CN105284875A - Composition containing cyanthoate and purpose - Google Patents

Abstract

The invention belongs to the technical field of pesticide compounding, and particularly relates to a composition containing cyanthoate and a purpose. Effective constituents of the composition are etrimfos and the cyanthoate, wherein the mass ratio of the effective constituents is that etrimfos: cyanthoate is 1-20 to 1. The composition has obvious synergism, reduces production cost and use cost, more importantly, can delay the generation of drug resistance, has remarkable prevention and cure effects, and can prevent and cure multiple diseases.

Description

A kind of composition and purposes containing cyanthoate

Technical field

The invention belongs to the technical field of agriculture chemical compounding, be specially a kind of composition and the purposes that contain cyanthoate.

Background technology

Etrimfos

Another name O, O-dimethyl-O-(6-ethyoxyl-2-ethyl-4-pyrimidine radicals) thiophosphate; Ethoxy Diothyl.

CASNO.38260-54-7。

EINECS253-855-9。

Molecular formula C ₁₀h ₁₇n ₂o ₄pS.

Molecular structural formula:

Molecular weight 292.29.

Flash-point >100 DEG C, sterling is colorless oil liquid, m.p.-3.4 DEG C, relative density 1.195 (20 DEG C), refractive index n20D1.5068, can dissolve each other with acetone, chloroform, methyl alcohol, ethanol, hexanol, dimethyl sulfoxide (DMSO), dimethylbenzene, in water, solvability is 10g/L, 25 DEG C of hydrolysising half-lifes are 0.4d (pH=3), 16d (pH=6), 14d (pH=9).Pyrimethamine sulphur sterling is unstable, but stable in weak solution in non-polar solven.

Efficiently, wide spectrum, non-internal-absorting are tagged and stomach insecticide.Be mainly used in fruit tree, vegetables, rice field, potato, corn, olive and clover preventing and treating coleoptera, Lepidoptera, Semiptera, Corrodentia insect.Effective formulation rate 0.25 ~ 0.75kg/hm ²if be 1 ~ 1.5kg/hm2 with granule control rice borer, lasting period 7 ~ 14d.

The physicochemical property of cyanthoate:

Sterling is weak yellow liquid, slightly has offensive odour; Density d 194 is 1.191; L.4845 index of refraction n25D is.Industrial goods purity is 90%, is orange liquid, has semen armeniacae amarae taste; Density d 204 is 1.200; Index of refraction n25D is 1.4850.Be 70g/L 20 DEG C of solvability in water, slightly soluble in most of organic solvent.

Toxicity:

Acute official ceremonial dress LD50 value rat is 3.2mg/kJ, and mouse and cavy are 13mg/kg; Rat acute through low LD50 (contacting 4 hours) value be 105mg/kg; Feed rat after 3 months with 0.035mgai/kg days, do not find that there is obvious intoxication.

At present, cyanthoate and the composite report of etrimfos is not still had.

Summary of the invention

The object of the present invention is to provide a kind of composition and use thereof had containing cyanthoate, said composition active ingredient is etrimfos and cyanthoate, mass ratio wherein containing active ingredient is, etrimfos: cyanthoate 1-20:1, there is obvious synergistic effect, and reduce production cost and use cost, the more important thing is and can delay the drug-fast generation in key, there is significant control efficiency, can multiple diseases be prevented and treated.

Technical scheme of the present invention is:

A composition containing cyanthoate, active ingredient is etrimfos and cyanthoate.

As preferably, the mass ratio of described active ingredient is, etrimfos: cyanthoate=1-20:1.

As preferably, the mass ratio of described active ingredient is, etrimfos: cyanthoate=8-16:1.

As preferably, described etrimfos and cyanthoate quality in the formulation accounts for 1 ~ 30% of the whole quality of the pharmaceutical preparations.

As preferably, described etrimfos and cyanthoate quality in the formulation accounts for 5 ~ 15% of the whole quality of the pharmaceutical preparations.

Composition containing etrimfos of the present invention, is added in agricultural chemicals the auxiliary element allowing to use, as auxiliary agent and excipients etc., can makes various preparation, comprise suspending agent, water dispersible granules.The preparation method of described formulation is the preparation method of this area routine.

