrasound, as a kind of mechanical wave, is generated by the vibration of an object (sound source) and causes its propagation through the compression and expansion of the medium. Medical ultrasound usually refers to sound waves with a frequency in the range of 20kHz to 10MHz. In addition to the general properties of waves, ultrasound has another important feature. Its attenuation in human tissues such as water and muscle is very small, and it can reach deeper human tissues. The interaction between medical ultrasound and human tissue mainly applies the basic physical characteristics of the interaction between sound waves and matter, and has three acoustic effects, namely wave effect, mechanical effect and thermal effect. These effects have important applications or great potential in biomedicine. Traditional ultrasound is based on the wave effect and thermal effect, and has developed into two basic functions of imaging diagnosis and thermal ablation therapy. The wave effect can be used in B-ultrasound, color Doppler ultrasound, contrast-enhanced imaging and other ultrasonic imaging diagnostic techniques that are widely used in clinical practice; the thermal effect can be used in the thermal ablation of tumors and the treatment of nerve nucleus damage, such as high-intensity focused ultrasound (HIFU). An advantage of ultrasound nerve stimulation and modulation is its non-invasive nature. The latest scientific evidence on the neural regulation of ultrasound at the molecular, cellular, animal and human brain levels has strongly proved that ultrasound can pass through the human skull non-invasively and effectively regulate synaptic plasticity, neuron regulation and neural nuclei in deep brain regions.
虽然超声神经刺激被证明治疗效果较好,但是因颅内环境较为复杂,相关工作人员无法直观获得治疗位置及效果是否达到预期,所设置参数是否合适,因此使得超声神经刺激无法得到有效推广。Although ultrasonic nerve stimulation has been proven to have a good therapeutic effect, due to the complex intracranial environment, relevant staff cannot intuitively obtain the treatment location, whether the effect is as expected, and whether the set parameters are appropriate. Therefore, ultrasonic nerve stimulation cannot be effectively promoted.
发明内容Contents of the invention
本发明涉及一种可以用于脑部刺激的磁兼容超声刺激系统,采用该刺激系统,再辅以配套的超声电子系统和磁共振系统能够对动物大脑致病细胞核团进行精准超声刺激,并使用磁共振系统对刺激位置、力度和效果进行监控,从而探索和验证超声对灵长类动物的脑部疾病的治疗效果,操作简单,使用方便。The invention relates to a magnetically compatible ultrasonic stimulation system that can be used for brain stimulation. Using the stimulation system, supplemented by a supporting ultrasonic electronic system and a magnetic resonance system, it is possible to perform precise ultrasonic stimulation on the nuclei of pathogenic cells in the brain of animals, and use The magnetic resonance system monitors the stimulation position, strength and effect, so as to explore and verify the therapeutic effect of ultrasound on the brain diseases of primates. It is easy to operate and easy to use.
为达上述目的,本发明具体所提供的磁兼容超声刺激系统,具体包含超声探头模块、磁共振线圈模块、磁共振模块和支撑模块;所述超声探头模块和所述磁共振线圈模块设置在所述支撑模块上;其中,所述超声探头模块用于发送超声波刺激待治疗动物大脑深脑核团;所述磁共振线圈模块分别与所述超声探头模块和所述磁共振模块相连,用于对被超声波刺激待测动物待治疗动物的刺激效果和刺激位置进行监控,并通过外部磁共振系统显示输出;所述支撑模块用于限制待治疗动物活动,将待治疗动物固定在预定区域。In order to achieve the above purpose, the magnetically compatible ultrasonic stimulation system specifically provided by the present invention specifically includes an ultrasonic probe module, a magnetic resonance coil module, a magnetic resonance module and a support module; the ultrasonic probe module and the magnetic resonance coil module are arranged in the on the support module; wherein, the ultrasonic probe module is used to send ultrasonic waves to stimulate the deep brain nucleus of the animal to be treated; the magnetic resonance coil module is connected with the ultrasonic probe module and the magnetic resonance module respectively, for The stimulation effect and stimulation position of the animal to be treated are monitored by ultrasonic stimulation, and the output is displayed through an external magnetic resonance system; the support module is used to limit the activity of the animal to be treated, and fix the animal to be treated in a predetermined area.
在上述磁兼容超声刺激系统中,优选的,所述系统还包含空心连接杆,所述空心连接杆用于提供所述超声探头模块和所述磁共振线圈模块的连接线缆的通道。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the system further includes a hollow connecting rod, and the hollow connecting rod is used for providing a channel for connecting cables between the ultrasonic probe module and the magnetic resonance coil module.
