CN105326786A - Nasal irrigant composition and preparation method thereof - Google Patents
Nasal irrigant composition and preparation method thereof Download PDFInfo
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- CN105326786A CN105326786A CN201510751281.9A CN201510751281A CN105326786A CN 105326786 A CN105326786 A CN 105326786A CN 201510751281 A CN201510751281 A CN 201510751281A CN 105326786 A CN105326786 A CN 105326786A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000002639 sodium chloride Nutrition 0.000 claims abstract description 34
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 25
- 229920001661 Chitosan Polymers 0.000 claims abstract description 24
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 21
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000010447 xylitol Nutrition 0.000 claims abstract description 21
- 239000000811 xylitol Substances 0.000 claims abstract description 21
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 21
- 229960002675 xylitol Drugs 0.000 claims abstract description 21
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 20
- 239000008215 water for injection Substances 0.000 claims abstract description 20
- 239000011780 sodium chloride Substances 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 235000017550 sodium carbonate Nutrition 0.000 claims abstract description 9
- 239000000243 solution Substances 0.000 claims description 57
- 210000003928 nasal cavity Anatomy 0.000 claims description 49
- 238000004140 cleaning Methods 0.000 claims description 32
- 239000012530 fluid Substances 0.000 claims description 30
- 238000005374 membrane filtration Methods 0.000 claims description 16
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- 230000008961 swelling Effects 0.000 claims description 10
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims description 9
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 9
- 239000012467 final product Substances 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 9
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 206010039083 rhinitis Diseases 0.000 description 9
- 206010028748 Nasal obstruction Diseases 0.000 description 6
- 239000013535 sea water Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
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- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
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- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
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- 239000003814 drug Substances 0.000 description 2
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- 229940013618 stevioside Drugs 0.000 description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 2
- 235000019202 steviosides Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
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- 210000003135 vibrissae Anatomy 0.000 description 2
- 206010002653 Anosmia Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010009137 Chronic sinusitis Diseases 0.000 description 1
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- 206010061218 Inflammation Diseases 0.000 description 1
- 241001484259 Lacuna Species 0.000 description 1
- 206010065334 Mucosal hyperaemia Diseases 0.000 description 1
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- 230000001886 ciliary effect Effects 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a nasal irrigant composition, in particular to the nasal irrigant composition containing chitosan, physiological salt, sodium carbonate, xylitol and water for injection and a preparation method thereof. The physiological salt is natural sea salt or sodium chloride, the mass concentration of salt ranges from 0.9% to 6.0%, the mass concentration of chitosan ranges from 0.01% to 2%, the mass concentration of sodium carbonate ranges from 1% to 6%, and the mass concentration of xylitol ranges from 3% to 30%.
Description
[technical field]
The present invention relates to a kind of nasal cavity cleaning fluid composition, particularly relate to a kind of nasal wash composition and method of making the same containing chitosan, physiology salt, sodium carbonate, xylitol, water for injection.
[background technology]
Nasal cavity is the long and narrow lacuna of a narrow bottom width in top, front prenaris, after terminate in choana, communicate with nasopharynx part.Be divided into two chambeies, left and right with nasal septum, every side nasal cavity comprises nasal vestibule and cavum nasi proprium two parts.Be the chamber of arcuation at higher vertebrate, between basis cranii and oral cavity push up, the chamber surrounded by bone and cartilage, inner face is covered with mucosa and skin.Nasal cavity by the nasal septum of a stringer be divided into left and right two chambeies, nasal septum because of position often amesiality, so how asymmetric the size and geometric of left and right nasal cavity is.Nasal cavity communicates to front lower nostril of borrowing with the external world, and stuffy nose relieving pharynx claims choana backward.Every side nasal cavity is divided into again nasal vestibule and cavum nasi proprium two parts.Have vibrissa in nasal cavity, vibrissa, to the air filtration sucked, can reduce the suction of the harmful substances such as dust.Olfactory cell and secretion body of gland is had in nasal membrane, and quite abundant blood capillary.
