CN105310917A - Sunscreen anti-allergic aqueous agent - Google Patents
Sunscreen anti-allergic aqueous agent Download PDFInfo
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- CN105310917A CN105310917A CN201410338736.XA CN201410338736A CN105310917A CN 105310917 A CN105310917 A CN 105310917A CN 201410338736 A CN201410338736 A CN 201410338736A CN 105310917 A CN105310917 A CN 105310917A
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Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a sunscreen anti-allergic aqueous agent and applications thereof in cosmetics, and provides a natural plant-origin sunscreen anti-allergic factor. Soybean total flavone and bamboo leaf total flavone can prevent sunburn, free radicals, oxidation, radiation, and bacteria, inhibit bacteria, promote skin cell proliferation, prevent skin damage caused by oxidation, reduce the synthesis of melanin, and delay aging of skin, does not stimulate the skin and mucosa, is non-allergic to skin and mucosa, and can be used in many daily cosmetics such as sunscreen skincare product, anti-wrinkle whitening cream, face washing lotion, shampoo, bath lotion, and the like.
Description
Technical field
The present invention relates to a kind of contact skin cosmetics of everyday use, be specifically related to the agent of a kind of sun-proof antianaphylaxis aqueous, belong to the technical field of daily cosmetics.
Background technology
Along with going deep into of medical research, consumers in general hold more careful attitude to using the cosmetics of synthetics manufacture, and in recent years, Cosmetic Manufacture starts naturalization of raw material, forms world's upsurge of exploitation natural resources.The lifting of the quality of the life come along with economic development; make how slow down aging process becomes the most popular topic; everybody wishes to have health, beautiful, young skin, it is desirable that can not only protect skin and contribute to the skin care item of delay skin aging.Thus, there are the cosmetics developed for alleviating aging sign that get more and more in contemporary skin care product market.
Skin safeguards human life and healthy pith, and direct and extraneous contact is the first barrier of body, is very easily subject to the impact of environmental factors and causes damage.Except the aging action that the age brings, stress, pollution, sunlight and ultraviolet irradiation are all the major reasons causing skin to occur wrinkle or gauffer.
In addition, somebody's skin is easily irritated, and some is that some is the allergy too much caused for ultraviolet radiation because pollen allergic.
Skin aging is mainly manifested in two aspects: 1. skin follows the string formation wrinkle gradually: 2. skin appearance produces the various mottle such as chloasma, senile plaque gradually.According to the free-radical theory of aging, in the process of skin aging, the damage of radical pair skin is a key factor.Reactive oxygen free radical excessive in body and unsaturated fatty acid effect generate the materials such as malonaldehyde (MDA), and the protein etc. on MDA and cell membrane acts on and generates brown pigment, is deposited on skin and just becomes various mottle.Free radical also can make the collagen fiber in skin, elastic fiber interlinkage and degeneration, becomes fragile, follow the string, and when water deficient in skin, easily makes elastic fibers break and forms wrinkle.The renewal metabolism that the profound cause of skin aging also comprises epidermal keratinocytes is slowed down, and dermal fibroblast multiple fission speed reduces.Old people is compared with adolescence, and epiderm skin is thinning, and skin keratin forms cell and fibroblast obviously reduces, and therefore promotes that the propagation of ageing skin cell is one of pursuing a goal of many skin care item.If chemicals can reduce the generation of skin free radical; improve the activity of SOD; to Skin Cell, there is certain proliferation function again; skin histology just can be made to upgrade accelerate, collagen fiber generate and increase, the moisture of protection skin; thus slowing down skin aging " Huang Hansheng; anti-aging skin care item, daily chemical industry collected translation, 1994 (2): 35-38 " effectively
Skin care item industry is unanimously thought, fruitfully nursing skin must be noted that following 2 points: 1. should bring into use moistening skin care item in one's early years; 2. skin must be defendd to be subject to ultraviolet injury.Although alleviating technical elements that skin lines manifests, oneself makes some progress, and the best way remains the appearance delaying wrinkle and the appearance as far as possible reducing wrinkle.The Mausner of Chapel company thinks, the aging of social population and the deterioration of environment will cause the aging of people's skin and be on the rise, and people more and more will need long-acting, efficient modulability and preventative skin care item.ElizabethArden company is thought, the trend of skin care item industry is the future development to Cosmeceuticals (meaning and functional nutrient type cosmetics).
The characteristics of the times of aged tendency of population and the special industry background residing for cosmetics are that the application of the plant extract with physiologically actives such as free radical resisting, antioxidation, radioprotective, antibacterial, antiinflammatories provides wide space.
