CN1055619C - Health Vitamin B6 Cigarette Plaster and its prepn. method - Google Patents
Health Vitamin B6 Cigarette Plaster and its prepn. method Download PDFInfo
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- CN1055619C CN1055619C CN96120931A CN96120931A CN1055619C CN 1055619 C CN1055619 C CN 1055619C CN 96120931 A CN96120931 A CN 96120931A CN 96120931 A CN96120931 A CN 96120931A CN 1055619 C CN1055619 C CN 1055619C
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- nicotine
- plaster
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- Expired - Fee Related
Links
- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 18
- 239000011505 plaster Substances 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title abstract description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 title 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 title 1
- 239000011726 vitamin B6 Substances 0.000 title 1
- 235000019158 vitamin B6 Nutrition 0.000 title 1
- 229940011671 vitamin b6 Drugs 0.000 title 1
- 229960002715 nicotine Drugs 0.000 claims abstract description 26
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 21
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims abstract description 9
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 238000010521 absorption reaction Methods 0.000 claims abstract description 5
- 239000011248 coating agent Substances 0.000 claims abstract description 5
- 238000000576 coating method Methods 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- 238000005520 cutting process Methods 0.000 claims abstract description 3
- 238000012856 packing Methods 0.000 claims abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 7
- 239000000084 colloidal system Substances 0.000 claims description 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 5
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 5
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 5
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
- 239000005642 Oleic acid Substances 0.000 claims description 5
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 5
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 5
- 239000004584 polyacrylic acid Substances 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 5
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 238000013270 controlled release Methods 0.000 claims description 3
- 239000003623 enhancer Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000005096 rolling process Methods 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 208000035126 Facies Diseases 0.000 claims description 2
- 238000007598 dipping method Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000007888 film coating Substances 0.000 claims description 2
- 238000009501 film coating Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 235000011837 pasties Nutrition 0.000 claims description 2
- 239000003208 petroleum Substances 0.000 claims description 2
- 238000004080 punching Methods 0.000 claims description 2
- 241000208125 Nicotiana Species 0.000 abstract 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 230000001473 noxious effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000005586 smoking cessation Effects 0.000 description 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- -1 nicotine 95.0-98.0%) Chemical compound 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical compound C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 description 1
- GVVBQSHWDITPFX-UHFFFAOYSA-N C1=CC=C2C3=CC=CC=C3C3=CC=CC4=CC=C1C2=C34.C1=CC=C2C3=CC=CC=C3C3=CC=CC4=CC=C1C2=C34 Chemical compound C1=CC=C2C3=CC=CC=C3C3=CC=CC4=CC=C1C2=C34.C1=CC=C2C3=CC=CC=C3C3=CC=CC4=CC=C1C2=C34 GVVBQSHWDITPFX-UHFFFAOYSA-N 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a health-care cigarette plaster and a preparation method of the plaster. The health-care cigarette plaster which comprises natural tobacco extracts, natural plant medicine extracts, slow-release control release materials, permeation enhancer and pressure sensitive adhesives is prepared by the steps of extraction, material proportioning, mixing, coating, film covering, cutting, packing, etc. Compared with a plaster prepared from natural tobacco extracts or artificially synthesized nicotine, the health-care cigarette plaster is safe and effective and has the functions for removing toxin, promoting absorption, relieving inflammation, alleviating pain and resisting allergy. In the processes of preparation, a patent coating device is used for reducing cost.
Description
The present invention relates to a kind of by natural baccy extract, formulated percutaneous plaster of natural medicinal plant extract and preparation method thereof in addition.
Natural baccy extract-nicotine, its contained main component is a nicotine.The smoker is by lighting medicated cigarette, make scorching hot smog, be mingled with nearly thousand kinds of chemical compounds such as carbon monoxide, tar and nicotine and entering oral cavity, trachea and pulmonary, the reason of its addiction only is the dependence of smoker to nicotine, then is that scorching hot aerosol, carbon monoxide, tar etc. have open-minded, noxious substance for the companion with it.
To this, Chinese patent CN1074583A: the preparation technology of chewing gum for giving-up smoking; CN1090149A: a kind of manufacture method of cigarette candy; CN1110115A: non-poisonous anthypnotic cigarette; U.S. Pat 5144966A: harmless cigarette provides technical scheme separately respectively.In addition, natural baccy extract-nicotine or synthetic nicotine made contain the nicotine patch, stick skin surface in the smoker, by skin nicotine is imported in the body, satisfy the dependence of smoker to nicotine, making other people that live in same environment avoid being injured again, is the desirable articles for use of a kind of generation cigarette, smoking cessation.