在上述磁兼容超声刺激系统中,优选的,所述系统还包含控制模块,所述控制模块与所述超声探头模块相连,用于根据所述外部磁共振系统显示输出的监控情况输出控制指令调整所述超声探头模块输出超声波的刺激强度和刺激位置In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the system further includes a control module, the control module is connected to the ultrasonic probe module, and is used to output control instructions for adjustment according to the monitoring conditions displayed and output by the external magnetic resonance system The ultrasound probe module outputs the stimulation intensity and stimulation position of ultrasound
在上述磁兼容超声刺激系统中,优选的,所述超声探头模块包含二维面阵换能器、换能器固定框和换能器插座;所述二维面阵换能器用于根据控制指令发送超声波刺激大脑深脑核团;所述换能器插座用于提供所述二维面阵换能器接收控制指令的数据接口;所述换能器固定框用于将所述二维面阵换能器固定于所述支撑模块上。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the ultrasonic probe module includes a two-dimensional area transducer, a transducer fixing frame and a transducer socket; the two-dimensional area transducer is used to Sending ultrasonic waves to stimulate the deep brain nuclei of the brain; the transducer socket is used to provide a data interface for the two-dimensional array transducer to receive control instructions; the transducer fixed frame is used to connect the two-dimensional array The transducer is fixed on the support module.
在上述磁兼容超声刺激系统中,优选的,所述二维面阵换能器的超声频率为0.2M至5M,且所述二维面阵换能器包含多个超声波阵元,所述多个超声波阵元组成与待治疗动物的头部弯曲程度一致的弧面结构。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the ultrasonic frequency of the two-dimensional area array transducer is 0.2M to 5M, and the two-dimensional area array transducer includes a plurality of ultrasonic array elements, the plurality of Each ultrasonic array element forms an arc structure consistent with the bending degree of the head of the animal to be treated.
在上述磁兼容超声刺激系统中,优选的,所述磁共振线圈模块包含线圈单元和放大器单元;所述线圈单元包含磁共振线圈、线圈上盖和线圈下盖;其中所述磁共振线圈用于输出射频信号;所述线圈上盖与所述线圈下盖用于组合保护所述磁共振线圈;所述放大器单元包含放大器和放大器盖;其中所述放大器用于放大所述射频信号;所述放大器盖用于保护所述放大器。In the above magnetically compatible ultrasonic stimulation system, preferably, the magnetic resonance coil module includes a coil unit and an amplifier unit; the coil unit includes a magnetic resonance coil, a coil upper cover and a coil lower cover; wherein the magnetic resonance coil is used for output radio frequency signal; the coil upper cover and the coil lower cover are used to protect the magnetic resonance coil in combination; the amplifier unit includes an amplifier and an amplifier cover; wherein the amplifier is used to amplify the radio frequency signal; the amplifier A cover is used to protect the amplifier.
在上述磁兼容超声刺激系统中,优选的,所述换能器固定框与所述线圈下盖固定连接,所述放大器与所述线圈下通过旋转轴连接,所述换能器插座与所述支撑模块固定连接。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the fixed frame of the transducer is fixedly connected to the lower cover of the coil, the amplifier is connected to the bottom of the coil through a rotating shaft, and the socket of the transducer is connected to the lower cover of the coil. The supporting modules are fixedly connected.
在上述磁兼容超声刺激系统中,优选的,所述支撑模块包含躯体限位模块、颈部限位模块、耳部限位模块和面部限位模块;所述躯体限位模块用于限定待治疗动物躯体动作;所述颈部限位模块用于限定待治疗动物颈部晃动;所述耳部限位模块用于限定待治疗动物头部晃动;所述面部限位模块用于抵靠待治疗动物头部,限定待治疗动物头部动作。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the support module includes a body limit module, a neck limit module, an ear limit module, and a face limit module; the body limit module is used to limit the The body movement of the animal; the neck limit module is used to limit the neck shaking of the animal to be treated; the ear limit module is used to limit the head shake of the animal to be treated; the face limit module is used to abut against the animal to be treated Animal head, limiting the head movement of the animal to be treated.
在上述磁兼容超声刺激系统中,优选的,所述躯体限位模块包含底座、至少两个支撑横梁和至少四个支撑架;所述支撑架一端与所述底座垂直连接,所述支撑横梁与所述支撑架另一端垂直连接;所述底座与所述支撑横梁上分别设置有穿绳孔,所述躯体限位模块通过所述穿绳孔与绳索将待治疗动物固定于所述支撑横梁上;所述底座还设有平衡调节螺钉,所述平衡调节螺钉用于调节所述躯体限位模块平衡。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the body restraint module includes a base, at least two support beams and at least four support frames; one end of the support frame is vertically connected to the base, and the support beams are connected to the base The other end of the support frame is vertically connected; the base and the support beam are respectively provided with stringing holes, and the body limiting module fixes the animal to be treated on the support beam through the stringing holes and ropes ; The base is also provided with a balance adjustment screw, and the balance adjustment screw is used to adjust the balance of the body limiting module.
