CN105358128A - Oral biofilm remover and composition for oral cavity - Google Patents

Abstract

Disclosed is an oral biofilm remover comprising (A) an alpha-olefin sulfonate and (B) a condensed phosphate (B-1) and/or an amphoteric surfactant (B-2), and an oral composition having a high oral biofilm removing effect, which is obtained by containing the component (A) and the component (B).

Description

Oral biofilm remover and composition for oral cavity

technical field

The present invention relates to an oral biofilm removing agent and a composition for oral cavity that chemically and efficiently remove biofilm that is the cause of dental caries.

Background technique

Conventionally, techniques for removing plaque (tartar) in dentifrices include physical removal by cleaning agents such as abrasives, biochemical removal by enzymes, and the like.

When removing with a cleaning agent, it is necessary to increase the amount of the abrasive and increase the hardness in order to exert its effect, but as the abrasive force increases, there is a possibility that harmfulness and irritation such as damage to teeth and gums may easily occur. On the other hand, in order to stabilize the mixed enzyme, it is necessary to use various stabilizers in combination, which may affect the usability such as foaming and taste.

In addition, in recent years, if the plaque can be captured as a biofilm and the biofilm can be removed, the plaque can be removed more effectively. For the removal of biofilm in the oral cavity, not only the physical method of brushing teeth with a toothbrush is useful, but also the chemical method of removing the biofilm that cannot be touched by the toothbrush. Biofilms are composed of co-aggregates of various oral bacteria and exopolysaccharides. Therefore, as a chemical removal method, there are known methods using erythritol, which has a co-aggregation-inhibiting effect, and protease, dextranase, mutanase, etc., which decompose exopolysaccharide enzymes, but the effect is still room for improvement.

In addition, surfactants are known to have a cleansing effect and can be used in oral compositions as cleansers. In this case, sodium lauryl sulfoacetate is known to be an active agent that does not have the irritation peculiar to anionic surfactants (Patent Document 1: Japanese Patent Laid-Open No. 6-72836).

However, the status quo has always been that surfactants, from the viewpoint of their penetrating action and surface cleaning action, are considered to have a tartar removal effect although they have only a slight effect, but they are not considered to be effective when they are used alone. Sufficient plaque and biofilm removal effect.

In addition, Patent Document 2 (Japanese Patent Publication No. 2008-519043) discloses a method of using an alkali metal salt or an ammonium salt of an alkyl sulfoacetate and a water-soluble zinc salt in combination, but the alkyl sulfoacetate is used for Compounds that reduce the astringency of zinc salts did not show a biofilm removal effect. Furthermore, Patent Document 3 (Japanese Patent Laid-Open No. 9-508120) discloses a toothpaste containing sodium lauryl sulfoacetate as an oral composition for reducing irritation to the oral mucosa, but does not refer to improving the biofilm removal effect .

On the other hand, it is known that condensed phosphates have the effect of chemically removing tooth stains (Patent Document 4: Japanese Patent Laid-Open No. 9-175966), but it is not considered that condensed phosphates alone have sufficient tartar and biological stain removal effects. Membrane removal effect.

prior art literature

patent documents

Patent Document 1: Japanese Patent Laid-Open No. 6-72836

Patent Document 2: Japanese Patent Application Publication No. 2008-519043

Patent Document 3: Japanese Patent Laid-Open No. 9-508120

Patent Document 4: Japanese Patent Laid-Open No. 9-175966

Contents of the invention

The problem to be solved by the invention

An object of the present invention is to provide an oral biofilm removing agent and a composition for oral cavity that chemically and efficiently remove biofilm that is a cause of dental caries in view of the above circumstances.

means of solving problems

As a result of intensive studies in order to achieve the above-mentioned subject of the present invention, the present invention found that by using (A) α-olefin sulfonate and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2) in combination The above-mentioned problems can be solved.

Specifically, the present inventors have found that by combining (A) α-olefin sulfonate and (B) condensed phosphate (B-1), the effect of removing oral biofilm can be significantly improved, and the effect of (A) component can be suppressed. Unique bitterness, in addition, can impart appropriate foaming (1st invention).

In the first invention, when the mass ratio of (A) component to (B-1) component, especially (A)/(B-1) is in the range of 0.1 to 10, they act specifically and synergistically to enhance dispersion removal The role of oral biofilms. Moreover, the bitterness originating in (A) component can be suppressed, and the appropriate foaming by (A) component can be provided.

