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CL2019002739A1 - Receptores de antígenos quiméricos y células t y métodos de uso. (divisional solicitud 201802762). - Google Patents

Receptores de antígenos quiméricos y células t y métodos de uso. (divisional solicitud 201802762).

Info

Publication number
CL2019002739A1
CL2019002739A1 CL2019002739A CL2019002739A CL2019002739A1 CL 2019002739 A1 CL2019002739 A1 CL 2019002739A1 CL 2019002739 A CL2019002739 A CL 2019002739A CL 2019002739 A CL2019002739 A CL 2019002739A CL 2019002739 A1 CL2019002739 A1 CL 2019002739A1
Authority
CL
Chile
Prior art keywords
cells
methods
chimeric antigen
divisional application
antigen receptors
Prior art date
Application number
CL2019002739A
Other languages
English (en)
Inventor
Jed Wiltzius
Original Assignee
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of CL2019002739A1 publication Critical patent/CL2019002739A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K—PEPTIDES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA INVENCIÓN PROPORCIONA UN RECEPTOR DE ANTÍGENO QUIMÉRICO (CAR) O UN RECEPTOR DE CÉLULAS T (TCR) QUE COMPRENDE UN DOMINIO EXTRACELULAR DIVULGADO EN LA PRESENTE. ALGUNOS ASPECTOS DE LA INVENCIÓN SE REFIEREN A UN POLINUCLEÓTIDO QUE CODIFICA UN RECEPTOR DE ANTÍGENO QUIMÉRICO (CAR) O UN RECEPTOR DE CÉLULAS T (TCR) QUE COMPRENDE EL DOMINIO EXTRACELULAR DIVULGADO EN LA PRESENTE. OTROS ASPECTOS DE LA INVENCIÓN SE REFIEREN A CÉLULAS QUE COMPRENDEN EL CAR O EL TCR Y SU USO EN UNA TERAPIA DE CÉLULAS T.
CL2019002739A 2016-04-01 2019-09-26 Receptores de antígenos quiméricos y células t y métodos de uso. (divisional solicitud 201802762). CL2019002739A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662317258P 2016-04-01 2016-04-01

Publications (1)

Publication Number Publication Date
CL2019002739A1 true CL2019002739A1 (es) 2020-02-28

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CL2018002762A CL2018002762A1 (es) 2016-04-01 2018-09-27 Receptores de antígeno quimérico y células t y métodos de uso.
CL2019002739A CL2019002739A1 (es) 2016-04-01 2019-09-26 Receptores de antígenos quiméricos y células t y métodos de uso. (divisional solicitud 201802762).

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CL2018002762A CL2018002762A1 (es) 2016-04-01 2018-09-27 Receptores de antígeno quimérico y células t y métodos de uso.

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US (2) US10603380B2 (es)
EP (2) EP3984559A1 (es)
JP (2) JP7034934B2 (es)
KR (2) KR102584280B1 (es)
CN (1) CN109328074A (es)
AR (2) AR108427A1 (es)
AU (2) AU2017240667C1 (es)
BR (1) BR112018070073A2 (es)
CA (1) CA3019149A1 (es)
CL (2) CL2018002762A1 (es)
CO (1) CO2018010453A2 (es)
CR (1) CR20180461A (es)
CU (1) CU20180121A7 (es)
DO (1) DOP2018000213A (es)
EA (1) EA201891965A1 (es)
EC (1) ECSP18073833A (es)
ES (1) ES2891578T3 (es)
IL (2) IL261941B2 (es)
MX (2) MX391308B (es)
PE (1) PE20190173A1 (es)
PH (1) PH12018550163A1 (es)
PL (1) PL3436079T3 (es)
PT (1) PT3436079T (es)
SA (1) SA518400135B1 (es)
SG (2) SG10201912489QA (es)
SI (1) SI3436079T1 (es)
SV (1) SV2018005756A (es)
TW (3) TWI691596B (es)
WO (1) WO2017173256A1 (es)

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GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
AU2015270912B9 (en) * 2014-06-02 2021-01-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting CD-19
US11253546B2 (en) 2014-12-15 2022-02-22 The Regents Of The University Of California Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR20180029201A (ko) 2015-05-18 2018-03-20 티씨알2 테라퓨틱스 인크. 융합 단백질을 이용하는 tcr 리프로그래밍을 위한 조성물 및 방법
KR20230148387A (ko) 2015-05-28 2023-10-24 카이트 파마 인코포레이티드 T 세포 요법을 위한 진단 방법
BR112017025166A2 (en) * 2015-05-28 2018-07-31 Kite Pharma, Inc. Methods of Conditioning Patients for T-Cell Therapy
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