CN105466984B - Prior-warning device and its application method for the non-explicit damage of kidney - Google Patents
Prior-warning device and its application method for the non-explicit damage of kidney Download PDFInfo
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- CN105466984B CN105466984B CN201610025621.4A CN201610025621A CN105466984B CN 105466984 B CN105466984 B CN 105466984B CN 201610025621 A CN201610025621 A CN 201610025621A CN 105466984 B CN105466984 B CN 105466984B
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- 230000006378 damage Effects 0.000 title claims abstract description 33
- 210000003734 kidney Anatomy 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims description 8
- 238000012545 processing Methods 0.000 claims abstract description 29
- 239000000523 sample Substances 0.000 claims abstract description 22
- 210000002700 urine Anatomy 0.000 claims abstract description 20
- 239000011159 matrix material Substances 0.000 claims abstract description 19
- 238000000556 factor analysis Methods 0.000 claims abstract description 16
- 230000005540 biological transmission Effects 0.000 claims abstract description 9
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims abstract description 7
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims abstract description 7
- 230000005484 gravity Effects 0.000 claims abstract description 7
- 102000012192 Cystatin C Human genes 0.000 claims abstract description 5
- 108010061642 Cystatin C Proteins 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 25
- 238000001514 detection method Methods 0.000 claims description 22
- 208000027418 Wounds and injury Diseases 0.000 claims description 17
- 208000014674 injury Diseases 0.000 claims description 17
- 238000005070 sampling Methods 0.000 claims description 12
- 238000011156 evaluation Methods 0.000 claims description 6
- 230000002572 peristaltic effect Effects 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 230000000422 nocturnal effect Effects 0.000 claims 1
- 238000011161 development Methods 0.000 abstract description 2
- 238000007689 inspection Methods 0.000 abstract description 2
- 239000012530 fluid Substances 0.000 abstract 3
- 239000006260 foam Substances 0.000 abstract 2
- 230000006870 function Effects 0.000 description 6
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 206010061481 Renal injury Diseases 0.000 description 3
- 230000003907 kidney function Effects 0.000 description 3
- 208000037806 kidney injury Diseases 0.000 description 3
- 206010029446 nocturia Diseases 0.000 description 3
- 102000015833 Cystatin Human genes 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 108050004038 cystatin Proteins 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000010234 longitudinal analysis Methods 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
Abstract
This case is related to the prior-warning device for the non-explicit damage of kidney, comprising: fluid pipe；Air-foam detector is arranged at two ports of fluid pipe；Central processing unit is connected with air-foam detector；Microfluidic control drives probe, and setting is electrically connected on fluid pipe, and with central processing unit；Biological matrix single factor analysis module, and central processing unit data connection, and connect with microfluidic control driving probe by pipeline；Wherein, biological matrix single factor analysis module includes: specific gravity of urine detecting electrode, beta-2-microglobulin detecting electrode and cystatin C detecting electrode；Power supply is connected with central processing unit；Wherein, central processing unit is also integrated with wireless transmission port.The prior-warning device of this case drives probe by microfluidic control, can draw urine in urine collection bag system automatically, be detected according to preset frequency, and without interrupting metering, inspection cost is low, and the level of informatization is high, and convenient and efficient, development potentiality is huge.
Description
Technical Field
The invention relates to a dynamic detection device for kidney injury, in particular to an early warning device for kidney non-dominant injury and a using method thereof.