That is, as shown in Examples and Comparative Examples described later, when the α-olefin sulfonate of the component (A) was used alone, the removal rate of the produced biofilm stagnated at less than 70%. In addition, it was found that even if the biofilm removal rate in the condensed phosphate (B-1) was less than 50%, it did not have a sufficient biofilm removal effect, but when the (A) component and (B-1) component were used together, unexpectedly, both These ingredients work synergistically to obtain a sufficient biofilm removal effect. In addition, in this case, it was found that even if an anionic surfactant other than component (A), such as sodium lauryl sulfate, was used in combination with condensed phosphate, a sufficient biofilm removal effect could not be obtained. The above biofilm removal effect was Specific effect when (A) component and (B-1) component are used together. Furthermore, α-olefin sulfonate has a bitter taste. Although its use has been disclosed in the literature, it is actually a material to be avoided in oral preparations. 1) When the components are used together, the bitterness derived from the (A) component can be suppressed, a good feeling can be provided, and the appropriate foaming caused by the (A) component can be maintained, and a formulation suitable for practical use can be prepared, thereby completing the present invention.

Furthermore, as a result of intensive research by the present inventors in order to achieve the above-mentioned subject of the present invention, it was found that the combination of (A) α-olefin sulfonate and (B) amphoteric surfactant (B-2) can significantly improve the oral cavity biofilm The bitterness peculiar to (A) component can be suppressed while removing an effect, and can provide appropriate foaming (II invention).

In the (II) invention, when the mass ratio of (A) component and (B-2) component, especially (A)/(B-2) is in the range of 0.2 to 8, they act specifically and synergistically to enhance Disperses the action of removing oral biofilm. Moreover, the bitterness originating in (A) component can be suppressed, and the appropriate foaming by (A) component can be provided.

That is, as shown in Examples and Comparative Examples described later, when the α-olefin sulfonate of the component (A) was used alone, the removal rate of the produced biofilm stagnated at less than 70%. In addition, it was found that although the biofilm removal rate in the amphoteric surfactant (B-2) is less than 50%, it does not have a sufficient biofilm removal effect, and even if it is used in combination with other surfactants, it is not considered that the biofilm The removal effect was improved, but when the (A) component and the (B-2) component were used together, both components unexpectedly acted synergistically, and a sufficient biofilm removal effect was obtained by the surfactant system. In addition, it was found that in this case, even if an anionic surfactant other than component (A), such as sodium lauryl sulfate, is used in combination with an amphoteric surfactant, a sufficient biofilm removal effect cannot be obtained. It is the specific action effect when the component (A) and the component (B-2) are used together. Furthermore, it was found that α-olefin sulfonate has a bitter taste, and although its use has been disclosed in the literature, its use has actually been avoided. However, when components (A) and (B-2) are used together , can suppress the bitterness originating from (A) component, can impart favorable use feeling, can maintain the appropriate foaming caused by (A) component in addition, can make the formulation suitable for actual use, and completed the present invention.

In the second invention, when the (C) quaternary ammonium salt, (D) xylitol, and/or erythritol are further mixed, a more excellent oral biofilm removal effect can be specifically imparted.

In this case, it is more preferable to contain (A) component, (B-2) component, the dentifrice composition containing (C) component is more preferable, or it is more preferable to contain (A) component, (B-2) component, More preferably, the mouthwash composition containing (D)component.

Therefore, the present invention (first invention) provides the following oral biofilm removing agent and oral composition.

[I-1] An oral biofilm removing agent comprising (A) α-olefin sulfonate and (B-1) condensed phosphate.

[I-2] The oral biofilm removing agent according to [I-1], wherein the mass ratio of (A)/(B-1) is 0.1-10.

[I-3] The oral biofilm removing agent according to [I-1] or [I-2], wherein the α-olefin sulfonate of the component (A) is an α-olefin having 14 to 16 carbon atoms Sulfonate.

[I-4] An oral composition comprising (A) α-olefin sulfonate and (B-1) condensed phosphate.

[I-5] The composition for oral cavity according to [I-4], wherein the mass ratio of (A)/(B-1) is 0.1-10.

[I-6] The composition for oral cavity according to [I-4] or [I-5], which contains (A) component α-olefin sulfonate in an amount of 0.3 to 5% by mass.

[I-7] The composition for oral cavity according to [1-4], [I-5] or [I-6], which contains 0.1 to 5% by mass of the polycondensed phosphate as the component (B-1).

[I-8] The composition for oral cavity according to any one of [I-4] to [I-7], which is a dentifrice composition or a mouthwash composition.

[I-9] The oral composition according to any one of [I-4] to [I-8], which is an oral composition for removing oral biofilm.

Therefore, this invention (II invention) provides the following oral cavity biofilm removal agent and oral cavity composition.

[II-1] An oral biofilm removing agent comprising (A) an α-olefin sulfonate and (B-2) an amphoteric surfactant.

[II-2] The oral biofilm removing agent according to [II-1], wherein the mass ratio of (A)/(B-2) is 0.2-8.

[II-3] The oral biofilm removing agent described in [II-1] or [II-2], wherein the amphoteric surfactant of the component (B-2) is selected from fatty acid amide alkyl betaine, imidazolinium One or more betaine-based amphoteric surfactants selected from betaine and glycine betaine.

[II-4] The oral biofilm removing agent according to [II-1], [II-2] or [II-3], wherein the α-olefin sulfonate of the component (A) has 14 carbon atoms ~16 α-olefin sulfonates.

