CN105769235A - Animal experimental device for precision radiotherapy research - Google Patents

Abstract

The invention discloses an animal experiment device for precision radiotherapy research in the technical field of medical devices, comprising: a C-shaped frame rotating platform and a loading motion platform, wherein: the rotation center axis of the C-shaped rotating platform and the loading motion The rotation center axes of the platforms intersect perpendicularly. The C-shaped frame rotating platform includes: a C-shaped bracket with a translation device, an X-ray light source with a grating, a cone-beam CT imaging detector, a SPECT imaging detector and a rotating drive device. The device involved in the present invention accurately simulates the precise radiotherapy process of the human body, and can realize functions such as structure and function precise image real-time guidance, and precise irradiation of the target area. A new type of radiotherapy scientific research simulation platform integrating precision multi-mode reverse radiotherapy planning, suitable for pre-clinical research on radiation oncology, such as tumor generation and development mechanism, treatment response, tumor and normal tissue radiobiological effects and other pre-clinical research applications.

Description

Animal Experimental Setup for Precision Radiation Therapy Research

technical field

The present invention relates to a device in the technical field of medical devices, in particular to an animal experiment device for precision radiotherapy research.

Background technique

Radiation therapy (RT), as an effective and cost-effective means of cancer treatment, is a vital and integral part of the comprehensive treatment of tumors. With its advantages of side effects and less damage to patients, precision radiotherapy has partially replaced the previous tumor treatment that used surgery as the main treatment. Pre-clinical research is an indispensable part of the theoretical research of new radiotherapy. The main reason is that the ionizing radiation produced by high-energy rays can cause great damage to normal tissues. The theoretical research needs to be fully verified in the pre-clinical environment before entering human clinical trials. Perform radiation therapy simulations on ex vivo and living samples to verify theoretical reliability, such as animal experiments. Existing animal radiotherapy equipment has relatively large limitations, which limit its application in various scientific research environments, mainly in several aspects such as mechanical structure, image guidance method, and dose delivery method: 1) The mechanical system generally adopts the experimental bench structure , although the mechanical structure is relatively simple, it lacks the realistic environment of human radiotherapy equipment, and the treatment method cannot be directly applied to human body equipment; 2) Lack of an effective real-time image guidance system, it is difficult to accurately locate the tumor target area, resulting in uncertainty of the actual dose received by biological tissues , hindering the implementation of clinically relevant radiotherapy strategies; 3) lack of a precise radiotherapy planning system suitable for small animals, unable to conformally and accurately deliver radiation doses to the anatomical structures of interest, resulting in a large amount of excess dose entering adjacent normal tissues, resulting in toxicity, This makes the execution of experiments and interpretation of results difficult.

Contents of the invention

Aiming at the above-mentioned deficiencies in the prior art, the present invention provides an animal experiment device for precision radiation therapy research, which solves the problems of mismatch between precision radiation therapy animal experiment and clinical application, lack of real-time image guidance, etc., and has the ability to accurately simulate human body precision radiation therapy The characteristics of real-time guidance of precise images of process, structure and function, and precise irradiation of target areas have important applications for preclinical research on radiation oncology, such as tumor generation and development mechanism, treatment response, tumor and normal tissue radiobiological effects, etc. value.

The present invention is achieved through the following technical solutions: an animal experimental device for precision radiotherapy research, including: a C-shaped frame rotating platform and a loading motion platform, wherein: the rotation center axis of the C-shaped frame rotating platform and the loading motion platform The rotation center axes of the motion platforms intersect vertically.

Further, the C-shaped frame rotating platform includes: a C-shaped bracket with a translation device, an X-ray light source with a grating, a cone-beam CT imaging detector, a SPECT imaging detector and a rotary drive device, wherein: the C-shaped One end of the bracket with a translation device fixes the cone beam CT imaging detector, and the opposite end fixes the X-ray light source. The X-ray central line beam is perpendicular to the plane of the cone beam CT imaging detector, and the SPECT imaging detector is fixed on the other side of the C-shaped bracket. An orthogonal end is placed parallel to the main axis of the cone beam CT imaging, and the rotation driving device is fixedly connected with the rotation center of the C-shaped bracket.

