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CL2018000805A1 - Compuestos terapéuticos y sus métodos de uso. - Google Patents

Compuestos terapéuticos y sus métodos de uso.

Info

Publication number
CL2018000805A1
CL2018000805A1 CL2018000805A CL2018000805A CL2018000805A1 CL 2018000805 A1 CL2018000805 A1 CL 2018000805A1 CL 2018000805 A CL2018000805 A CL 2018000805A CL 2018000805 A CL2018000805 A CL 2018000805A CL 2018000805 A1 CL2018000805 A1 CL 2018000805A1
Authority
CL
Chile
Prior art keywords
methods
therapeutic compounds
compounds
ring
compositions
Prior art date
Application number
CL2018000805A
Other languages
English (en)
Inventor
Sultan Chowdhury
Brian Safina
Christoph Martin Dehnhardt
Michael Edward Grimwood
Zhiguo Liu
Daniel Sutherlin
Phillipe Bergeron
Kristen Burford
Thilo Focken
Abid Hasan
Kwong Wah Lai
Steven Mckerrall
Teresa Phuongtram Nguyen
Tao Wang
Original Assignee
Genentech Inc
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Xenon Pharmaceuticals Inc filed Critical Genentech Inc
Publication of CL2018000805A1 publication Critical patent/CL2018000805A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)

Abstract

<p>LA INVENCIÓN PROPORCIONA UN COMPUESTO DE FÓRMULA, O UNA SAL DE ESTE, DONDE LAS VARIABLES RAA, N, ANILLO A, ANILLO B, Rlb, Rla, R2, R3, R4, R5, R6, R7, R8 y R9 TIENEN EL SIGNIFICADO DESCRITO EN LA PRESENTE Y COMPOSICIONES QUE CONTIENEN ESTOS COMPUESTOS Y MÉTODOS PARA USAR TALES COMPUESTOS Y COMPOSICIONES. </p>
CL2018000805A 2015-09-28 2018-03-28 Compuestos terapéuticos y sus métodos de uso. CL2018000805A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562233863P 2015-09-28 2015-09-28
US201662298817P 2016-02-23 2016-02-23
CN2016096659 2016-08-25

Publications (1)

Publication Number Publication Date
CL2018000805A1 true CL2018000805A1 (es) 2018-07-06

Family

ID=57137267

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018000805A CL2018000805A1 (es) 2015-09-28 2018-03-28 Compuestos terapéuticos y sus métodos de uso.

Country Status (21)

Country Link
US (2) US10787446B2 (es)
EP (1) EP3356360A1 (es)
JP (1) JP6987746B2 (es)
KR (1) KR20180067561A (es)
CN (1) CN108290881B (es)
AU (1) AU2016330503B2 (es)
BR (1) BR112018006189A2 (es)
CA (1) CA2999769A1 (es)
CL (1) CL2018000805A1 (es)
CO (1) CO2018003909A2 (es)
CR (1) CR20180242A (es)
HK (1) HK1258056A1 (es)
IL (1) IL258192A (es)
MX (1) MX386501B (es)
PE (1) PE20181003A1 (es)
PH (1) PH12018500668A1 (es)
RU (1) RU2018115718A (es)
SG (1) SG10202007787RA (es)
TW (1) TWI726916B (es)
WO (1) WO2017058821A1 (es)
ZA (1) ZA201802134B (es)

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CN112321494B (zh) * 2020-11-17 2022-04-19 上海凌凯医药科技有限公司 一种制备2-氯-4-异丙基吡啶的方法
WO2023028056A1 (en) * 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
TWI860146B (zh) * 2023-10-30 2024-10-21 泰盈光電股份有限公司 電致變色組成物及電致變色裝置

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