[II-5] The oral biofilm removing agent according to any one of [II-1] to [II-4], further comprising (C) a quaternary ammonium salt.

[II-6] The oral biofilm removing agent according to [II-5], wherein the quaternary ammonium salt of the component (C) is at least one selected from cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride .

[II-7] The oral biofilm removing agent according to any one of [II-1] to [II-6], further comprising (D) xylitol and/or erythritol.

[II-8] An oral composition comprising (A) α-olefin sulfonate and (B-2) an amphoteric surfactant.

[II-9] The composition for oral cavity according to [II-8], wherein the mass ratio of (A)/(B-2) is 0.2-8.

[II-10] The composition for oral cavity according to [II-8] or [II-9], which contains (A) component α-olefin sulfonate in an amount of 0.1 to 3% by mass, (B-2) component amphoteric Surfactant 0.05-5% by mass.

[II-11] The composition for oral cavity according to [II-8], [II-9] or [II-10], further comprising 0.003 to 0.05% by mass of (C) a quaternary ammonium salt.

[II-12] The oral composition according to any one of [II-8] to [II-11], further comprising (D) xylitol and/or erythritol in an amount of 0.1 to 2% by mass.

[II-13] The composition for oral cavity according to any one of [II-8] to [II-12], which is a dentifrice composition or a mouthwash composition.

[II-14] The oral composition according to any one of [II-8] to [II-13], which is an oral composition for removing oral biofilm.

The effect of the invention

The oral biofilm removing agent and composition for oral cavity of the present invention are excellent in chemically removing oral biofilm which is the cause of dental caries. In addition, it is possible to suppress bitterness, provide a good feeling in use, and provide appropriate foaming.

detailed description

Hereinafter, the present invention will be described in further detail.

The present invention is an oral biofilm removing agent comprising (A) α-olefin sulfonate, (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2). Moreover, this invention is a composition for oral cavity containing said (A) and (B) component.

In the present invention, the first invention is characterized in that (A) α-olefin sulfonate and polycondensed phosphate (B-1) as the component (B) are used in combination.

By using (A) α-olefin sulfonate and (B-1) component in combination, the dispersion removal effect of biofilm can be significantly improved, and the bitterness of (A) component can be suppressed, and foaming property can be imparted suitably.

As (A) α-olefin sulfonate, alkali metal salts such as sodium and potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, preferably α-olefin sulfonate having 14 carbon atoms. These may be available commercial products that can be used for oral preparations.

When the condensed phosphate (B-1) of the (B) component used in the first invention is used in combination with the (A) component, the biofilm removal effect is improved, and bitterness is suppressed, and appropriate foaming properties are imparted.

As the polycondensed phosphate of the component (B), linear water-soluble polyphosphate represented by the following general formula (1) can be used. For example, sodium pyrophosphate or potassium pyrophosphate with a degree of polymerization of n=2, sodium or potassium tripolyphosphate with n=3, sodium or potassium tetrapolyphosphate with n=4, Sodium pentapolyphosphate, sodium metaphosphate or potassium metaphosphate with a further high degree of polymerization, etc. These can be used individually by 1 type or in combination of 2 or more types, Among them, sodium pyrophosphate, potassium pyrophosphate, and sodium tripolyphosphate are suitable from the viewpoint of effect expression, and sodium tripolyphosphate is especially preferable.

M _n+2 P _n O3 _n+1 (1)

(In the formula, M represents Na or K, n≧2.)

Specifically, sodium pyrophosphate (manufactured by Taihei Chemical Industry Co., Ltd., Tohoku Chemical Co., Ltd.), potassium pyrophosphate (manufactured by Taihei Chemical Industry Co., Ltd., Toa Gosei Chemical Co., Ltd.), sodium tripolyphosphate (manufactured by Taihei Chemical Industry Co., Ltd. Co., Ltd., Central Glass Co., Ltd. (Central Glass Co., Ltd.), Nippon Builder Co., Ltd. (Nippon Builder Co., Ltd.), potassium tripolyphosphate (Taihei Chemical Industry Co., Ltd.), sodium tetrapolyphosphate (Taihei Chemical Co., Ltd. Sangyo Co., Ltd.), sodium pentapolyphosphate (made by Taihei Chemical Industry Co., Ltd.), etc.

In the first invention, when the mixing ratio of (A) component and (B-1) component is in a specific range, the effect of removing oral biofilm is more excellent. The ratio of (A)/(B-1) is not particularly limited, but is preferably 0.1-10 as a mass ratio, more preferably 0.2-5, still more preferably 0.6-3, particularly preferably 1.2-3.

Within the range of the above ratio, the biofilm removal effect is more excellent. In addition, the ratio is preferably 10 or less from the viewpoint of suppressing bitterness and imparting favorable foam.

