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CN105832331A - Non-contact cerebral hemorrhage detection device based on broadband antenna technology and detection method of detection device - Google Patents

Non-contact cerebral hemorrhage detection device based on broadband antenna technology and detection method of detection device Download PDF

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CN105832331A
CN105832331A CN201610156716.XA CN201610156716A CN105832331A CN 105832331 A CN105832331 A CN 105832331A CN 201610156716 A CN201610156716 A CN 201610156716A CN 105832331 A CN105832331 A CN 105832331A
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张海生
秦明新
陈明生
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Army Medical University
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Abstract

本发明公开了一种基于宽带天线技术的非接触脑出血检测装置及其检测方法,检测装置包括信号发生单元、发射天线与接收天线、信号采集单元和信号处理显示单元。信号发生单元生成激励信号和参考信号,发射天线将激励信号定向发射,信号穿透脑组织,带走脑出血病变信息,然后被接收天线捕获;信号采集单元检测出参考信号和接收信号,由A/D转换器转换为数字信号;信号处理显示单元对两路信号进行比幅和鉴相。本发明装置的检测方法检测颅内组织的相对介电常数的变化,使得信号的传输系数发生变化,通过信号处理单元得出发射信号与接收信号之间的传输系数。本发明采用了宽带技术,系统工作频带1.2GHz~2.1GHz,提高了检测灵敏度和稳定性。

The invention discloses a non-contact cerebral hemorrhage detection device based on broadband antenna technology and a detection method thereof. The detection device includes a signal generating unit, a transmitting antenna and a receiving antenna, a signal collecting unit and a signal processing and displaying unit. The signal generation unit generates the excitation signal and the reference signal, and the transmitting antenna transmits the excitation signal in a directional manner. The signal penetrates the brain tissue, takes away the information of the cerebral hemorrhage, and is then captured by the receiving antenna; the signal acquisition unit detects the reference signal and the receiving signal, and the A The /D converter is converted into a digital signal; the signal processing and display unit compares the amplitude and phase of the two signals. The detection method of the device of the present invention detects the change of the relative permittivity of the intracranial tissue, so that the transmission coefficient of the signal changes, and the transmission coefficient between the transmitted signal and the received signal is obtained through the signal processing unit. The invention adopts the broadband technology, and the system working frequency band is 1.2GHz-2.1GHz, which improves the detection sensitivity and stability.

Description

基于宽带天线技术的非接触脑出血检测装置及其检测方法Non-contact cerebral hemorrhage detection device and detection method based on broadband antenna technology

技术领域technical field

本发明涉及生物医学医疗设备技术领域,具体涉及一种基于宽带天线技术的非接触脑出血检测装置及其检测方法。The invention relates to the technical field of biomedical medical equipment, in particular to a non-contact cerebral hemorrhage detection device based on broadband antenna technology and a detection method thereof.

背景技术Background technique

脑出血是指非外伤性脑实质内血管破裂引起的出血,发生的原因与高血脂、糖尿病、高血压、血管的老化以及吸烟等密切相关。世界卫生组织研究表明,我国脑卒中发生率正以每年约9%的速率上升,其中脑出血占全部脑卒中的20%~30%,发病者月30%死亡,70%的幸存者中多数留有不同程度的运动障碍、认知障碍、言语吞咽障碍等后遗症。脑出血如果在早期得到治疗,可以有效防止疾病的发展、传变,并极大的减少中风的后遗症。治疗越及时,对患者的身体和病情恢复越好。因此实时地监护脑出血的严重程度以及及时评价脑出血的发展过程,是重症监护及抢救治疗成败的关键。Cerebral hemorrhage refers to hemorrhage caused by rupture of blood vessels in the non-traumatic brain parenchyma. The causes are closely related to hyperlipidemia, diabetes, hypertension, aging of blood vessels, and smoking. According to the research of the World Health Organization, the incidence of stroke in my country is increasing at a rate of about 9% per year, of which cerebral hemorrhage accounts for 20% to 30% of all strokes, 30% of the patients die, and most of the 70% of the survivors stay. There are different degrees of sequelae such as motor impairment, cognitive impairment, and speech and swallowing impairment. If cerebral hemorrhage is treated in the early stage, it can effectively prevent the development and transmission of the disease, and greatly reduce the sequelae of stroke. The more timely the treatment, the better for the patient's body and recovery. Therefore, real-time monitoring of the severity of cerebral hemorrhage and timely evaluation of the development of cerebral hemorrhage are the key to the success of intensive care and rescue treatment.

目前使用较多的脑出血检查方法有ICP(颅内压)测量推定法以及CT或MRI影像学方法。ICP检测方法需要将压力传感器放入颅内,产生损伤,易感染,且无法推定颅内压的升高是脑出血、脑缺血还是脑水肿。CT和MRI影像学方法,存在检查滞后性,无法应对早期的急性脑出血,因此病人常常错过治疗的最佳时间而导致严重的脑损伤甚至死亡,且存在检查价格较贵、无法实施床旁和急救现场监护等问题,所以当前急需一种可以进行有效连续床旁监护,非接触,无创伤的脑出血检测方法。At present, the most widely used examination methods for cerebral hemorrhage include ICP (intracranial pressure) measurement method and CT or MRI imaging method. The ICP detection method needs to put the pressure sensor into the brain, which causes damage and is susceptible to infection, and it is impossible to deduce whether the increase in intracranial pressure is cerebral hemorrhage, cerebral ischemia or cerebral edema. CT and MRI imaging methods have inspection lag and cannot deal with early acute cerebral hemorrhage, so patients often miss the best time for treatment, resulting in severe brain damage or even death, and there are inspections that are expensive and cannot be implemented at the bedside. Emergency on-site monitoring and other issues, so there is an urgent need for a non-contact, non-invasive cerebral hemorrhage detection method that can perform effective and continuous bedside monitoring.