In addition the chain reaction that brings of bovine spongiform encephalopathy in recent years, animal derived skin-protecting factor very easily causes the psychological probably J of people flurried, therefore growing to the demand of phytochemistry element.The vegetalitas cosmetic products released both at home and abroad divide by the floristics added kind more than 50, and concrete effect can be summarized as the aspects such as wrinkle resistant, whitening, speckle dispelling, antipruritic, moisturizing, fat-reducing.The extract of these natural plants has the features such as side effect is little, curative effect is good, and the cosmetics made both had maintained the characteristic of cosmetics, had again good treatment, health-care effect.
Flavone compound (Flavonoids, hereinafter referred to as flavonoid) is distributed widely in plant kingdom, up to the present, find kind more than 2000, most exist with the form of former times, and minority exists with free state, and its physiological action and biological activity are diversified.Due to the common rumble of its structure, strong absorption is all shown to Uv and visible light, and stablize at visible and ultra-violet (UV) band inner height.The flavonoid of natural origin also has antibacterial, anti-light quick, antioxidation, detoxify and the effect such as to brighten, the free radical in skin can be removed, avoid the damage of radical pair cell, promote the metabolism of skin, improve the elasticity of skin, the generation of delaying skin wrinkle, reduces the calmness of pigment, moist skin, reach significant whitening effect [Wang Jianguo, Liu Haifeng, Wang Jianxin, the research of sunscreen Parsol1789 photolysis inhibition, fragrance flavor and cosmetic, 2002Cl): 17-20].Such as, the canopy skin element be extensively present in vegetable and fruit has free radical resisting, antioxidation, antibacterial, antiviral and antiinflammatory, antianaphylactic biological activity and pharmacological action.Luteolin is to H.Sui: virus has very strong inhibitory action, and concentration can suppress the growth of staphylococcus and bacillus subtilis when 1:35000, also have inhibitory action to bacterium such as mucositis, Candida albicans, distortion; There is antiinflammatory usefulness, can dermatitis be treated with phospholipid compatibility; Penetration on skin is strong, can hyaluronidase inhibitor, with hyaluronic acid with the physiologically active that can extend this material; Can suppress and eliminate skin splash (as senile plaque).With a small amount of luteolin (} 0.0l% in nial polish) fingernail glazed layer can be made to keep smooth.Rutin has antioxygen, antiinflammatory, anti-Stomatovirus effect.Rutin and limonene coordinate with 50:1 has good inhibitory action to active oxygen, powerful can absorb ultraviolet, can be used for sun-proof, brighten, hair care category cosmetics (Wang Jianxin, natural active cosmetic, China Light Industry Press, 1997:214].The soybean isoflavone adding 0.1^'0.2% in whitening type cosmetics can prevent skin aging, melanism and prevention brown patch; In suppurative mastitis, add 2% Absorbable rod ultraviolet and maintain hair gloss.Radix Consolidae in anthocyan have very strong antioxygen and antiinflammatory action, and can suppress the courses of infection that scalp or skin cause because Excess sebum production causes skin void, in astringent, consumption is 1%; The Radix Asteris obtained from Callistephus chinensis is spent to add in astringent can provide good denseness and soft and smooth sense, and have effect [Wang Qiuan of deodorant, convergence, the physiological function of natural flavone compounds and application thereof, fragrance flavor and cosmetic, 1999 (1): 28-33].Flavonoid has wide practical use in medicine, food and cosmetics because of its various active had and nontoxic, harmless safety thereof, and (Huang Xingyu, fourth are recognized entirely, canopy skin element and the function and mechanism of derivant in cosmetics thereof, fragrance flavor and cosmetic, 1998 (3): I7-18].
The Flavonoids extract of current own industrialization development, as Semen sojae atricolor total flavones, tea polyphenols, Semen Vitis viniferae extract, Cortex Pini Massonianae extract, licoflavone, soybean isoflavone, Radix Puerariae isoflavone etc., is manyly applied to cosmetic industry.For example, over nearly 30 years, research is extensively and profoundly carried out to Semen Ginkgo both at home and abroad, develop many patentability medicines, cosmetics and health product [Liu Yan, Chen Jinghua, the applied research of Semen Ginkgo in anti-aging cosmetics, daily chemical industry, 2002,32 (4): 79-81].Ginkgetin is strong reactive oxygen free radical scavenger, Skin Cell can be protected not affect by snperoxiaized, thus extend the life-span of Skin Cell, strengthen its antidotal ability; Extremely also can accelerate metabolism in Semen Ginkgo, improve blood circulation, strengthen cell viability; In addition, Semen sojae atricolor total flavones also has broad-spectrum bactericidal action, all have obvious inhibitory action, and this antibacterial action just can show to common pathogenic bacterium of infecting skin such as staphylococcus aureus, bacillus pyocyaneus and acrothesium floccosums when extremely low concentration.The feature of this high-efficiency antimicrobial, for it as cosmetic functional raw material, is very favourable condition [little remove thousand spring etc., skin preparations for extenal use, Japan: Unexamined Patent 5-70333,1993-03-23].
