CN104666917A - Preparation method of agent for treating senile pneumonia in intensive care unit - Google Patents
Preparation method of agent for treating senile pneumonia in intensive care unit Download PDFInfo
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- CN104666917A CN104666917A CN201510109540.8A CN201510109540A CN104666917A CN 104666917 A CN104666917 A CN 104666917A CN 201510109540 A CN201510109540 A CN 201510109540A CN 104666917 A CN104666917 A CN 104666917A
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- herba
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- 206010035664 Pneumonia Diseases 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 20
- 239000003595 mist Substances 0.000 claims abstract description 13
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 16
- 241000862508 Ceriops Species 0.000 claims description 8
- 241000287828 Gallus gallus Species 0.000 claims description 8
- 241001091572 Kalanchoe Species 0.000 claims description 8
- 240000002853 Nelumbo nucifera Species 0.000 claims description 8
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 8
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 8
- 240000005332 Sorbus domestica Species 0.000 claims description 8
- 235000010425 Sorbus domestica Nutrition 0.000 claims description 8
- 244000025254 Cannabis sativa Species 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000003643 water by type Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000007919 dispersible tablet Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 241001444063 Aronia Species 0.000 abstract 1
- 241000862497 Ceriops tagal Species 0.000 abstract 1
- 235000008956 Dioscorea cirrhosa Nutrition 0.000 abstract 1
- 241001648081 Dioscorea cirrhosa Species 0.000 abstract 1
- 241000594394 Hedyotis Species 0.000 abstract 1
- 240000004835 Kalanchoe laciniata Species 0.000 abstract 1
- 241000350362 Monachosorum flagellare Species 0.000 abstract 1
- 241000725605 Pilea notata Species 0.000 abstract 1
- 241000904334 Plumbagella micrantha Species 0.000 abstract 1
- 240000008199 Rhododendron molle Species 0.000 abstract 1
- 241000285052 Saxifraga unguiculata Species 0.000 abstract 1
- 240000004802 Stachys palustris Species 0.000 abstract 1
- 235000008044 Stachys palustris Nutrition 0.000 abstract 1
- 241001643425 Tinospora sinensis Species 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 238000005303 weighing Methods 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 description 9
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 210000003714 granulocyte Anatomy 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 4
- 230000003448 neutrophilic effect Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 238000009534 blood test Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002685 pulmonary effect Effects 0.000 description 3
- 206010037833 rales Diseases 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010007558 Cardiac failure chronic Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010035720 Pneumonia lipoid Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 208000007067 lipid pneumonia Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method of an agent for treating senile pneumonia in an intensive care unit. The preparation method is characterized by comprising the following steps of weighing and grinding 900g herba eupatorii heterophylli, 700g chokeberry, 600g kalanchoe laciniata, 650g ceriops tagal, 500g saxifraga unguiculata, 500g capitellate hedyotis herb, 500g monachosorum flagellare, 450g dioscorea cirrhosa, 450g plumbagella micrantha, 400g tinospora sinensis merr, 450g herba cypripedii japonici, 400g Chinese azalea fruit, 400g lespedesa virgata, 350g stachys palustris and 300g pilea notata, sieving with a 30-mesh sieve, adding 18000mL water, heating for backflow for 5h in a flask equipped with a condenser tube, then filtering to form filtrate 1 and filter residue 1; 2) adding 16000mL water into the filter residue 1, heating in the flask equipped with the condenser tube for 3h, and filtering to form filtrate 2 and filter residue 2; and 3) merging the filtrate 1 and the filtrate 2, cooling room temperature, and putting in mist arresters, with 50mL filtrate in each mist arrester.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of preparation method for the treatment of the medicament of senile pneumonia in ICU.
Background technology
Senile pneumonia belongs to the category such as the traditional Chinese medical science " pathogenic wind-warm ", " lung-heat ", " cough ", " phlegm retention ", " the syndrome of dyspnea ", how due to worn with age, outer evil by wind-warm syndrome, caused by interior impairment of ZANG FU-organs.Modern medicine thinks that old people's function of immune system increases with the age and goes down, one of major reason that immune depression is senile pneumonia morbidity, case fatality rate increases.