The described auxiliary element used that allows in agricultural chemicals comprises: solvent, emulsifier, antifreeze, defoamer, thickener, dispersant, wetting agent, stabilizing agent, disintegrant, filler.

Described solvent is selected from: solvent naphtha, cyclohexanone, dimethyl formamide, acetone or vegetable oil, N-pyrrolidones, toluene, dimethyl sulfoxide (DMSO), diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, propyl alcohol, turpentine-based vegetable oil code name are ND-45 butanols, ethylene glycol, dimethylbenzene, biodiesel, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, in one or more.

Described emulsifier is selected from: calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, agriculture breast 500 ^#(alkyl benzene calcium sulfonate), alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast 600 ^#(phenyl phenol polyoxyethyl ether), peaceful breast 36 ^#(phenethyl fluosite polyoxyethyl ether), styrylphenol polyoxyethylene ether, ethylene oxide-propylene oxide block copolymer, polyoxyethylene nonylphenol ether, alkylphenol polyoxyethylene sulfosuccinate, castor oil polyoxyethylene ether, Span series (sorbitan monostearate), polyoxyethylene aliphatic alcohol ether, TWEEN Series (sorbitan fatty acid ester APEO), fatty alcohol-polyoxyethylene ether, aliphatic acid polyethenoxy base ester, agriculture breast 400 ^#(benzyl dimethyl phenol polyoxyethyl ether), in one or more.

Described antifreeze is selected from: one or more in propane diols, polyethylene glycol, sorbierite or urea, ethylene glycol, glycerine.

Described defoamer is selected from: one or more in organic silicone oil, isooctanol, polyethers, higher alcohol, mineral oil, vegetable oil, silicone compound, CS-10 aliphatic alcohols compound.

Described thickener is selected from: gum Arabic, bentonite, silicic acid, carboxymethyl cellulose, CMC, carboxyethyl cellulose, one or more in xanthans, Magnesiumaluminumsilicate, cyanethyl cellulose, polyvinyl alcohol.

Described dispersant is selected from: polycarboxylate code name is LG-3, GY-D1252, GY-D1256, SNWGF-01, lignosulfonates code name is 201107, 201108, alkyl benzene sulfonate calcium salt, aliphatic amine polyoxyethylene ether, sodium phosphate trimer, alkyl naphthalene formaldehyde condensation product (NNO), polycarboxylate (2700), diffusion agent N O, diffusant FO, poly-naphthalene formaldehyde sulfonate salt, to methoxyl group fatty acid benzene sulfonic acid sodium salt, alkylphenol polyoxyethylene methyl ether condensate sulfate, alkylphenol polyoxyethylene, polyoxyethylene carboxylate, aliphatic amine polyoxyethylene ether, fatty acid glyceride APEO, sodium methylene bis-naphthalene sulfonate, acrylic copolymer sodium salt, polyoxyethylene polyoxypropylene block copolymer, one or more in naphthalene sulfonic acid-formaldehyde condensation product sodium salt.

Wetting agent described in the present invention is: calcium dodecyl benzene sulfonate, Nekal BX, tea is withered, spaonin powder, silkworm excrement, laruyl alcohol polyvinylether sodium sulphate, sldium lauryl sulfate, Tween 80, penetrant t, moistening bleeding agent F alkylsurfuric acid sodium salt, naphthalene sulfonate, lauryl sodium sulfate, alkyl naphthalene sulfonic acid sodium salt, one or more in alkylaryl polyoxyethylene ether sulfate.

Described stabilizing agent is selected from sodium citrate, the one in resorcinol.

Disintegrant described in the present invention is: bentonite, urea, attapulgite, aluminium chloride, citric acid, succinic acid, one or more in sodium bicarbonate starch, white carbon, anhydrous sodium sulfate, sodium carboxymethyl starch.

Filler of the present invention is: precipitated calcium carbonate, starch, white carbon, the one in diatomite, potter's clay, kaolin, white carbon, attapulgite, talcum powder, bentonite.

Composition containing etrimfos of the present invention, for preventing and treating cabbage caterpillar, prodenia litura, is particularly useful for preventing and treating cabbage caterpillar.