The inflammation of the bronchia mucosal that rhinitis and nasal cavity inflammatory diseases are virus, antibacterial, allergen, various physical and chemical factor and some systemic disease cause.
The main pathological change of rhinitis is bronchia mucosal hyperemia, swelling, ooze out, hypertrophy, atrophy or necrosis etc.Main clinical manifestation is:
(1) have a stuffy nose: nasal obstruction feature is intermittent.By day, sky heat, work or motion time nasal obstruction alleviate, and night, sit quietly or cold time nasal obstruction increase the weight of.Another feature of nasal obstruction is alternately.During as lain on one's side, occupy the congestion of downside, upside nasal airflow is good.Due to nasal obstruction, or have hyposmia, headache, giddy, speak in symptoms such as closed rhinolalias.
(2) many tears: be often mucus or glutinous purulence, occasionally become purulence.Purulence occurs after sending out sexy dye season.
(3) olfactory sensation declines: mostly be caused by two kinds of reasons, one is tunica mucosa nasi swelling, nasal obstruction, and air-flow can not enter olfactory region; Two for regio olfactoria mucosa is by chronic inflammatory disease long-time stimulus, and olfactory function goes down or disappears.
(4) headache, giddy: chronic sinusitis shows as a sense of heaviness more.
(5) general manifestation: majority have headache, inappetence, easily tired, hypomnesis and insomnia etc.
The treatment of current above-mentioned disease mainly contains following method: (1) intranasal glucocorticoid.(2) nasal cavity cleaning of physical property.(3) medicinal intranasal Decongestant.
Wherein glucocorticoid has good antiinflammatory action, and final generation congestion effect, but hormone medicine uses for a long time and can produce organic injury to human body; Intranasal Decongestant is as 0.5% ~ 1% ephedrine, and life-time service can damage nasal mucosa ciliary structures, and some drugs is verified causes medicamentous rhinitis.The nasal cavity cleaning agent of physical property is more and more subject to the favor of doctor and patient comparatively speaking, nasal cavity cleaning agent main on market is the normal saline solution of 0.9%, because concentration is a little more than nasal membrane tissue fluid, nasal membrane can thinning being convenient to of dehydration be ventilated, relative to traditional stuffy nose relieving product, nasal cavity cleaning fluid composition provided by the invention has good biocompatibility; Good viscosity and adhesiveness, be easier to remove the noxious bacteria in nasal cavity; Have under the salinity of Thief zone and better dredge nasal cavity, repair the function of nasal mucosa damage; The formation protection that can continue at nasal mucosal surface and reparation mediation system, strengthen the time of dredging nasal cavity; There is isolate bacteria, physics is antibacterial, ion is antibacterial effect; Aseptic, there is the nasal cavity cleaning fluid composition of better storage stability.
[summary of the invention]
The object of the present invention is to provide a kind of nasal wash composition and method of making the same containing chitosan, physiology salt, sodium carbonate, xylitol, water for injection.
The present invention achieves the goal by the following technical programs:
A kind of nasal cavity cleaning fluid composition, is characterized in that composition comprises following composition: chitosan, physiology salt, water for injection.
A kind of nasal cavity cleaning fluid composition, is characterized in that composition also can comprise sodium carbonate.
A kind of nasal cavity cleaning fluid composition, is characterized in that composition also can comprise xylitol.
Preferably, physiology salt as claimed in claim 1 is natural sea salt or sodium chloride for injection.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of salt is 0.9 ~ 6.0%.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of salt is 0.9%.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of salt is 2.3%.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of chitosan is 0.01 ~ 2%.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of chitosan is 0.1%.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of chitosan is 0.4%.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 2, wherein the mass concentration of sodium carbonate is 1 ~ 6%.