Background
Kidney damage may be caused by various factors, such as insufficient volume resulting in relatively low perfusion pressure and reduced blood flow; hemoglobin micro-embolus deposits in glomerulus, renal tubule and other reasons, and is easy to cause circulatory failure, renal insufficiency and the like, and when clinical detection finds that dominant renal function injury exists, even if treatment is given in time, part of patients still progress to chronic renal insufficiency, and the life quality is influenced. Therefore, how to find and diagnose the kidney in time when the kidney is subjected to non-dominant injury, find out possible reasons, remove the factors causing the kidney injury in advance, and take intervention measures is always a troublesome problem in current clinical medicine.
the kidney function is evaluated mainly by detecting the concentration of creatinine and urea nitrogen, when the concentration of creatinine and urea nitrogen is increased, the kidney is damaged, but at the moment, the kidney is damaged, the kidney is delayed and lagged from the aspects of diagnosis and treatment, and actually, the kidney is at the early stage of the invisible damage, the physicochemical property and the contained substances of the urine are changed, if the invisible change of the kidney is found in time, the early diagnosis and treatment of diseases can be facilitated, the treatment difficulty and the medical burden are reduced.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to obtain a device capable of detecting dynamic changes of several physical and chemical properties in urine through the structural integration of several single detection devices, and calculate the probability of dysfunction or damage of the kidney through the horizontal and longitudinal analysis of various measured data by establishing an intelligent mathematical model, so that the non-dominant damage of the kidney can be timely found in the early stage of asymptomatic damage of the kidney, and effective help is provided for clinical early treatment.
In order to achieve the purpose, the invention is realized by the following technical scheme:
an early warning device for a kidney non-overt injury, comprising:
the liquid flow pipeline is internally provided with a cavity for containing liquid to be measured;
bubble detectors disposed at two ports of the flow conduit;
a central processor connected to the bubble detector;
the micro-flow control driving probe is arranged on the liquid flow pipeline and is electrically connected with the central processing unit, and the central processing unit controls the micro-flow control driving probe to extend into liquid to be detected in the liquid flow pipeline for sampling;
the biological matrix single-factor analysis module is in data connection with the central processing unit, is also connected with the micro-fluidic driving probe through a pipeline and is used for detecting the liquid to be detected obtained by sampling the micro-fluidic driving probe, wherein the biological matrix single-factor analysis module comprises a urine specific gravity detection electrode, an β -2-microglobulin detection electrode and a cystatin C detection electrode;
the power supply is connected with the central processing unit;
wherein, the central processing unit is also integrated with a wireless transmission port.
Preferably, the early warning device for the non-dominant kidney injury, wherein the bio-matrix single-factor analysis module further comprises a urine volume detection module and a daily urine/nocturia ratio detection module.
Preferably, the early warning device for the non-overt damage of the kidney, wherein the micro-flow control driving probe comprises a sampling needle head, a peristaltic pump capable of pumping the liquid to be detected into the pipeline and a pinch-off valve for controlling whether the liquid to be detected enters the pipeline.
Preferably, the early warning device for the non-overt damage of the kidney is characterized in that a preamplifier is further arranged between the biological matrix single-factor analysis module and the central processing unit.
A method for using the warning device for the non-overt damage of the kidney according to any one of the above schemes, comprising:
turning on a power supply and turning on a bubble detector;
micro-fluidic control driving probe sampling;
analyzing by a biological matrix single-factor analysis module to obtain parameters including urine specific gravity Ug, β -2-microglobulin Bmg and cystatin CCys;
respectively counting association probabilities pUg, pBmg and pCys of Ug, Bmg and Cys and actual damage of the kidney;
establishing a kidney non-dominant injury evaluation function in a central processing unit:
wherein,
and setting a threshold, and comparing the result obtained according to the evaluation function with the threshold so as to judge the probability of the kidney being subjected to the non-dominant injury.
The invention has the beneficial effects that:
1. the early warning device of present case passes through micro-fluidic system drive probe, can absorb the urine in collection urine bag system automatically, detects according to predetermined frequency, need not to interrupt the measurement, and inspection cost is low, and information-based degree is high, convenient and fast, and development potential is huge.
2. The early warning device and the use method thereof can find early changes of the kidney function in time, and ensure to provide early intervention in time by calculating the probability and possible reasons of damage through a model, thereby avoiding irreversibility of kidney failure caused by serious damage.
3. The wireless transmission function and the portable remote monitoring function of a mobile phone and the like can be realized, the operability is good, and the real-time and real-time monitoring is convenient.
