CN106039386A - Anti-infection surgical suture - Google Patents
Anti-infection surgical suture Download PDFInfo
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- CN106039386A CN106039386A CN201610431320.1A CN201610431320A CN106039386A CN 106039386 A CN106039386 A CN 106039386A CN 201610431320 A CN201610431320 A CN 201610431320A CN 106039386 A CN106039386 A CN 106039386A
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- parts
- infective
- powder
- suture thread
- operation suture
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- 230000002924 anti-infective effect Effects 0.000 title claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 17
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 15
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 102000008186 Collagen Human genes 0.000 claims abstract description 8
- 108010035532 Collagen Proteins 0.000 claims abstract description 8
- 229920001436 collagen Polymers 0.000 claims abstract description 8
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 claims abstract description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 7
- CPUHNROBVJNNPW-UHFFFAOYSA-N aloin A Natural products OC1C(O)C(O)C(CO)OC1OC1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 CPUHNROBVJNNPW-UHFFFAOYSA-N 0.000 claims abstract description 7
- AFHJQYHRLPMKHU-WEZNYRQKSA-N aloin B Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-WEZNYRQKSA-N 0.000 claims abstract description 7
- 125000003118 aryl group Chemical group 0.000 claims abstract description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 7
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 claims abstract description 7
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960000282 metronidazole Drugs 0.000 claims abstract description 7
- 230000007935 neutral effect Effects 0.000 claims abstract description 7
- 229920000728 polyester Polymers 0.000 claims abstract description 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 7
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 6
- 108090001060 Lipase Proteins 0.000 claims abstract description 3
- 239000004367 Lipase Substances 0.000 claims abstract description 3
- 102000004882 Lipase Human genes 0.000 claims abstract description 3
- 235000019421 lipase Nutrition 0.000 claims abstract description 3
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims description 6
- 241000207925 Leonurus Species 0.000 claims description 6
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims description 6
- 241000657665 Rhopilema esculentum Species 0.000 claims description 6
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 claims description 4
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 claims description 4
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 claims description 4
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 claims description 4
- 229920002414 procyanidin Polymers 0.000 claims description 4
- 241000533849 Gleditsia Species 0.000 claims description 3
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 17
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 229920001661 Chitosan Polymers 0.000 abstract description 2
- 241000242583 Scyphozoa Species 0.000 abstract 1
- 206010048038 Wound infection Diseases 0.000 abstract 1
- 239000012620 biological material Substances 0.000 description 7
- 229920002101 Chitin Polymers 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
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- -1 poly-ethylidene carbon Chemical compound 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical group [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 2
- 101710084376 Lipase 3 Proteins 0.000 description 2
- 101710084385 Lipase 8 Proteins 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 238000006065 biodegradation reaction Methods 0.000 description 2
- 239000003519 biomedical and dental material Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 239000004594 Masterbatch (MB) Substances 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 239000002729 catgut Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 239000002648 laminated material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003356 suture material Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses an anti-infection surgical suture, comprising the following components according to parts by weight: 60-70 parts of aromatic polyester, 2-8 parts of ethylene glycol, 2-9 parts of polyvinylpyrrolidone, 10-20 parts of Radix Angelicae Dahuricae powder, 2-8 parts of titanium dioxide, 10-20 parts of Herba Leonuri powder, 3-7 parts of aloin, 5-10 parts of sodium carboxymethyl cellulose, 3-8 parts of neutral lipase, 12-18 parts of jellyfish collagen, 11-14 parts of chitosan, and 3-8 parts of metronidazole. The anti-infection surgical suture has good blood compatibility and tissue compatibility, is effective in preventing wound infections, has a wide range of material source, is low in price and has no increased economic burden for patients.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to a kind of anti-infective operation suture thread.
Background technology
Biomaterial is for tissue and the diagnosis of organ, the class High-tech Material repairing or promoting its function,
I.e. being used for replacing, repairing living tissue natural or artificial material, its drugs with function is irreplaceable.Biomaterial can perform, promote
Or replace certain function lost because of disease, damage etc., and rejected region can not be recovered.Since the later stage nineties, the world is raw
Thing material science and technology develop rapidly, even if under the overall situation that current global economy is low, biomaterial still remains
Annual 13% rapid growth, has fully demonstrated its powerful vitality and vast potential for future development.Modern medicine forward regeneration and
Rebuild impaired tissue and organ, recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment and develop.