In China, in toothpaste and shampoo, add the history that tea extract has the more than ten years.Now, Mitsui agricultural company oneself release multiple containing tea polyphenols (tea catechin class). product, for foods and cosmetics [former levy a man of virtue and ability etc., food industry, 1995,38 (2): 71].Flavonoid in tea is flavonol and flavonol mainly, and its major function is antioxidation, anticancer, antimicrobial and deodorization.Catechin belongs to flavanol compound, accounts for 20 ~ 30% of green tea dry weight, and flavonol main in tea comprises canopy skin element, four light base flavone and myricetines, accounts for 2 ~ 3% of tea soluble extract.Antibacterial and the deodorization of catechin has delayed rotten (anti-caries) of tooth, and improve breath freshening degree, therefore, can add in toothpaste, collutory, chewing gum and flavorants, also can be applicable in other article of everyday use, as much shampoo, moisten in cream, perfume and sunscreen and all contain tea extract, it is believed that they can play sedation to skin, and prevent skin to be subject to the attack " Jia Xudong; teas flavonoid function and application thereof; foreign medical science hygiology fascicle, 2001,28 (6): 369-371 " of free radical as antioxidant.
The main component of Radix Puerariae comprises osajin, three examination of mushroom soap class and alkaloids etc., and wherein of greatest concern is the isoflavones components such as puerarin, the general unit of Semen sojae atricolor.Isoflavone like substance in Radix Puerariae can the catalytic activity of remarkable restraint of tyrosinase, interrupts melanocyte oxidizing process, suppresses generation and the formation of melanocyte, thus prevent chloasma, day sunburn isochrome element deposition.So it is that another comes from the skin depigmentation component of green plants that Radix Puerariae is described as by international cosmetic circle, and be used for cosmetics by the Japan of cosmetics lead in the development of science and technology, Japanese Kao company oneself using Radix Puerariae isoflavone as active substance be applied to fair complexion cream " Tang Chunhong, Chen Qi; the research and development present situation of Pueraria lobota alimentary health-care function both at home and abroad; Food Additives Used in China; 2002, (6): 56^58].
Flavonoids of Glycyrrhiza from the oil-soluble extract that licorice is obtained through refining, has inhibit activities to the seat skin ulcer of skin.
The exploitation of its water soluble preparation also obtain successfully, is obtained for proof to the preventive and therapeutic effect of a skin ulcer, acne on human body: the seat skin ulcer (to anti-androgen receptor) that fully recover from an illness skin ulcer and the androgen that cause emerald green ball ketone-5a reductase cause has interception; Also there is preventive and therapeutic effect to the microbial seat skin ulcer of seat skin ulcer, also have interception [Yamamoto is entered, the water soluble preparation of the new raw material information-flavonoids of Glycyrrhiza of cosmetics, 2001, p12-13] to the seat skin ulcer that lipase and phosphorus lipase are reason.
The erythema that other flavonoid can prevent ultraviolet from causing Skin Cell lipid peroxidation as Pericarpium Citri Reticulatae former times and cause and skin carcinoma, this means that it can be used as desirable feedstock [Ou Shiyi, the pharmacological action of Pericarpium Citri Reticulatae battalion, the Chinese crude drug of sun care preparations, 2002,25 (7): 531-533].Containing flavone battalion, Coumarins, organic acid etc. in Sarcandra glabra effective constituent, its extract has been tried out in the products such as shampoo, cleansing milk, bath gel, sunscreen cream and toothpaste by Jiangxi Herba Pileae Scriptae group company " Hu Guoshun; the performance of sarcandra glabra fluid extract and the application in cosmetics; detergents and cosmetic I industry, 2000 (4): 61-64].