在上述磁兼容超声刺激系统中,优选的,所述颈部限位模块包含颈部连接件和颈部限位件;所述颈部连接件一端沿所述支撑横梁平行方向垂直且活动安装于所述底座上;所述颈部限位件包含上半圆限位结构和下半圆限位结构,所述上半圆限位结构与所述颈部连接件另一端固定连接,所述下半圆限位结构与所述上半圆限位结构活动连接。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the neck limiting module includes a neck connecting piece and a neck limiting piece; one end of the neck connecting piece is vertically and movably installed on the On the base; the neck stopper includes an upper semicircle stopper structure and a lower semicircle stopper structure, the upper semicircle stopper structure is fixedly connected to the other end of the neck connector, and the lower semicircle stopper The structure is flexibly connected with the upper semicircle limiting structure.
在上述磁兼容超声刺激系统中,优选的,所述耳部限位模块包含耳针、耳针支撑块和耳针连接件;所述耳针连接件与所述支撑横梁活动连接;所述耳针支撑块与所述耳针连接件活动链接,所述耳针固定于所述耳针支撑块上;其中所述耳针用于插入待治疗动物耳部,以限制动物头部左右移动;所述耳针支撑块用于固定所述耳针和调节所述耳针位置;所述耳针连接件用于提供所述耳针支撑块于所述支撑横梁上的移动通道。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the ear limiting module includes an ear needle, an ear needle support block, and an ear needle connector; the ear needle connector is movably connected to the support beam; the ear needle The needle support block is movably linked with the ear acupuncture connector, and the ear acupuncture is fixed on the ear acupuncture support block; wherein the ear acupuncture is used to be inserted into the ear of the animal to be treated, so as to limit the animal's head from moving left and right; The auricle support block is used to fix the auricle and adjust the position of the auricle; the auricle connector is used to provide a movement channel for the auricle support block on the support beam.
在上述磁兼容超声刺激系统中,优选的,所述面部限位模块包含舌块、脸抵片和支撑单元;所述支撑单元包含支撑上板、支撑后板和两块支撑侧板;所述舌块平行于所述支撑上板的外表面设置,用于置入待治疗动物口腔中,限制待治疗动物口腔移动;所述脸抵片活动设置在所述支撑上板上,用于限定动物头部前后移动;所述支撑侧板固定设置于所述支撑横梁和所述底座之间;所述支撑后板分别与两块支撑侧板和所述支撑横梁相连;所述支撑上板设置于所述支撑侧板和所述支撑后板之间,且与所述支撑侧板和所述支撑后板活动连接。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the face-limiting module includes a tongue block, a face support piece, and a support unit; the support unit includes a support upper plate, a support rear plate, and two support side plates; the The tongue piece is arranged parallel to the outer surface of the support upper plate, and is used to be placed in the mouth of the animal to be treated, so as to limit the movement of the mouth of the animal to be treated; The head moves back and forth; the supporting side board is fixedly arranged between the supporting beam and the base; the supporting rear board is respectively connected with two supporting side boards and the supporting beam; the supporting upper board is arranged on The supporting side board and the supporting rear board are connected flexibly with the supporting side board and the supporting rear board.
在上述磁兼容超声刺激系统中,优选的,所述支撑模块由电木或环氧树脂或聚砜(psu,Polysulfone)构成。In the above-mentioned magnetically compatible ultrasonic stimulation system, preferably, the support module is made of Bakelite, epoxy resin or polysulfone (psu, Polysulfone).
本发明的有益技术效果在于:通过采用该刺激系统,再辅以配套的超声电子系统和磁共振系统能够对动物大脑致病细胞核团进行精准超声刺激,并使用磁共振系统对刺激位置、力度和效果进行监控,从而探索和验证超声对灵长类动物的脑部疾病的治疗效果,操作简单,使用方便。The beneficial technical effects of the present invention are: by adopting the stimulation system, supplemented with the supporting ultrasonic electronic system and magnetic resonance system, it is possible to carry out precise ultrasonic stimulation on the nuclei of pathogenic cells in the animal brain, and use the magnetic resonance system to adjust the stimulation position, strength and The effect is monitored, so as to explore and verify the therapeutic effect of ultrasound on primate brain diseases. It is easy to operate and easy to use.