Preferably, nasal cavity cleaning fluid composition as claimed in claim 3, wherein the mass concentration of xylitol is 3 ~ 30%
A preparation method for nasal cavity cleaning fluid composition, is characterized in that: comprise the steps:
Step 1: add in water for injection under stirring by chitosan, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Step 2: physiology salt, xylitol, sodium carbonate are added in step 1 solution, is stirred to and dissolves completely;
Step 3: above-mentioned solution is filtered by titanium rod;
Step 4: by above-mentioned solution by 0.45um water solublity membrane filtration;
Step 5: by above-mentioned solution by 0.22um water solublity membrane filtration;
Step 6: loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
Advantage of the present invention is:
(1) nasal cavity cleaning fluid composition of the present invention, has good biocompatibility.
(2) nasal cavity cleaning fluid composition of the present invention, has good viscosity and adhesiveness, is easier to remove the noxious bacteria in nasal cavity.
(3) nasal cavity cleaning fluid composition of the present invention, has and better dredges nasal cavity under the salinity of Thief zone, repairs the function of nasal mucosa damage.
(4) nasal cavity cleaning fluid composition of the present invention, the formation protection that can continue at nasal mucosal surface and reparation mediation system, strengthen the time of dredging nasal cavity, is more conducive to patient at night and has a rest.
(5) nasal cavity cleaning fluid composition of the present invention, has isolate bacteria, physics is antibacterial, ion is antibacterial effect, can resist the Rhinitis Symptoms that many reasons causes.
(6) nasal wash preparation method of composition provided by the invention, can prepare stable, aseptic, has the nasal cavity cleaning fluid composition of better storage stability.
[detailed description of the invention]
Below in conjunction with specific embodiment, the invention will be further described:
Embodiment one:
Take chitosan 4 weight portion, natural sea salt 9 weight portion, sodium carbonate 25 weight portion, xylitol 70 weight portion, water for injection 1000 weight portion, for subsequent use.
Chitosan is added in water for injection under stirring, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Natural sea salt, sodium carbonate, xylitol are added in above-mentioned solution, is stirred to and dissolves completely, for subsequent use;
Above-mentioned solution is filtered by titanium rod;
By above-mentioned solution by 0.45um water solublity membrane filtration;
By above-mentioned solution by 0.22um water solublity membrane filtration;
Loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
Embodiment two:
Take chitosan 1 weight portion, natural sea salt 9 weight portion, sodium carbonate 10 weight portion, xylitol 30 weight portion, water for injection 1000 weight portion, for subsequent use.
Chitosan is added in water for injection under stirring, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Natural sea salt, sodium carbonate, xylitol are added in above-mentioned solution, is stirred to and dissolves completely, for subsequent use;
Above-mentioned solution is filtered by titanium rod;
By above-mentioned solution by 0.45um water solublity membrane filtration;
By above-mentioned solution by 0.22um water solublity membrane filtration;
Loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
Embodiment three:
Take chitosan 4 weight portion, natural sea salt 2.3 weight portion, sodium carbonate 15 weight portion, xylitol 50 weight portion, water for injection 1000 weight portion, for subsequent use.
Chitosan is added in water for injection under stirring, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Natural sea salt, sodium carbonate, xylitol are added in above-mentioned solution, is stirred to and dissolves completely, for subsequent use;
Above-mentioned solution is filtered by titanium rod;
By above-mentioned solution by 0.45um water solublity membrane filtration;
By above-mentioned solution by 0.22um water solublity membrane filtration;
Loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
Embodiment four:
Take natural sea salt 2.3 weight portion, water for injection 1000 weight portion, be stirred to and dissolve completely, for subsequent use;
Above-mentioned solution is filtered by titanium rod;
By above-mentioned solution by 0.45um water solublity membrane filtration;
By above-mentioned solution by 0.22um water solublity membrane filtration;
Loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
Embodiment five:
Take chitosan 4 weight portion, natural sea salt 9 weight portion, xylitol 200 weight portion, water for injection 1000 weight portion, for subsequent use.