Moreover, in this invention, II invention is characterized by using together (A) α-olefin sulfonate, and the amphoteric surfactant (B-2) which is (B) component.

By using (A) α-olefin sulfonate and (B-2) component together, the dispersion removal effect of biofilm can be significantly improved, and the bitterness of (A) component can be suppressed, and foaming property can be imparted suitably.

In this case, (A) component is the same as the said 1st invention.

The (B) component amphoteric surfactant (B-2) used in the second invention is used in combination with (A) component to remarkably improve the dispersion and removal effect of oral biofilm, and to suppress bitterness and impart appropriate foaming properties.

As the amphoteric surfactant, betaines such as fatty acid amidoalkyl betaines, imidazolinium betaines, and glycine betaines can be used. Among them, the fatty acid has 8 to 18 carbon atoms, preferably a fatty acid amidoalkyl betaine having an alkyl group of 1 to 5 carbon atoms, and more preferably a fatty acid amidopropyl betaine. As such a fatty acid amidopropyl betaine, coco fatty acid amidopropyl betaine described in the foreign standard (Standards for Quasi-Drug Raw Materials) can be used.

As the amphoteric surfactant, commercially available ones that can be used in oral preparations may be used. Specifically, as coco fatty acid amidopropyl betaine, commercially available brand name TEGO Betain CKOK (made by EVONIK company) is mentioned.

In the second invention, when the mixing ratio of (A) component and (B-2) component is in a specific range, the effect of removing oral biofilm is more excellent. In this case, the (A)/(B-2) ratio is preferably 0.2 to 8 by mass ratio, more preferably 0.4 to 5, still more preferably 0.4 to 4, particularly preferably 0.5 to 3.1. Within the range of the above ratio, the biofilm removal effect is more excellent. Moreover, it is preferably 8 or less from the viewpoint of imparting better foaming and further suppressing bitterness.

In the present invention, especially in the second invention, it is preferable to further mix the (C) quaternary ammonium salt. When the (C) quaternary ammonium salt is mixed, the effect of dispersing and removing oral biofilm is further improved. In addition, foaming is further improved.

As the quaternary ammonium salt of the (C) component, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, etc. can be mentioned, and these can be used alone or in two or more kinds, especially from the aspect of biofilm removal effect, More preferred is cetylpyridinium chloride.

When mixing (C)component, it is preferable to mix (A)/(C) within the range of 10-500 by mass ratio from a viewpoint of improving biofilm removal effect.

In the present invention, especially in the second invention, it is preferable to further mix (D) xylitol and/or erythritol. When (D) xylitol and/or erythritol are mixed, the effect of dispersing and removing oral biofilm is further improved. Moreover, as (D)component, xylitol or erythritol may be mixed independently, and xylitol and erythritol may be mixed.

When mixing (D) component, it is preferable to mix (A)/(D) in the range of 0.01-5 in mass ratio from a viewpoint of improving biofilm removal effect.

The oral biofilm removing agent of the first invention can be appropriately mixed with the oral composition. In this case, in the oral composition of the first invention, the compounding amount of the component (A) is preferably 0.3 to 5% (mass%, the same below) of the entire composition, more preferably 0.5 to 5.0%. The larger the blending amount, the higher the biofilm removal effect, and at 0.3% or more, a sufficient biofilm removal effect can be imparted. In addition, good foamability can be imparted. When it is 5% or less, the bitterness does not become strong, which is preferable in use.

In addition, in the oral composition of the first invention, the compounding amount of the component (B-1) is preferably 0.1 to 5%, more preferably 0.2 to 5%, and even more preferably 0.3 to 5% of the entire composition. (B-1) The larger the compounding amount of the component, the higher the biofilm removal effect, but it is preferably 5% or less from the viewpoint of suppressing bitterness, imparting good foaming, and obtaining a material suitable for use.

The oral biofilm removing agent of the second invention is preferably mixed in a composition for oral cavity, which contains (A) α-olefin sulfonate and amphoteric surfactant (B-2) as (B) component, and more preferably contains ( C) The quaternary ammonium salt further preferably contains (D) xylitol and/or erythritol. Particularly if it is a dentifrice composition containing (A) component, (B-2) component, more preferably containing (C) component, or containing (A) component, (B-2) component, more preferably containing (D ) components, the oral biofilm removal effect is further improved.

In the composition for oral cavity of 2nd invention, it is preferable that the compounding quantity of (A) component is 0.1-3% of the whole composition. In this case, especially in the dentifrice composition, it is preferable to mix (A) component 0.3-3%, and it is especially preferable to mix 0.5-2.5%. Moreover, in a mouthwash composition, it is preferable to mix (A) component 0.1-3%, especially preferably 0.1-2.5%, and especially preferably mix 0.1-1%. The larger the blending amount, the higher the biofilm removal effect, and at 0.1% or more, a sufficient biofilm removal effect can be imparted. In addition, good foamability can be imparted. When it is 3% or less, the bitterness does not become strong, which is preferable in use.