Summary of the invention
The object of this invention is to provide a kind of preparation method for the treatment of the medicament of senile pneumonia in ICU.
In order to realize object of the present invention, the invention provides a kind of preparation method for the treatment of the medicament of senile pneumonia in ICU, it is characterized in that, the method comprises the following steps: to take red stalk grass 900 grams, Sorbus domestica 700 grams, Herba Kalanchoes Laciniatae 600 grams, Ceriop tagl (perr), c. B. Rob 650 grams, pawl Herba Saxifragae 500 grams, Lignum seu Radix Acronychiae 500 grams, the rare sub-Herba pteridii latiusculi 500 grams of caudal lobe, 450 grams, Sanguis Gallus domesticus lotus, Herba Plumbagellae Micranthae 450 grams, Herba Lycopodii 400 grams, Herba cypripedii japonici 450 grams, Fructus Rhododendri Mollis 400 grams, Herba lespedezae virgatae 400 grams, Wangjiang blue or green 350 grams and Rhizoma Belamcandae 300 grams, pulverize, cross 30 mesh sieves, add 18000 ml waters, reflux 5 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1, 2) in filtering residue 1, add 16000 ml waters, heat 3 hours in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2, 3) merge described filtrate 1, filtrate 2, be cooled to room temperature, load in mist arrester, 50 milliliters of filtrates are housed in each mist arrester.
The present invention also provides compositions being prepared in ICU the purposes for the treatment of in the medicine of senile pneumonia, and described compositions is made up of the material of following weight portion: red stalk careless 50-100 part, Sorbus domestica 50-80 part, Herba Kalanchoes Laciniatae 50-70 part, Ceriop tagl (perr), c. B. Rob 60-80 part, pawl Herba Saxifragae 40-70 part, Lignum seu Radix Acronychiae 40-60 part, the rare sub-Herba pteridii latiusculi 40-60 part of caudal lobe, Sanguis Gallus domesticus lotus 40-50 part, Herba Plumbagellae Micranthae 40-50 part, Herba Lycopodii 30-50 part, Herba cypripedii japonici 40-50 part, Fructus Rhododendri Mollis 30-50 part, Herba lespedezae virgatae 30-50 part, the blue or green 30-50 part in Wangjiang and Rhizoma Belamcandae 10-50 part.
Preferably, described compositions is made up of the material of following weight portion: red stalk grass 90 parts, Sorbus domestica 70 parts, Herba Kalanchoes Laciniatae 60 parts, Ceriop tagl (perr), c. B. Rob 65 parts, pawl Herba Saxifragae 50 parts, Lignum seu Radix Acronychiae 50 parts, the rare sub-Herba pteridii latiusculi 50 parts of caudal lobe, 45 parts, Sanguis Gallus domesticus lotus, Herba Plumbagellae Micranthae 45 parts, Herba Lycopodii 40 parts, Herba cypripedii japonici 45 parts, Fructus Rhododendri Mollis 40 parts, Herba lespedezae virgatae 40 parts, Wangjiang blue or green 35 parts and Rhizoma Belamcandae 30 parts.
More preferably, described medicine can be tablet, dispersible tablet, capsule, soft capsule or the agent of suction mist.
In the present compositions, red stalk grass, Sorbus domestica are monarch drug; Herba Kalanchoes Laciniatae, Ceriop tagl (perr), c. B. Rob, pawl Herba Saxifragae, Lignum seu Radix Acronychiae, the rare sub-Herba pteridii latiusculi of caudal lobe are ministerial drug; Sanguis Gallus domesticus lotus, Herba Plumbagellae Micranthae, Herba Lycopodii, Herba cypripedii japonici, Fructus Rhododendri Mollis, Herba lespedezae virgatae, Wangjiang green grass or young crops are adjuvant drug; Rhizoma Belamcandae coordinating the actions of various ingredients in a prescription, for making medicine.