Further, the C-shaped support with a translation device includes: a central support seat, an X-ray light source support arm, a cone-beam CT imaging detector support arm, a SPECT imaging detector support arm and a translation device, wherein: the X-ray light source The support arm and the cone-beam CT imaging detector support arm are respectively fixedly connected to the central support seat, and are opposite to each other at 180 degrees in the circumferential direction. The SPECT imaging detector support arm is fixedly connected to the central support seat, and is connected to the X-ray source support arm and the cone. The supporting arm of the beam CT imaging detector is arranged at 90 degrees in the circumferential direction, and the translation device is arranged at the same end of the supporting arm of the cone-beam CT imaging detector.

Further, the central support base is fixedly connected with the rotary driving device.

Further, the translation device includes: a guide rail, a slider and a driving part, wherein: the guide rail is fixed on the central support seat, a slider is arranged on the guide rail, the slider is fixed on the support arm of the cone beam CT imaging detector, and the drive The fixed end of the part is connected with the central support seat, and the moving end of the driving part is connected with the support arm of the cone-beam CT imaging detector.

Further, the X-ray light source with a grating includes: a grating collimator and an X-ray tube, wherein: the grating collimator is arranged at the light exit hole of the X-ray tube.

Further, the object-carrying motion platform includes: a stage, an x-direction translation device, a y-direction translation device, a z-direction translation device and a z-axis rotation device, wherein: the object stage is fixed on the z-direction translation device, z The translation device in the x direction is fixed on the translation device in the x direction, the translation device in the x direction is fixed on the translation device in the y direction, and the translation device in the y direction is fixed on the z axis rotation device.

Further, the surface of the stage is parallel to the x-y plane, one end is suspended in the air, and the other end is fixedly connected to the z-direction translation device.

Further, the z-axis of the rotation center of the object-carrying motion platform is coplanar with the imaging axis of the cone-beam CT.

The working principle of this device is as follows:

The C-shaped rotating platform is highly integrated with multi-mode image data acquisition equipment and radiotherapy equipment. The dual-purpose X-ray source for imaging and treatment is placed opposite to the cone-beam CT imaging detector. The SPECT imaging detector is placed parallel to the cone-beam CT imaging axis. Avoid X-rays from the light source from interfering with nuclear medicine imaging. The C-shaped bracket can be driven to rotate freely around the central axis of rotation through the rotating drive device. The relative positions of the X-ray light source, cone-beam CT imaging detector and SPECT imaging detector and the C-shaped bracket are fixed, and follow the C-shaped bracket around the central axis of rotation for 360 degrees. Rotation, so that it can realize the rotation function around the stage, and perform 360-degree CT scan imaging and radiation therapy beam projection. Through the translation device on the C-shaped bracket, the cone-beam CT imaging detector can be driven to move parallel to the C-shaped bracket in a direction perpendicular to the axis of the rotation center, and the distance between the detector and the rotation center can be adjusted, so that the cone of objects of various scales can be realized. beam CT imaging.

The object-carrying motion platform has translation degrees of freedom along the three directions of x-y-z and rotation degrees of freedom around the central axis. Driven by the z-direction translation device, the stage can move in parallel along the z-axis direction; driven by the x-direction translation device, it can move in parallel along the x-axis direction; driven by the y-direction translation device, it can move in parallel along the y-axis direction, so that Realize the real-time online dynamic adjustment of the spatial position of the tested object. The stage is driven by a z-axis rotating device and can freely rotate around the z-axis, so that non-coaxial CT scan imaging and radiotherapy can be realized.

Description of drawings

Fig. 1 is the structural representation of embodiment 1.

Fig. 2 is a schematic structural diagram of a C-shaped stent.

Fig. 3 is a schematic structural diagram of the object-carrying motion platform.

In the figure: 1 C-shaped structure rotating platform, 2 loading motion platform, 3 C-shaped support with translation device, 4 X-ray light source with grating, 5 cone-beam CT imaging detector, 6 SPECT imaging detector, 7 rotating drive Device, 8 central support seats, 9 X-ray light source support arms, 10 cone beam CT imaging detector support arms, 11 SPECT imaging detector support arms, 12 translation devices, 13 guide rails, 14 sliders, 15 drive components, 16 grating collimator , 17X-ray tube, 18 stage, 19x translation device, 20y translation device, 21z translation device, 22z axis rotation device.

detailed description

The embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following the described embodiment.