In addition, in the oral composition of the second invention, the compounding amount of the component (B-2) is preferably 0.05 to 5% of the entire composition, particularly preferably 0.1 to 5%, more preferably 0.3 to 5%, and even more preferably 0.5-3%. (B-2) The larger the compounding amount of the component, the higher the biofilm removal effect and impart good foaming, but it is preferably 5% or less in order not to generate bitterness.

When mixing (C) quaternary ammonium salt, especially in the dentifrice composition which concerns on II invention, the compounding quantity becomes like this. Preferably it is 0.003-0.05% of the whole composition, More preferably, it is 0.005-0.01%. The more the mixing amount, the higher the biofilm removal effect. In order not to cause mucosal irritation of the quaternary ammonium salt, it is preferably 0.05% or less.

When mixing (D) xylitol and/or erythritol, especially in the mouthwash composition according to the second invention, the mixing amount is preferably 0.1 to 2%, more preferably 0.3 to 1% of the entire composition . The larger the mixing amount, the higher the biofilm removal effect. In order not to produce a bitter taste, it is preferably 2% or less.

The oral composition of the present invention can be prepared in the form of liquid, liquid, paste, etc., and can be prepared into toothpaste, liquid dentifrice, liquid dentifrice, moisturizing tooth powder (moisturizing dentifrice), etc. medicine, mouthwash, etc.

In this case, in addition to the above-mentioned components, other arbitrary components may be mixed according to the dosage form as needed within the range not impairing the effect of the present invention. Specifically, in the case of dentifrices, abrasives, binders, thickeners, surfactants, sweeteners, preservatives, fragrances, coloring agents, various active ingredients, solvents such as water, and pH adjusters can be mixed. Wait. In addition, in the case of mouthwash, wetting agents, surfactants, solvents, pH adjusters, preservatives, bactericides, fragrances, sweeteners, coloring agents, and various active ingredients can be mixed.

Specific examples of optional components are shown below, but the components that can be mixed in the composition of the present invention are not limited to these components.

As the abrasive, silica-based abrasives such as crystalline silica, amorphous silica, silica gel, and aluminum silicate, zeolite, anhydrous calcium hydrogen phosphate, dihydrate calcium hydrogen phosphate, calcium pyrophosphate, Calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, trimagnesium phosphate, zirconium silicate, tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, synthetic resin abrasives, etc. In the case of a dentifrice, these abrasives may be mixed generally at 5 to 70% of the entire composition, particularly at 10 to 50% of the entire composition.

Examples of binders include pullulan, gelatin, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium alginate, xanthan gum, poly Sodium acrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinylpyrrolidone, etc. may be used alone or in combination of two or more. These binders can usually be mixed in an amount of 0 to 10%, especially 0.1 to 5%, of the whole composition.

Examples of the thickener (humectant) include polyhydric alcohols such as sorbitol, propylene glycol, butylene glycol, glycerin, and polyethylene glycol. The compounding quantity of these thickeners is 0-70% of the whole composition normally, especially 3-50%.

As the surfactant, anionic surfactants and nonionic surfactants other than the (A) component can be mixed, for example, anionic surfactants such as alkyl sulfates and glycerin fatty acid ester sulfates can be used, poly Oxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, polyoxyethylene glycerin fatty acid ester, sucrose fatty acid ester, fatty acid alkylolamide and other nonionic surfactants . One or more of these surfactants can be used, and usually 0 to 10% of the entire composition, particularly 0.1 to 5%, can be mixed. Moreover, although the compounding quantity of the anionic surfactant other than (A) component may be 0%, when compounding, 0.1-1.5% is preferable, and 0.1-1.0% is especially preferable.

Examples of sweeteners include sodium saccharin, stevioside, neohesperidin dihydrochalcone, and the like. As a preservative, parabens such as sodium benzoate, methyl paraben, and ethyl paraben can be mixed.

As spices, peppermint oil (peppermint oil), spearmint oil, fennel oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint can be used in combination Oil (Hacka Oil), Cardamom Oil, Coriander Oil, Orange Peel Oil, Lime Oil, Lavender Oil, Rosemary Oil, Bay Oil, Chamomile Oil, Fennel Oil, Marjoram Oil, Laurel Oil, Lemongrass Oil, Oregano oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, platinum pomelo oil (スウィーティー oil), pomelo oil, iris extract, peppermint essential oil, rose essential oil, orange blossom and other natural fragrances, And the spices obtained by processing these natural flavors (removing the front fraction, removing the rear fraction, fractionation, liquid-liquid extraction, refining, spice powder treatment), and l-menthol, carvone, anethole, eucalyptol , methyl salicylate, cinnamaldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate Esters, N-substituted-p-menthane-3-carboxamides, pinene, octanal, citral, pulegone, carvyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, cyclohexylpropionate Propyl ester, Methyl anthranilate, Ethyl methyl phenylglycidate, Vanillin, Undecanolide, Hexanal, Butanol, Isoamyl alcohol, Hexenol, Dimethyl sulfide , methylcyclopentenolone, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate and other single flavors, as well as strawberry, apple, banana, pineapple, grape, mango Known flavoring materials that can be used in oral compositions such as flavoring, buttery flavoring, milky flavoring, fruit blend flavoring, tropical fruity flavoring and the like.