正在发展中的磁感应相移(MIPS)测量法具有小型化、非接触和无创伤的特点,是检测脑出血较好的方法。但是由于在10MHz频率附近,生物组织的电导率很小(0.1s/m~2s/m),因此由外界磁场产生的涡流非常弱,涡流产生的二次磁场也非常弱,导致磁感应测量灵敏度低、稳定性差,且容易受到外界磁场、环境温度、外界容积导体耦合等干扰。且该方法通常采用单一频点作为检测依据,已受到随机信号的干扰,误差较大,检测系统灵敏度和稳定性打不到临床需求,很难有效的区分出脑出血的严重程度。The developing magnetic induction phase shift (MIPS) measurement method has the characteristics of miniaturization, non-contact and non-invasive, and it is a better method for detecting cerebral hemorrhage. However, since the conductivity of biological tissue is very small (0.1s/m~2s/m) near the frequency of 10MHz, the eddy current generated by the external magnetic field is very weak, and the secondary magnetic field generated by the eddy current is also very weak, resulting in low sensitivity of magnetic induction measurement , Poor stability, and susceptible to interference from external magnetic field, ambient temperature, external volume conductor coupling, etc. Moreover, this method usually uses a single frequency point as the detection basis, which has been interfered by random signals and has large errors. The sensitivity and stability of the detection system cannot meet the clinical needs, and it is difficult to effectively distinguish the severity of cerebral hemorrhage.

本发明在理论分析与实验研究基础上,提出采用基于宽带天线技术的非接触电磁感应方法检测脑出血严重程度,原理基于正常脑组织和血液具有不同介电性质,从而产生的不同电磁波传输特性。该检测方法的灵敏度较高,稳定性和一致性较好,且具有高度的实验可重复性。为脑出血的实时监测和准确、有效地评估脑出血的严重程度及脑出血的发展过程提供了基础条件。Based on theoretical analysis and experimental research, the present invention proposes a non-contact electromagnetic induction method based on broadband antenna technology to detect the severity of cerebral hemorrhage. The principle is based on the different dielectric properties of normal brain tissue and blood, resulting in different electromagnetic wave transmission characteristics. The detection method has high sensitivity, good stability and consistency, and high experimental repeatability. It provides basic conditions for the real-time monitoring of cerebral hemorrhage and the accurate and effective evaluation of the severity of cerebral hemorrhage and the development process of cerebral hemorrhage.

发明内容Contents of the invention

本发明所要解决的技术问题在于克服磁感应相移(MIPS)法测量脑出血时灵敏度低、稳定性差,且容易受到外界磁场影响的缺点,而提出一种基于宽带天线技术的非接触的脑出血检测装置及其检测方法。The technical problem to be solved by the present invention is to overcome the shortcomings of low sensitivity, poor stability, and easy to be affected by external magnetic fields when measuring cerebral hemorrhage by the magnetic induction phase shift (MIPS) method, and propose a non-contact cerebral hemorrhage detection based on broadband antenna technology Device and detection method thereof.

一种基于宽带天线技术的非接触的脑出血检测装置包括信号发生单元、发射天线与接收天线、信号采集单元以及信号处理显示单元。A non-contact cerebral hemorrhage detection device based on broadband antenna technology includes a signal generating unit, a transmitting antenna and a receiving antenna, a signal collecting unit, and a signal processing and displaying unit.

所述信号发生单元为射频微波信号源,幅度、频率和相位均可调。信号发生单元产生激励信号与检测信号,分别传输给发射天线与信号采集单元。实际工作时,所述信号发生单元输出功率一定、频率范围为0~3GHz、以扫频模式运行、频率连续性变化的正弦波激励信号。The signal generating unit is a radio frequency microwave signal source, and the amplitude, frequency and phase can be adjusted. The signal generation unit generates an excitation signal and a detection signal, which are transmitted to the transmitting antenna and the signal acquisition unit respectively. In actual operation, the signal generation unit outputs a sine wave excitation signal with a constant power, a frequency range of 0-3 GHz, and a frequency sweep mode that operates in a continuously changing frequency.

所述发射天线与接收天线结构一致,发射天线与接收天线均是专为本发明装置设计。设计该天线时基于以下思路考虑:天线辐射波束应该覆盖整个头颅,且为避免外界干扰,天线辐射方向为单向,波束宽度60度为宜;天线应该具有较宽的工作频带,为整个检测系统采用宽带技术提供支持;天线的面积应该尽量小,易于集成于整个检测系统中。综合考虑上述因素,通过仿真与实验,最终选择天线形式为侧边接地的微带天线,天线整体长宽高尺寸为49mm╳24mm╳14mm,辐射层与接地层采用光刻印刷板制作,厚度分别为2mm,辐射层与接地层之间采用高密度泡沫填充,厚度10mm,辐射层尺寸37mm╳16mm,辐射层其中一条宽与天线整体的宽齐平布置。接地面尺寸49mm╳24mm,侧边接地墙采用自黏式铜箔,设置在所述辐射层宽与天线整体的宽齐平所在的侧边。馈电点设置在天线整体的中部,穿透接地层、高密度泡沫以及辐射层。采用了短路壁接地技术减小天线的面积,使得天线能较好的集成于系统中,同时采用了超厚介质层加大天线的带宽,提高了检测的灵敏度和稳定性。The transmitting antenna and the receiving antenna have the same structure, and both the transmitting antenna and the receiving antenna are specially designed for the device of the present invention. The design of the antenna is based on the following considerations: the radiation beam of the antenna should cover the entire head, and in order to avoid external interference, the radiation direction of the antenna is unidirectional, and the beam width is 60 degrees; Broadband technology is used to provide support; the area of the antenna should be as small as possible, and it is easy to integrate into the entire detection system. Considering the above factors comprehensively, through simulation and experiments, the antenna form is finally selected as a microstrip antenna with side grounding. The overall length, width and height of the antenna are 49mm╳24mm╳14mm. The radiation layer and the ground layer are made of photolithographic printing plates, and the thickness is respectively 2mm, between the radiation layer and the ground layer is filled with high-density foam, the thickness is 10mm, the size of the radiation layer is 37mm╳16mm, and the width of one of the radiation layers is flush with the overall width of the antenna. The size of the ground plane is 49mm╳24mm, and the side ground wall is made of self-adhesive copper foil, which is set on the side where the width of the radiation layer is flush with the overall width of the antenna. The feed point is set in the middle of the antenna as a whole, penetrating the ground layer, high-density foam and radiation layer. The short-circuit wall grounding technology is used to reduce the area of the antenna, so that the antenna can be better integrated in the system. At the same time, the ultra-thick dielectric layer is used to increase the bandwidth of the antenna, which improves the detection sensitivity and stability.