Beneficial effect of the present invention is:

Said composition is complex composition, the mass ratio of active ingredient is, etrimfos: cyanthoate 1-20:1, there is obvious synergistic effect, and reduce production cost and use cost, the more important thing is and can delay the drug-fast generation in key, have significant control efficiency, can multiple diseases be prevented and treated.

Embodiment

Be described in detail technical scheme of the present invention below by specific embodiment, the angle of raw survey and outdoor preventive effect, sets forth the compound synergic of active ingredient of the present invention indoor.

One. indoor biometrics part

Adopt cabbage caterpillar, calculate the co-toxicity coefficient (CTC value) of pharmacy mix according to the abundant method of Sun Yun, if co-toxicity coefficient CTC is greater than 120 for synergistic effect; Co-toxicity coefficient (CTC) is less than 80 for antagonism; Co-toxicity coefficient (CTC) shows as summation action between 80-120.

Concrete outcome is in table 1.

Table 1 different ratio relation is to the toxicity test result of cabbage caterpillar

Process

Co-toxicity coefficient

Etrimfos 1: cyanthoate 1	123.5
		Etrimfos 8: cyanthoate 1	190.2
Etrimfos 12: cyanthoate 1	237.8
		Etrimfos 16: cyanthoate 1	192.5
Etrimfos 20: cyanthoate 1	130.4
		Etrimfos
Cyanthoate

As can be seen from Table 1, co-toxicity coefficient is far longer than 120, has very high synergistic effect, and composite effect is fine, has good biological action, especially etrimfos: during cyanthoate=8-16:1, synergistic effect is more obvious to cabbage caterpillar.

Two. specific embodiment and control in field effect

For the preparation method of the different dosage form in specific embodiment, be the preparation method of this area routine.

Embodiment 1

13% suspending agent

Etrimfos 12%,

Cyanthoate 1%,

Glycerine 3%,

Mineral oil 0.5%,

Carboxymethyl cellulose 1%,

Fatty acid glyceride APEO 5%,

Sodium phosphate trimer 5%,

Surplus is water.

Embodiment 29% suspending agent

Etrimfos 8%,

Cyanthoate 1%,

Glycerine 3%,

Mineral oil 0.5%,

Carboxymethyl cellulose 1%,

Fatty acid glyceride APEO 5%,

Sodium phosphate trimer 5%,

Surplus is water.

Embodiment 38.5% water dispersible granules

Etrimfos 8%,

Cyanthoate 0.5%,

Sodium phosphate trimer 5%,

Calcium dodecyl benzene sulfonate 8%,

Sodium bicarbonate starch 1%,

Surplus is precipitated calcium carbonate.

Embodiment 421% water dispersible granules

Etrimfos 20%,

Cyanthoate 1%,

Sodium phosphate trimer 5%,

Calcium dodecyl benzene sulfonate 8%,

Sodium bicarbonate starch 1%,

Surplus is precipitated calcium carbonate.

Be watered 60 kilograms by every mu of medication amount of formulation and carry out even spraying, for preventing and treating cabbage caterpillar.

Concrete preventive effect the results are shown in Table 2.

Table 2 control efficiency table

As shown in Table 2, composite control efficiency is far away higher than single dose.

Claims (8)

1. the composition containing cyanthoate, active ingredient is etrimfos and cyanthoate.

2. the composition containing cyanthoate according to claim 1, it is characterized in that, the mass ratio of described active ingredient is, etrimfos: cyanthoate=1-20:1.

3. the composition containing cyanthoate according to claim 2, it is characterized in that, the mass ratio of described active ingredient is, etrimfos: cyanthoate=8-16:1.

4. the composition containing cyanthoate according to claim 1, it is characterized in that, described etrimfos and cyanthoate quality in the formulation accounts for 1 ~ 30% of the whole quality of the pharmaceutical preparations.

5. the composition containing cyanthoate according to claim 4, it is characterized in that, described etrimfos and cyanthoate quality in the formulation accounts for 5 ~ 15% of the whole quality of the pharmaceutical preparations.

6. the composition containing cyanthoate according to claim 1, it is characterized in that, the preparation made comprises suspending agent, water dispersible granules.

7. the composition containing cyanthoate according to claim 1 is for preventing and treating the purposes of cabbage caterpillar, prodenia litura.

8. the composition containing cyanthoate according to claim 1 is for preventing and treating the purposes of cabbage caterpillar.