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CL2023002705A1 - Nuevos derivados de tiazolopirimidinona - Google Patents

Nuevos derivados de tiazolopirimidinona

Info

Publication number
CL2023002705A1
CL2023002705A1 CL2023002705A CL2023002705A CL2023002705A1 CL 2023002705 A1 CL2023002705 A1 CL 2023002705A1 CL 2023002705 A CL2023002705 A CL 2023002705A CL 2023002705 A CL2023002705 A CL 2023002705A CL 2023002705 A1 CL2023002705 A1 CL 2023002705A1
Authority
CL
Chile
Prior art keywords
new
thiazolopyrimidinone
derivatives
thiazolopyrimidinone derivatives
compound
Prior art date
Application number
CL2023002705A
Other languages
English (en)
Inventor
Cosimo Dolente
Hasane Ratni
Virginie Brom
Delphine Gaufreteau
Nadine Grether
Fionn Susannah O'hara
Matilde Piras
Michael Reutlinger
Walter Vifian
Claudio Zambaldo
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2023002705A1 publication Critical patent/CL2023002705A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a un compuesto de fórmula (I); en el que R1-R4 y A1-A3 son como se definen en la descripción y en las reivindicaciones. El compuesto de fórmula (I) se puede usar como un medicamento.
CL2023002705A 2021-03-17 2023-09-11 Nuevos derivados de tiazolopirimidinona CL2023002705A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP21163259 2021-03-17

Publications (1)

Publication Number Publication Date
CL2023002705A1 true CL2023002705A1 (es) 2024-03-15

Family

ID=74947249

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002705A CL2023002705A1 (es) 2021-03-17 2023-09-11 Nuevos derivados de tiazolopirimidinona

Country Status (16)

Country Link
US (1) US20240018163A1 (es)
EP (1) EP4308576B1 (es)
JP (1) JP2024514421A (es)
KR (1) KR20230157367A (es)
CN (1) CN116981674A (es)
AU (1) AU2022240935A1 (es)
BR (1) BR112023018466A2 (es)
CA (1) CA3212341A1 (es)
CL (1) CL2023002705A1 (es)
CO (1) CO2023012574A2 (es)
CR (1) CR20230437A (es)
IL (1) IL305203A (es)
MX (1) MX2023010719A (es)
PE (1) PE20241189A1 (es)
TW (1) TW202302604A (es)
WO (1) WO2022194801A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022020418A2 (pt) * 2020-04-08 2023-05-02 Remix Therapeutics Inc Compostos e métodos para modulação de splicing
WO2023064879A1 (en) * 2021-10-13 2023-04-20 Remix Therapeutics Inc. Compounds and methods for modulating nucleic acid splicing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119528903A (zh) 2012-02-10 2025-02-28 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
PL3663296T3 (pl) 2014-05-15 2023-08-07 F. Hoffmann-La Roche Ag Sposób wytwarzania związków użytecznych w leczeniu rdzeniowego zaniku mięśni
KR20200033249A (ko) * 2017-06-05 2020-03-27 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 화합물
CA3067591A1 (en) * 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
MX2020002711A (es) 2017-09-22 2020-07-20 Hoffmann La Roche Proceso para preparacion de 7-(4,7-diazaespiro[2.5]octan-7-il)-2-( 2,8-dimetilimidazo[1,2-b]piridazin-6-il)pirido[1,2-a]pirimidin-4- ona.
EP3814360B8 (en) * 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
EA202092899A1 (ru) * 2018-06-27 2021-05-14 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Гетероарильные соединения для лечения болезни гентингтона
BR112022020418A2 (pt) * 2020-04-08 2023-05-02 Remix Therapeutics Inc Compostos e métodos para modulação de splicing

Also Published As

Publication number Publication date
WO2022194801A1 (en) 2022-09-22
BR112023018466A2 (pt) 2023-10-10
CN116981674A (zh) 2023-10-31
PE20241189A1 (es) 2024-06-03
CA3212341A1 (en) 2022-09-22
AU2022240935A1 (en) 2023-08-24
EP4308576A1 (en) 2024-01-24
IL305203A (en) 2023-10-01
MX2023010719A (es) 2023-09-20
EP4308576C0 (en) 2025-04-23
CO2023012574A2 (es) 2023-09-29
TW202302604A (zh) 2023-01-16
KR20230157367A (ko) 2023-11-16
JP2024514421A (ja) 2024-04-02
EP4308576B1 (en) 2025-04-23
US20240018163A1 (en) 2024-01-18
CR20230437A (es) 2023-10-16

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