CN105228658A

CN105228658A - A kind of medical dressing hydrogel compound fabric and its preparation method and application

Info

Publication number: CN105228658A
Application number: CN201580000491.2A
Authority: CN
Inventors: 韩晋; 袁海龙; 徐和; 徐平华; 申宝德
Original assignee: 302th Hospital of PLA
Current assignee: 302th Hospital of PLA
Priority date: 2014-01-10
Filing date: 2015-01-08
Publication date: 2016-01-06
Anticipated expiration: 2035-01-08
Also published as: HK1218631A1; CN103736140B; WO2015103988A1; CN103736140A; CN105228658B

Abstract

A kind of medical dressing hydrogel compound fabric and its preparation method and application.Described preparation method comprises, by NIPA and initiator dissolution with solvents, with nitrogen gas foaming; Gossypin carries out initiation reaction in initiator solution; Gossypin after initiation reaction soaks in NIPA and dimethyl formamide mixed solution, and polymerization reaction take place obtains poly-N-isopropyl acrylamide-gossypin under a nitrogen atmosphere; Poly-N-isopropyl acrylamide-gossypin and alginate are dissolved in distilled water, form hydrogel on top layer; Remove solvent, obtain medical dressing hydrogel compound fabric.

Description

A kind of medical dressing hydrogel compound fabric and its preparation method and application

The invention name of the specification: medical dressing hydrogel composite fabric and preparation method and application technical field thereof

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations and preparation methods thereof, and particularly relates to a medicinal dressing hydrogel composite fabric, a preparation method and application thereof, which are mainly used for hemostasis and tissue repair of various acute and chronic wounds.

Background

[0002] Local wounds and bleeding, infection and ulcer caused by the local wounds are common injuries, and improper treatment often causes wound inflammation, suppuration and even infection and ulcer. The traditional method generally adopts sterile gauze and external antibiotic drugs for treatment. The traditional gauze dressing can not keep the wound surface moist, prevent the tissue cells from epithelization and delay the wound surface healing; dressing fibers are easy to fall off, foreign body reaction is caused, and healing is affected; wound granulation tissues are easy to grow into meshes of the dressing to be adhered, and the dressing change time often destroys new epithelium and granulation tissues to cause bleeding, so that the wound healing is not facilitated, and the pain of a patient is difficult to endure; the water absorption is not strong, the hemostatic effect is not good, and pathogens easily permeate gauze to infect wounds; the workload of dressing change is large.

[0003] The hydrogel is a macromolecule with a three-dimensional space structure formed by cross-linking hydrophilic macromolecular compounds among molecules. Because of the peculiar hydrophilic structure of the hydrogel polymer, a large amount of water can be absorbed and retained in the hydrogel structure, and therefore, the hydrogel polymer has good water absorption and retention properties. Since the 1962 s that the british scientist George Winter discovered that a moist environment is beneficial to wound healing, various new dressings such as hydrogel dressings, hydrocolloid dressings, mineral-based dressings, nanotechnology dressings and the like have been widely developed in the past half century. Compared with other dressings, the hydrogel dressing has unique advantages that the hydrogel dressing can prevent excessive loss of moisture and body fluid to achieve the effect of hemostasis; the antibacterial and anti-inflammatory fabric has good permeability to water and oxygen without allowing bacteria to pass through, can resist the invasion of bacteria and inhibit the growth of bacteria, and has antibacterial and anti-inflammatory functions; can be well attached to the wound surface, but can not be adhered to the wound surface so as to avoid secondary damage caused by dressing replacement; the wound healing liquid is moisture permeable and air permeable, enables the wound surface to be in a moist environment without effusion, has good biocompatibility, has the function of promoting wound healing, and is more and more valued by various countries. For example, Yangqing et al (Yang Qing, Wuying, Zhangyuting. a medical chitosan transparent hydrogel wound dressing and preparation and application thereof: 20091004724.5[ P ] 2009-3-13) discloses a medical chitosan transparent hydrogel wound dressing and preparation and application thereof. The preparation method comprises the steps of preparing chitosan slurry, polyvinylpyrrolidone (PVP) solution and sodium polyvinyl acetate solution, mixing, adding an initiator and a cross-linking agent, pouring into a mold, reacting at 40-75 ℃ to obtain a primary product, adding a preservative on the surface of the primary product, drying, cutting and packaging. But the defect of poor mechanical strength exists, and the application time is often fixed, which causes inconvenience.