But in use find: 1. toxic because of nicotine itself, in the body metabolism process, have such as untoward reaction such as skin allergy, prurituss; 2. pure nicotine patch, the smoking cessation effect that it is simple can produce tired making an uproar, and causes smoking cessation syndromes such as blood pressure, dizziness.
The objective of the invention is to: fully keep the effective ingredient of original nicotine patch, and on this basis, reject noxious substance, natural medicinal plant in addition, thus a kind of percutaneous plaster with health role and preparation method thereof is provided.
Technical scheme of the present invention is as follows: health Vitamin B 6 Cigarette Plaster is made up of natural baccy extract-nicotine, high molecular slow-release controlled-release material, Percutaneous absorption enhancer, natural medicinal plants extract, pressure sensitive adhesive.Said mixture is by weight percentage: natural baccy extract-nicotine 4.0-12.0; The extract 0.1-0.5 of natural medicinal plants Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli; Sustained-release and controlled release material carboxymethyl cellulose 0.1-1.0, the carboxylic third methylcellulose 0.1-1.0, sodium polyacrylate 0.5-1.5, polyvinyl alcohol 0.5-1.5, Percutaneous absorption enhancer azone 0.5-1.5, oleic acid 2.0-6.0, glycerol 5.0-15.0, polyvinylpyrrolidone 0.5-1.5, dimethyl formamide 1.0-3.0, polyacrylic acid pressure sensitive adhesive 65.0-75.0.
Preparation method: the 1. extraction of nicotine, natural baccy is put into the plant pulverizer to be shredded, after the adding petroleum ether mixes with it, in extraction tower, soak and stirring, afterwards organic facies is told, put into the rectifying column internal heating, rectification under 247 ℃ of temperature, the pressure 745Hg/mm, isolate nicotine (including nicotine 95.0-98.0%), and remove noxious substance, as carcinogen Benzpyrene benzpyrene; 2. the extraction of natural medicinal plants Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli was put into Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli the Chinese medicine extraction drying tower by weight 2: 2: 1, and is added 70% alcohol solution dipping, refluxed one hour, put into knockout tower, isolate extracting solution, 40 ℃ of dry down getting final product; 3. the preparation of cigarette subsides, under the room temperature, in a mixing drum, add carboxymethyl cellulose successively, hydroxypropyl methylcellulose, sodium polyacrylate, polyvinyl alcohol, and be dissolved in glycerol, and under 60 rev/mins, stir into heavy-gravity pasty state liquid, add the extract of nicotine and Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli afterwards, restir is even, add azone, oleic acid, polyvinylpyrrolidone, dimethyl formamide, and the glycerol of surplus, restir evenly after, make into colloid through colloid mill.Other gets a mixing drum, puts into the polyacrylic acid pressure sensitive adhesive, adds the gained colloid again, and stirring under 20 rev/mins gets final product.Adopt the spiral fashion so medicine film coating machine of CN95210946.8, finish processes such as coating, multiple film, rolling, wherein coated substrate is selected polyethylene or non-woven fabrics for use, and multiple film selects for use silicone grease to make protecting film.Cigarette after the rolling pastes through the punching press cutting device, is cut into the fillet paster of 3.5cm * 4.5cm, and every contains nicotine 10-50mg.On blister packaging machine, pack at last.
The cigarette plaster formula (by weight percentage) that uses the optional treating excess syndrome of above-mentioned preparation method to execute: nicotine 8.0, natural medicinal plants extract 0.4, carboxymethyl cellulose 0.5, hydroxypropyl methylcellulose 0.5, sodium polyacrylate 1.0, polyvinyl alcohol 1.0, azone 1.0, oleic acid 4.0, glycerol 10.0, polyvinylpyrrolidone 1.0, dimethyl formamide 2.0, polyacrylic acid pressure sensitive adhesive 70.6.
Advantage of the present invention is: 1. add natural medicinal plants, cigarette pasted have detoxifcation, short absorption, antiinflammatory, pain relieving, reach the effect of anti-skin allergy, use safer; 2. harmful, noxious substance such as Benzpyrene, tar is rejected in the rectification in the natural baccy preparation process effectively; 3. use the patent coating apparatus, reduce cost.