Medicament of the present invention interacts, and synergism complements each other, and plays the merit of monarch altogether, treats senile pneumonia Be very effective in ICU, and clinic is promoted.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The agent of embodiment suction mist of the present invention
Take red stalk grass 900 grams, Sorbus domestica 700 grams, Herba Kalanchoes Laciniatae 600 grams, Ceriop tagl (perr), c. B. Rob 650 grams, pawl Herba Saxifragae 500 grams, Lignum seu Radix Acronychiae 500 grams, the rare sub-Herba pteridii latiusculi 500 grams of caudal lobe, 450 grams, Sanguis Gallus domesticus lotus, Herba Plumbagellae Micranthae 450 grams, Herba Lycopodii 400 grams, Herba cypripedii japonici 450 grams, Fructus Rhododendri Mollis 400 grams, Herba lespedezae virgatae 400 grams, Wangjiang blue or green 350 grams and Rhizoma Belamcandae 300 grams, pulverize, cross 30 mesh sieves, add 18000 ml waters, reflux 5 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1; 2) in filtering residue 1, add 16000 ml waters, heat 3 hours in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2; 3) merge described filtrate 1, filtrate 2, be cooled to room temperature, load in mist arrester, 50 milliliters of filtrates are housed in each mist arrester.
Experimental example
Diagnostic criteria
By " Community-Acquired Pneumonia and treatment guidelines (draft) " clinical criteria (respirology branch of Chinese Medical Association that respirology branch of Chinese Medical Association works out in April, 1999, Community-Acquired Pneumonia and treatment guidelines (draft) [J]. Chinese tuberculosis and breathing magazine, 19922 (4): 200.).Get rid of less than 60 years old age, the hurried deterioration person of the 24h state of an illness of being admitted to hospital, and radiation pneumonia, hypersensitivity pneumonitis, lipid pneumonia patient.
Choose patient 60 example meeting above-mentioned diagnostic criteria, man 34 example, female 26 example, age 61-82 year, average (71.5 ± 3.5) year.Wherein heating 9 example, cough 11 example, 10 examples of coughing up phlegm, 8 examples of panting, chest pain 7 example, 15 examples uncomfortable in chest, leukocyte>=10 × 10
9/ L or neutrophilic granulocyte are higher than 0.70 35 examples, and x-ray inspection abnormal 25 is routine.Underlying diseases is respectively chronic bronchitis 9 example, hypertension 19 example, diabetes 12 example, chronic heart failure 10 example, arrhythmia 10 example.
Use the suction mist agent prepared in embodiment to treat, every day 3 times, each patient puts on 1 mist arrester and treats, continuously treatment 10 days.
The standard of curative effect evaluation
Effective: to cough, disappearance of coughing up phlegm, pulmonary's moist rales disappears, and x-ray rabat shows that inflammation obviously disappears, routine blood test show neutrophilic granulocyte percentage when total white blood cells recover normal.Effective: to cough, alleviation of coughing up phlegm, pulmonary's moist rales alleviates, and x-ray rabat shows inflammation range shorter, routine blood test show neutrophilic granulocyte percentage when total white blood cells be tending towards normal.Invalid: cough, cough up phlegm and do not alleviate or increase the weight of, pulmonary's moist rales does not have unchanged or increases the weight of, and x-ray rabat shows that inflammation scope does not reduce, routine blood test show neutrophilic granulocyte percentage when total white blood cells without improvement.
Result
Through treatment, in 60 routine patients, effective 32 examples, effective 26 examples, invalid 2 examples, total effective rate is 96.7%.And do not find obvious untoward reaction over the course for the treatment of.
Claims (4)
1. in ICU, treat the preparation method of the medicament of senile pneumonia for one kind, it is characterized in that, the method can comprise the following steps: to take red stalk grass 900 grams, Sorbus domestica 700 grams, Herba Kalanchoes Laciniatae 600 grams, Ceriop tagl (perr), c. B. Rob 650 grams, pawl Herba Saxifragae 500 grams, Lignum seu Radix Acronychiae 500 grams, the rare sub-Herba pteridii latiusculi 500 grams of caudal lobe, 450 grams, Sanguis Gallus domesticus lotus, Herba Plumbagellae Micranthae 450 grams, Herba Lycopodii 400 grams, Herba cypripedii japonici 450 grams, Fructus Rhododendri Mollis 400 grams, Herba lespedezae virgatae 400 grams, Wangjiang blue or green 350 grams and Rhizoma Belamcandae 300 grams, pulverize, cross 30 mesh sieves, add 18000 ml waters, reflux 5 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1, 2) in filtering residue 1, add 16000 ml waters, heat 3 hours in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2, 3) merge described filtrate 1, filtrate 2, be cooled to room temperature, load in mist arrester, 50 milliliters of filtrates are housed in each mist arrester.