Technical problem

[0004] Hydrogels can be classified as chemical gels and physical gels depending on the way they are cross-linked. The polymer molecular chains of the chemical gel are linked through covalent bonds, and the physical gel is combined through non-covalent bonds such as hydrogen bonds, ionic effects, hydrophobic effects and the like. The water absorption effect of the hydrogel has close relation with the composition, the type and the link density of the polymer, the environmental temperature, the pH value and the ionic strength. In addition, the particle size of the hydrogel, and the size of the micropores contained therein, also have an effect on the rate of water absorption. Common hydrogels include polyhydroxyethylmethacrylate, polyhydroxypropylacrylate, polypyrrolidone, polyacrylic acid, polyacrylamide, etc.

[0005] The temperature-sensitive intelligent hydrogel based on N-isopropylacrylamide is a typical heat-shrinkable temperature-sensitive hydrogel, swells or shrinks in response to the change of environmental temperature, has the lowest critical solution temperature of about 32 ℃, is close to the surface temperature of a human body, and can be widely used for tissue repair of body surface wounds as a medical dressing. The chitosan has obvious bacteriostatic action and obvious inhibitory action on skin bacteria existing in the epidermis of the general human body, such as staphylococcus aureus, pseudomonas aeruginosa, streptococcus pyogenes and the like. In the same time, the chitosan can promote the regeneration of epithelial cells, accelerate the speed of wound healing and improve the quality of wound healing. Chitosan can be degraded into oligosaccharide, oligosaccharide and even monosaccharide, which is beneficial to accelerating cell proliferation and strengthening tissue remodeling. And the chitosan with different molecular weights has the advantages, the chitosan with large molecular weight has the characteristics of good film forming strength, the chitosan with small molecular weight has the characteristics of high biological activity and good water retention, and the chitosan with large molecular weight and the chitosan with small molecular weight can be used for preparing medical dressings with excellent performance.

[0006] The invention aims to provide a medicinal dressing hydrogel composite fabric which is public and has high safety; compared with other dressings, the hydrogel composite fabric has unique advantages as a medical dressing, and the hydrogel dressing can prevent excessive loss of moisture and body fluid to play a role in hemostasis; the antibacterial and anti-inflammatory fabric has good permeability to water and oxygen without allowing bacteria to pass through, can resist the invasion of bacteria and inhibit the growth of bacteria, and has antibacterial and anti-inflammatory functions; can be well attached to the wound surface, but can not be adhered to the wound surface so as to avoid secondary damage caused by dressing replacement; the wound surface is in a moist environment without effusion, has good biocompatibility and can promote wound healing.

[0007] The second purpose of the invention is to disclose a preparation method of the hydrogel composite fabric for the medical dressing.

[0008] The third purpose of the invention is to disclose the application of the medical dressing hydrogel composite fabric in the preparation of antibacterial, anti-inflammatory and hemostatic medicines; the hydrogel composite fabric is used as dressing, and some common antibacterial, anti-inflammatory and hemostatic medicines, such as butyl flufenamate, matrine or berberine hydrochloride, are used as active ingredients. Solution to the problem

Technical solution

[0009] The purpose of the invention is realized by the following technical scheme:

[0010] a preparation method of a hydrogel composite fabric for a medical dressing comprises the following steps:

[0011] dissolving N-isopropyl acrylamide and an initiator by using a solvent, and foaming by using nitrogen; the initiator is selected from one of ammonium cerium nitrate and ammonium persulfate;

[0012] weighing 200mg of cotton cellulose, and reacting with 10mL of 10-20 mM hair dye solution for 15min;

[0013] 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide as a crosslinking agent were dissolved in 0.1M nitric acid

To obtain a mixed solution of N-isopropyl acrylamide and dimethylformamide;

[0014] soaking the cotton cellulose subjected to the initiation reaction in the step (2) in 5mL of the solution obtained in the step (3) for 30min, spreading the solution on a dry glass disc, and performing polymerization reaction for 48h under the nitrogen condition to obtain poly-N-isopropylacrylamide-cotton cellulose;

[0015] dissolving the prepared poly-N-isopropylacrylamide-cotton cellulose and alginate in distilled water, forming hydrosol on the surface layer, and removing the solvent by using a low-pressure rotary evaporator to obtain the hydrogel composite fabric for the medical dressing.

