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CL2018001634A1 - Compuestos sustituidos de 4-fenilpiridina como agonistas de tgr5 no sistémicos - Google Patents

Compuestos sustituidos de 4-fenilpiridina como agonistas de tgr5 no sistémicos

Info

Publication number
CL2018001634A1
CL2018001634A1 CL2018001634A CL2018001634A CL2018001634A1 CL 2018001634 A1 CL2018001634 A1 CL 2018001634A1 CL 2018001634 A CL2018001634 A CL 2018001634A CL 2018001634 A CL2018001634 A CL 2018001634A CL 2018001634 A1 CL2018001634 A1 CL 2018001634A1
Authority
CL
Chile
Prior art keywords
substituted
systemic
tgr5 agonists
diabetes
phenylpyridine compounds
Prior art date
Application number
CL2018001634A
Other languages
English (en)
Inventor
Jason G Lewis
Michael Robert Leadbetter
Jeremy Caldwell
Dean Dragoli
Noah Bell
Jeffrey W Jacobs
Patricia Finn
Rakesh Jain
Tao Chen
Matthew Siegel
Original Assignee
Ardelyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardelyx Inc filed Critical Ardelyx Inc
Publication of CL2018001634A1 publication Critical patent/CL2018001634A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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Abstract

LA INVENCIÓN SE REFIERE AGONISTAS DE TGR5 NO SISTÉMICO DE FÓRMULA: (1) DONDE LAS VARIABLES SE DESCRIBEN EN LA PRESENTE, ÚTILES PARA TRATAR DIARREA I L INDUCIDA POR QUIMIOTERAPIA, ALTERACIONES EN EL METABOLISMO DEL AZÚCAR R, (DIABETES, DM II, HIPERGLICEMIA, INSULINORESISTENCIA, ETC), OBESIDAD, SÍNDROME R METABÓLICO, COLITIS ULCERANTE, CROHN, TRASTORNOS DE LA NUTRICIÓN PARENTERAL [1 ESPECIALMENTE EN EL SÍNDROME DE INTESTINO CORTO Y DE COLON IRRITABLE Y OTRAS ENFERMEDADES Y TRASTORNOS ASOCIADOS CON TGR5.
CL2018001634A 2015-12-18 2018-06-15 Compuestos sustituidos de 4-fenilpiridina como agonistas de tgr5 no sistémicos CL2018001634A1 (es)

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