附图说明Description of drawings
此处所说明的附图用来提供对本发明的进一步理解,构成本申请的一部分,并不构成对本发明的限定。在附图中:The drawings described here are used to provide further understanding of the present invention, constitute a part of the application, and do not limit the present invention. In the attached picture:
图1为本发明所提供的磁兼容超声刺激系统的整体结构示意图;Fig. 1 is a schematic diagram of the overall structure of the magnetic compatibility ultrasonic stimulation system provided by the present invention;
图2为本发明所提供的磁兼容超声刺激系统的整体爆炸示意图;Fig. 2 is the overall explosion schematic diagram of the magnetic compatibility ultrasonic stimulation system provided by the present invention;
图3为本发明所提供的磁兼容超声刺激系统中超声探头模块和磁共振线圈模块结构示意图;FIG. 3 is a structural schematic diagram of the ultrasonic probe module and the magnetic resonance coil module in the magnetically compatible ultrasonic stimulation system provided by the present invention;
图4为本发明所提供的磁兼容超声刺激系统中颈部限位模块结构示意图;Fig. 4 is a schematic structural diagram of the neck limit module in the magnetically compatible ultrasonic stimulation system provided by the present invention;
图5为本发明所提供的磁兼容超声刺激系统中耳部限位模块结构示意图;Fig. 5 is a structural schematic diagram of the ear limit module in the magnetically compatible ultrasonic stimulation system provided by the present invention;
图6为本发明所提供的磁兼容超声刺激系统中面部限位模块结构示意图。Fig. 6 is a schematic diagram of the structure of the facial limit module in the magnetically compatible ultrasonic stimulation system provided by the present invention.
附图标号Reference number
100、超声探头模块;200、磁共振线圈模块;300、支撑模块;400、支撑部件;500、连接杆;110、二维面阵换能器;120、换能器固定框;130、换能器插座;210、线圈上盖;220、线圈下盖;230、放大器单元;240、放大器盖;311、底座;312、支撑架;313、支撑横梁;314、穿绳孔;315、平衡调节螺钉;321、上半圆限位结构;322、下半圆限位结构;323、颈部连接件;331、耳针;332、耳针支撑块;333、耳针连接件;341、舌块;342、脸抵片;343、支撑上板;344、支撑侧板;345、支撑后板;100. Ultrasonic probe module; 200. Magnetic resonance coil module; 300. Support module; 400. Support component; 500. Connecting rod; 110. Two-dimensional array transducer; Socket; 210, coil upper cover; 220, coil lower cover; 230, amplifier unit; 240, amplifier cover; 311, base; 312, support frame; 313, support beam; 314, rope hole; 315, balance adjustment screw ; 321, upper semicircle limit structure; 322, lower semicircle limit structure; 323, neck connector; 331, ear acupuncture; 332, ear acupuncture support block; 333, ear acupuncture connector; 341, tongue block; 342, Face plate; 343, support upper plate; 344, support side plate; 345, support rear plate;
具体实施方式detailed description
为使本发明实施例的目的、技术方案和优点更加清楚明白,下面结合实施例和附图,对本发明做进一步详细说明。在此,本发明的示意性实施例及其说明用于解释本发明,但并不作为对本发明的限定。In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, the present invention will be further described in detail below in conjunction with the embodiments and the accompanying drawings. Here, the exemplary embodiments and descriptions of the present invention are used to explain the present invention, but not to limit the present invention.
请参考图1和图2所示,本发明提供了一种磁兼容超声刺激系统,具体包含超声探头模块100、磁共振线圈模块200、磁共振模块(未图示)和支撑模块300;所述超声探头模块100和所述磁共振线圈模块200设置在所述支撑模块300上;其中,所述超声探头模块100用于发送超声波刺激待治疗动物大脑深脑核团;所述磁共振线圈模块200分别与所述超声探头模块100和所述磁共振模块相连,用于对被超声波刺激待治疗动物的刺激效果和刺激位置进行监控;所述磁共振模块用于根据监控情况通过所述磁共振线圈模块调整所述超声探头模块100输出超声波的刺激强度和刺激位置;所述支撑模块300用于限制待治疗动物活动,将待治疗动物固定在预定区域。其中,所述超声探头模块100和所述磁共振线圈模块200可通过支撑部件400来固定在所述支撑模块300上,该支撑部件400在以下做详细介绍。Please refer to FIG. 1 and FIG. 2, the present invention provides a magnetically compatible ultrasonic stimulation system, which specifically includes an ultrasonic probe module 100, a magnetic resonance coil module 200, a magnetic resonance module (not shown) and a support module 300; The ultrasonic probe module 100 and the magnetic resonance coil module 200 are arranged on the support module 300; wherein, the ultrasonic probe module 100 is used to send ultrasonic waves to stimulate the deep brain nucleus of the animal to be treated; the magnetic resonance coil module 200 Respectively connected with the ultrasonic probe module 100 and the magnetic resonance module, used to monitor the stimulation effect and stimulation position of the animal to be treated by ultrasonic stimulation; the magnetic resonance module is used to pass the magnetic resonance coil according to the monitoring situation The module adjusts the stimulation intensity and stimulation position of the ultrasound output by the ultrasound probe module 100; the support module 300 is used to limit the movement of the animal to be treated, and fix the animal to be treated in a predetermined area. Wherein, the ultrasound probe module 100 and the magnetic resonance coil module 200 can be fixed on the support module 300 through a support member 400, which will be described in detail below.