[0016] The preparation method of the hydrogel composite fabric for the medical dressing comprises the following technical scheme, wherein in the step (1), the volume ratio of N-isopropylacrylamide is 25% -50 < microspheres, and the mass volume ratio of the hair tonic agent I is 2% -5%.

[0017] The preparation method of the hydrogel composite fabric for the medical dressing in the technical scheme comprises the following specific steps of (1): 0.4g of ammonium ceric nitrate, 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide were dissolved in O.lmol nitric acid solution and bubbled with nitrogen.

[0018] The preparation method of the hydrogel composite fabric for the medical dressing in the technical scheme comprises the following specific steps of (1): 0.2g of ammonium persulfate, 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide were dissolved in O.lmol nitric acid solution and bubbled with nitrogen.

[0019] The preparation method of the hydrogel composite fabric for the medical dressing comprises the following step (5), wherein the alginate is sodium alginate or calcium alginate.

[0020] The medical dressing hydrogel composite fabric is prepared by the preparation method in the technical scheme. [0021] The medical dressing hydrogel composite fabric is characterized in that the content of N-isopropylacrylamide in the medical dressing hydrogel composite fabric is 6-30 percent by mass of microspheres.

[0022] The application of the medical dressing hydrogel composite fabric in the preparation of the antibacterial, anti-inflammatory and hemostatic drugs comprises a dressing and an active ingredient, wherein the active ingredient is butyl flufenamate, matrine or berberine hydrochloride, and the dressing is the medical dressing hydrogel composite fabric in the technical scheme.

[0023] The application of the medical dressing hydrogel composite fabric in the technical scheme in the preparation of antibacterial, anti-inflammatory and hemostatic medicines is characterized in that the active ingredients account for 2-5% of the medicines by mass.

Advantageous effects of the invention

Advantageous effects

[0024] The invention has the following beneficial effects:

[0025] the hydrogel composite fabric for the medical dressing adopts natural biodegradable high polymer materials, has certain antibacterial and anti-inflammatory effects and good biocompatibility, and greatly reduces the risk of immunological rejection.

[0026] The medical dressing hydrogel composite fabric is added with medicines, such as flufenamic acid butyl ester, matrine, berberine hydrochloride and the like, so that the hydrogel composite fabric has good functions of resisting bacteria, diminishing inflammation, stopping bleeding and promoting wound healing, and infection in the external environment and the dressing change process is avoided; meanwhile, the hydrogel composite fabric has good water absorption and retention performance, creates a moist environment for wounds, and is beneficial to wound healing and dressing change.

[0027] The hydrogel composite fabric for the medical dressing is a temperature-sensitive intelligent material, and the hydrogel composite fabric swells or shrinks due to the change of the surface temperature of a receptor, so that the medicine can be slowly released, the action period of the medicine is prolonged, the medicine changing frequency is reduced, and the workload is reduced.

[0028] The preparation process of the medical dressing hydrogel composite fabric is simple and feasible, and the used reagents and raw materials are commercially available and can be continuously produced.

Brief description of the drawings

Drawings

[0029] FIG. 1 is a graph of swelling kinetics of a hydrogel composite fabric at 37 ℃;

[0030] FIG. 2 is a pathological section of rat skin (a is a model group, b is a normal group, c is a positive control group, d is a combination drug group of common gauze and drug, e is a group of a hydrogel composite fabric without containing a liquid medicine, f is a hydrogel composite fabric [0031] FIG. 3 is an in-vitro drug release curve of the hydrogel composite fabric.

[0032] In order to facilitate understanding of the technical scheme of the invention, the hydrogel composite fabric for the medical dressing, the preparation method and the application thereof are further described in the following by combining specific test examples.

