CN104739478B - Spring coil and production method thereof - Google Patents
Spring coil and production method thereof Download PDFInfo
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- CN104739478B CN104739478B CN201310751427.0A CN201310751427A CN104739478B CN 104739478 B CN104739478 B CN 104739478B CN 201310751427 A CN201310751427 A CN 201310751427A CN 104739478 B CN104739478 B CN 104739478B
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- coiling
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- 238000004519 manufacturing process Methods 0.000 title abstract description 4
- 239000000463 material Substances 0.000 claims abstract description 38
- 230000015556 catabolic process Effects 0.000 claims abstract description 22
- 238000006731 degradation reaction Methods 0.000 claims abstract description 22
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 14
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 11
- 239000004626 polylactic acid Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 229920000954 Polyglycolide Polymers 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 239000004633 polyglycolic acid Substances 0.000 claims description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 5
- 229910052737 gold Inorganic materials 0.000 claims description 5
- 239000010931 gold Substances 0.000 claims description 5
- 229910001260 Pt alloy Inorganic materials 0.000 claims description 4
- 229910001080 W alloy Inorganic materials 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 3
- 229910045601 alloy Inorganic materials 0.000 claims description 3
- 239000000956 alloy Substances 0.000 claims description 3
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- 229960004275 glycolic acid Drugs 0.000 claims description 2
- 229910052702 rhenium Inorganic materials 0.000 claims description 2
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 claims description 2
- 229910052709 silver Inorganic materials 0.000 claims description 2
- 239000004332 silver Substances 0.000 claims description 2
- 229910052715 tantalum Inorganic materials 0.000 claims description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 2
- 229910052721 tungsten Inorganic materials 0.000 claims description 2
- 239000010937 tungsten Substances 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 abstract description 15
- 229910052751 metal Inorganic materials 0.000 abstract description 8
- 239000002184 metal Substances 0.000 abstract description 8
- 239000012620 biological material Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 9
- 208000007536 Thrombosis Diseases 0.000 description 6
- 201000008450 Intracranial aneurysm Diseases 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 208000005189 Embolism Diseases 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000010102 embolization Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 206010068052 Mosaicism Diseases 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
- 108010007568 Protamines Proteins 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229950008679 protamine sulfate Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000003765 sex chromosome Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to the field of medical instruments, in particular to a spring coil and a production method thereof. The spring coil comprises a first coil body and a second coil body, the second coil body is wound on the outer side face of the first coil body, one of the coil bodies is made of degradable materials while the other coil body is made of radiopaque materials, and the volume of the coil body made of the degradable materials accounts for 75-95% of that of the spring coil. The spring coil made of metal and the degradable materials is capable of accelerating fibrosis of thrombi in arterial aneurysm after being implanted, and along with degradation of biological materials, in-aneurysm fibrous tissues shrink continuously to enable the arterial aneurysm to shrink continuously, so that mass effect of the spring coil is reduced.
Description
Technical field
The present invention relates to medical instruments field.Specifically, the present invention relates to a kind of turn and preparation method thereof.
Background technology
Cerebral aneurysm or intracranial aneurysm, drastically influence the health of people.Progress and Ink vessel transfusing with image technology
The development of biomaterial, intravascular Interventional Treatment is lower than the risk of surgical operation therapy because of it, replaces surgical aneurysm to press from both sides
Closing operation becomes the prefered method for the treatment of intracranial aneurysm.
The method of PCI intracranial aneurysm is a lot, mainly there is the close net support of reconstructing blood vessel carried out on parent artery
Embolization in art and aneurysm cavity.And embolism turn is to treat aneurysmal main method at present in aneurysm cavity.Mesh
The turn of front aneurysm embolization is broadly divided into two kinds：One kind be bare metal turn, the such as GDC of Boston Scientific
The MicroPlex turns of turn and Microvention；Another kind is bio-modification turn, such as Codman companies
The Matrix of Cerecyte turns, the Hydrogel hydrogels turn of Microvention and Boston Scientific
Turn.
Chinese patent application No.CN201120007508.6 discloses a kind of embolism spring that can quickly produce thrombus
Circle product.This turn surface causes thrombus medicine with quick, and such as protamine sulfate, the control release of medicine is to pass through
What carrier was realized, carrier is a kind of degradable medical macromolecular material.Can quickly produce after this turn implantation aneurysm
Thrombus, by the complete embolism of aneurysm, and catabolite (oligomer) of the biodegradable carrier in human body can promote thrombus to turn
Cellular tissue parenchyma is turned to, can accelerate aneurysmal to heal completely.