Chitosan is added in water for injection under stirring, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Natural sea salt, xylitol are added in above-mentioned solution, is stirred to and dissolves completely, for subsequent use;
Above-mentioned solution is filtered by titanium rod;
By above-mentioned solution by 0.45um water solublity membrane filtration;
By above-mentioned solution by 0.22um water solublity membrane filtration;
Loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
Embodiment six:
Take chitosan 4 weight portion, natural sea salt 9 weight portion, sodium carbonate 40 weight portion, water for injection 1000 weight portion, for subsequent use.
Chitosan is added in water for injection under stirring, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Natural sea salt, sodium carbonate, xylitol are added in above-mentioned solution, is stirred to and dissolves completely, for subsequent use;
Above-mentioned solution is filtered by titanium rod;
By above-mentioned solution by 0.45um water solublity membrane filtration;
By above-mentioned solution by 0.22um water solublity membrane filtration;
Loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
Embodiment seven:
Take chitosan 4 weight portion, sodium chloride for injection 9 weight portion, sodium carbonate 30 weight portion, xylitol 150 weight portion, water for injection 1000 weight portion, for subsequent use.
Chitosan is added in water for injection under stirring, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Sodium chloride for injection, sodium carbonate, xylitol are added in above-mentioned solution, is stirred to and dissolves completely, for subsequent use;
By above-mentioned solution through Co 60 radiosterilization;
Loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
In Example one, sample and control sample (0.9% physiology sea water solution) design 50 couples of patients with rhinitis respectively and carry out by a definite date January, at random, contrast, double blind experiment, every day 3 times, often inferior to each nostril spray 2 spray, be that judge index is tested with total effective rate, result is as follows:
| Classification | Effective | Effectively | Invalid |
| Embodiment one | 36 | 13 | 1 |
| 0.9% physiology sea water solution | 21 | 16 | 13 |
Result shows, embodiment one sample total effective rate reaches 98%, is better than 0.9% physiology sea water solution matched group, has obvious clinical advantage.
In Example one, sample and control sample (0.9% physiology sea water solution) design nasal cavity cleaning capacity experimental respectively, enter group for rhinitis group and non-rhinitis matched group, each 40 examples, under room temperature environment, the upright sitting of experimenter, stevioside powder is placed in nasal cavity surface, and covers completely, spray 3 times, often inferior to each nostril spray 5 spray, the stevioside powder detecting period of record patient, be that judge index is tested with checkout time, result is as follows:
| Classification | The rhinitis group time (min) | Non-rhinitis matched group time (min) |
| Embodiment one | 27.9 | 16.4 |
| 0.9% physiology sea water solution | 35.1 | 23.5 |
Result shows, the cleaning efficiency of embodiment one sample to nasal cavity is significantly higher than the elimination efficiency of 0.9% physiology sea water solution.
Claims (8)
1. a nasal cavity cleaning fluid composition, is characterized in that composition comprises following composition: chitosan, physiology salt, water for injection.
2. nasal cavity cleaning fluid composition as claimed in claim 1, composition comprises sodium carbonate.
3. nasal cavity cleaning fluid composition as claimed in claim 1, composition comprises xylitol.
4. physiology salt as claimed in claim 1 is natural sea salt or sodium chloride.
5. nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of salt is 0.9 ~ 6.0%.
6. nasal cavity cleaning fluid composition as claimed in claim 1, wherein the mass concentration of chitosan is 0.01 ~ 2%.
7. nasal cavity cleaning fluid composition as claimed in claim 2, wherein the mass concentration of sodium carbonate is 1 ~ 6%.