The title that China have " bamboo kingdom ", has very abundant bamboo resource and bamboo culture of long standing and well established.Have bamboo class more than 40 to belong to more than 400 within the border to plant, bamboo grove area about 4,000,000 ha.According to incompletely statistics, China has that population more than 100,000,000 is all or part of obtains living expenses from bamboo grove and bamboo grove Product processing.Bamboo plant, as the important component part of the forest reserves, not only has higher economic worth, and has ecological and social benefit widely.Bamboo, with features such as the biology of its uniqueness, ecology and multipurposes, is day by day subject to people's attention, is just playing more and more important effect in Sustainable Development Strategy of China.
China is in the leading level in the world in the research and development of bamboo effective ingredient.Folium Bambosae extract is a kind of plant flavonoids preparation that Zhang Ying equals the exploitation nineties in 20th century, and its patent of invention " a kind of health-care beer (ZL98104563.4) adding bamboo leaf flavone " and " from Folium Bambusae, extracting the production method (ZL98104564.2) of flavonoid compound extract or powder " obtain the mandate of State Patent Office respectively at 2000 and calendar year 2001.Large quantifier elimination shows, Folium Bambosae flavone has excellent free radical resisting, antioxidation, defying age, antibacterial, antiviral and the biological effectiveness such as protection cardiovascular and cerebrovascular vessel, control neurodegenerative disease.
And with the preparation quality of its abundant raw material sources, clear and definite functional factor, compellent safety, efficient stable and pure and fresh fragrant and sweet bamboo local flavor, to show up prominently [Zhang Ying at functional food and Medicines and Health Product field in recent years, natural function additive-Folium Bambosae extract, meticulous and specialty chemicals, 2002,10 (7): 20^22].
The functional factor mainly C mono-sugar battalion flavone of Folium Bambosae extract, compared with four kinds of main Folium Bambusae carbon former times flavone are medicinal herbs general (Orientin) respectively, different squid grass former times (Homoorientin), the general flavone of Herba Viticis Cannabifoliae general (Vitexin) general with different Herba Viticis Cannabifoliae (Isovitexin) o carbon seek flavone with oxygen, there is the outstanding advantages of following several respects: (1) Stability Analysis of Structures, is not easily degraded; (2) can lesions position be goed deep into, directly play curative effect; <3) hydrophilic strengthens, and is conducive to the exploitation of food, medicine, cosmetics.International academic community starts to pay close attention to the general flavone of carbon from the nineties, and this field belongs to up-to-date study frontier.
Japan starts from 20 century 70s to the research and development of bamboo effective ingredient, but a large amount of work mainly concentrate on there is Japan's resource features a class draft type bamboo " claim bamboo grass (English) Bamboograss; i.e. SasaalbomargintaMakino & Shibata etc.) on, relate to Phyllostachys kind on a small quantity.
Up to now, the patent of Japan does not explicitly point out the bamboo effective ingredient relevant to such use with the document of open report is flavone compound.
Summary of the invention
The object of the invention is to, the agent of a kind of sun-proof antianaphylaxis aqueous is provided, to overcome the above-mentioned shortcoming and defect existing for prior art.
The technical problem that will solve required for the present invention, can be achieved through the following technical solutions:
As a first aspect of the present invention, the agent of a kind of sun-proof antianaphylaxis aqueous, is characterized in that, according to weight parts, its formula is:
20 ~ 30 parts, Cera Flava,
15 ~ 20 parts, vaseline,
Lanoline 3 ~ 7 parts,
8 ~ 12 parts, olive oil,
Sorbitol 2 ~ 6 parts,
Hyaluronic acid 1 ~ 3 part,
Total flavones 0.005 ~ 0.05 part,
Vitamin 1 ~ 3 part,
Polyethylene glycol 6000 1 ~ 5 part,
Alcohols 5 ~ 10 parts,
Spice 0.1 ~ 1 part,
20 ~ 50 parts, water.
Preferably formula is:
25 parts, Cera Flava,
15 parts, vaseline,
Lanoline 5 parts,
10 parts, olive oil,
Sorbitol 5 parts,
Hyaluronic acid 2 parts,
Total flavones 0.02 part,
Vitamin 2 parts,
Polyethylene glycol 6000 3 parts,
Alcohols 5 parts,
Spice 1 part,
30 parts, water.
Further, described total flavones is Folium Bambusae total flavones and Semen sojae atricolor total flavones, wherein, and Folium Bambusae total flavones 0.005 ~ 0.03 part and Semen sojae atricolor total flavones 0.005 ~ 0.03 part.
Further, described vitamin is vitamin C and vitamin E, wherein, and vitamin C 1 ~ 2 part, vitamin e1 ~ 2 part.