4. The micro-processing of the traditional equipment does not change a specific detection mode, and the multi-group electrodes detect the micro-processing of the traditional equipment, so that the accuracy is high and the precision is better.
Drawings
Fig. 1 is a schematic structural diagram of an early warning device for kidney non-overt injury.
Detailed Description
The present invention is further described in detail below with reference to the attached drawings so that those skilled in the art can implement the invention by referring to the description text.
As shown in fig. 1, the present disclosure provides an early warning device for a non-overt injury of a kidney, including:
the liquid flow pipeline is internally provided with a cavity for containing liquid to be measured;
bubble detectors provided at both ports of the liquid flow conduit;
a central processor connected to the bubble detector; when the bubble detector detects that bubbles exist or the bubble existence amount is larger than a set value, the central processing unit counts the data acquired this time as waste data, and the data are not considered and are re-sampled.
The micro-flow control driving probe is arranged on the liquid flow pipeline and is electrically connected with the central processing unit, and the central processing unit controls the micro-flow control driving probe to extend into liquid to be tested in the liquid flow pipeline for sampling;
the biological matrix single-factor analysis module is in data connection with the central processing unit, is also connected with the micro-fluidic control driving probe through a pipeline and is used for detecting liquid to be detected obtained by sampling the micro-fluidic control driving probe, wherein the biological matrix single-factor analysis module comprises a urine specific gravity detection electrode, an β -2-microglobulin detection electrode and a cystatin C detection electrode;
the power supply is connected with the central processing unit; power is supplied to the whole device;
wherein, the central processing unit is also integrated with a wireless transmission port. The wireless transmission may be implemented by existing transmission techniques such as bluetooth or WiFi.
As another embodiment of the present disclosure, the bio-matrix single-factor analysis module further includes a urine volume detection module and a daily urine/nocturia ratio detection module. The detection module here may preferably be a detection electrode or any detection device in the form of a kit capable of urine volume measurement or daily urine/nocturia ratio detection.
In the above embodiment, the micro-fluidic drive probe includes a sampling needle, a peristaltic pump capable of pumping the liquid to be measured into the tube, and a pinch-off valve controlling whether the liquid to be measured enters the tube.
In the above embodiment, a preamplifier is further disposed between the bio-matrix single-factor analysis module and the central processing unit, and is used to improve the signal-to-noise ratio of the system and reduce the influence of external interference.
A method for using the warning device for the non-overt damage of the kidney according to any one of the above schemes, comprising:
turning on a power supply and turning on a bubble detector;
micro-fluidic control driving probe sampling;
analyzing by a biological matrix single-factor analysis module to obtain parameters including urine specific gravity Ug, β -2-microglobulin Bmg and cystatin CCys;
respectively counting association probabilities pUg, pBmg and pCys of Ug, Bmg and Cys and actual damage of the kidney; statistics of these association probabilities need to be done clinically.
Establishing a kidney non-dominant injury evaluation function in a central processing unit:
wherein,
(pUg pBmg pCysc) is a single row matrix;
is a single-column matrix;
and setting a threshold, and comparing the result obtained according to the evaluation function with the threshold so as to judge the probability of the kidney being subjected to the non-dominant injury.
The result output can realize the remote transmission of the network by wireless transmission, and the remote reading and remote alarming of the data can be realized by a network platform.
While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable in various fields of endeavor to which the invention pertains, and further modifications may readily be made by those skilled in the art, it being understood that the invention is not limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.