As a coloring matter, what can be used for an oral composition can be used according to the target color tone. Examples of food colorings include brilliant blue, tartrazine, and the like, and examples of pigments include titanium oxide and the like.

As active ingredients (medicinal ingredients), bactericidal or bacteriostatic agents such as chlorhexidine, triclosan, isopropylmethylphenol, zinc gluconate, and zinc citrate can be used in an effective amount within the scope of pharmacy, Dental calculus preventive agents such as ethanehydroxy diphosphate, anti-inflammatory agents such as tranexamic acid, glycyrrhizic acid and its salts, allantoin basic aluminum chloride, fluorides such as sodium fluoride and sodium monofluorophosphate, hydroxyethyl Coating agents such as cellulose dimethyl diallyl ammonium chloride, enzyme agents such as dextranase, mutase, and lysozyme chloride, vitamins such as ascorbic acid and tocopheryl acetate, and astringent agents such as sodium chloride , Aluminum lactate, strontium chloride, potassium nitrate and other hypersensitivity inhibitors, sodium fluoride, sodium monofluorophosphate, stannous fluoride and other fluorides, etc.

Moreover, ethanol, water, etc. can be mixed as a solvent.

When the oral composition is a dentifrice composition, the solvent is preferably water, and the water content is preferably 60% or less of the entire composition. Furthermore, when the oral composition is a mouthwash composition, the solvent is preferably water or a mixed solvent of water and ethanol, and ethanol is preferably 10% or less of the entire composition.

The pH of the composition may be within the range of common oral compositions, but the pH at 25°C is preferably 5.5-8.5, more preferably 6-8. In addition, the pH can be adjusted using a pH adjuster as needed, and examples of the pH adjuster include sodium hydroxide, hydrochloric acid, sodium carbonate, sodium bicarbonate, boric acid, or salts thereof, among which sodium hydroxide, potassium hydroxide, hydrochloric acid, and the like are suitable. . The compounding quantity of these pH adjusters should just be able to adjust pH to the said range.

[Example]

Hereinafter, although an Example, a comparative example, and a formulation example are shown, and this invention is concretely demonstrated, this invention is not limited to a following example. In addition, in the following examples, % represents mass % unless there is a particular limitation.

[Example 1, Comparative Example 1]

Dentifrice compositions with the components shown in Tables 1 and 2 were prepared according to the methods shown below, and evaluated by the following methods. The results are recorded in Tables 1 and 2 together.

The preparation method of dentifrice composition:

First, mix the polycondensed phosphate of the component (B-1) and the water-soluble components used in purified water containing a thickener such as sorbitol liquid at room temperature, and then further mix a binder and a stabilizer, and carry out the process with a disperser. dispersion. Add the dispersion liquid and the grinding agent to the kneader and mix, then add the fragrance and (A) component α-olefin sulfonate. The inside of the kneader was depressurized to about 5 kPa to defoam, and further mixing was continued to obtain a dentifrice composition. In addition, the composition of the comparative example was prepared according to the above-mentioned method.

＜Evaluation method of oral biofilm removal effect＞

(1) Preparation method of model biofilm

A hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) with a diameter of 7 mm x a thickness of 3.5 mm was treated with human non-irritating saliva filtered through a 0.45 μm filter for 4 hours, used as a carrier for the production of a model biofilm, and cultured As the medium, minimally buffered methanol (Beisal Medium) culture medium (BMM) ^*1 was used. The strains used to make the model biofilm were Actinomyces viscosus ATCC43146, Veillonella parvula ATCC17745, Fusobacterium nucleatum ATCC10953 purchased from the American Type Culture Collection. Streptococcus (Streptococcus oralis) ATCC10557, Streptococcus mutans (Streptococcusmutans) ATCC25175. These five strains were inoculated at 1×10 ⁷ cfu/mL (cfu: colony forming unit) into a rotating disk reactor (culture tank) pre-filled with 3000 mL of BMM, together with the HA carrier treated with saliva Cultivate at 37° C. under anaerobic conditions (5 vol% carbon dioxide, 95 vol% nitrogen) for 24 hours. Then, under the same conditions, the BMM medium was continuously supplied with a replacement rate of 5 vol%/hour for 10 days, and a model biofilm in which 5 strains were mixed was formed on the surface of HA.