Further, described spice is 1 part, essence.
Further, described alcohols is propylene glycol or ethanol.
As a second aspect of the present invention, the application of a kind of sun-proof antianaphylaxis aqueous agent, is characterized in that, the agent of described sun-proof antianaphylaxis aqueous is applied in cosmetics as Anti-aging Factor For Skin Protection.
Further, the agent of described sun-proof antianaphylaxis aqueous brightens honey, sunscreen cream, cleansing milk, bath gel, shampoo as crease-resistant.
Beneficial effect of the present invention:
Sun-proof antianaphylaxis aqueous of the present invention agent, provides a kind of sun-proof antianaphylaxis factor of natural botanical source.Semen sojae atricolor total flavones, Folium Bambusae total flavones have sun-proof, free radical resisting, antioxidation, radioprotective, antibacterial, antibacterial, promote skin cell proliferation, prevent the oxidative damage of skin, reduce the beauty functions such as melanin genesis, delay skin aging, and to skin with mucosa is non-stimulated, anaphylactic reaction.
Can application in cosmetics, the multiple daily cosmetics such as such as sun-proof skin care agent, wrinkle resistance, whitening agent, facial milk cleanser, shampoo, bath gel.
Detailed description of the invention
Below in conjunction with specific embodiment, progressive explanation is done to the present invention.Should be understood that following examples only for illustration of the present invention but not for limiting scope of the present invention.
Prepared by embodiment 1
A kind of sun-proof antianaphylaxis aqueous agent, it is characterized in that, according to weight parts, its formula is:
20 ~ 30 parts, Cera Flava,
15 ~ 20 parts, vaseline,
Lanoline 3 ~ 7 parts,
8 ~ 12 parts, olive oil,
Sorbitol 2 ~ 6 parts,
Hyaluronic acid 1 ~ 3 part,
Total flavones 0.005 ~ 0.05 part,
Vitamin 1 ~ 3 part,
Polyethylene glycol 6000 1 ~ 5 part,
Ethanol 5 ~ 10 parts,
Spice 0.1 ~ 1 part,
20 ~ 50 parts, water.
Table 1 formulation weight number
The agent of a kind of sun-proof antianaphylaxis aqueous, be applied in cosmetics as Anti-aging Factor For Skin Protection.Make and crease-resistantly brighten honey, sunscreen cream, cleansing milk, bath gel, shampoo.
Embodiment 2 free radical resisting, radiation resistance
By laboratory facilities such as faint chemiluminescence analysis and fluorophotometric analysiss, O removed by comparative study tea polyphenols, Semen sojae atricolor total flavones and Folium Bambusae total flavones three kind of plant flavonoid
2 -with the activity of OH and to 6 " in Co-Y irradiation and CuS04-Phen-Vc-H10z-DNA system ' protective effect of DNA damage caused by OH.
2.1 raw material
2.1.1 sample source
Tea polyphenols: content 990, lot number 991227, Zhejiang University's agricultural provides with Biotechnology Institute Yang Xianqiang professor.
Semen sojae atricolor total flavones: the general content >24% of total flavones sugar, lot number 20000041, herbal pharmaceutical factory of Ningbo City produces.
Folium Bambusae total flavones: total flavones sugar former times content >-24%, lot number 980625, Zhejiang University's biosystem engineering and Food Science institute professor Zhang Ying provide.
With tri-distilled water, said sample is mixed with respectively the stock solution of lmg/ml, stand-by.
2.1.2 medicine and reagent
Crash the cry of certain animals of calf thymus DNA, secondary Huang, yellow crash cry of certain animals oxidase, luminol, adjacent Féraud beautiful jade (Phen), fluorescent probe (EB) are Sigma Co., USA's product; The medicine of potassium nitrate, copper sulfate, preparation PBS and CBS and reagent etc. are analytical pure; Zymosan suspension is made by oneself from active dry yeast; Uc and hydrogen peroxide solution now with the current.
2.1.3 instrument
RF-5000 type spectrofluorophotometer, Japanese Shimadzu Corporation produces; BPCL-II superweak luminescence instrument, manufactured by Chinese Academy of Sciences's biophysics.
2.2 experimental technique
2.1.1 scavenging capacity oxygen-derived free radicals (O
2 -and OH) ability measure
Adopt Vc-Cu respectively
2+-H
2o
2-zymosan system produces OH, yellow crash cry of certain animals oxidase one Luminol of secondary cry of certain animals one of drifting down the Yellow River produces O
2, suppress with the sample of debita spissitudo scope, superweak luminescence instrument measures luminous value that is blank and test system, calculates suppression ratio, and calculates various sample to OH and O further by equation of linear regression
2503nhibiting concentration (IC
50).