在上述实施例中,所述系统还包含空心连接杆500和控制模块(未图式),所述空心连接杆500用于提供所述超声探头模块100和所述磁共振线圈模块200的连接线缆的通道;所述控制模块分别与所述超声探头模块100和所述磁共振线圈模块200相连,用于根据所述磁共振线圈模块200输出的控制指令调整所述超声探头模块100输出超声波的刺激强度和刺激位置。In the above embodiment, the system further includes a hollow connecting rod 500 and a control module (not shown), and the hollow connecting rod 500 is used to provide a connecting line between the ultrasonic probe module 100 and the magnetic resonance coil module 200 The channel of the cable; the control module is connected to the ultrasonic probe module 100 and the magnetic resonance coil module 200 respectively, and is used to adjust the output of the ultrasonic probe module 100 according to the control command output by the magnetic resonance coil module 200. Stimulation intensity and stimulus location.
具体的,本发明所提供的磁兼容超声刺激系统包括:超声探头模块100,磁共振线圈模块200和支撑结构模块300;其中超声探头模块100和磁共振线圈模块200通过支撑部件400和连接杆500与支撑结构模块300连接,连接杆500可以是空心连接杆500,使得超声探头模块100和磁共振线圈模块200的线缆可以从空心连接杆500中引出。Specifically, the magnetically compatible ultrasonic stimulation system provided by the present invention includes: an ultrasonic probe module 100, a magnetic resonance coil module 200 and a support structure module 300; Connected with the supporting structure module 300 , the connecting rod 500 may be a hollow connecting rod 500 , so that the cables of the ultrasound probe module 100 and the magnetic resonance coil module 200 can be drawn out from the hollow connecting rod 500 .
请参考图1至图3所示,在本发明一优选的实施例中,所述超声探头模块100包含二维面阵换能器110、换能器固定框120和换能器插座130;所述二维面阵换能器110用于根据控制指令发送超声波刺激大脑深脑核团;所述换能器插座130用于插放所述二维面阵换能器110,且提供所述二维面阵换能器110接收控制指令的数据接口;所述换能器固定框120用于将所述二维面阵换能器110固定于所述换能器插座130上;其中,所述二维面阵换能器110的超声频率为0.2M至5M,且所述二维面阵换能器110包含多个超声波阵元,所述多个超声波阵元组成与待治疗动物的头部弯曲程度一致的弧面结构。Please refer to FIGS. 1 to 3, in a preferred embodiment of the present invention, the ultrasonic probe module 100 includes a two-dimensional array transducer 110, a transducer fixing frame 120 and a transducer socket 130; The two-dimensional array transducer 110 is used to send ultrasonic waves to stimulate the deep brain nuclei according to control instructions; the transducer socket 130 is used to insert and place the two-dimensional array transducer 110, and provide the two A data interface for the two-dimensional area array transducer 110 to receive control instructions; the transducer fixing frame 120 is used to fix the two-dimensional area array transducer 110 on the transducer socket 130; wherein, the The ultrasonic frequency of the two-dimensional area array transducer 110 is 0.2M to 5M, and the two-dimensional area array transducer 110 includes a plurality of ultrasonic array elements, and the plurality of ultrasonic array elements are composed of the head of the animal to be treated. Arc structure with consistent curvature.
再请参考请参考图1至图3所示,所述磁共振线圈模块200包含线圈单元(未图示)和放大器单元230;所述线圈单元包含磁共振线圈、线圈上盖210和线圈下盖220;其中所述磁共振线圈用于输出射频信号;所述线圈上盖210与所述线圈下盖220用于组合保护所述磁共振线圈;所述放大器单元230包含放大器和放大器盖240;其中所述放大器用于放大所述射频信号;所述放大器盖240用于保护所述放大器;所述换能器固定框120与所述线圈下盖220固定连接,所述放大器与所述线圈下通过旋转轴连接,所述换能器插座130与所述支撑模块300固定连接。Please refer to FIGS. 1 to 3 again, the magnetic resonance coil module 200 includes a coil unit (not shown) and an amplifier unit 230; the coil unit includes a magnetic resonance coil, a coil upper cover 210 and a coil lower cover 220; wherein the magnetic resonance coil is used to output radio frequency signals; the coil upper cover 210 and the coil lower cover 220 are used to protect the magnetic resonance coil in combination; the amplifier unit 230 includes an amplifier and an amplifier cover 240; wherein The amplifier is used to amplify the radio frequency signal; the amplifier cover 240 is used to protect the amplifier; the transducer fixing frame 120 is fixedly connected to the coil lower cover 220, and the amplifier and the coil pass through The rotating shaft is connected, and the transducer socket 130 is fixedly connected with the support module 300 .