所述信号采集单元包括混频接收机以及A/D转换器,混频接收机接收由信号发生单元输出的参考信号和接收天线输出的检测信号,然后对信号进行下变频后通过A/D转换器变为数字信号,发送给信号处理显示单元。The signal acquisition unit includes a frequency mixing receiver and an A/D converter. The frequency mixing receiver receives the reference signal output by the signal generating unit and the detection signal output by the receiving antenna, and then converts the signal through A/D after down-converting the signal. Converter into a digital signal, sent to the signal processing display unit.

所述信号处理显示单元为一台内部带有专用软件的通用计算机,包括信号处理单元与信号显示单元,信号处理单元为带有软件的计算机逐级,对信号采集单元传输过来的参考信号和检测信号处理,采取VB编写的专用软件对两组信号进行鉴幅与鉴相,得到二者的幅度差与相位差,从而得出所述发射天线与接收天线的传输系数,比较脑出血前后传输系数的变化,可以监视脑出血的严重程度,最后传输至给信号显示单元进行显示。The signal processing and display unit is a general-purpose computer with special software inside, including a signal processing unit and a signal display unit. The signal processing unit is a computer with software step by step, and the reference signal and detection signal transmitted by the signal acquisition unit For signal processing, the special software written in VB is used to perform amplitude discrimination and phase discrimination on the two groups of signals to obtain the amplitude difference and phase difference between the two, so as to obtain the transmission coefficient of the transmitting antenna and the receiving antenna, and compare the transmission coefficients before and after cerebral hemorrhage The change of the cerebral hemorrhage can monitor the severity of the cerebral hemorrhage, and finally transmit it to the signal display unit for display.

所述信号发生单元的两个通道分别通过传输线与发射天线和信号采集单元的通道连接,接收天线通过传输线连接到信号采集单元另一个通道。所述信号采集单元通过传输线与信号处理显示单元连接。所有的传输线均采用射频同轴电缆。The two channels of the signal generation unit are respectively connected to the channel of the transmitting antenna and the signal acquisition unit through a transmission line, and the receiving antenna is connected to another channel of the signal acquisition unit through a transmission line. The signal acquisition unit is connected with the signal processing and display unit through a transmission line. All transmission lines are radio frequency coaxial cables.

进一步的,检测装置的工作频带这样确定,系统装置连接好之后,两组天线传输系数大于-30dB的频率区间1.2~2.0GHz。在此宽频带内,用于检测脑出血的工作频点数较多,频点间距合理,各频点检测结果之间的相关性较小,因此可以提高系统的检测稳定性。Further, the working frequency band of the detection device is determined in such a way that after the system device is connected, the frequency range 1.2-2.0 GHz where the transmission coefficient of the two sets of antennas is greater than -30 dB. In this wide frequency band, there are many working frequency points for detecting cerebral hemorrhage, the frequency point spacing is reasonable, and the correlation between the detection results of each frequency point is small, so the detection stability of the system can be improved.

所述一种基于宽带天线技术的非接触脑出血检测装置的检测方法,具体实施步骤如下:The detection method of the non-contact cerebral hemorrhage detection device based on broadband antenna technology, the specific implementation steps are as follows:

1)将被测头颅放置于发射天线和接收天线之间,调整天线位置与距离,使头颅位于天线中心连线上。信号发生器产生激励信号与检测信号,分别传输给发射天线与信号采集单元,接收天线连接到信号采集单元另一个通道,所有的传输线均采用射频同轴电缆。1) Place the head to be tested between the transmitting antenna and the receiving antenna, adjust the position and distance of the antenna so that the head is located on the line connecting the center of the antenna. The signal generator generates an excitation signal and a detection signal, which are transmitted to the transmitting antenna and the signal acquisition unit respectively, and the receiving antenna is connected to another channel of the signal acquisition unit, and all transmission lines adopt radio frequency coaxial cables.

2)信号发生单元输出功率一定、频率范围为0~3GHz、以扫频模式运行、频率连续线性变化的正弦波激励信号。并将宽带电磁信号定向发射,电磁波穿过整个脑部区域,然后被接收天线捕获。电磁波的传播受到颅内组织介电常数与电导率的影响,而血液的介电常数与电导率异于正常脑组织,因此在脑出血前后,电磁波的传播的幅度与相位将产生变化,通过宽带天线技术,可以在较宽的工作频带内观察到幅度与相位的变化。2) The signal generation unit outputs a sine wave excitation signal with a constant output power, a frequency range of 0-3 GHz, a frequency sweep mode, and a continuous linear change in frequency. Directly transmit broadband electromagnetic signals, the electromagnetic waves pass through the entire brain area, and then are captured by the receiving antenna. The propagation of electromagnetic waves is affected by the dielectric constant and conductivity of intracranial tissue, and the dielectric constant and conductivity of blood are different from normal brain tissue. Therefore, the amplitude and phase of electromagnetic wave propagation will change before and after cerebral hemorrhage. Through broadband Antenna technology that can observe amplitude and phase changes over a wide operating frequency band.