2.1.2 the protective effect of DNA damage is measured
2.1.2.1EB-DNA system fluorescence intensity detection method
In 1ml fluorescence cup, add 25 μ gNDA and μ gEB, then add certain density sample solution, the potassium nitrate solution of insufficient section 10mmol/L is supplied, and carries out the mensuration of fluorescence intensity after leaving standstill l0min.
Test condition is: slit Ex=5nm, Em=5nm, excitation wavelength 520nm, medium scanning speed, sweep limits is 550 ~ 720nm, the fluorescence intensity (near 580.8nm) of emission maximum under mensuration different condition, and calculates the suppression ratio work of sample to fluorescence intensity.
2.1.2.2 superweak luminescence detection method
CuS0 is prepared with 0.lmol/LCBS (pH=10.5)
4-Phen-DNA solution l0ml (adds 10
-2the adjacent Féraud beautiful jade 490,10 of mo1/L
-2the CuS0 of mo1/L
470H1,4 × 10
-4the DNA35.1 of g/L), get above-mentioned solution 858 μ 1, add 10
-2mo1/LVc solution 42H1, obtains the mixed liquor that volume is 900 μ l.Add the sample of variable concentrations in mixed liquor after, supply with CBS and make cumulative volume be 1000 to sleep, insert in light-emitting appearance measuring chamber.Last with the H of 200 μ l3%
2o
2start reaction, record chemiluminescent kinetic curve.
2.1.3 the irradiation damage experiment of anti-DNA
In 5ml finger-type plastic centrifuge tube, add the DNA solution (containing DNAl00 μ g) of 0.4ml, add 0,20,40, the various sample of 80.160 μ g/ml, with distilled water polishing to 2ml.The variable concentrations of each sample all establishes three Duplicate Samples, carries out Y-roentgenization to above-mentioned serial vial.
60the source strength of CO is about 1440000i.Five dosage are established in experiment altogether, and be respectively 0,0.8,2,8,20Gy, but all process all adopting identical close rate, is 0.5Gy/min.Measure by the method in 2.1.1 rapidly in 2.5h after irradiation completes.
2.3 result
2.3.1 O is removed
2 -with the comparison of OH ability
Table 2
Relatively O removed by three kinds of samples
2 -with the ability of OH, closely, tea polyphenols is slightly better than them for Folium Bambusae total flavones and Semen sojae atricolor total flavones, infers relevant with its high-purity (table 2).
2.3.2 to the protective effect of DNA radiation damage
Irradiation can produce direct effect and indirect effect to DNA solution.Direct effect can cause that DNA molecular hydrogen bond destroys, Double helix is untied, base comes off, Single and double strand breakage etc.; The free radical of indirect effect mainly owing to producing during irradiation, especially OH, attacks DNA chain, causes the damage of DNA molecular.Result causes EB and DNA binding site to reduce, and fluorescence intensity level also just reduces.
Tea polyphenols, Semen sojae atricolor total flavones, Folium Bambusae total flavones are in the concentration range of 20 ~ 160 μ g/ml, under different dosage, the equal fluorescence intensity of EB-DNA that can make remains on higher level, illustrates that they have the effect of protection DNA irradiation damage, and display density dependence.Look down upon greatly from the protective effect of three kinds of extracts, tea polyphenols is slightly better than Semen sojae atricolor total flavones and Folium Bambusae total flavones, and the latter two are close.
This luminescence system is deposited in case at tea polyphenols, Semen sojae atricolor total flavones, Folium Bambusae total flavones three kinds of samples, and leading peak, rear peak-to-peak value decline quite obvious, and its 503nhibiting concentration is about 0.2 μ g/ml.Cause the decline of luminescence peak to be the OH etc. starting chain reaction due to antioxidant for clearing, decrease the DNA damage that OH etc. causes, think that flavonoid serves the effect of prevention type antioxidant.Also find out, the time of occurrence of front peak-to-peak value has almost no change, and then peak-to-peak value is delayed simultaneously, and with the increase of antioxidant concentration, after peak value, shift time extends.Think and cause the time delay of postpeak luminescence peak to be because sample removes the Intermediate radical of free chain reaction, chain reaction is interrupted, play the effect of protection DNA radical damage, illustrate that flavonoid has been the antioxidant of chain scission.Work as primary antioxidants and secondary antioxidants while of demonstrating the flavonoidss such as tea polyphenols, Semen sojae atricolor total flavones, Folium Bambusae total flavones [Xu Bing; several Natural antioxidant is to the research of the protective effect of DNA and molecular radiobiology mechanism thereof; Zhejiang University's master thesis, 2001].