8. nasal cavity cleaning fluid composition as claimed in claim 3, wherein the mass concentration of xylitol is 3 ~ 30%
A preparation method for nasal cavity cleaning fluid composition, is characterized in that: comprise the steps:
Step 1: add in water for injection under stirring by chitosan, continues to be stirred to completely swelling, transparent solution, for subsequent use;
Step 2: physiology salt, xylitol, sodium carbonate are added in step 1 solution, is stirred to and dissolves completely;
Step 3: above-mentioned solution is filtered by titanium rod;
Step 4: by above-mentioned solution by 0.45um water solublity membrane filtration;
Step 5: by above-mentioned solution by 0.22um water solublity membrane filtration;
Step 6: loaded by above-mentioned solution in the spray bottle of ethane via epoxyethane sterilizing, add a cover, sealing, to obtain final product.
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| CN201510751281.9A CN105326786A (en) | 2015-11-09 | 2015-11-09 | Nasal irrigant composition and preparation method thereof |
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| CN201510751281.9A CN105326786A (en) | 2015-11-09 | 2015-11-09 | Nasal irrigant composition and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581148A (en) * | 2017-02-28 | 2017-04-26 | 四川艾医生医疗科技有限公司 | Nasal irrigation care solution |
| CN107802644A (en) * | 2017-11-28 | 2018-03-16 | 安徽徽科生物工程技术有限公司 | Nasal wash and nasal irrigator |
| CN109939069A (en) * | 2019-04-11 | 2019-06-28 | 永仁榄庄生物科技有限公司 | A kind of production method of olive nasal spray |
| CN110507603A (en) * | 2019-09-12 | 2019-11-29 | 沈阳大得医疗器械产品有限公司 | A kind of solidification seawater gel and preparation method thereof |
| CN110876715A (en) * | 2019-11-26 | 2020-03-13 | 杭州飞羊生物科技有限公司 | Nasal cavity flushing fluid |
| CN111714448A (en) * | 2020-07-06 | 2020-09-29 | 上海诺斯清生物科技有限公司 | Preparation method of nasal cavity care solution and application of nasal cavity care solution to nasal cavity care sprayer |
| CN112739324A (en) * | 2018-11-13 | 2021-04-30 | 赛义德·贾卢利 | Brine composition, method for producing same and use thereof |
| CN113694024A (en) * | 2021-08-05 | 2021-11-26 | 广州零界医药有限公司 | Physiological seawater nasal cavity sprayer |
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| CN106581148A (en) * | 2017-02-28 | 2017-04-26 | 四川艾医生医疗科技有限公司 | Nasal irrigation care solution |
| CN107802644A (en) * | 2017-11-28 | 2018-03-16 | 安徽徽科生物工程技术有限公司 | Nasal wash and nasal irrigator |
| CN112739324A (en) * | 2018-11-13 | 2021-04-30 | 赛义德·贾卢利 | Brine composition, method for producing same and use thereof |
| US11878032B2 (en) | 2018-11-13 | 2024-01-23 | Saïd DJELLOULI | Aqueous saline composition, process for the production of same, and use of same |
| CN109939069A (en) * | 2019-04-11 | 2019-06-28 | 永仁榄庄生物科技有限公司 | A kind of production method of olive nasal spray |
| CN110507603A (en) * | 2019-09-12 | 2019-11-29 | 沈阳大得医疗器械产品有限公司 | A kind of solidification seawater gel and preparation method thereof |
| CN110876715A (en) * | 2019-11-26 | 2020-03-13 | 杭州飞羊生物科技有限公司 | Nasal cavity flushing fluid |
| CN111714448A (en) * | 2020-07-06 | 2020-09-29 | 上海诺斯清生物科技有限公司 | Preparation method of nasal cavity care solution and application of nasal cavity care solution to nasal cavity care sprayer |
| CN113694024A (en) * | 2021-08-05 | 2021-11-26 | 广州零界医药有限公司 | Physiological seawater nasal cavity sprayer |
| CN113694024B (en) * | 2021-08-05 | 2022-05-17 | 广州零界医药有限公司 | Physiological seawater nasal cavity sprayer |
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Application publication date: 20160217 |