3)信号采集单元的混频接收机接收由扫频信号源输出的参考信号和接收天线输出的检测信号,经过A/D转换器转换后发送给信号处理单元进行处理。3) The frequency mixing receiver of the signal acquisition unit receives the reference signal output by the frequency sweep signal source and the detection signal output by the receiving antenna, and sends it to the signal processing unit for processing after being converted by the A/D converter.

4)信号处理单元处理由所述信号采集单元传输过来的的参考信号和接收天线传输过来的检测信号,在整个工作频带内,对参考信号与检测信号进行鉴幅与鉴相,得到二者的幅度差与相位差,从而得出所述发射天线与接收天线的传输系数,通过比较脑出血前后传输系数的变化,可以监视脑出血的严重程度。4) The signal processing unit processes the reference signal transmitted by the signal acquisition unit and the detection signal transmitted by the receiving antenna, performs amplitude discrimination and phase discrimination on the reference signal and the detection signal in the entire working frequency band, and obtains the difference between the two The amplitude difference and the phase difference are used to obtain the transmission coefficients of the transmitting antenna and the receiving antenna, and the severity of the cerebral hemorrhage can be monitored by comparing the changes of the transmission coefficients before and after cerebral hemorrhage.

随着脑出血量的变化,传输系数的幅度与相位均会发生改变,且幅度与相位改变值大小与个体相关,因此不单独比较幅度或相位的变化量,而是采用传输系数欧氏距离来反映脑出血量的变化,充分利用了矢量信号的幅度信息与相位信息,具体公式如式1:As the amount of cerebral hemorrhage changes, both the amplitude and phase of the transmission coefficient will change, and the amplitude and phase changes are related to the individual. Therefore, the change in amplitude or phase is not compared separately, but the Euclidean distance of the transmission coefficient is used. To reflect the changes in the amount of cerebral hemorrhage, the amplitude information and phase information of the vector signal are fully utilized. The specific formula is as follows:

ΔΔ SS →&Right Arrow; == SS →&Right Arrow; aa -- SS →&Right Arrow; bb == || SS →&Right Arrow; aa || 22 ++ || SS →&Right Arrow; bb || 22 -- 22 ·&Center Dot; || SS →&Right Arrow; aa || ·&Center Dot; || SS →&Right Arrow; bb || coscos (( θθ aa -- θθ bb )) -- -- -- (( 11 ))

式中,为出血前后传输系数欧氏距离,为出血后传输系数的矢量值,为出血前传输系数的矢量值,为出血后传输系数的幅度值,为出血前传输系数的幅度值,θa为出血后传输系数的相位值,θb为出血前传输系数的相位值。In the formula, is the transmission coefficient Euclidean distance before and after bleeding, is the vector value of the transfer coefficient after bleeding, is the vector value of the transmission coefficient before bleeding, is the amplitude value of the transmission coefficient after bleeding, is the amplitude value of the transmission coefficient before bleeding, θ a is the phase value of the transmission coefficient after bleeding, and θ b is the phase value of the transmission coefficient before bleeding.

5)显示单元将得到的结果进行实时显示,通过欧式距离的变化量来判断脑出血的严重程度和发展变化。5) The display unit displays the obtained results in real time, and judges the severity and development of the cerebral hemorrhage through the variation of the Euclidean distance.

本发明提出的基于宽带天线技术的非接触式脑出血检测方法,主要依据血液的介电常数与电导率与正常脑组织不同,通过电磁感应影响电磁波的传输,从而使得该系统天线传输系数的发生变化,并根据传输系数的变化值来检测脑出血的变化。The non-contact cerebral hemorrhage detection method based on broadband antenna technology proposed by the present invention is mainly based on the fact that the dielectric constant and conductivity of blood are different from normal brain tissue, and the transmission of electromagnetic waves is affected by electromagnetic induction, so that the antenna transmission coefficient of the system occurs. Changes, and changes in cerebral hemorrhage were detected based on the changing values of the transfer coefficient.

本发明的优点在于两个方面:一是采用了宽带技术,系统工作频率1.2GHz~2.0GHz,取样间隔5MHz,在工作频率内有261个频点,最终脑出血严重程度的鉴别正是通过261个频点的传输参数综合得出,宽带技术的使用,避免了磁感应相移(MIPS)测量法单个频点随机误差大、最佳测量频率难以确定的缺点;二是采用了矢量鉴别技术,通过传输参数检测脑出血过程中,综合采用了传输参数的幅度与相位,通过计算传输系数的欧氏距离,减小了脑出血个体差异带来的影响,更好的从测试参数中挖掘了有用信息。因此本发明能够较好提高非接触式脑出血检测装置灵敏度和稳定性。The advantages of the present invention lie in two aspects: one is that broadband technology is adopted, the system operating frequency is 1.2GHz to 2.0GHz, the sampling interval is 5MHz, and there are 261 frequency points in the operating frequency, and the final identification of the severity of cerebral hemorrhage is precisely through 261 The transmission parameters of each frequency point are comprehensively concluded that the use of broadband technology avoids the shortcomings of large random errors at a single frequency point and difficulty in determining the best measurement frequency in the magnetic induction phase shift (MIPS) measurement method; the second is the use of vector identification technology. In the process of detecting cerebral hemorrhage by transmission parameters, the amplitude and phase of transmission parameters are comprehensively adopted, and the influence of individual differences in cerebral hemorrhage is reduced by calculating the Euclidean distance of transmission coefficients, and useful information is better mined from test parameters . Therefore, the present invention can better improve the sensitivity and stability of the non-contact cerebral hemorrhage detection device.