Example 1

As shown in FIG. 1 , this example includes: a C-shaped structure rotating platform 1 and an object-carrying motion platform 2 , wherein: the rotation center axis of the C-shape structure rotation platform 1 and the rotation center axis of the object-carrying motion platform 2 perpendicularly intersect.

The C-shaped frame rotating platform 1 includes: a C-shaped support 3 with a translation device, an X-ray light source 4 with a grating, a cone-beam CT imaging detector 5, a SPECT imaging detector 6 and a rotary drive device 7, wherein One end of the C-shaped support 3 with a translation device fixes the cone-beam CT imaging detector 5, and the other end opposite to it fixes the X-ray light source 4, the X-ray central line beam is perpendicular to the plane of the cone-beam CT imaging detector 5, and the SPECT imaging detection The device 6 is fixed on the other orthogonal end of the C-shaped bracket 3 and placed parallel to the main axis of the cone-beam CT imaging. The rotary drive device 7 is fixedly connected to the rotation center of the C-shaped bracket 3 .

The C-shaped bracket 3 with a translation device includes: a central support base 8, an X-ray light source support arm 9, a cone-beam CT imaging detector support arm 10, a SPECT imaging detector support arm 11 and a translation device 12, wherein: The X-ray source support arm 9 and the cone-beam CT imaging detector support arm 10 are fixedly connected to the central support base 8 respectively, and are opposed at 180 degrees in the circumferential direction, and the SPECT imaging detector support arm 11 is fixedly connected to the central support base 8, and The X-ray source support arm 9 and the cone-beam CT imaging detector support arm 10 are arranged at 90 degrees in the circumferential direction, and the translation device 12 is arranged at the same end of the cone-beam CT imaging detector support arm 10 .

The central support base 8 is fixedly connected with the rotary driving device 7 .

The translation device 12 includes: a guide rail 13, a slider 14 and a driving part 15, wherein: the guide rail 13 is fixed on the central support base 8, the guide rail 13 is provided with a slider 14, and the slider 14 is fixed on the cone beam CT imaging detection On the support arm 10 of the detector, the fixed end of the driving part 15 is connected to the central support base 8 , and the moving end of the driving part 15 is connected to the support arm 10 of the cone beam CT imaging detector.

The X-ray light source 4 with a grating includes: a grating collimator 16 and an X-ray tube 17 , wherein: the grating collimator 16 is arranged at the light exit hole of the X-ray tube 17 .

The object-carrying motion platform 2 includes: a stage 18, an x-direction translation device 19, a y-direction translation device 20, a z-direction translation device 21 and a z-axis rotation device 22, wherein: the object stage 18 is fixed on the z-direction translation On the device 21 , the z-direction translation device 21 is fixed on the x-direction translation device 19 , the x-direction translation device 19 is fixed on the y-direction translation device 20 , and the y-direction translation device 20 is fixed on the z-axis rotation device 22 .

The z-axis of the rotation center of the object-carrying motion platform 2 is coplanar with the main axis of the cone-beam CT imaging.

The surface of the stage 18 is parallel to the x-y plane, one end is suspended, and the other end is fixedly connected to the z-direction translation device 21 .

The working process of this device is as follows:

The C-shaped rotating platform 1 is highly integrated with multi-mode image data acquisition equipment and radiotherapy equipment. The dual-purpose X-ray source 4 for imaging and treatment is placed opposite to the cone-beam CT imaging detector 5, and the SPECT imaging detector 6 is used for cone-beam CT imaging. The main axis is placed in parallel to avoid the interference of X-rays from the light source on nuclear medicine imaging. The C-shaped support 3 can be driven to rotate freely around the central axis of rotation by the rotating drive device 7, and the relative positions of the X-ray light source 4, the cone-beam CT imaging detector 5 and the SPECT imaging detector 6 and the C-shaped support 3 are fixed, following the C-shaped support 3. Rotate 360 degrees around the rotation center axis, so as to realize the function of rotating around the stage 18, and perform 360-degree CT scanning imaging and radiotherapy beam projection. Through the translation device 12 on the C-shaped bracket 3, the cone-beam CT imaging detector 5 can be driven to move parallel to the C-shaped bracket 3 in a direction perpendicular to the axis of the rotation center, and the distance between the cone-beam CT imaging detector 5 and the rotation center can be adjusted. Cone beam CT imaging of objects of various scales can thus be realized.