在上述实施例中,磁共振线圈模块200用于配合磁共振系统对刺激效果和刺激位置进行成像观察,并进一步调整刺激强度和位置。放大器单元230用于对磁共振线圈模块200的射频信号进行放大;二维面阵换能器110置于换能器固定框120内,换能器固定框120与线圈下盖220固定连接,线圈置于线圈上盖210和线圈下盖220之间;放大器230与线圈下盖220通过旋转轴连接,放大器230可以以旋转轴为轴心旋转;换能器插座130与支持部件固定连接,并与二维面阵换能器110电连。换能器插座130用于二维面阵换能器110与超声电子系统进行连接。二维面阵换能器110超声频率为0.2M~5M,阵元数为1~4096。本发明所使用二维面阵换能器110弯曲成与动物颅骨弯曲程度相一致的弧面,以便声波从颅骨垂直入射,减少声波在传播过程中的因折射造成的衰减。In the above embodiments, the magnetic resonance coil module 200 is used to cooperate with the magnetic resonance system to observe the stimulation effect and the stimulation position by imaging, and further adjust the stimulation intensity and position. The amplifier unit 230 is used to amplify the radio frequency signal of the magnetic resonance coil module 200; the two-dimensional area array transducer 110 is placed in the transducer fixing frame 120, and the transducer fixing frame 120 is fixedly connected to the coil lower cover 220, and the coil Placed between the coil upper cover 210 and the coil lower cover 220; the amplifier 230 is connected to the coil lower cover 220 through a rotating shaft, and the amplifier 230 can rotate around the rotating shaft; the transducer socket 130 is fixedly connected to the support component, and The two-dimensional area transducer 110 is electrically connected. The transducer socket 130 is used for connecting the two-dimensional area transducer 110 with the ultrasonic electronic system. The ultrasonic frequency of the two-dimensional area array transducer 110 is 0.2M-5M, and the number of array elements is 1-4096. The two-dimensional area array transducer 110 used in the present invention is bent into an arc consistent with the curvature of the animal's skull, so that the sound wave is incident vertically from the skull and reduces the attenuation caused by refraction during the propagation of the sound wave.
请参考图1和图2所示,本发明所提供的支撑模块300包含躯体限位模块310、颈部限位模块320、耳部限位模块330和面部限位模块340;所述躯体限位模块310用于限定待治疗动物躯体动作;所述颈部限位模块320用于限定待治疗动物颈部晃动;所述耳部限位模块330用于限定待治疗动物头部晃动;所述面部限位模块340用于抵靠待治疗动物头部,限定待治疗动物头部动作。Please refer to Figure 1 and Figure 2, the support module 300 provided by the present invention includes a body limit module 310, a neck limit module 320, an ear limit module 330 and a face limit module 340; Module 310 is used to limit the body movement of the animal to be treated; the neck limit module 320 is used to limit the neck shaking of the animal to be treated; the ear limit module 330 is used to limit the head shake of the animal to be treated; The limit module 340 is used to abut against the head of the animal to be treated, and limit the movement of the head of the animal to be treated.
为更清楚的解释上述支撑模块300,以下分别对其各部件做详细说明:In order to explain the above-mentioned supporting module 300 more clearly, each component thereof is described in detail below:
请参考图1和图2所示在上述实施例中,所述躯体限位模块310包含底座311、至少两个支撑横梁313和至少四个支撑架312;所述支撑架312一端与所述底座311垂直连接,所述支撑横梁313与所述支撑架312另一端垂直连接;所述底座311与所述支撑横梁313上分别设置有穿绳孔,所述躯体限位模块310通过所述穿绳孔与绳索将待治疗动物固定于所述支撑横梁313上;所述底座311还设有平衡调节螺钉,所述平衡调节螺钉用于调节所述躯体限位模块310平衡。其中所述支撑横梁的数目和支撑架的数据可根据实际需要设置,目的仅在于保持磁兼容超声刺激系统的平衡和帮助固定待治疗动物,本发明在此并不做具体数目的限定。Please refer to FIG. 1 and FIG. 2 in the above embodiment, the body restraint module 310 includes a base 311, at least two support beams 313 and at least four support frames 312; one end of the support frame 312 is connected to the base 311 is vertically connected, and the support beam 313 is vertically connected with the other end of the support frame 312; the base 311 and the support beam 313 are respectively provided with stringing holes, and the body limiting module 310 passes through the stringing holes. Holes and ropes fix the animal to be treated on the support beam 313; the base 311 is also provided with a balance adjustment screw, and the balance adjustment screw is used to adjust the balance of the body limiting module 310. The number of supporting beams and the data of the supporting frame can be set according to actual needs, the purpose is only to maintain the balance of the magnetically compatible ultrasonic stimulation system and help fix the animals to be treated, and the present invention does not limit the specific number here.