United States Patent (USP) No.US8,388,643B2 discloses biologically absorbable polymer implant and produces embolism using it
Method.Specifically, the patent is that a kind of novel embolizing agent (biologically absorbable polymer material) is mixed into the de- bullet of electrolysis
In spring coil (GDC), so as to improve intravascular Interventional Treatment intracranial aneurysm in long-term treatment effects.
Although current turn is greatly improved at aspects such as raising filling consistency, reduction aneurysm recurrence rates,
But occupation time process of the turn in knurl chamber can not be solved always.
The content of the invention
Present invention seek to address that the problems such as long-term safety and occupation time process after existing turn implantation human body, and for this
A kind of turn and preparation method thereof is provided.
The present invention relates to a kind of turn, it is characterised in that including first coil and the second coil, second coil around
In the lateral surface of the first coil, one of which coil is degradation material, and another kind of coil is radiopaque material,
It is 75%～95% that the volume of the degradation material accounts for the percentage of the turn volume.
The first coil is by diameter D1For 0.00001 inch～0.008 inch, preferably 0.0008 inch～0.004
The silk chain of inch is made.
Second coil is by diameter D2For 0.00001 inch～0.008 inch, preferably 0.0008 inch～0.002
The silk chain of inch is made.
The degradation material is selected from PLA (PLA), polyglycolic acid (PGA), PLLA (PLLA), poly- hydroxyl
Acetic acid/copolymer of poly lactic acid (PLGA), polylcaprolactone (PCL) etc., preferably polyglycolic acid/copolymer of poly lactic acid
(PLGA)。
Radiopaque material includes the alloy of one or more in platinum group metal, rhenium, tungsten, tantalum, gold or silver.Institute
State radiopaque material and be preferably platinum/tungsten alloy.These metals have a significant radiopacity, and by adjust alloy into
Divide to reach appropriate elasticity and rigidity.
The degradation time of the turn is 2～4 months, preferably 3 months.
The invention further relates to a kind of preparation method of turn, it is characterised in that comprise the following steps：
First chain and second chain are provided, one of which silk chain is degradation material, and another kind of silk chain is radiopaque
Material, and the volume of the degradation material account for the turn volume percentage be 75%～95%；
First chain is wound on plug and makes first coil；
Second chain is wound on into first coil outside and makes the second coil；And
Heat treatment will be carried out on mould according to pre-set shape around the first coil for making and the second coil.
According to the present invention, the coiling direction of the radiopaque material is in opposite direction with the coiling of the degradation material.
By the way of oppositely wound, the first coil in manufacturing process can be avoided mutually embedding with the second coil, make manufacture craft more suitable
Freely.
According to the present invention, the spacing of the radiopaque material coiling is more than the spacing of the degradation material coiling.
" around the controlling angle " of the present invention is defined as the silk chain of the first or second coil and the axial direction of metal mandrel is formed
Angle.
The turn of the present invention is made up of metal and degradable high polymer material, and thrombus in aneurysm can be accelerated after implantation
Fibrillatable, and with the degraded of biomaterial, fibr tissue constantly shrinks in knurl makes aneurysm constantly reduce, so as to mitigate spring
The occupation time process of circle, higher degradation material percent by volume, for solution occupation time process and long-term safety sex chromosome mosaicism bring
More significant effect.
Description of the drawings
Fig. 1-4 is the longitudinal cross-section view of various embodiments of the invention turn；
Fig. 5 is the degraded schematic diagram after turn implantation aneurysm；And
Fig. 6 is that turn is implanted into aneurysmal therapeutic effect schematic diagram.
Specific embodiment
For a further understanding of the present invention, the preferred version of the present invention is described below in conjunction with embodiment.These
Description is merely illustrative the feature and advantage of turn of the present invention and preparation method thereof, and the protection model of the unrestricted present invention
Enclose.
Embodiment 1
Second coil is wound on the outside of first coil, as shown in Figure 1.Second coil by degradation material polyglycolic acid/
Copolymer of poly lactic acid (PLGA) is constituted, and the diameter of silk chain is 0.003 "（Inch）；First coil adopts good biocompatibility, can show
Shadow platinum/tungsten alloy filament 0.001 ".It is 83.3% that second winding volume accounts for the percentage of whole turn volume.