Claims (2)
1. one kind by natural baccy extract-nicotine, the natural medicinal plants extract, the high molecular slow-release controlled-release material, Percutaneous absorption enhancer, and the health Vitamin B 6 Cigarette Plaster of pressure sensitive adhesive composition, the proportioning (by weight percentage) that it is characterized in that said mixture is: nicotine 4.0-12.0, Radix Glycyrrhizae, Herba Menthae, the extract 0.1-0.5 of Flos Caryophylli, carboxymethyl cellulose 0.1-1.0, hydroxypropyl methylcellulose 01-1.0, sodium polyacrylate 0.5-1.5, polyvinyl alcohol 0.5-1.5, azone 0.5-1.5, oleic acid 2.0-6.0, glycerol 5.0-15.0, polyvinylpyrrolidone 0.5-1.5, dimethyl formamide 1.0-3.0, polyacrylic acid pressure sensitive adhesive 65.0-75.0.
2. the preparation method of health Vitamin B 6 Cigarette Plaster: the 1. extraction of nicotine, natural baccy is put into the plant pulverizer to be shredded, after adding petroleum ether and mixing, in extraction tower, soak and stirring, afterwards organic facies is told, put into the rectifying column internal heating, nicotine is isolated in rectification under 247 ℃ of temperature, the pressure 745Hg/mm; 2. the extraction of natural medicinal plants Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli was put into Radix Glycyrrhizae, Herba Menthae, Flos Caryophylli the Chinese medicine extraction drying tower by weight 2: 2: 1, and is added 70% alcohol solution dipping, refluxed one hour, put into knockout tower, isolate extracting solution, 40 ℃ dry down; 3. the preparation of cigarette subsides, under the room temperature, in a mixing drum, add carboxymethyl cellulose successively, hydroxypropyl methylcellulose, sodium polyacrylate, polyvinyl alcohol, and be dissolved in glycerol is under 60 rev/mins, stir into heavy-gravity pasty state liquid, add nicotine and Radix Glycyrrhizae afterwards, Herba Menthae, the extract of Flos Caryophylli, restir is even, adds azone, oleic acid, polyvinylpyrrolidone, dimethyl formamide, and the glycerol of surplus, stir, make into colloid through colloid mill, other gets a mixing drum, puts into the polyacrylic acid pressure sensitive adhesive, add the gained colloid again, stirring under 20 rev/mins gets final product, and adopts the spiral fashion so medicine film coating machine of CN95210946.8, finishes coating, multiple film, after the rolling, cut out packing through the punching press cutting device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96120931A CN1055619C (en) | 1996-08-13 | 1996-12-04 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96110903 | 1996-08-13 | ||
| CN96110903.3 | 1996-08-13 | ||
| CN96120931A CN1055619C (en) | 1996-08-13 | 1996-12-04 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1173329A CN1173329A (en) | 1998-02-18 |
| CN1055619C true CN1055619C (en) | 2000-08-23 |
Family
ID=25743992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96120931A Expired - Fee Related CN1055619C (en) | 1996-08-13 | 1996-12-04 | Health Vitamin B6 Cigarette Plaster and its prepn. method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1055619C (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5089840B2 (en) * | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | Nicotine-containing film preparation |
| IL177071A0 (en) * | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
| CN101791360B (en) * | 2010-04-09 | 2012-06-20 | 杭州灵泽生物科技有限公司 | Health-care tobacco patch |
| CN103751060B (en) * | 2014-01-21 | 2016-03-30 | 江苏中烟工业有限责任公司 | A kind of moist humidity-preserving type tobacco gel composition composition and method of making the same |
| CN104305516B (en) * | 2014-08-25 | 2016-08-31 | 上海烟草集团有限责任公司 | The SMD smoke-free tobacco product in a kind of oral cavity |
| CN104940408A (en) * | 2015-07-16 | 2015-09-30 | 云南拓宝科技有限公司 | Hydrogel emergency tobacco control patch formula and method for preparing tobacco control patch |
| CN104970445B (en) * | 2015-07-21 | 2017-11-07 | 中国烟草总公司广东省公司 | A kind of spacetabs type aerosol mouth cigarette |
| CN106491569B (en) * | 2016-11-28 | 2019-10-01 | 南京工业大学 | A kind of hydrogel patch for smoking cessation and preparation method thereof |
| CN112915195A (en) * | 2021-03-12 | 2021-06-08 | 南京康天生物科技有限公司 | Smoking cessation paste and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070338A (en) * | 1992-09-24 | 1993-03-31 | 张�林 | The method of manufacture and use thereof of plaster for giving up smoking |
-
1996
- 1996-12-04 CN CN96120931A patent/CN1055619C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070338A (en) * | 1992-09-24 | 1993-03-31 | 张�林 | The method of manufacture and use thereof of plaster for giving up smoking |
Non-Patent Citations (1)
| Title |
|---|
| 《中国药房》5(6) 1994.1.1 龚旭龄等，常用透皮制剂的药理和临床 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1173329A (en) | 1998-02-18 |
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