请参考图4所示,在上述实施例中,所述颈部限位模块320包含颈部连接件323和颈部限位件;所述颈部连接件323一端沿所述支撑横梁313平行方向垂直且活动安装于所述底座311上;所述颈部限位件包含上半圆限位结构321和下半圆限位结构322,所述上半圆限位结构321与所述颈部连接件323另一端固定连接,所述下半圆限位结构322与所述上半圆限位结构321活动连接,具体的,该颈部限位模块320活动安装在底座311上,且能够在底座311上在与横梁平行的方向上移动,颈部限位模块320包括上半圆限位结构321、下半圆限位结构322和颈部连接件323,上半圆限位结构321和下半圆限位结构322活动连接,使得两个半圆圈能够兼容不同动物的颈部大小;下半圆限位结构322与颈部连接件323活动连接,下半圆限位结构322可上下移动,使得颈部限位模块320可以兼容不同动物的颈部高低。Please refer to FIG. 4 , in the above embodiment, the neck limiting module 320 includes a neck connector 323 and a neck limiting member; one end of the neck connector 323 is along the parallel direction of the support beam 313 It is vertically and movably installed on the base 311; the neck limiter includes an upper semicircle limit structure 321 and a lower semicircle limit structure 322, and the upper semicircle limit structure 321 and the neck connector 323 are separately One end is fixedly connected, and the lower semicircle limit structure 322 is movably connected with the upper semicircle limit structure 321. Specifically, the neck limit module 320 is movably installed on the base 311, and can be mounted on the base 311 with the beam Moving in a parallel direction, the neck limit module 320 includes an upper semicircle limit structure 321, a lower semicircle limit structure 322 and a neck connector 323, and the upper semicircle limit structure 321 and the lower semicircle limit structure 322 are flexibly connected, so that The two semicircles can be compatible with the neck sizes of different animals; the lower semicircle limiting structure 322 is movably connected with the neck connector 323, and the lower semicircle limiting structure 322 can move up and down, so that the neck limiting module 320 can be compatible with the neck size of different animals. High and low neck.
请参考图5所示,在上述实施例中,所述耳部限位模块330包含耳针331、耳针支撑块332和耳针连接件333;所述耳针连接件333与所述支撑横梁313活动连接;所述耳针支撑块332与所述耳针连接件333活动链接,所述耳针331固定于所述耳针支撑块332上;其中所述耳针331用于插入待治疗动物耳部,以限制动物头部左右移动;所述耳针支撑块332用于固定所述耳针331和调节所述耳针331位置;所述耳针连接件333用于提供所述耳针支撑块332于所述支撑横梁313上的移动通道;实际使用中,该耳部限位模块330有左右两个,均包括耳针331、耳针支撑块332和耳针连接件333,耳针331用于插入动物耳朵,以限制动物头部左右运动。耳部限位模块330通过耳针连接件333与支撑横梁313连接,且耳针连接件333可带动耳部限位模块330在支撑横梁313上移动;耳针331活动设置在耳针支撑块332上,两个耳针331活动设置,通过缩短其相对的距离以兼容不同脑部大小的动物;耳针支撑块332与耳针连接件333活动连接,用以调节耳针331的高度。Please refer to FIG. 5 , in the above embodiment, the ear position limiting module 330 includes an ear pin 331, an ear pin support block 332 and an ear pin connector 333; the ear pin connector 333 is connected to the support beam 313 is movably connected; the auricle support block 332 is movably linked with the auricle connector 333, and the auricle 331 is fixed on the auricle support block 332; wherein the auricle 331 is used for inserting into the animal to be treated ear, to limit the movement of the head of the animal; the ear needle support block 332 is used to fix the ear needle 331 and adjust the position of the ear needle 331; the ear needle connector 333 is used to provide support for the ear needle block 332 on the moving channel of the support beam 313; in actual use, the ear position limiting module 330 has two left and right, each including ear needles 331, ear needle support blocks 332 and ear needle connectors 333, ear needles 331 Used to insert into the animal's ears to limit the side to side movement of the animal's head. The ear position limiting module 330 is connected to the support beam 313 through the ear pin connector 333, and the ear pin connector 333 can drive the ear position limit module 330 to move on the support beam 313; the ear pin 331 is movably set on the ear pin support block 332 Above, the two ear needles 331 are movable, and the relative distance is shortened to be compatible with animals of different brain sizes; the ear needle support block 332 is movably connected with the ear needle connector 333 to adjust the height of the ear needles 331 .