Preparation method is：(1) coiling first on metal mandrel in a diameter of 0.0001 "～0.1 ", preferably 0.005 "
Coil, the tight coiling of coil, spacing is 0.001 ", it is 85 ° around controlling angle；(2) oppositely wound second line on the outside of first coil
Circle, the tight coiling of coil, spacing is 0.003 ", it is 85 ° around controlling angle；(3) by around the first coil for making and the second coil by
Heat treatment is carried out on mould according to pre-set shape；(4) biomaterial starts drop after the turn implantation aneurysm
Solution, as shown in figure 5, the time of degraded is 3 months；(5) fibrillatable of thrombus in artery knurl is implanted into, and with biomaterial
Degraded, the contraction of fibr tissue in knurl can also reduce aneurysm, and mitigate the occupation time process of turn, as shown in Figure 6.
Embodiment 2
Second coil is wound on the outside of first coil, as shown in Figure 2.First coil is by degradation material PLA (PLA)
Composition, the diameter of silk chain is 0.004 "；Second coil using good biocompatibility, the spun gold that can develop, spun gold it is a diameter of
0.0008″.It is 75% that the first coil volume accounts for the percentage of whole turn volume.Preparation method is：(1) a diameter of
0.003 " coiling first coil on metal mandrel, the tight coiling of coil, spacing is 0.004 ", it is 75 ° around controlling angle；(2) exist
Oppositely wound second coil on the outside of first coil, the tight coiling of coil, spacing is 0.0008 ", it is 75 ° around controlling angle；(3) will be around
The first coil and the second coil for making carries out heat treatment according to pre-set shape on mould.
Embodiment 3
Second coil is wound on the outside of first coil.Second winding volume accounts for the percentage of whole turn volume
95%.Wherein (1) inner coil is first coil, using the platinum wire of good biocompatibility, from a diameter of of platinum wire
0.002 ", the sparse coiling of coil, spacing is 0.01 ", it is 90 ° around controlling angle；(2) outer coil is the second coil, and employing can drop
Solution material polyglycolic acid/copolymer of poly lactic acid (PLGA) silk, the diameter of degradation material silk chain is 0.0008 ", coil is tight
Coiling, spacing is 0.0008 ", it is 60 ° around controlling angle, as shown in Figure 3.
Embodiment 4
Second coil is wound on the outside of first coil.Wherein (1) inner coil is first coil, poly- using degradation material
Hydroxyacetic acid/copolymer of poly lactic acid (PLGA) silk, the diameter of degradation material silk chain is 0.008 ", the tight coiling of coil, spacing
For 0.008 ", it is 90 ° around controlling angle；(2) outer coil is the second coil, using the platinum/tungsten alloy filament of good biocompatibility, choosing
With a diameter of the 0.0001 of platinum wire ", the sparse coiling of coil, spacing is 0.002 ", it is 60 ° around controlling angle, as shown in Figure 4.
The explanation of above example is only intended to the core concept for helping understand the present invention.It should be pointed out that for this area
Those of ordinary skill for, under the premise without departing from the principles of the invention, can also to the present invention turn and its preparation
Method carries out some improvement and modification, but these are improved and modification is also fallen in the range of the claims in the present invention are claimed.
Claims (11)
1. a kind of turn, including first coil and the second coil, it is characterised in that second coil is wound on the First Line
The lateral surface of circle, one of which coil is degradation material, and another kind of coil is radiopaque material, the degradation material
It is 75%～95% that volume accounts for the percentage of the turn volume.
2. turn as claimed in claim 1, it is characterised in that the first coil is by diameter D1For 0.00001 inch～
0.008 inch of silk chain is made.
3. turn as claimed in claim 2, it is characterised in that the first coil by diameter D1 be 0.0008 inch～
0.004 inch of silk chain is made.
4. turn as claimed in claim 1, it is characterised in that second coil is by diameter D2For 0.00001 inch～
0.008 inch of silk chain is made.
5. turn as claimed in claim 4, it is characterised in that second coil by diameter D2 be 0.0008 inch～
0.002 inch of silk chain is made.
6. the turn as described in any one of claim 1-5, it is characterised in that the degradation material is selected from PLA, poly-
Hydroxyacetic acid, PLLA, polyglycolic acid/copolymer of poly lactic acid or polylcaprolactone.
7. the turn as described in any one of claim 1-5, it is characterised in that radiopaque material is selected from platinum family gold
The alloy of one or more in category, rhenium, tungsten, tantalum, gold or silver.
8. turn as claimed in claim 7, it is characterised in that radiopaque material is platinum/tungsten alloy.
9. the preparation method of the turn as any one of claim 1-8, it is characterised in that comprise the following steps：
First chain and second chain are provided, one of which silk chain is degradation material, and another kind of silk chain is radiopaque material,
And the volume of the degradation material account for the turn volume percentage be 75%～95%,
First chain is wound on plug and makes first coil,
Second chain is wound on into first coil outside and makes the second coil,
And
Heat treatment will be carried out on mould according to pre-set shape around the first coil for making and the second coil.