The conventional materials such as traditional abiotic medical metal, macromolecule, bioceramic can not meet the requirement of medical development, biological
Medical material scientific and engineering is faced with new opportunities and challenges.In future, the market share of bio-medical material may well
Medicine will be caught up with.Therefore, strengthen clinical application research and the popularization and application of bio-medical material, give priority to China's bio-medical
The research of material, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice, country is current at biology
Fundamentals of Material Science research aspect has been achieved for important breakthrough progress, walks in world's rank of advanced units, but industrialization level is still
Waiting to improve, industry size is little, development relatively lags behind, and is not met by being actually needed of Medicare health care.At national policy, warp
Under the support energetically of Ji, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen the ability of autonomous innovation, further
Solve to rely on the situation of import, add large outlet dynamics, it is achieved spanning development simultaneously, expand Chinese biological material product in the world
Power of influence.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial includes that metal material is (such as alkali
Metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyapatite etc.) and organic material three major types.Organic material
In mainly polymeric set laminate material, macromolecular material is generally divided into synthesis macromolecular material (polyurethane, poly-by material properties
Ester, polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber etc.), natural macromolecular material
(such as collagen, fibroin, cellulose, chitosan etc.)；According to the purposes of material, these materials can be divided into again biologically inert
(bioinert), biological activity (bioactive) or biodegradation (biodegradable) material, in high molecular polymer, root
Can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again Bioabsorbable and biological nonabsorable
Property.Blood compatible polymer and blood then it is divided into according to the state that affects on blood constituent, performance after material and contacting blood
Incompatibility.To the affinity of body cell and report situations according to material, biocompatibility and bio-incompatibility can be divided into
Polymer etc..Wherein, operation suture thread just belongs to the one in biodegradation material, refers in the middle of surgical operation, is used for hindering
Mouth ligation Suture hemostasis and the special line of one of tissue apposition.Two classes can be divided into: can not inhale according to its biodegradability
Take-up and absorbable thread.The former has that tension intensity is high, be prone to sterilization, feature that tissue reaction is low, but the most not
Degraded, so needing after Feng Heing to take out stitches, easily brings secondary pain and infection and scar；The latter can be degraded in vivo
For soluble product, it is absorbed by the body and progressively excretes external, thus it is painful to alleviate patient.Clinical practice preferably may be used
Absorb suture material and should meet following condition: versatility, aseptic, electroless property, without surface tension, without anaphylaxis with without carcinogenic
Property, it is easy to operation, it is unfavorable for bacterial growth, during knotting, can ensure that line is tied safely and without abrasion or cutting, can be resisted in-house
Shrinking, stitching purpose can be absorbed by tissue after reaching and react slight.But the absorbable suture that medical circle is commonly used mostly is
, there is poor biocompatibility in catgut, polymer chemistry synthetic thread, easily causes tissue immunity reaction, absorb and do not fill during use
Point and the problem such as bad mechanical property.Current this preferable absorbable operation suture thread there is no.And for operation not
Absorbable thread, effect is the most single, accordingly, it would be desirable to improve further, develops a kind of energy anti-infective operation stitching
Line.
Summary of the invention
It is an object of the invention to provide a kind of anti-infective operation suture thread.
To achieve these goals, the invention provides a kind of anti-infective operation suture thread, including according to parts by weight
Meter following component: aromatic polyester 60-70 part, ethylene glycol 2-8 part, polyvinylpyrrolidone 2-9 part, Radix Angelicae Dahuricae powder 10-20 part, two
Titanium oxide 2-8 part, motherwort powder 10-20 part, aloin 3-7 part, sodium carboxymethyl cellulose 5-10 part, neutral lipase 3-8 part,
Rhopilema esculenta collagen 12-18 part, chitin 11-14 part, metronidazole 3-8 part.
It also comprises poly-ethylenecarbonate 5-10 part.
It also comprises procyanidin 5-10 part.
It also comprises Fructus Gleditsia powder 5-8 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in reactor, the most ultrasonic 1-6h
After, it is then heated to 50-90 DEG C, stirs 1-3h, obtain blend；Blend is extruded, water-cooled, air-dry, pelletizing, obtain mother
Grain；By master batch heating and melting, deaeration and spray webbing, form primary filament, then by primary filament water-bath succeeding stretch, obtain infection
Operation suture thread.
Beneficial effect: a kind of anti-infective operation suture thread of the present invention, has good blood compatibility and tissue phase
Capacitive, can effectively prevent the infection of wound, and raw material sources are extensive, cheap, do not increase patient economy burden.
Detailed description of the invention
Embodiment 1
The anti-infective operation suture thread of the present embodiment, the following component including in parts by weight: aromatic polyester 60
Part, ethylene glycol 2 parts, polyvinylpyrrolidone 2 parts, 10 parts of Radix Angelicae Dahuricae powder, titanium dioxide 2 parts, motherwort powder 10 parts, aloin 3 parts,
Sodium carboxymethyl cellulose 5 parts, neutral lipase 3 parts, Rhopilema esculenta collagen 12 parts, chitin 11 parts, metronidazole 3 parts.
Embodiment 2
The anti-infective operation suture thread of the present embodiment, the following component including in parts by weight: aromatic polyester 70
Part, ethylene glycol 8 parts, polyvinylpyrrolidone 9 parts, 20 parts of Radix Angelicae Dahuricae powder, titanium dioxide 8 parts, motherwort powder 20 parts, aloin 7 parts,
Sodium carboxymethyl cellulose 10 parts, neutral lipase 8 parts, Rhopilema esculenta collagen 18 parts, chitin 14 parts, metronidazole 8 parts, poly-ethylidene carbon
Acid esters 10 parts.