(2) Removal effect of model biofilm

The formed model biofilm was transferred to a 24-well multiwell plate (manufactured by Sumitomo Bakelite Co., Ltd.), and 2 mL of the prepared dentifrice composition (centrifuged supernatant diluted 3-fold with saliva collected from a healthy person) was added. (10000rpm, 10 minutes)), dipped for 3 minutes (the group without adding the dentifrice composition was used as a control sample). Then, it was washed 6 times with 1 mL of PBS (manufactured by Wako Pure Chemical Industries, Ltd.), and dispersed by ultrasonic treatment (200 μA, 10 seconds) in a test tube (diameter 13 mm×10 mm) to which 2 mL of the same PBS was added. The turbidity (OD) of the dispersion liquid at a wavelength of 550 nm was measured to measure the remaining amount of biofilm.

For the biofilm removal effect of the test composition, the removal rate relative to the control group was obtained from the following formula, and the oral biofilm removal effect was judged from the removal rate according to the following criteria.

Biofilm removal rate (%)=(turbidity of control group-turbidity of test composition)/turbidity of control group×100

Criteria for judging the effect of oral biofilm removal

◎◎: Biofilm removal rate is above 95%

◎: Biofilm removal rate is above 90% and less than 95%

○: Biofilm removal rate is above 80% and less than 90%

△: Biofilm removal rate is above 70% and less than 80%

×: Biofilm removal rate is above 50% and less than 70%

××: Biofilm removal rate is less than 50%

^*1 Composition of BMM: Expressed by mass in 1 liter.

Peptone (manufactured by Becton and Dickinson): 4g/L

Tryptone (manufactured by Becton and Dickinson): 2g/L

Yeast extract (manufactured by Becton and Dickinson): 2g/L

Mucin (manufactured by Sigma): 5g/L

Hemin (manufactured by Sigma): 2.5 mg/L

Vitamin K (manufactured by Wako Pure Chemical Industry Co., Ltd.): 0.5 mg/L

KCl (manufactured by Wako Pure Chemical Industry Co., Ltd.): 1g/L

Cysteine (manufactured by Wako Pure Chemical Industries Ltd.): 0.2g/L

Distilled water: remaining amount (constant volume so that the total amount reaches 1L, and autoclave at 121°C for 20 minutes.)

＜How to evaluate the presence or absence of bitterness and the quality of foaming＞

The presence or absence of bitterness and the quality of foaming of the dentifrice compositions shown in the table were sensory evaluated by the following methods.

Take 1 g of the dentifrice composition on the toothbrush, brush your teeth for 3 minutes, and evaluate according to the following scoring criteria. The presence or absence of bitterness and the quality of foaming were evaluated by 6 evaluators based on the following evaluation criteria.

presence or absence of bitterness

Evaluation benchmark

5: Bitterness is not sensed

4: Almost no bitterness is felt

3: feel a little bitter

2: feel bitter

1: Feel strong bitterness

Evaluation benchmark

◎: The average value is between 4 and 5

○: The average value is more than 3 points and less than 4 points

△: The average value is more than 2 points and less than 3 points

×: The average value is more than 1 point and less than 2 points

Advantages and disadvantages of foaming

Evaluation benchmark

5: Very good foaming

4: slightly better foaming

3: Moderate foaming

2: slightly poor foaming

1: Poor foaming

Evaluation Benchmark

◎: The average value is between 4 and 5

○: The average value is more than 3 points and less than 4 points

△: The average value is more than 2 points and less than 3 points

×: The average value is more than 1 point and less than 2 points

Detailed instructions for using raw materials are given below.

(A) Ingredients

Sodium tetradecene sulfonate (sodium α-olefin (C14) sulfonate): manufactured by Lion Corporation

(B) Ingredients

(B-1) Sodium tripolyphosphate: Taihei Chemical Industry Co., Ltd. make

(B-1) Sodium pyrophosphate: Taihei Chemical Industry Co., Ltd. make

(B-1) Potassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd.

【Table 1】

【Table 2】

[Example II, Comparative Example II]

Prepare the oral composition of the components shown in Tables 3 to 6 according to the method shown below (Tables 3 and 4 are dentifrice compositions, and Tables 5 and 6 are mouthwash compositions), using the same method as above Make an evaluation. The results are also described in Tables 3-6.

In addition, sensory evaluation was performed for the presence or absence of bitterness and the quality of foaming of the mouthwash composition by the following methods.

10 mL of mouthwash was contained in the mouth and swished for 20 seconds, and the presence or absence of bitterness at the time of gargling was judged based on the above scoring criteria. Evaluation was performed based on the average of 6 evaluators based on the above evaluation criteria.

The preparation method of dentifrice composition:

First, water-soluble components such as sodium fluoride are mixed with purified water containing thickeners such as sorbitol liquid at room temperature, and then the binder and (B-2) components are further mixed at the same time, and further mixed ( C) Components are dispersed with a disperser. Add the above-mentioned dispersion liquid, abrasive powder, etc. powder to the kneader and mix, then add fragrance and (A) component. The inside of the kneader was depressurized to about 5 kPa to defoam, and further mixing was continued to obtain a dentifrice composition.