10. preparation method as claimed in claim 9, it is characterised in that the coiling direction of the radiopaque material with it is described
The coiling of degradation material is in opposite direction.
11. preparation methods as claimed in claim 9, it is characterised in that the spacing of the radiopaque material coiling is more than institute
State the spacing of degradation material coiling.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310751427.0A CN104739478B (en) | 2013-12-31 | 2013-12-31 | Spring coil and production method thereof |
| PCT/CN2014/095745 WO2015101308A1 (en) | 2013-12-31 | 2014-12-31 | Spring coil and manufacturing method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310751427.0A CN104739478B (en) | 2013-12-31 | 2013-12-31 | Spring coil and production method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104739478A CN104739478A (en) | 2015-07-01 |
| CN104739478B true CN104739478B (en) | 2017-05-10 |
Family
ID=53493254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310751427.0A Active CN104739478B (en) | 2013-12-31 | 2013-12-31 | Spring coil and production method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104739478B (en) |
| WO (1) | WO2015101308A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109009308A (en) * | 2018-06-22 | 2018-12-18 | 威海维心医疗设备有限公司 | Substance and preparation method thereof is shunk for aneurysmal degradable embolism |
| CN110141294B (en) * | 2019-06-28 | 2025-07-18 | 微创神通医疗科技（上海）有限公司 | Medical spring ring |
| CN110179516B (en) * | 2019-06-28 | 2024-03-15 | 微创神通医疗科技（上海）有限公司 | Medical spring ring and manufacturing method and using method thereof |
| CN112274204B (en) * | 2020-06-12 | 2022-07-19 | 微创神通医疗科技（上海）有限公司 | Medical spring ring |
| CN112617949B (en) * | 2020-12-31 | 2022-04-15 | 神遁医疗科技(上海)有限公司 | Spring ring and preparation method thereof |
| CN112754583B (en) * | 2020-12-31 | 2022-04-15 | 微创神通医疗科技（上海）有限公司 | Spring ring and preparation method thereof |
| CN113303859B (en) * | 2020-12-31 | 2023-06-30 | 神遁医疗科技(上海)有限公司 | Embolic material and preparation method thereof |
| CN112656476A (en) * | 2020-12-31 | 2021-04-16 | 微创神通医疗科技（上海）有限公司 | Embolism material and preparation method thereof |
| CN113288307B (en) * | 2021-05-31 | 2025-09-12 | 微创神通医疗科技（上海）有限公司 | Medical implant and method for preparing the same |
| CN116672017A (en) * | 2022-02-23 | 2023-09-01 | 神遁医疗科技(上海)有限公司 | Embolization device |
| CN114886496B (en) * | 2022-04-19 | 2024-10-29 | 江苏畅医达医疗科技有限公司 | Quick electrolytic stripping and conveying device and application method thereof |
| CN115054307B (en) * | 2022-06-30 | 2024-08-23 | 上海微创医疗器械（集团）有限公司 | Occlusion implant and method for the production thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6723112B2 (en) * | 1998-11-10 | 2004-04-20 | Scimed Life Systems, Inc. | Bioactive three loop coil |
| US6585754B2 (en) * | 2001-05-29 | 2003-07-01 | Scimed Life Systems, Inc. | Absorbable implantable vaso-occlusive member |
| AU2007309715A1 (en) * | 2006-03-24 | 2008-05-02 | Biomerix Corp | Self-expandable endovascular device for aneurysm occlusion |
| US8702746B2 (en) * | 2008-04-29 | 2014-04-22 | Cook Medical Technologies Llc | Device and method for occlusion of fluid flow through a body vessel |
| US20110184454A1 (en) * | 2010-01-27 | 2011-07-28 | Penumbra, Inc. | Embolic implants |
| US9186149B2 (en) * | 2010-10-12 | 2015-11-17 | Boston Scientific Scimed, Inc. | Vaso-occlusive device |
| EP2672899A1 (en) * | 2011-02-11 | 2013-12-18 | Stryker Corporation | Vaso-occlusive device |
| US9011480B2 (en) * | 2012-01-20 | 2015-04-21 | Covidien Lp | Aneurysm treatment coils |
-
2013
- 2013-12-31 CN CN201310751427.0A patent/CN104739478B/en active Active
-
2014
- 2014-12-31 WO PCT/CN2014/095745 patent/WO2015101308A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015101308A1 (en) | 2015-07-09 |
| CN104739478A (en) | 2015-07-01 |
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