附图说明Description of drawings

图1为本发明提供的基于宽带天线技术的非接触脑出血检测装置的结构示意图;FIG. 1 is a schematic structural diagram of a non-contact cerebral hemorrhage detection device based on broadband antenna technology provided by the present invention;

图2为本发明采用的矢量值欧氏距离计算方法的示意图;Fig. 2 is the schematic diagram of the vector value Euclidean distance calculating method that the present invention adopts;

图3为本发明提供的用于发射与接收脑出血探测信号的微带天线结构示意图;FIG. 3 is a schematic structural diagram of a microstrip antenna for transmitting and receiving cerebral hemorrhage detection signals provided by the present invention;

图4为脑出血检测装置的有效工作频带示意图;Fig. 4 is a schematic diagram of the effective working frequency band of the cerebral hemorrhage detection device;

图5为本发明实施例提供的检测家兔脑出血实验获得的其中一只家兔的宽带范围内传输系数欧氏具体与出血量关系曲线示意图,Fig. 5 is a schematic diagram of the relationship curve between the Euclidean specific transmission coefficient and the amount of bleeding in one of the rabbits obtained from the experiment of detecting cerebral hemorrhage in rabbits provided by the embodiment of the present invention,

图中:1为信号发生单元,2-1为发射天线,2-2为接收天线,3为信号采集单元,3-1为混频接收机,3-2为A/D转换器,4为信号处理显示单元,4-1为信号处理单元,4-2为信号显示单元。In the figure: 1 is the signal generating unit, 2-1 is the transmitting antenna, 2-2 is the receiving antenna, 3 is the signal acquisition unit, 3-1 is the frequency mixing receiver, 3-2 is the A/D converter, 4 is the Signal processing display unit, 4-1 is a signal processing unit, 4-2 is a signal display unit.

具体实施方式detailed description

下面结合附图和实施例对本发明作进一步说明,但不应该理解为本发明上述主题范围仅限于下述实施例。在不脱离本发明上述技术思想的情况下,根据本领域普通技术知识和惯用手段,做出各种替换和变更,均应包括在本发明的保护范围内。The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but it should not be understood that the scope of the subject matter of the present invention is limited to the following embodiments. Without departing from the above-mentioned technical ideas of the present invention, various replacements and changes made according to common technical knowledge and conventional means in this field shall be included in the protection scope of the present invention.

实施例1:Example 1:

本实施例公开一种基于宽带天线技术的非接触脑出血检测装置,包括信号发生单元1、发射天线2-1与接收天线2-2、信号采集单元3与信号处理显示单元4组成。This embodiment discloses a non-contact cerebral hemorrhage detection device based on broadband antenna technology, which includes a signal generating unit 1 , a transmitting antenna 2 - 1 and a receiving antenna 2 - 2 , a signal collecting unit 3 and a signal processing and displaying unit 4 .

具体的装置结构及细节本实施例优选以下型号:所述信号发生单元1为矢量信号发生器,采用市购的AV1441信号源,该信号源具有发射信号频率范围宽,频率分辨率与精度高,以及相位噪声低等优点,能实现线性扫频输出,同时能等幅同相输出参考信号,能够满足本装置系统的需求。Concrete device structure and details The following models are preferred in this embodiment: the signal generating unit 1 is a vector signal generator, which adopts a commercially available AV1441 signal source, which has a wide range of transmitting signal frequencies, high frequency resolution and precision, As well as the advantages of low phase noise, it can realize linear frequency sweep output, and can output reference signals with equal amplitude and same phase at the same time, which can meet the requirements of the device system.

所述发射天线2-1与接收天线2-2是专为该测试系统设计。设计该天线时基于以下思路考虑:天线辐射波束应该覆盖整个头颅,且为避免外界干扰,天线辐射方向为单向,波束宽度60度为宜;天线应该具有较宽的工作频带,为整个检测系统采用宽带技术提供支持;天线的面积应该尽量小,易于集成于整个检测系统中。综合考虑上述因素,通过仿真与实验,最终选择天线形式为侧边接地的微带天线,天线整体长宽高尺寸为49mm╳24mm╳14mm,辐射层与接地层采用光刻印刷板制作,厚度分别为2mm,辐射层与接地层之间采用高密度泡沫填充,厚度10mm,辐射层尺寸37mm╳16mm,辐射层其中一条宽与天线整体的宽齐平布置。接地面尺寸49mm╳24mm,侧边接地墙采用自黏式铜箔,设置在所述辐射层宽与天线整体的宽齐平所在的侧边。馈电点设置在天线整体的中部,穿透接地层、高密度泡沫以及辐射层。微带天线结构示意图具体参见图3,采用了短路壁接地技术减小天线的面积,使得天线能较好的集成于系统中,同时采用了超厚介质层加大天线的带宽,提高了检测的灵敏度和稳定性。The transmitting antenna 2-1 and receiving antenna 2-2 are specially designed for the test system. The design of the antenna is based on the following considerations: the radiation beam of the antenna should cover the entire head, and in order to avoid external interference, the radiation direction of the antenna is unidirectional, and the beam width is 60 degrees; Broadband technology is used to provide support; the area of the antenna should be as small as possible, and it is easy to integrate into the entire detection system. Considering the above factors comprehensively, through simulation and experiments, the antenna form is finally selected as a microstrip antenna with side grounding. The overall length, width and height of the antenna are 49mm╳24mm╳14mm. The radiation layer and the ground layer are made of photolithographic printing plates, and the thickness is respectively 2mm, between the radiation layer and the ground layer is filled with high-density foam, the thickness is 10mm, the size of the radiation layer is 37mm╳16mm, and the width of one of the radiation layers is flush with the overall width of the antenna. The size of the ground plane is 49mm╳24mm, and the side ground wall is made of self-adhesive copper foil, which is set on the side where the width of the radiation layer is flush with the overall width of the antenna. The feed point is set in the middle of the antenna as a whole, penetrating the ground layer, high-density foam and radiation layer. Refer to Figure 3 for the schematic diagram of the microstrip antenna structure. The short-circuit wall grounding technology is used to reduce the area of the antenna, so that the antenna can be better integrated in the system. At the same time, the ultra-thick dielectric layer is used to increase the bandwidth of the antenna and improve the detection accuracy sensitivity and stability.