Embodiment 3
The anti-infective operation suture thread of the present embodiment, the following component including in parts by weight: aromatic polyester 60
Part, ethylene glycol 2 parts, polyvinylpyrrolidone 2 parts, 10 parts of Radix Angelicae Dahuricae powder, titanium dioxide 2 parts, motherwort powder 10 parts, aloin 3 parts,
Sodium carboxymethyl cellulose 5 parts, neutral lipase 3 parts, Rhopilema esculenta collagen 12 parts, chitin 11 parts, metronidazole 3 parts, poly-ethylidene carbon
Acid esters 5 parts, procyanidin 5 parts.
Embodiment 4
The anti-infective operation suture thread of the present embodiment, the following component including in parts by weight: aromatic polyester 70
Part, ethylene glycol 8 parts, polyvinylpyrrolidone 9 parts, 20 parts of Radix Angelicae Dahuricae powder, titanium dioxide 8 parts, motherwort powder 20 parts, aloin 7 parts,
Sodium carboxymethyl cellulose 10 parts, neutral lipase 8 parts, Rhopilema esculenta collagen 18 parts, chitin 14 parts, metronidazole 8 parts, poly-ethylidene carbon
Acid esters 10 parts, procyanidin 10 parts, 8 parts of Fructus Gleditsia powder.
The above, be only presently preferred embodiments of the present invention, and the present invention not makees any pro forma restriction, though
So the present invention is disclosed above with preferred embodiment, but is not limited to the present invention, any technology people being familiar with this specialty
Member, in the range of without departing from technical solution of the present invention, when the technology contents of available the disclosure above makes a little change or modification
For the Equivalent embodiments of equivalent variations, as long as being the content without departing from technical solution of the present invention, the technical spirit of the foundation present invention
Any simple modification, equivalent variations and the modification being made above example, all still falls within the range of technical solution of the present invention.
Claims (4)
1. an anti-infective operation suture thread, it is characterised in that include following component in parts by weight: aromatic polyester
60-70 part, ethylene glycol 2-8 part, polyvinylpyrrolidone 2-9 part, Radix Angelicae Dahuricae powder 10-20 part, titanium dioxide 2-8 part, motherwort powder
10-20 part, aloin 3-7 part, sodium carboxymethyl cellulose 5-10 part, neutral lipase 3-8 part, Rhopilema esculenta collagen 12-18 part, carapace
Element 11-14 part, metronidazole 3-8 part.
Anti-infective operation suture thread the most according to claim 1, it is characterised in that: it also comprises poly-ethylenecarbonate
5-10 part.
Anti-infective operation suture thread the most according to claim 2, it is characterised in that: it also comprises procyanidin 5-10
Part.
Anti-infective operation suture thread the most according to claim 3, it is characterised in that: it also comprises Fructus Gleditsia powder 5-8 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610431320.1A CN106039386A (en) | 2016-06-16 | 2016-06-16 | Anti-infection surgical suture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610431320.1A CN106039386A (en) | 2016-06-16 | 2016-06-16 | Anti-infection surgical suture |
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| Publication Number | Publication Date |
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| CN106039386A true CN106039386A (en) | 2016-10-26 |
Family
ID=57169258
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| CN201610431320.1A Withdrawn CN106039386A (en) | 2016-06-16 | 2016-06-16 | Anti-infection surgical suture |
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| CN (1) | CN106039386A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729946A (en) * | 2016-11-25 | 2017-05-31 | 江苏爱西施科技服务咨询股份有限公司 | A kind of silk suture with antibacterial anti hemorrhagic effect and preparation method thereof |
| CN109224117A (en) * | 2018-10-11 | 2019-01-18 | 天津科技大学 | A kind of production method of the bacteria cellulose operation suture thread of antibacterial |
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| CN104368039A (en) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | Medical absorbable suture line and preparation method thereof |
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| CN105251043A (en) * | 2015-10-28 | 2016-01-20 | 钊桂英 | Medical polylactic acid (PLA) suture line and manufacturing method |
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| CN1256700A (en) * | 1997-04-03 | 2000-06-14 | 吉尔福德药物有限公司 | Biodegradable terephthalate polyester-polyphosphate polymers, compositions, articles, and methods of making and using the same |
| CN104368039A (en) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | Medical absorbable suture line and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106729946A (en) * | 2016-11-25 | 2017-05-31 | 江苏爱西施科技服务咨询股份有限公司 | A kind of silk suture with antibacterial anti hemorrhagic effect and preparation method thereof |
| CN109224117A (en) * | 2018-10-11 | 2019-01-18 | 天津科技大学 | A kind of production method of the bacteria cellulose operation suture thread of antibacterial |
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Application publication date: 20161026 |