[0033] Example 1: preparation of the hydrogel composite fabric for the medical dressing:

[0034] 0.4g of ceric ammonium nitrate, 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide are dissolved in o.lmol nitric acid solution and bubbled with nitrogen;

[0035] weighing 200mg of cotton cellulose, initiating reaction for 15min by using 10mL of 20mM cerium ammonium nitrate solution, and removing the redundant cerium ammonium nitrate solution by using a paper towel for suction drying;

[0036] then soaking the cotton cellulose subjected to the initiation reaction in 5mL of mixed solution of N-isopropylacrylamide and dimethylformamide (prepared by dissolving 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide serving as a cross-linking agent in 0.1M nitric acid) for 30 min; spreading cotton cellulose on a dry glass disc, carrying out polymerization reaction on the obtained substrate for 48 hours under the condition of nitrogen, washing the product after complete reaction with water to remove residues on the surface, and drying the obtained clean sample at 80 ℃ under vacuum; wherein the operation principle of washing with water to remove the residue on the surface is that the residue embedded in the hydrogel needs to be removed repeatedly in three swelling and deswelling cycles, and the aqueous solution is replaced each time; each cycle comprises soaking in an aqueous solution at 45 ℃ for 2h and soaking at room temperature for 2h, i.e. above or below the minimum critical solution temperature (LCST) of N-isopropylacrylamide;

[0037] dissolving the prepared poly-N-isopropylacrylamide-cotton cellulose and a small amount of calcium alginate in distilled water to form hydrosol on the surface layer, and removing the solvent by using a low-pressure rotary evaporator to obtain the medical dressing hydrogel composite fabric. The calcium alginate in the step has the function of providing ion pairs for the mesh aperture formed by hydrogel crosslinking, and the effect can be promoted by a small amount without limitation of the amount.

[0038] Example 2: preparation of the hydrogel composite fabric for the medical dressing:

[0039] 0.4g of ceric ammonium nitrate, 25mL of N-isopropylacrylamide and 1.6g of dimethylformamide are dissolved in o.lmol nitric acid solution and bubbled with nitrogen;

[0040] weighing 200mg of cotton cellulose, initiating reaction for 15min by using 10mL of 20mM cerium ammonium nitrate solution, and removing the redundant cerium ammonium nitrate solution by using a paper towel to suck;

[0041] then soaking the cotton cellulose subjected to the initiation reaction in 5mL of mixed solution of N-isopropylacrylamide and dimethylformamide (prepared by dissolving 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide serving as a cross-linking agent in 0.1M nitric acid) for 30 min; spreading cotton cellulose on a dry glass plate; carrying out polymerization reaction on the obtained substrate for 48h under the nitrogen condition, washing the product after complete reaction with water to remove residues on the surface, and drying the obtained clean sample at 80 ℃ under vacuum; wherein the operation principle of washing with water to remove the residue on the surface is that the residue embedded in the hydrogel needs to be removed repeatedly in three swelling and deswelling cycles, and the aqueous solution is replaced each time; each cycle comprises soaking in 45 deg.C water solution for 2h and soaking at room temperature for 2h

h, i.e. at a temperature above or below the minimum critical solution temperature (LCST) of N-isopropylacrylamide;

[0042] dissolving the prepared poly-N-isopropylacrylamide-cotton cellulose and a small amount of calcium alginate in proper water to form hydrosol on the surface layer, and removing the solvent by using a low-pressure rotary evaporator to obtain the hydrogel composite fabric for the medical dressing. The calcium alginate in the step has the function of providing ion pairs for the mesh pore size formed by hydrogel crosslinking, and the effect can be promoted by a small amount without limitation of the amount.

[0043] Example 3: preparation of the hydrogel composite fabric for the medical dressing:

[0044] 0.2g ammonium persulfate, 25mL N-isopropylacrylamide and 1.2g dimethylformamide were dissolved in O.lmol nitric acid solution and bubbled with nitrogen;

[0045] weighing 200mg of cotton cellulose, initiating reaction for 15min by using 10mL of 20mM cerium ammonium nitrate solution, and removing the redundant cerium ammonium nitrate solution by using a paper towel for suction drying;

[0046] then soaking the cotton cellulose subjected to the initiation reaction in 5mL of mixed solution of N-isopropylacrylamide and dimethylformamide (prepared by dissolving 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide serving as a cross-linking agent in 0.1M nitric acid) for 30 min; spreading cotton cellulose on a dry glass disc, carrying out polymerization reaction on the obtained substrate for 48 hours under the condition of nitrogen, washing the product after complete reaction with water to remove residues on the surface, and drying the obtained clean sample at 80 ℃ under vacuum; the operating principle in which the surface is cleaned with water to remove residues is that the residues embedded in the hydrogel need to be removed repeatedly in three swelling, deswelling cycles, each time the aqueous solution is replaced. Each cycle comprises soaking in 45 deg.C water solution for 2h and soaking at room temperature for 2h

[0047] dissolving the prepared poly-N-isopropylacrylamide-cotton cellulose and a small amount of sodium alginate in proper water to form hydrosol on the surface layer, and removing the solvent by using a low-pressure rotary evaporator to obtain the medical dressing hydrogel composite fabric. The calcium alginate in the step has the function of providing ion pairs for the mesh pore size formed by hydrogel crosslinking, and the effect can be promoted by a small amount without limitation of the amount.