Claims (4)
1. An early warning device for a non-overt injury to a kidney, comprising:
the liquid flow pipeline is internally provided with a cavity for containing liquid to be measured;
bubble detectors disposed at two ports of the flow conduit;
a central processor connected to the bubble detector;
the micro-flow control driving probe is arranged on the liquid flow pipeline and is electrically connected with the central processing unit, and the central processing unit controls the micro-flow control driving probe to extend into liquid to be detected in the liquid flow pipeline for sampling;
the biological matrix single-factor analysis module is in data connection with the central processing unit, is also connected with the micro-fluidic driving probe through a pipeline and is used for detecting the liquid to be detected obtained by sampling the micro-fluidic driving probe, wherein the biological matrix single-factor analysis module comprises a urine specific gravity detection electrode, an β -2-microglobulin detection electrode and a cystatin C detection electrode;
the power supply is connected with the central processing unit;
the central processing unit is also integrated with a wireless transmission port;
the use method of the early warning device comprises the following steps:
turning on a power supply and turning on a bubble detector;
micro-fluidic control driving probe sampling;
analyzing by a biological matrix single-factor analysis module to obtain parameters including urine specific gravity Ug, β -2-microglobulin Bmg and cystatin C Cys;
respectively counting association probabilities pUg, pBmg and pCys of Ug, Bmg and Cys and actual damage of the kidney;
establishing a kidney non-dominant injury evaluation function in a central processing unit:
wherein,
and setting a threshold, and comparing the result obtained according to the evaluation function with the threshold so as to judge the probability of the kidney being subjected to the non-dominant injury.
2. The warning apparatus for renal non-overt injury as claimed in claim 1, wherein the bio-matrix one-factor analysis module further comprises a urine volume detection module and a daily/nocturnal ratio detection module.
3. The warning device for renal non-overt injury of claim 1, wherein the micro-flow control drive probe comprises a sampling needle, a peristaltic pump capable of pumping the liquid to be tested into the conduit, and a pinch-off valve that controls whether the liquid to be tested enters the conduit.
4. The warning apparatus for renal non-overt injury as claimed in claim 1, wherein a preamplifier is further disposed between the bio-matrix monofactor analysis module and the central processing unit.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610025621.4A CN105466984B (en) | 2016-01-14 | 2016-01-14 | Prior-warning device and its application method for the non-explicit damage of kidney |
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| CN201610025621.4A CN105466984B (en) | 2016-01-14 | 2016-01-14 | Prior-warning device and its application method for the non-explicit damage of kidney |
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| CN105466984B true CN105466984B (en) | 2018-12-28 |
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| CN106361289A (en) * | 2016-09-30 | 2017-02-01 | 重庆工商大学 | Early warning system for chronic renal failure |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010091231A1 (en) * | 2009-02-06 | 2010-08-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102967701A (en) * | 2012-11-28 | 2013-03-13 | 长春迪瑞医疗科技股份有限公司 | Urine analysis system and analysis method thereof |
| CN103874923A (en) * | 2011-08-26 | 2014-06-18 | 阿斯图特医药公司 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20140262777A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Point Of Care Inc. | Biosensor structures for improved point of care testing and methods of manufacture thereof |
| CN204379865U (en) * | 2014-12-03 | 2015-06-10 | 郑以山 | The networking on-line measuring device of a kind of miniature human body environment checkout gear and blood purification environment |
| CN205317718U (en) * | 2016-01-14 | 2016-06-15 | 郑以山 | A early warning device that is used for non - dominance of kidney to harm |
-
2016
- 2016-01-14 CN CN201610025621.4A patent/CN105466984B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010091231A1 (en) * | 2009-02-06 | 2010-08-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN103874923A (en) * | 2011-08-26 | 2014-06-18 | 阿斯图特医药公司 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102967701A (en) * | 2012-11-28 | 2013-03-13 | 长春迪瑞医疗科技股份有限公司 | Urine analysis system and analysis method thereof |
| US20140262777A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Point Of Care Inc. | Biosensor structures for improved point of care testing and methods of manufacture thereof |
| CN204379865U (en) * | 2014-12-03 | 2015-06-10 | 郑以山 | The networking on-line measuring device of a kind of miniature human body environment checkout gear and blood purification environment |
| CN205317718U (en) * | 2016-01-14 | 2016-06-15 | 郑以山 | A early warning device that is used for non - dominance of kidney to harm |
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