Antibacterial, the antiinflammatory action of embodiment 3 total flavones
3.1 experiment raw materials
3.1.1 bacterium source
Enterococcus faecalis (E.faecalis), micrococcus scarlatinae (S.pyogenes), staphylococcus epidermidis (S.epidermidis), proteus vulgaris (P.vulgaris), Klebsiella Pneumoniae (K.pneumoniae), from the clinical Urogenital Specimens of Zhejiang Provincial People's Hospital, are tested in first 3 months separating obtained.Standard strain staphylococcus aureus S.aureus (ATCC25923), escherichia coli E.coli (ATCC25922) are provided by Medical College, Shanghai Communication Univ..
3.1.2 laboratory animal
ICR mice (cleaning grade), body weight 18^}21g, male.
3.1.3 sample
Folium Bambusae total flavones: the general content of total flavones sugar is more than or equal to 50%, Semen sojae atricolor total flavones: be less than or equal to 50%, is cryodesiccated sepia crystalline powder, puts in exsiccator and store, face the used time and prepare with distilled water, ultrasound wave hydrotropy.
3.1.4 medicine and reagent
2% Oleum Tiglii: it is formulated with 2% Oleum Tiglii, 20% dehydrated alcohol, 5% distilled water and 73% ether to face the used time; Indometacin: crude drug, is so kind as to give by Ningbo Medicine Mfg. Factory, faces the used time to hang formulated with lf%CMC-Na rod.
Dimethylbenzene: Hangzhou chemical reagent factory: M-H meat soup, M-H agar are purchased from the military region, Zhejiang Province factory of logistics inspection institute.
The bacteria filters of 0.22 μm is U.S. Milipore Products; Newborn calf serum; Super without mycoplasma, purchased from Sijiqing Bioengineering Material Inst., Hangzhou City.
3.1.5 instrument and equipment
Shell/JB3200 type CO, cultivates phase, U.S. Sheldon Products; DG-3022A type enzyme-linked immunosorbent assay instrument, East China Electronics Co., Ltd pipe factory produces; The biological inverted microscope of COIC type, Chongqing optical instrument factory manufactures; SC mono-type horizontal laminar flow clean work station, Suzhou clean technology institute manufactures; CQ250 ultrasonic cleaner, one seven two six ultrasonic instrument factories of No. 7 Institute of Zhong Chuan head office produce.
3.2 method and result
3.2.1 bacteriostasis
With reference to " Department of Medical Administration of Ministry of Health of the People's Republic of China whole nation Clinical Laboratory rule of operation)) second edition related content carries out.
Micrococcus scarlatinae is undertaken by pharmaceutical liquid dilution method: the calf serum adding 10% amount deactivation in sterilizing M-H meat soup, then adds after sample makes 25mg/ml concentration, through sterilizing large syringe dress bacteria filters aseptic filtration process.Its bacteria-free filtrate dilutes with sterilizing M-H serum free culture system base fluid by 2 times of successives, often pipe 1ml.Each pipe add cultivated through 2 ~ 3.5 hours young age streptococcus pyogenes liquid 0.05ml (total bacteria containing amount is 10
4c.f.u), after putting 35 DEG C of calorstats cultivation 20^-24h, do not occur that the minimum medicament contg pipe of bacterial growth is as its MIC value using it.
Other antibacterials carry out with medicine two-fold dilution method: after the M-H agar of each bottle subpackage, autoclaving being dissolved, be cooled to about 55 DEG C, add not commensurability sample, make it to become 25.0 respectively, 12.5,6.25,3.125,1.56,0.78 and 0.39mg/ml concentration, if the M-H agar of a not dosing is as adding Growth positive contrast ware after bacterium.Then in each ware, 6 kinds (see 3.1.1 bacterium sources) are dripped through (total bacteria containing amount is 10 than the turbid bacterium liquid 0.05ml determining bacteria concentration
4c.f.u), paint little garden speckle (being 4 ~ 6h children bacterium in age) with inoculating loop, cover ware after dry, after putting 35 DEG C of constant temperature culture 16 ~ 20h, do not occur that the minimum sample solution concentration pipe of bacterial growth is as its MIC value using it.