所述信号采集单元3采用市购型号为Agilent 34970A的数据采集器,该采集器采集速率快,采集精度高,可同时采集两个通道的矢量信号,且可扩展性强,适用于本发明装置的使用。The signal acquisition unit 3 adopts a commercially available data collector of Agilent 34970A, which has a fast collection rate and high collection accuracy, can simultaneously collect the vector signals of two channels, and has strong scalability, and is applicable to the device of the present invention usage of.

所述信号处理显示单元4包括信号处理单元4-1和信号显示单元4-2。信号处理单元4-1主要构架是基于VB语言的矢量信号计算程序,参考信号与检测信号经过数据采集器后变为两路数字序列,在软件中进行FFT运算,得到信号的幅度与相位,然后将两路矢量信号进行差值运算就得到传输系数,然后以0ml出血量的传输系数作为基准值,分别用1ml、2ml和3ml的传输系数与0ml的传输系数做矢量差值,得到不同出血量条件下传输系数的欧式距离,最后信号显示单元4-1将其实时显示出来。The signal processing display unit 4 includes a signal processing unit 4-1 and a signal display unit 4-2. The main structure of the signal processing unit 4-1 is a vector signal calculation program based on VB language. The reference signal and the detection signal are converted into two-way digital sequences after passing through the data collector, and the FFT operation is performed in the software to obtain the amplitude and phase of the signal, and then The transmission coefficient is obtained by performing difference calculation on the two vector signals, and then the transmission coefficient of 0ml blood loss is used as the reference value, and the transmission coefficient of 1ml, 2ml and 3ml is used as the vector difference with the transmission coefficient of 0ml to obtain different bleeding volumes The Euclidean distance of the transmission coefficient under the conditions, and finally the signal display unit 4-1 displays it in real time.

所述信号发生单元4-1的两个通道分别通过传输线与发射天线2-1和信号采集单元3的通道连接,接收天线2-2通过传输线连接到信号采集单元3另一个通道。所述信号采集单元3通过传输线与信号处理显示单元4连接。所有的传输线均采用射频同轴电缆。The two channels of the signal generating unit 4-1 are respectively connected to the channels of the transmitting antenna 2-1 and the signal collecting unit 3 through a transmission line, and the receiving antenna 2-2 is connected to another channel of the signal collecting unit 3 through a transmission line. The signal acquisition unit 3 is connected to the signal processing and display unit 4 through a transmission line. All transmission lines are radio frequency coaxial cables.

实施例2:Example 2:

本发明实施例的基于天线技术的非接触式脑出血检测装置的检测方法步骤如下:The steps of the detection method of the non-contact cerebral hemorrhage detection device based on antenna technology in the embodiment of the present invention are as follows:

1)打开检测装置进行预热30分钟,将被测头颅放置在发射天线2-1与接收天线2-2连线中心位置,矢量信号源连接到发射天线2-1与参考信号采集端,所有的连线均采用射频同轴电缆。1) Turn on the detection device to warm up for 30 minutes, place the head under test at the center of the line connecting the transmitting antenna 2-1 and the receiving antenna 2-2, connect the vector signal source to the transmitting antenna 2-1 and the reference signal acquisition end, all All connections are radio frequency coaxial cables.

2)设置矢量信号源输出功率为0dBm、频率范围为0-3000MHz,以线性扫频模式输出正弦波激励信号。参考信号直接进入信号采集单元3,激励信号经过发射天线2-1、头颅、接收天线2-2后进入信号采集单元3,激励信号在头颅内的幅度和相位的变化与颅内脑出血造成的颅脑整体介电常数和电导率的变化密切相关,随着脑出血严重程度增加,组织含水量增加,颅内整体介电常数与电导率增大,测到的检测信号的幅度与相位变化增大。2) Set the output power of the vector signal source to 0dBm, the frequency range to 0-3000MHz, and output the sine wave excitation signal in linear frequency sweep mode. The reference signal directly enters the signal acquisition unit 3, and the excitation signal enters the signal acquisition unit 3 after passing through the transmitting antenna 2-1, the skull, and the receiving antenna 2-2. The changes in the overall dielectric constant and electrical conductivity of the brain are closely related. As the severity of cerebral hemorrhage increases, the tissue water content increases, the overall dielectric constant and electrical conductivity of the brain increase, and the amplitude and phase changes of the detected detection signals increase. Big.

3)信号采集单元3的混频接收机3-1通道1采集矢量信号源输出的参考信号,通道2采集接收天线2-2输出的检测信号,采集到的信号经过A/D转换器3-2,转换为矢量数字信号并传输至信号处理单元4-1,对数据进行下一步分析处理;3) The frequency mixing receiver 3-1 channel 1 of the signal acquisition unit 3 collects the reference signal output by the vector signal source, and the channel 2 collects the detection signal output by the receiving antenna 2-2, and the collected signal passes through the A/D converter 3- 2. Convert it into a vector digital signal and transmit it to the signal processing unit 4-1 for further analysis and processing of the data;

4)信号处理单元4-1对两路矢量数字信号进行比幅与鉴相,得到两路信号的矢量差,也就是传输系数。在不同出血量情况下,分别用该情况下传输系数与0ml脑出血量的传输系数做矢量差值,得到不同出血量情况下传输系数的欧式距离,并计算欧氏距离的模值,输出至信号显示单元4-2进行实时显示。4) The signal processing unit 4-1 performs amplitude comparison and phase discrimination on the two-way vector digital signals to obtain the vector difference of the two-way signals, that is, the transmission coefficient. In the case of different blood loss, use the transmission coefficient in this case and the transmission coefficient of 0ml cerebral hemorrhage to make the vector difference to obtain the Euclidean distance of the transmission coefficient in different blood loss, and calculate the modulus of the Euclidean distance, and output to The signal display unit 4-2 performs real-time display.