请参考图6所示,在上述实施例中,所述面部限位模块340包含舌块341、脸抵片342和支撑单元;所述支撑单元包含支撑上板343、支撑后板345和两块支撑侧板344;所述舌块341平行于所述支撑上板343的外表面设置,用于置入待治疗动物口腔中,限制待治疗动物口腔移动;所述脸抵片342活动设置在所述支撑上板343上,用于限定动物头部前后移动;所述支撑侧板344固定设置于所述支撑横梁313和所述底座311之间;所述支撑后板345分别与两块支撑侧板344和所述支撑横梁313相连;所述支撑上板343设置于所述支撑侧板344和所述支撑后板345之间,且与所述支撑侧板344和所述支撑后板345活动连接。具体来说,在实际工作中面部限位模块340可包括舌块341、两个脸抵片342、支撑上板343、两个支撑侧板344和支撑后板345,舌块341可以放入动物的口腔中、脸抵片342可以抵住动物的脸部,限制动物头部的运动。舌块341平行于支撑上板343的上表面设置,脸抵片342活动设置在支撑上板343上,脸抵片342可调节与动物脸部的距离,以兼容不同动物脑袋的大小。支撑侧板344固定设置在支撑横梁313和底板之间,支撑后板345分别与支撑侧板344和支撑横梁313的端点固定连接,支撑上板343分别与支撑侧板344和支撑后板345活动连接,支撑上板343可在垂直方向上移动,使得舌块341和脸抵片342的高度可调。Please refer to Fig. 6, in the above embodiment, the face limiting module 340 includes a tongue block 341, a face contact piece 342 and a support unit; the support unit includes a support upper plate 343, a support rear plate 345 and two Support side plate 344; described tongue block 341 is arranged parallel to the outer surface of described support upper plate 343, is used for inserting in the oral cavity of animal to be treated, limits the oral cavity movement of animal to be treated; The support upper plate 343 is used to limit the front and rear movement of the animal head; the support side plate 344 is fixedly arranged between the support beam 313 and the base 311; the support rear plate 345 is connected with the two support sides respectively. The plate 344 is connected to the support beam 313; the support upper plate 343 is arranged between the support side plate 344 and the support rear plate 345, and is movable with the support side plate 344 and the support rear plate 345 connect. Specifically, in actual work, the face limiting module 340 may include a tongue block 341, two face contact pieces 342, a support upper plate 343, two support side plates 344 and a support rear plate 345, and the tongue block 341 can be put into the animal. In the oral cavity, the face stop sheet 342 can be against the face of the animal, limiting the movement of the animal's head. The tongue piece 341 is arranged parallel to the upper surface of the support upper plate 343, and the face contact piece 342 is movably arranged on the support upper plate 343, and the face contact piece 342 can adjust the distance with the animal face to be compatible with the size of different animal heads. The support side plate 344 is fixedly arranged between the support beam 313 and the bottom plate, the support rear plate 345 is fixedly connected with the end points of the support side plate 344 and the support beam 313 respectively, and the support upper plate 343 is respectively movable with the support side plate 344 and the support rear plate 345 Connected, the supporting upper plate 343 can move in the vertical direction, so that the heights of the tongue piece 341 and the face support piece 342 can be adjusted.
再请参考图1和图6所示,本发明所提供的磁兼容超声刺激系统中的支撑部件400主要包括竖直的支撑块和水平的支撑杆,竖直的支撑块与面部限位模块340的支撑后板345连接;水平的支撑杆一端与竖直的支撑块连接,另一端与支撑连接杆500连接,水平的支撑杆的中部还设置有转轴,超声探头模块100和磁共振线圈模块200可以通过该转轴进行水平方向上的旋转。Please refer to Fig. 1 and Fig. 6 again, the support member 400 in the magnetic compatible ultrasonic stimulation system provided by the present invention mainly includes vertical support blocks and horizontal support rods, the vertical support blocks and the face limit module 340 The support back plate 345 is connected; one end of the horizontal support rod is connected with the vertical support block, and the other end is connected with the support connecting rod 500, and the middle part of the horizontal support rod is also provided with a rotating shaft, the ultrasonic probe module 100 and the magnetic resonance coil module 200 Rotation in the horizontal direction can be performed through the rotating shaft.
在实际工作中,基于环保和磁通量的考虑,所述支撑模块300可由电木或环氧树脂或聚砜(psu,Polysulfone)等磁兼容材料构成。In actual work, based on considerations of environmental protection and magnetic flux, the support module 300 may be made of magnetically compatible materials such as bakelite, epoxy resin, or polysulfone (psu, Polysulfone).
通过采用该刺激系统,再辅以配套的超声电子系统和磁共振系统能够对动物大脑致病细胞核团进行精准超声刺激,并使用磁共振系统对刺激位置、力度和效果进行监控,从而探索和验证超声对灵长类动物的脑部疾病的治疗效果,操作简单,使用方便。By using this stimulation system, supplemented by the supporting ultrasonic electronic system and magnetic resonance system, it is possible to perform precise ultrasonic stimulation on the nuclei of pathogenic cells in the animal brain, and use the magnetic resonance system to monitor the stimulation position, strength and effect, so as to explore and verify The therapeutic effect of ultrasound on primate brain diseases is simple and convenient to use.
以上所述的具体实施例,对本发明的目的、技术方案和有益效果进行了进一步详细说明,所应理解的是,以上所述仅为本发明的具体实施例而已,并不用于限定本发明的保护范围,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。The specific embodiments described above have further described the purpose, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above descriptions are only specific embodiments of the present invention and are not intended to limit the scope of the present invention. Protection scope, within the spirit and principles of the present invention, any modification, equivalent replacement, improvement, etc., shall be included in the protection scope of the present invention.
Claims (13)
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