CL2022000758A1 - Tienopirimidonas como inhibidores de trpa1 - Google Patents
Tienopirimidonas como inhibidores de trpa1Info
- Publication number
- CL2022000758A1 CL2022000758A1 CL2022000758A CL2022000758A CL2022000758A1 CL 2022000758 A1 CL2022000758 A1 CL 2022000758A1 CL 2022000758 A CL2022000758 A CL 2022000758A CL 2022000758 A CL2022000758 A CL 2022000758A CL 2022000758 A1 CL2022000758 A1 CL 2022000758A1
- Authority
- CL
- Chile
- Prior art keywords
- thienopyrimidones
- trpa1 inhibitors
- inhibitors
- diseases
- trpa1
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101100482465 Caenorhabditis elegans trpa-1 gene Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 101000764872 Homo sapiens Transient receptor potential cation channel subfamily A member 1 Proteins 0.000 abstract 1
- 102100026186 Transient receptor potential cation channel subfamily A member 1 Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invención se refiere a tienopirimidinonas y a su uso como inhibidores de la actividad de TRPA1, a composiciones farmacéuticas que las contienen, y a métodos para usarlas como agentes para el tratamiento y/o la prevención de enfermedades fibróticas, enfermedades inflamatorias y autoinmunitarias y enfermedades relacionadas con el SNC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19203171 | 2019-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022000758A1 true CL2022000758A1 (es) | 2023-01-20 |
Family
ID=68289872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2022000758A CL2022000758A1 (es) | 2019-10-15 | 2022-03-25 | Tienopirimidonas como inhibidores de trpa1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11136336B2 (es) |
| EP (1) | EP4045509A1 (es) |
| JP (1) | JP7376706B2 (es) |
| KR (1) | KR20220083778A (es) |
| CN (1) | CN114929712B (es) |
| AU (1) | AU2020366553A1 (es) |
| BR (1) | BR112022003862A2 (es) |
| CA (1) | CA3153618A1 (es) |
| CL (1) | CL2022000758A1 (es) |
| IL (1) | IL292093A (es) |
| MX (1) | MX2022004565A (es) |
| PH (1) | PH12022550843A1 (es) |
| TW (1) | TW202132309A (es) |
| WO (1) | WO2021074196A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7612682B2 (ja) | 2019-10-15 | 2025-01-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なテトラゾール |
| TW202229292A (zh) * | 2020-10-14 | 2022-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為trpa1抑制劑之四唑衍生物 |
| IL301717A (en) * | 2020-10-14 | 2023-05-01 | Boehringer Ingelheim Int | Tetrazole history as TRPA1 inhibitors |
| JP7617306B2 (ja) * | 2021-04-14 | 2025-01-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｔｒｐａ１阻害剤としてのウラシル誘導体 |
| EP4323364A1 (en) * | 2021-04-14 | 2024-02-21 | Boehringer Ingelheim International GmbH | Imidazo[4,5-d]pyridazinonyl derivatives as trpa1 inhibitors |
| AU2022257269A1 (en) | 2021-04-14 | 2023-08-17 | Boehringer Ingelheim International Gmbh | 3H,4H-THIENO[2,3-d]PYRIMIDIN-4-ONE DERIVATIVES AS TRPA1 INHIBITORS |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8592398B2 (en) * | 2010-12-20 | 2013-11-26 | Glenmark Pharmaceuticals, S.A. | 2-amino-4-arylthiazole compounds as TRPA1 antagonists |
| RU2014100744A (ru) * | 2011-06-13 | 2015-07-20 | Гленмарк Фармасьютикалс С.А. | Лечение респираторных нарушений с помощью trpa1 антагонистов |
| JP6573968B2 (ja) | 2014-08-11 | 2019-09-11 | ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | ＴＲＰＣ５調節因子としての、精神神経障害の処置のためのチエノおよびフロ［２，３−ｄ］ピリミジン−２，４［１Ｈ，３Ｈ］−ジオン誘導体 |
| CN105335639A (zh) * | 2014-08-15 | 2016-02-17 | 中兴通讯股份有限公司 | 一种电子设备中功能锁的实现方法和装置 |
| WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
| WO2017060488A1 (en) * | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
-
2020
- 2020-10-14 MX MX2022004565A patent/MX2022004565A/es unknown
- 2020-10-14 CN CN202080072028.XA patent/CN114929712B/zh active Active
- 2020-10-14 CA CA3153618A patent/CA3153618A1/en active Pending
- 2020-10-14 AU AU2020366553A patent/AU2020366553A1/en not_active Abandoned
- 2020-10-14 KR KR1020227016329A patent/KR20220083778A/ko not_active Withdrawn
- 2020-10-14 PH PH1/2022/550843A patent/PH12022550843A1/en unknown
- 2020-10-14 WO PCT/EP2020/078853 patent/WO2021074196A1/en not_active Ceased
- 2020-10-14 TW TW109135462A patent/TW202132309A/zh unknown
- 2020-10-14 JP JP2022521748A patent/JP7376706B2/ja active Active
- 2020-10-14 BR BR112022003862A patent/BR112022003862A2/pt not_active Application Discontinuation
- 2020-10-14 EP EP20790303.0A patent/EP4045509A1/en active Pending
- 2020-10-15 US US17/071,081 patent/US11136336B2/en active Active
-
2022
- 2022-03-25 CL CL2022000758A patent/CL2022000758A1/es unknown
- 2022-04-10 IL IL292093A patent/IL292093A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020366553A1 (en) | 2022-03-31 |
| CN114929712B (zh) | 2024-07-23 |
| MX2022004565A (es) | 2022-05-06 |
| KR20220083778A (ko) | 2022-06-20 |
| CN114929712A (zh) | 2022-08-19 |
| PH12022550843A1 (en) | 2023-07-03 |
| JP2022551712A (ja) | 2022-12-13 |
| TW202132309A (zh) | 2021-09-01 |
| US11136336B2 (en) | 2021-10-05 |
| BR112022003862A2 (pt) | 2022-08-23 |
| EP4045509A1 (en) | 2022-08-24 |
| CA3153618A1 (en) | 2021-04-22 |
| US20210107918A1 (en) | 2021-04-15 |
| IL292093A (en) | 2022-06-01 |
| WO2021074196A1 (en) | 2021-04-22 |
| JP7376706B2 (ja) | 2023-11-08 |
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