5)信号显示单元4-2实时显示随出血程度变化的欧氏距离的模值。实验中脑出血检测装置的有效工作频带具体参见图4。5) The signal display unit 4-2 displays in real time the modulus of the Euclidean distance that changes with the degree of bleeding. The effective working frequency band of the cerebral hemorrhage detection device in the experiment is specifically shown in FIG. 4 .

实施例3:Example 3:

通过以下动物实验对本发明的基于宽带天线技术的非接触电磁感应脑出血检测方法进行了进一步的验证和效果说明:The non-contact electromagnetic induction cerebral hemorrhage detection method based on broadband antenna technology of the present invention is further verified and explained by the following animal experiments:

1、选取购买新西兰大白兔12只,体重2.1-2.5Kg。1. Select and purchase 12 New Zealand white rabbits, weighing 2.1-2.5Kg.

2、建立家兔自体血注射脑出血模型。兔子麻醉采用25%氨基甲酸乙酯按5ml/kg的剂量耳缘静脉注射。自体血取自兔子股静脉,并加入少许肝素钠抗凝剂。注射位置:以兔脑“十字缝”交叉点为基点,沿冠状缝向右侧旁开6mm,再平行矢状缝往后1mm为穿刺进针点,深度13mm。使用微量注射泵按照1ml/每分钟的速度匀速注入1ml,分三次注入,每次注完后采用本系统测量出血量引起的矢量差信号模值。2. Establish a rabbit model of cerebral hemorrhage injected with autologous blood. Rabbits were anesthetized by injecting 25% ethyl carbamate into the ear vein at a dose of 5ml/kg. Autologous blood was taken from rabbit femoral vein, and a little heparin sodium anticoagulant was added. Injection location: Based on the intersection point of the "cross suture" of the rabbit brain, open 6 mm to the right side along the coronal suture, and then parallel to the sagittal suture 1 mm behind is the puncture point, with a depth of 13 mm. Use a micro-injection pump to inject 1ml at a constant speed of 1ml/min, and inject three times. After each injection, use this system to measure the modulus of the vector difference signal caused by the amount of bleeding.

3、图4是检测12只家兔脑出血实验获得的其中一只兔子的传输系数的幅度值示意图。可以看出,传输系数大于-30dB的频率范围1.2GHz~2.0GHz,此频段内通过兔脑并被接收天线采集的激励信号能量相对较大,故采用此频段的数据进行判别与分析。3. Figure 4 is a schematic diagram of the amplitude value of the transmission coefficient of one of the rabbits obtained from the experiment of detecting cerebral hemorrhage in 12 rabbits. It can be seen that the frequency range of 1.2GHz to 2.0GHz where the transmission coefficient is greater than -30dB, the energy of the excitation signal collected by the rabbit brain and the receiving antenna in this frequency band is relatively large, so the data in this frequency band is used for discrimination and analysis.

4、图5是检测12只家兔脑出血实验获得的其中一只兔子的欧式距离矢量差值示意图。欧式距离矢量差值计算方法是分别用1ml、2ml和3ml脑出血量的传输系数与0ml脑出血量的传输系数做矢量差值。可以清楚的看出不同脑出血量欧式距离矢量差值的变化情况,每1ml脑出血量平均的矢量差值达到了约5dB,而采用MIPS方法测量1ml脑出血量相位差一般达不到5°,且通常为单一频点测量值,随机误差较大。4. Figure 5 is a schematic diagram of the Euclidean distance vector difference of one of the rabbits obtained in the experiment of detecting cerebral hemorrhage in 12 rabbits. The Euclidean distance vector difference calculation method is to use the transmission coefficient of 1ml, 2ml and 3ml cerebral hemorrhage volume and the transmission coefficient of 0ml cerebral hemorrhage volume as vector difference respectively. It can be clearly seen the change of the Euclidean distance vector difference for different cerebral hemorrhage volumes. The average vector difference per 1ml cerebral hemorrhage volume reaches about 5dB, while the phase difference of 1ml cerebral hemorrhage volume measured by MIPS method generally does not reach 5° , and is usually a single frequency point measurement value, with a large random error.

由此可见,采用基于宽带天线技术的电磁感应脑出血检测方法的灵敏度比采用MIPS检测方法提高了一个数量级,并提高了系统的可靠性。由于实验操作复杂,每只兔子的手术操作不可能做到完全一致,因此每只兔子的变化量有一些差别,但总体趋势不变。It can be seen that the sensitivity of the electromagnetic induction cerebral hemorrhage detection method based on broadband antenna technology is improved by an order of magnitude compared with the MIPS detection method, and the reliability of the system is also improved. Due to the complexity of the experimental operation, the surgical operation of each rabbit cannot be completely consistent, so there are some differences in the amount of change in each rabbit, but the overall trend remains the same.

