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CL2019003820A1 - Compuestos y métodos para la modulación de smn2. (divisional solicitud 201900115) - Google Patents

Compuestos y métodos para la modulación de smn2. (divisional solicitud 201900115)

Info

Publication number
CL2019003820A1
CL2019003820A1 CL2019003820A CL2019003820A CL2019003820A1 CL 2019003820 A1 CL2019003820 A1 CL 2019003820A1 CL 2019003820 A CL2019003820 A CL 2019003820A CL 2019003820 A CL2019003820 A CL 2019003820A CL 2019003820 A1 CL2019003820 A1 CL 2019003820A1
Authority
CL
Chile
Prior art keywords
compounds
smn2
methods
modulation
divisional request
Prior art date
Application number
CL2019003820A
Other languages
English (en)
Inventor
Thazha P Prakash
Frank Rigo
Punit P Seth
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60952211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2019003820(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of CL2019003820A1 publication Critical patent/CL2019003820A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

EN LA PRESENTE SE DESCRIBEN COMPUESTOS, COMPOSICIONES Y MÉTODOS PARA MODULAR EL EMPALME DE SMN2. TAMBIÉN SE PROPORCIONAN USOS DE LOS COMPUESTOS Y COMPOSICIONES DESCRITOS EN LA FABRICACIÓN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE LA ATROFIA MUSCULAR ESPINAL.
CL2019003820A 2016-07-15 2019-12-23 Compuestos y métodos para la modulación de smn2. (divisional solicitud 201900115) CL2019003820A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662363195P 2016-07-15 2016-07-15

Publications (1)

Publication Number Publication Date
CL2019003820A1 true CL2019003820A1 (es) 2020-07-10

Family

ID=60952211

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019000115A CL2019000115A1 (es) 2016-07-15 2019-01-15 Compuestos y métodos para la modulación de smn2.
CL2019003820A CL2019003820A1 (es) 2016-07-15 2019-12-23 Compuestos y métodos para la modulación de smn2. (divisional solicitud 201900115)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2019000115A CL2019000115A1 (es) 2016-07-15 2019-01-15 Compuestos y métodos para la modulación de smn2.

Country Status (26)

Country Link
US (3) US20190323006A1 (es)
EP (2) EP4206213A1 (es)
JP (3) JP7197463B2 (es)
KR (1) KR102556825B1 (es)
CN (1) CN109844115B (es)
AU (2) AU2017297622A1 (es)
BR (1) BR112019000356A2 (es)
CA (1) CA3030864A1 (es)
CL (2) CL2019000115A1 (es)
CO (1) CO2019001236A2 (es)
DK (1) DK3484524T3 (es)
ES (1) ES2935658T3 (es)
FI (1) FI3484524T3 (es)
HR (1) HRP20221378T1 (es)
HU (1) HUE060831T2 (es)
IL (2) IL308256A (es)
LT (1) LT3484524T (es)
MX (1) MX2019000619A (es)
PE (1) PE20190513A1 (es)
PL (1) PL3484524T3 (es)
PT (1) PT3484524T (es)
RS (1) RS63928B1 (es)
SG (1) SG11201900238UA (es)
SI (1) SI3484524T1 (es)
SM (1) SMT202200489T1 (es)
WO (1) WO2018014041A2 (es)

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US9885040B2 (en) * 2013-04-12 2018-02-06 The Curators Of The University Of Missouri SMN2 element 1 antisense compositions and methods and uses thereof
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WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
EP3436461B1 (en) 2016-03-28 2023-11-01 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
MY208007A (en) 2017-09-27 2025-04-04 Incyte Corp Salts of pyrrolotriazine derivatives useful as tam inhibitors
AR117600A1 (es) 2018-06-29 2021-08-18 Incyte Corp Formulaciones de un inhibidor de axl / mer
BR112022000870A2 (pt) * 2019-07-19 2022-03-22 Biogen Ma Inc Métodos de tratamento ou prevenção da atrofia muscular espinhal
WO2021030766A1 (en) * 2019-08-15 2021-02-18 Biogen Ma Inc. Combination therapy for spinal muscular atrophy
JP7737667B2 (ja) * 2019-09-18 2025-09-11 国立大学法人東京科学大学 核酸複合体
JP7446443B2 (ja) * 2020-02-28 2024-03-08 アイオーニス ファーマシューティカルズ， インコーポレーテッド Ｓｍｎ２を調節するための化合物及び方法
EP4114401A1 (en) 2020-03-06 2023-01-11 Incyte Corporation Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
JP2024516183A (ja) * 2021-04-22 2024-04-12 モレキュラー アクシオム エルエルシー Ｓｏｓ遺伝子発現を調節するための組成物及び方法
FR3128873A1 (fr) 2021-11-10 2023-05-12 Biophytis Phytoecdysones et/ou dérivés de 20-hydroxyecdysone en combinaison avec un principe actif visant à restaurer l’expression SMN pour leur utilisation dans le traitement de l’amyotrophie spinale

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