[0048] Example 4: preparation of the hydrogel composite fabric for the medical dressing:

[0049] dissolving 0.2g of ammonium persulfate, 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide in an O.lmol nitric acid solution, and foaming with nitrogen;

[0050] weighing 200mg of cotton cellulose, initiating reaction for 15min by using 10mL of 20mM cerium ammonium nitrate solution, and removing the redundant cerium ammonium nitrate solution by using a paper towel for suction drying;

[0051] then soaking the cotton cellulose subjected to the initiation reaction in 5mL of mixed solution of N-isopropylacrylamide and dimethylformamide (prepared by dissolving 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide serving as a cross-linking agent in 0.1M nitric acid) for 30 min; spreading cotton cellulose on a dry glass disc, carrying out polymerization reaction on the obtained substrate for 48 hours under the condition of nitrogen, washing the product after complete reaction with water to remove residues on the surface, and drying the obtained clean sample at 80 ℃ under vacuum; the operating principle in which the surface is cleaned with water to remove residues is that residues embedded in the hydrogel need to be removed repeatedly in three swelling, deswelling cycles, each time the aqueous solution is replaced. Each cycle comprises soaking in 45 ℃ aqueous solution for 2h and soaking at room temperature for 2h, namely at the Lowest Critical Solution Temperature (LCST) condition higher or lower than that of N-isopropylacrylamide;

[0052] dissolving the prepared poly-N-isopropylacrylamide-cotton cellulose and a small amount of calcium alginate in proper water to form hydrosol on the surface layer, and removing the solvent by using a low-pressure rotary evaporator to obtain the hydrogel composite fabric for the medical dressing. The calcium alginate in the step has the function of providing ion pairs for the mesh pore size formed by hydrogel crosslinking, and the effect can be promoted by a small amount without limitation of the amount.

[0053] Example S: hydrogel composite fabric containing flufenamic acid butyl ester:

[0054] the hydrogel composite fabrics prepared in examples 1-4 were swollen and saturated with the flufenamic acid butyl ester solution at 25 ℃, dried, stored in a sealed condition, and stored at low temperature.

[0055] Example 6: hydrogel composite fabric containing berberine hydrochloride:

[0056] the hydrogel prepared in the example 1-4 is swelled and saturated by berberine hydrochloride-containing nano-emulsion solution at 25 ℃, dried, sealed and stored, and stored at low temperature.

[0057] Solid brain I Ί: the matrine-containing hydrogel composite fabric comprises the following components:

[0058] swelling the hydrogel obtained in examples 1-4 with matrine-containing solution at 25 deg.C, and drying

Sealing and storing at low temperature.

[0059] The performance of the medicinal dressing hydrogel composite fabric of the present invention was further verified by testing the prepared hydrogel composite fabric as follows:

[0060]1, balance swelling degree:

[0061]and (3) testing conditions are as follows: 37 ℃ and degree of swelling = (W)_t-W。)/W。[0062]W_tThe hydrogel composite fabric reached a weight, W, of swollen equilibrium inches. Dry hydrogel composite fabrics

[0063] According to the pandhun, classical, lonqingde, et al, swelling and drug release properties of NIPAAm-based copolymerized temperature-sensitive gel [ J ]. proceedings of the university of south and middle (nature science edition), 2007, 38 (5): 906-911. the test method in the above test conditions, the swelling dynamic performance of the hydrogel composite fabric of the medical dressing prepared in example 1 is shown in fig. 1, the hydrogel composite fabric rapidly reaches the swelling state within 5 minutes, the swelling balance among long inches is maintained, and the water absorption and retention performance is good.

[0064] The results of the tests of examples 2-4 were the same as those of example 1.