2. compositions is being prepared in ICU the purposes for the treatment of in the medicine of senile pneumonia, it is characterized in that, described compositions is made up of the material of following weight portion: red stalk careless 50-100 part, Sorbus domestica 50-80 part, Herba Kalanchoes Laciniatae 50-70 part, Ceriop tagl (perr), c. B. Rob 60-80 part, pawl Herba Saxifragae 40-70 part, Lignum seu Radix Acronychiae 40-60 part, the rare sub-Herba pteridii latiusculi 40-60 part of caudal lobe, Sanguis Gallus domesticus lotus 40-50 part, Herba Plumbagellae Micranthae 40-50 part, Herba Lycopodii 30-50 part, Herba cypripedii japonici 40-50 part, Fructus Rhododendri Mollis 30-50 part, Herba lespedezae virgatae 30-50 part, the blue or green 30-50 part in Wangjiang and Rhizoma Belamcandae 10-50 part.
3. purposes according to claim 2, it is characterized in that, described compositions is made up of the material of following weight portion: red stalk grass 90 parts, Sorbus domestica 70 parts, Herba Kalanchoes Laciniatae 60 parts, Ceriop tagl (perr), c. B. Rob 65 parts, pawl Herba Saxifragae 50 parts, Lignum seu Radix Acronychiae 50 parts, the rare sub-Herba pteridii latiusculi 50 parts of caudal lobe, 45 parts, Sanguis Gallus domesticus lotus, Herba Plumbagellae Micranthae 45 parts, Herba Lycopodii 40 parts, Herba cypripedii japonici 45 parts, Fructus Rhododendri Mollis 40 parts, Herba lespedezae virgatae 40 parts, Wangjiang blue or green 35 parts and Rhizoma Belamcandae 30 parts.
4. purposes according to claim 3, is characterized in that, described medicine can be tablet, dispersible tablet, capsule, soft capsule or the agent of suction mist.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510109540.8A CN104666917A (en) | 2015-03-12 | 2015-03-12 | Preparation method of agent for treating senile pneumonia in intensive care unit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510109540.8A CN104666917A (en) | 2015-03-12 | 2015-03-12 | Preparation method of agent for treating senile pneumonia in intensive care unit |
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| CN104666917A true CN104666917A (en) | 2015-06-03 |
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| CN201510109540.8A Pending CN104666917A (en) | 2015-03-12 | 2015-03-12 | Preparation method of agent for treating senile pneumonia in intensive care unit |
Country Status (1)
| Country | Link |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004041158A2 (en) * | 2002-09-23 | 2004-05-21 | Activbiotics, Inc. | Rifalazil compositions and therapeutic regimens |
| CN101947297A (en) * | 2010-09-17 | 2011-01-19 | 北京中医药大学东直门医院 | Chinese medicinal composition for treating senile pneumonia, decoction-free granules and preparation method thereof |
| CN103585508A (en) * | 2013-11-29 | 2014-02-19 | 青岛友铭辰生物技术有限公司 | Senile pneumonia treatment traditional Chinese medicine oral liquid and preparation method thereof |
-
2015
- 2015-03-12 CN CN201510109540.8A patent/CN104666917A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004041158A2 (en) * | 2002-09-23 | 2004-05-21 | Activbiotics, Inc. | Rifalazil compositions and therapeutic regimens |
| CN101947297A (en) * | 2010-09-17 | 2011-01-19 | 北京中医药大学东直门医院 | Chinese medicinal composition for treating senile pneumonia, decoction-free granules and preparation method thereof |
| CN103585508A (en) * | 2013-11-29 | 2014-02-19 | 青岛友铭辰生物技术有限公司 | Senile pneumonia treatment traditional Chinese medicine oral liquid and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张蕊: "清热化湿法治疗老年社区获得性肺炎湿热郁肺证的疗效研究", 《中国全科医学》 * |
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