The preparation method of mouthwash composition:

In preparation of the mouthwash composition, (A) component, (B-2) component, (D) component and other raw materials are sequentially added to purified water and stirred to dissolve uniformly. In addition, a three-in-one motor (BL1200, manufactured by HEIDON Corporation) was used in the production.

The dentifrice composition and the mouthwash composition of the comparative example were prepared according to the above-mentioned method.

Detailed instructions for using raw materials are given below.

(A) Ingredients

Sodium tetradecene sulfonate (sodium α-olefin (C14) sulfonate): manufactured by Lion Corporation

(B) Ingredients

(B-2) Coco fatty acid amidopropyl betaine: 30% product (the mixing amount in each example is the pure content), TEGO Betain CKOK, manufactured by EVONIK Co., Ltd.

(B-2) imidazolinium betaine: manufactured by Nikko Chemicals Co., Ltd.

(B-2) Glycine betaine: manufactured by Nikko Chemical Co., Ltd.

(C) Cetylpyridinium chloride: manufactured by Wako Pure Chemical Industries, Ltd.

(C) Benzalkonium chloride: manufactured by Wako Pure Chemical Industries, Ltd.

(C) Benzethonium chloride: manufactured by NOF Corporation

(D) Xylitol: manufactured by ROCKET JAPAN CO., LTD.

(D) Erythritol: manufactured by Wako Pure Chemical Industries, Ltd.

【table 3】

Dentifrice Composition

【Table 4】

Dentifrice Composition

【table 5】

mouthwash composition

【Table 6】

mouthwash composition

From the results in the table, it was found that the oral cavity biofilm removal effect was significantly improved when the (A) component and the (B) component were used in combination. In addition, bitterness is suppressed. Further, oral compositions, especially dentifrice compositions, have suitable foaming.

Prescription examples are shown below. In addition, the raw materials used are the same as above.

[Prescription Example I-1] Mouthwash

(A)/(B-1) ratio: 1.6

This mouthwash was excellent in the effect of removing oral biofilm, and in addition, bitterness was suppressed, and foaming was favorable.

[Prescription Example II-1] Mouthwash

(A)/(B-2) ratio: 3.0

This mouthwash was excellent in biofilm removal effect, and also suppressed bitterness.

Claims (17)

1. An oral biofilm removing agent comprising (A) α-olefin sulfonate, (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2). 2 . The oral biofilm removing agent according to claim 1 , wherein the component (B) is condensed phosphate (B-1), and the mass ratio of (A)/(B-1) is 0.1-10. 3. The oral biofilm removing agent according to claim 1, wherein the component (B) is an amphoteric surfactant (B-2), and the mass ratio of (A)/(B-2) is 0.2-8. 4. The oral biofilm removal agent according to claim 1 or 3, wherein the amphoteric surfactant (B-2) is selected from fatty acid amidoalkyl betaine, imidazolinium betaine and glycine betaine One or more betaine-based amphoteric surfactants. The oral biofilm removing agent according to any one of claims 1 to 4, wherein the α-olefin sulfonate of the component (A) is an α-olefin sulfonate having 14 to 16 carbon atoms. 6. The oral biofilm removing agent according to any one of claims 1 to 5, further comprising (C) a quaternary ammonium salt. 7. The oral biofilm removing agent according to claim 6, wherein the quaternary ammonium salt of the component (C) is at least one selected from the group consisting of cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride. 8. The oral biofilm removing agent according to any one of claims 1 to 7, further comprising (D) xylitol and/or erythritol. 9. An oral composition comprising (A) α-olefin sulfonate, (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2). 10 . The composition for oral cavity according to claim 9 , wherein the component (B) is condensed phosphate (B-1), and the mass ratio of (A)/(B-1) is 0.1-10. 11. The composition for oral cavity as claimed in claim 9 or 10, wherein, (B) component is condensed polyphosphate (B-1), and described composition for oral cavity contains (A) component α-olefin sulfonate 0.3 -5% by mass, 0.1-5% by mass of the (B-1) component. 12. The oral composition according to claim 9, wherein the component (B) is an amphoteric surfactant (B-2), and the mass ratio of (A)/(B-2) is 0.2-8. 13. The oral composition according to claim 9 or 12, wherein (B) component is an amphoteric surfactant (B-2), and the oral composition contains (A) component α-olefin sulfonate 0.1 to 3% by mass, and (B-2) component 0.05 to 5% by mass. 14. The oral composition according to any one of claims 9 to 13, further comprising (C) 0.003 to 0.05% by mass of a quaternary ammonium salt. 15. The oral composition according to any one of claims 9 to 14, further comprising (D) xylitol and/or erythritol in an amount of 0.1 to 2% by mass. 16. An oral composition according to any one of claims 9 to 15 which is a dentifrice composition or a mouthwash composition. 17. The oral composition according to any one of claims 9 to 16, which is an oral composition for removing oral biofilm.