Claims (5)

1. noncontact cerebral hemorrhage based on a broadband antenna technology detection device, its feature exists In: include signal generating unit (1), launch antenna (2-1) with reception antenna (2-2), Signal gathering unit (3) and signal processing display unit (4);
Described signal generating unit (1) is frequency microwave signal source, amplitude, frequency and phase place The most adjustable;Signal generating unit (1) produces pumping signal and detection signal, and point two-way is respectively It is transferred to launch antenna (2-1) and signal gathering unit (3);
Described transmitting antenna (2-1) is consistent with reception antenna (2-2) structure, and antenna form is equal For the microstrip antenna of side ground connection, radiating layer and ground plane use lithographic printing version to make, radiate Using high-density foam to fill between layer and ground plane, side ground connection wall is self-adhesive Copper Foil, The distributing point penetrating ground plane, high-density foam and radiating layer is had in the middle part of antenna entirety;Described Launching between antenna (2-1) and reception antenna (2-2) is head, from launching antenna (2-1) Send electromagnetic wave signal and become detection signal by reception antenna (2-2) after whole brain area Capture;
Described signal gathering unit (3) is by mixing receiver (3-1) and A/D converter (3-2) Constituting, described mixing receiver (3-1) receives the reference exported by signal generating unit (1) The detection signal that signal and reception antenna (2-2) export, after then carrying out down coversion to signal Become digital signal by A/D converter (3-2), be sent to signal processing display unit (4);
Described signal processing display unit (4) is internal with special-purpose software, comprises signal processing Unit (4-1) and signal display unit (4-2);Described signal processing unit (4-1) loads Special signal is had to process software, the reference signal that signal gathering unit is transmitted and detection Signal carries out amplitude discrimination and phase demodulation;Described signal display unit (4-2) is display device, receives Signal after signal processing unit (4-1) also shows;
Two passages of described signal generating unit (1) are respectively by transmission line and transmitting antenna (2-1) passage with signal gathering unit (3) connects, and reception antenna (2-2) is by passing Defeated line is connected to signal gathering unit (3) another passage;Described signal gathering unit is passed through Transmission line is connected with signal processing display unit (4);All of transmission line all uses radio frequency same Shaft cable.
A kind of noncontact brain based on broadband antenna technology the most according to claim 1 goes out Device is surveyed in blood examination, it is characterised in that: described transmitting antenna (2-1) and reception antenna (2-2) All use the microstrip antenna form of side ground connection;Antenna entirety length and width a height of 49mm 24mm 14mm, radiating layer makes with ground plane employing lithographic printing plate, and thickness is respectively 2mm;Radiation High-density foam is used to fill between layer and ground plane, thickness 10mm;Radiating layer size 37mm 16mm, a radiating layer wherein wide wide flush arrangement overall with antenna;Ground plane dimensions 49mm 24mm, side ground connection wall uses self-adhesive Copper Foil, is arranged on described radiation slice width and sky The width of line entirety flushes the side at place;Distributing point is arranged on the middle part that antenna is overall, penetrates and connects Stratum, high-density foam and radiating layer.
A kind of noncontact brain based on broadband antenna technology the most according to claim 1 goes out Device is surveyed in blood examination, it is characterised in that: described signal generating unit (1) is with linear frequency sweep pattern Running, output is certain, frequency range is 0~3000MHz and the sine wave of constant amplitude homophase Pumping signal and reference signal.
4. go out based on a kind of based on broadband antenna technology the noncontact brain described in claim 1 The detection method of device is surveyed in blood examination, it is characterised in that: include step content in detail below;
1) tested head is positioned between transmitting antenna (2-1) and reception antenna (2-2), adjusts All day, line position and distance, made head be positioned on center of antenna line, it is ensured that aerial radiation wave beam Cover whole head and aerial radiation direction is unidirectional;Signal generating unit (1) produces excitation Signal and detection signal, be transferred to launch antenna (2-1) and signal gathering unit (3) respectively;
2) signal generating unit (1) runs with frequency sweep mode, and output is certain, frequency model Enclosing is 0~3GHz and the sine wave exciting signal of frequency continuously linear change, and by broadband electricity Magnetic signal is by launching antenna (2-1) directional transmissions, and electromagnetic wave passes whole brain area, so Captured by reception antenna (2-2) afterwards;
3) the mixing receiver (3-1) of signal gathering unit (3) receives by signal generating unit (1) the detection signal that the reference signal exported and reception antenna (2-2) export, through A/D It is transferred to signal processing unit (4-1) after transducer (3-2) conversion process;
4) ginseng that signal gathering unit (1) described in signal processing unit (4-1) place reason exports Examine signal and detection signal that reception antenna (2-2) exports, in whole working band, right Reference signal carries out amplitude discrimination and phase demodulation with detection signal, obtains the two amplitude difference and phase contrast, Thus draw the transmission coefficient of described transmitting antenna (2-1) and reception antenna (2-2), pass through The relatively change of transmission coefficient before and after cerebral hemorrhage, monitors the order of severity of cerebral hemorrhage;And by vowing Amount authentication technique, obtains the situation of change of cerebral hemorrhage amount;
Described vector authentication technique uses transmission coefficient Euclidean distance to reflect the change of cerebral hemorrhage amount Change, concrete formula such as formula 1;
Δ S → = S → a - S → b = | S → a | 2 + | S → b | 2 - 2 · | S → a | · | S → b | cos ( θ a - θ b ) - - - ( 1 )
In formula,For transmission coefficient Euclidean distance before and after hemorrhage,For hemorrhage rear transmission coefficient Vector value,For the vector value of hemorrhage front transmission coefficient,For hemorrhage rear transmission coefficient Range value,For the range value of hemorrhage front transmission coefficient, θaPhase place for hemorrhage rear transmission coefficient Value, θbPhase value for hemorrhage front transmission coefficient;
5) result obtained is shown by signal display unit (4-2) in real time, by European The variable quantity of distance judges the order of severity and the development and change of cerebral hemorrhage.
5. go out based on a kind of based on broadband antenna technology the noncontact brain described in claim 4 The detection method of device is surveyed in blood examination, it is characterised in that: this method have employed broadband technology, system Operating frequency 1.2GHz~2.0GHz, sampling interval 5MHz, in operating frequency, use 261 The cerebral hemorrhage order of severity is differentiated by individual frequency transmission parameter.
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