[0065] The beneficial effects of the hydrogel composite fabric prepared by the invention are further illustrated by pharmacodynamic tests and in-vitro drug release characteristics of the hydrogel composite fabric prepared by the invention as follows:

[0066] trial riding example one: in vitro antibacterial anti-inflammatory activity assay:

[0067]30 SD rats are randomly divided into 6 groups, namely a model group, a normal group, a positive control group, a medicine group combining common gauze and medicines, a compound fabric group without liquid medicine gel and a berberine hydrogel containing hydrochloric acid (prepared in example 6), under general anesthesia, the backs of the rats are depilated, the depilated areas are cleaned by normal saline, an incision with the length of about 2 cm and the thickness of the whole layer is drawn by a scalpel, the normal group only carries out depilatory treatment, the incision parts of the other 5 groups except the normal group are inoculated with bacterial liquid with staphylococcus aureus, wound infection appears after 24 hours, the other four groups except the model group are respectively given Kaltostat calcium alginate fibers (the positive control group), the common gauze and berberine powder (the medicine group combining group), the compound fabric without liquid medicine gel and the medicine-containing hydrogel are fixedly protected by adhesive tapes after administration, the medicines are replaced every 3 days, animals are killed after one week, wound skin tissues are taken out, after 10% of formaldehyde is fixed for 24 hours, dehydration and embedded into 4 mu of paraffin, η, and the skin tissues of the HE are observed under an electron microscope to generate inflammatory cell staining condition.

[0068] As a result, as shown in FIG. 2, it was found that the drug-containing hydrogel composite fabric was effective in treating nonspecific inflammatory reactions on the body surface and significantly inhibiting infection by pathogenic microorganisms introduced during dressing change, wherein a was a model group, b was a normal group, c was a positive control group, d was a combination of ordinary gauze and drugs, e was a gel composite fabric group containing no liquid drug, and f was a drug-containing hydrogel composite fabric group)

[0069] Test a broken-down nag case two: in-vitro drug release experiment of the hydrogel composite fabric:

[0070] dynamic dialysis was used to determine the preparation and properties of matrine albumin microspheres [ J ] in China journal of pharmaceutical industry 2006, 37 (12): 824; Chenyongshun, Chenli. preparation of Silibinin gelatin microspheres and in vitro drug delivery [ J ] in China journal of Experimental formulae 2011,17(24): 23.) the degree of in vitro release of Berberine hydrogel composite fabrics. Taking 3 parts of berberine hydrogel composite fabric in parallel, respectively filling into treated dialysis bags, fastening two ends, and fixing on a stirring paddle of a dissolution instrument. 250 mL of physiological saline is used as a release medium, and an in vitro drug release experiment is carried out under the conditions that the temperature is 32 +/-0.5 ℃ and the rotating speed is lOO r.min-i. 1 mL of release medium was removed in 0, 1, 2, 4, 8, 12, 24, 48, 72 hours, and the same volume of fresh release medium was added in inches.

[0071] The result is shown in figure 3, the hydrogel composite fabric releases 46.52% of drug in 24 h, and the result shows that the hydrogel composite fabric carrier has a certain slow release effect.

[0072] While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims; in other words, all changes, modifications and variations that are equivalent to the above embodiments according to the spirit and techniques of the present invention are within the scope of the present invention.

Claims

The preparation method of the hydrogel composite fabric as the medicinal dressing according to claim 1, wherein the alginate in the step (5) is sodium alginate or calcium alginate. [ claim 11] A hydrogel composite fabric for medical dressing, which is characterized in that: the medical dressing hydrogel composite fabric is prepared by the preparation method of claims 1-5.
[ claim 12] the hydrogel composite fabric for medical dressing according to claim 6, wherein the hydrogel composite fabric is formed by laminating a plurality of layers of the hydrogel composite fabric

: the content of the N-isopropylacrylamide in the medicinal dressing hydrogel composite fabric is microspheres with the mass percent of 6< microspheres with the mass percent of 30< microspheres.
[ claim 13] use of a medical dressing hydrogel composite fabric for the preparation of an antibacterial, anti-inflammatory and hemostatic drug consisting of a dressing and an active ingredient, characterized in that: the active component is butyl flufenamate, matrine or berberine hydrochloride, and the dressing is the hydrogel composite fabric of the medical dressing of claim 6 or 7.
[ claim 14] use of the hydrogel composite fabric for medical dressing according to claim 8 for preparing antibacterial, anti-inflammatory and hemostatic drugs, wherein: the microspheres comprise 2 to 5 microspheres of active ingredients in percentage by mass of the drug.