The bacteriostasis minimal inhibitory concentration (MIC value) of table 3 total flavones
Result shows that Folium Bambusae total flavones/Semen sojae atricolor total flavones all has inhibitory action (table 3) in various degree to above-mentioned 7 kinds of antibacterials.
The evaluation test of embodiment 4 cutaneous safety
The Skin Irritation Test result of cosmetics prepared by the present invention is feminine gender, and display is without swashing property of skin irritation.
Test result shows, and the skin wound repair of Folium Bambusae total flavones, Semen sojae atricolor total flavones is feminine gender, shows under external preparation for skin condition, can not produce stimulation to human body skin and mucosa.
Test shows, Folium Bambusae total flavones, Semen sojae atricolor total flavones have good biological action to Skin Cell, can promote that skin keratin forms cell and fibroblastic multiplication capacity, improve SOD active simultaneously, reduce oxidative damage, the active substance that prompting Folium Bambusae total flavones can be used as delay skin aging is applied in cosmetics.Skin whitening efficacy test finds, Folium Bambusae total flavones can reduce the content of melanocyte synthesis melanocyte, points out the white-skinned face function that may have skin.
Be illustrated the specific embodiment of the present invention above, but the present invention is not as limit, only otherwise depart from aim of the present invention, the present invention can also have various change.
Claims (8)
1. a sun-proof antianaphylaxis aqueous agent, is characterized in that, according to weight parts, its formula is:
20 ~ 30 parts, Cera Flava,
15 ~ 20 parts, vaseline,
Lanoline 3 ~ 7 parts,
8 ~ 12 parts, olive oil,
Sorbitol 2 ~ 6 parts,
Hyaluronic acid 1 ~ 3 part,
Total flavones 0.005 ~ 0.05 part,
Vitamin 1 ~ 3 part,
Polyethylene glycol 6000 1 ~ 5 part,
Alcohols 5 ~ 10 parts,
Spice 0.1 ~ 1 part,
20 ~ 50 parts, water.
2. sun-proof antianaphylaxis aqueous according to claim 1 agent, is characterized in that: its formula is:
25 parts, Cera Flava,
15 parts, vaseline,
Lanoline 5 parts,
10 parts, olive oil,
Sorbitol 5 parts,
Hyaluronic acid 2 parts,
Total flavones 0.02 part,
Vitamin 2 parts,
Polyethylene glycol 6000 3 parts,
Alcohols 5 parts,
Spice 1 part,
30 parts, water.
3. sun-proof antianaphylaxis aqueous according to claim 1 agent, is characterized in that: described total flavones is Folium Bambusae total flavones and Semen sojae atricolor total flavones, wherein, and Folium Bambusae total flavones 0.005 ~ 0.03 part and Semen sojae atricolor total flavones 0.005 ~ 0.03 part.
4. sun-proof antianaphylaxis aqueous according to claim 1 agent, is characterized in that: described vitamin is vitamin C and vitamin E, wherein, and vitamin C 1 ~ 2 part, vitamin e1 ~ 2 part.
5. sun-proof antianaphylaxis aqueous according to claim 1 agent, is characterized in that: described spice is 1 part, essence.
6. sun-proof antianaphylaxis aqueous according to claim 1 agent, is characterized in that: described alcohols is propylene glycol or ethanol.
7. an application for sun-proof antianaphylaxis aqueous agent, is characterized in that, the agent of described sun-proof antianaphylaxis aqueous is applied in cosmetics as Anti-aging Factor For Skin Protection.
8. application according to claim 7, is characterized in that, the agent of described sun-proof antianaphylaxis aqueous brightens honey, sunscreen cream, cleansing milk, bath gel, shampoo as crease-resistant.
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| CN201410338736.XA CN105310917A (en) | 2014-07-16 | 2014-07-16 | Sunscreen anti-allergic aqueous agent |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389146A (en) * | 2016-11-16 | 2017-02-15 | 广东石油化工学院 | Exocarpium leaf naringin and rhoifolin sunscreen cream and preparation method thereof |
| CN116807210A (en) * | 2023-04-11 | 2023-09-29 | 瑞年科技(广东)有限公司 | Multifunctional mildew-proof tablecloth |
-
2014
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389146A (en) * | 2016-11-16 | 2017-02-15 | 广东石油化工学院 | Exocarpium leaf naringin and rhoifolin sunscreen cream and preparation method thereof |
| CN116807210A (en) * | 2023-04-11 | 2023-09-29 | 瑞年科技(广东)有限公司 | Multifunctional mildew-proof tablecloth |
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Application publication date: 20160210 |