The object-carrying motion platform 2 has translation degrees of freedom along the three directions of x-y-z and rotation degrees of freedom around the central axis. Driven by the z-direction translation device 21, the stage 18 can move parallelly along the z-axis direction; driven by the x-direction translation device 19, it can move parallel along the x-axis direction; driven by the y-direction translation device 20, it can move parallel along the y-axis direction Move, so that real-time online dynamic adjustment of the spatial position of the tested object can be realized. The stage 18 is driven by the z-axis rotation device 22 and can freely rotate around the z-axis, so that non-coaxial CT scan imaging and radiotherapy can be realized.

Claims (8)

1. An animal experimental device for precision radiotherapy research, characterized in that it comprises: a C-shaped frame rotating platform and a loading motion platform, wherein: the rotation center axis of the C-shaped frame rotating platform and the rotation of the loading motion platform The central axes intersect vertically; the C-shaped frame rotating platform includes: a C-shaped bracket with a translation device, an X-ray light source with a grating, a cone-beam CT imaging detector, a SPECT imaging detector and a rotary drive device, wherein: One end of the C-shaped bracket with a translation device fixes the cone-beam CT imaging detector, and the opposite end fixes the X-ray light source. The X-ray central line beam is perpendicular to the plane of the cone-beam CT imaging detector, and the SPECT imaging detector is fixed on the C-shaped The other orthogonal end of the bracket is placed parallel to the main axis of the cone beam CT imaging, and the rotation driving device is fixedly connected with the rotation center of the C-shaped bracket. 2. The animal experimental device for precise radiotherapy research according to claim 1, wherein the C-shaped support with a translation device comprises: a central support base, an X-ray light source support arm, a cone beam CT Imaging detector support arm, SPECT imaging detector support arm and translation device, wherein: X-ray light source support arm and cone beam CT imaging detector support arm are respectively fixedly connected with the central support seat, and are opposite to each other at 180 degrees in the circumferential direction. SPECT The imaging detector support arm is fixedly connected to the central support base, and is arranged at 90 degrees circumferentially with the X-ray light source support arm and the cone-beam CT imaging detector support arm, and the translation device is arranged at the same end of the cone-beam CT imaging detector support arm. 3. The animal experimental device for precision radiotherapy research according to claim 2, wherein the central support base is fixedly connected with the rotary drive device. 4. The animal experimental device for precise radiotherapy research according to claim 2, characterized in that, the translation device comprises: a guide rail, a slider and a driving part, wherein: the guide rail is fixed on the central support seat, and the guide rail The slider is fixed on the support arm of the cone-beam CT imaging detector, the fixed end of the driving part is connected with the central support seat, and the moving end of the driving part is connected with the support arm of the cone-beam CT imaging detector. 5. The animal experimental device for precise radiotherapy research according to claim 1, wherein said X-ray light source with a grating comprises: a grating collimator and an X-ray tube, wherein: the grating collimator The straightener is arranged at the light exit hole of the X-ray tube. 6. The animal experimental device for precision radiotherapy research according to claim 1, wherein the moving platform for carrying objects includes: an object stage, an x-direction translation device, a y-direction translation device, a z-direction translation device, and a z-direction translation device. device and z-axis rotation device, wherein: the stage is fixed on the z-direction translation device, the z-direction translation device is fixed on the x-direction translation device, the x-direction translation device is fixed on the y-direction translation device, and the y-direction translation device is fixed on the on the z-axis rotation device. 7. The animal experimental device for precision radiotherapy research according to claim 6, wherein the table top of the stage is parallel to the x-y plane, one end is suspended in the air, and the other end is fixedly connected to the z-direction translation device . 8 . The animal experimental device for precision radiotherapy research according to claim 1 , wherein the z-axis of the rotation center of the object-carrying motion platform is coplanar with the main axis of cone beam CT imaging.